Anti-Inflammatory and Active Biological Properties of the Plant-Derived Bioactive Compounds Luteolin and Luteolin 7-Glucoside

Nutrients, Journal Year: 2022, Volume and Issue: 14(6), P. 1155 - 1155

Published: March 9, 2022

Flavonoids are interesting molecules synthetized by plants. They can be found abundantly in seeds and fruits, determining the color, flavor, other organoleptic characteristics, as well contributing to important nutritional aspects. Beyond these due their biochemical properties they considered bioactive compounds. Several studies have demonstrated biological activity different cellular physiological processes high-order organisms including humans. The flavonoid molecular structure confers capability of reacting with neutralizing reactive oxygen species (ROS), behaving scavengers all generating this class molecules, such UV irradiation, a process widely present plant physiology. Importantly, recent scientific literature has that flavonoids, human physiology, active compounds acting not only but also role counteracting inflammation process. Among wide variety significant results been shown investigating flavones luteolin luteolin-7-O-glucoside (LUT-7G). For compounds, experimental an anti-inflammatory action, both vitro vivo, interaction JAK/STAT3, NF-κB, pathways described review. We describe effects metabolic connected inflammation, glycolysis, diabetes, lipid peroxidation, cancer cells. Moreover, inhibition inflammatory pathway endothelial tissue, NLRP3 inflammasome assembly, demonstrates key progression phenomena. Since micronutrient obtained from food, open new perspectives respect long-term health status healthy individuals, use coadjutant treatment specific diseases.

Language: Английский

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Flavonoids: Overview of Biosynthesis, Biological Activity, and Current Extraction Techniques

Plants, Journal Year: 2023, Volume and Issue: 12(14), P. 2732 - 2732

Published: July 23, 2023

Recently, increased attention has been paid to natural sources as raw materials for the development of new added-value products. Flavonoids are a large family polyphenols which include several classes based on their basic structure: flavanones, flavones, isoflavones, flavonols, flavanols, and anthocyanins. They have multitude biological properties, such anti-inflammatory, antioxidant, antiviral, antimicrobial, anticancer, cardioprotective, neuroprotective effects. Current trends research flavonoids relate identification, extraction, isolation, physico-chemical characterization, applications health benefits. This review presents an up-to-date survey most recent developments in flavonoid classes, activity representative flavonoids, current extraction techniques, perspectives.

Language: Английский

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The Interaction between Flavonoids and Intestinal Microbes: A Review

Foods, Journal Year: 2023, Volume and Issue: 12(2), P. 320 - 320

Published: Jan. 9, 2023

In recent years, research on the interaction between flavonoids and intestinal microbes have prompted a rash of food science, nutriology biomedicine, complying with future trends. The gut microbiota plays an essential role in maintenance homeostasis human health, but once flora dysregulation occurs, it may contribute to various diseases. Flavonoids shown variety physiological activities, are metabolized or biotransformed by microbiota, thereby producing new metabolites that promote health modulating composition structure flora. Herein, this review demonstrates key notion as well dysbiosis, aiming provide comprehensive understanding about how regulate diseases microbiota. Emphasis is placed microbiota-flavonoid bidirectional affects metabolic fate their metabolites, influencing mechanism, biotransformation, bioavailability bioactivity. Potentially focusing abundance diversity such bile acids, we discuss influence mechanism protecting barrier function immune system. Additionally, crucial regulating We explain underlying regulation several typical including gastrointestinal diseases, obesity, diabetes cancer, theoretical basis guideline for promotion treatment

Language: Английский

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Interactions between gut microbiota and polyphenols: A mechanistic and metabolomic review

Phytomedicine, Journal Year: 2023, Volume and Issue: 119, P. 154979 - 154979

Published: July 18, 2023

Language: Английский

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A Comprehensive Review of Free Radicals, Oxidative Stress, and Antioxidants: Overview, Clinical Applications, Global Perspectives, Future Directions, and Mechanisms of Antioxidant Activity of Flavonoid Compounds

Journal of Chemistry, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 21

Published: May 31, 2024

Absorption​ of free radicals in the body cannot be done by antioxidant compounds originating from human body, so exogenous antioxidants are required to help their natural action. Oxidative stress can caused an imbalance radical inhibitors and accumulation that enter cellular structures. Synthetic found external not primary choice because they harmful carcinogenic. Therefore, using ingredients provides a necessary alternative constructing novel antioxidants. Recent studies have highlighted critical analysis evaluation flavonoids unique class secondary metabolites plants used communities as traditional therapeutics with proven bioactivity. This could support new discoveries based on various herbal medicines addition, functional effectiveness against radicals. In this review, there several strengths discussion. First, study takes comprehensive approach covering aspects, including properties sources radicals, oxidative relation different diseases, defense mechanisms, specific mechanisms flavonoids. Second, focus antioxidants, especially flavonoids, also discussion about clinical applications studies, limitations, global perspectives, future research directions become references selection medicines. But, constraints should considered when interpreting findings review. mechanism is only discussed general one example compound (flavonoid) has potential antioxidant. lack regarding relationship between diseases Third, limited number investigated some discussed.

Language: Английский

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Flavonoids: Antioxidant Powerhouses and Their Role in Nanomedicine

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 922 - 922

Published: July 29, 2024

This study emphasizes the critical role of antioxidants in protecting human health by counteracting detrimental effects oxidative stress induced free radicals. Antioxidants-found various forms such as vitamins, minerals, and phytochemicals abundant fruits vegetables-neutralize radicals stabilizing them through electron donation. Specifically, flavonoid compounds are highlighted robust defenders, addressing inflammation to avert chronic illnesses like cancer, cardiovascular diseases, neurodegenerative diseases. research explores bioactive potential flavonoids, shedding light on their not only safeguarding health, but also managing conditions diabetes, review highlights novel integration South African-origin flavonoids with nanotechnology, presenting a cutting-edge strategy improve drug delivery therapeutic outcomes. interdisciplinary approach, blending traditional wisdom contemporary techniques, propels exploration flavonoid-mediated nanoparticles toward groundbreaking pharmaceutical applications, promising revolutionary advancements healthcare. collaborative synergy between knowledge modern science contributes underscores significant step sustainable impactful biomedical innovations, aligning principles environmental conservation.

Language: Английский

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Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(20), P. 11069 - 11069

Published: Oct. 14, 2021

The ongoing COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a globally leading public health concern over past two years. Despite development and administration of multiple vaccines, mutation newer strains challenges to universal immunity has shifted focus lack efficacious drugs for therapeutic intervention disease. As with SARS-CoV, MERS-CoV, other non-respiratory viruses, flavonoids present themselves as promising given their success in silico, vitro, vivo, more recently, clinical studies. This review focuses on data from vitro studies analyzing effects various key SARS-CoV-2 targets presents an analysis structure-activity relationships same. From 27 primary papers, 69 were investigated activities against targets, ranging 3C-like protease (3CLpro) less explored nucleocapsid (N) protein; most quercetin myricetin derivatives, baicalein, baicalin, EGCG, tannic acid. We further silico featuring list involving potential flavonoid-rich extracts combination synthetic or polyphenols suggest prospects future SARS-CoV-2.

Language: Английский

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Potential roles of gut microbes in biotransformation of natural products: An overview

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 29, 2022

Natural products have been extensively applied in clinical practice, characterized by multi-component and multi-target, many pharmacodynamic substances, complex action mechanisms, various physiological activities. For the oral administration of natural products, gut microbiota efficacy are closely related, but this relationship remains unclear. Gut microbes play an important role transformation utilization caused diversity enzyme systems. Effective components such as flavonoids, alkaloids, lignans, phenols cannot be metabolized directly through human digestive enzymes can transformed produced microorganisms then utilized. Therefore, focus is paid to metabolism microbiota. In present study, we systematically reviewed studies about their effect on biotransformation highlighted involved common bacteria, reaction types, pharmacological actions, research methods. This study aims provide theoretical support for application prevention treatment diseases new ideas studying based biotransformation.

Language: Английский

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Structures, Sources, Identification/Quantification Methods, Health Benefits, Bioaccessibility, and Products of Isorhamnetin Glycosides as Phytonutrients

Nutrients, Journal Year: 2023, Volume and Issue: 15(8), P. 1947 - 1947

Published: April 18, 2023

In recent years, people have tended to consume phytonutrients and nutrients in their daily diets. Isorhamnetin glycosides (IGs) are an essential class of flavonoids derived from dietary medicinal plants such as Opuntia ficus-indica, Hippophae rhamnoides, Ginkgo biloba. This review summarizes the structures, sources, quantitative qualitative analysis technologies, health benefits, bioaccessibility, marketed products IGs. Routine innovative assay methods, IR, TLC, NMR, UV, MS, HPLC, UPLC, HSCCC, been widely used for characterization quantification All therapeutic effects IGs discovered date collected discussed this study, with emphasis on relevant mechanisms health-promoting effects. exhibit diverse biological activities against cancer, diabetes, hepatic diseases, obesity, thrombosis. They exert through multiple networks underlying molecular signaling pathways. Owing these could be utilized make foods functional foods. higher bioaccessibility plasma concentrations longer average residence time blood than aglycones. Overall, very promising excellent application potential.

Language: Английский

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Gut microbial metabolites of dietary polyphenols and their potential role in human health and diseases

Journal of Physiology and Biochemistry, Journal Year: 2023, Volume and Issue: 79(4), P. 695 - 718

Published: Sept. 1, 2023

Language: Английский

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