20-Year Experience with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Sarcomatosis DOI Creative Commons

Antonios-Apostolos Tentes,

Dimitrios Kyziridis, Apostolos Kalakonas

et al.

Archives of Oncology and Cancer Therapy, Journal Year: 2024, Volume and Issue: 4(1), P. 25 - 35

Published: Jan. 1, 2024

Abstract Background-Aims: About 80-90% of Soft Tissue Sarcomas (STS) patients develop peritoneal sarcomatosis. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been used in the treatment sarcomatosis but their role has not clearly defined. The purpose study is presentation experience with CRS plus HIPEC review literature. Patients-Methods: All treated from 2004-2024 were retrospectively reviewed. Clinical histopathologic variables correlated to survival, recurrence, morbidity. Results: Thirty-one patients, mean age 59.3+15 (24-93) years underwent 42 cytoreductive surgical operations. was 33 cases. CC-0 possible 90.6%. 90 days hospital mortality zero. morbidity rate 24.3% severe complications recorded 7.3%. 10-year survival disease free 78% 76% respectively.The median follow-up time 26+27 (2-128) months, 15 months respectively. recurrence 53.5%. > 65 identified as an independent variable survival. No identified. Conclusion: A high proportion may undergo complete cytoreduction. It appears that some subtypes be offered significant benefit CRS.The heterogeneity histopathology, rarity disease, do allow us draw definitive conclusions. Further studies are required understand define proper Keywords: Surgery, HIPEC, Peritoneal Sarcomatosis, Survival, Recurrence, Morbidity. Impact Employee Compensation Benefits on Operating Performance This work licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Copyright © Author(s) retain copyright this article.

Language: Английский

Landmark Series: A Review of Landmark Studies in the Treatment of Primary Localized Retroperitoneal Sarcoma DOI
Megan Delisle, David Gyorki, Sylvie Bonvalot

et al.

Annals of Surgical Oncology, Journal Year: 2022, Volume and Issue: 29(12), P. 7297 - 7311

Published: Sept. 10, 2022

Language: Английский

Citations

21
CT and MR Imaging of Retroperitoneal Sarcomas: A Practical Guide for the Radiologist DOI Open Access
Giorgia Porrello, Roberto Cannella, A Randazzo

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(11), P. 2985 - 2985

Published: May 30, 2023

Primary retroperitoneal sarcomas (RPS) represent around 10–16% of all sarcomas, with liposarcomas and leiomyosarcomas being the most common subtypes. RPS have some peculiar characteristics, imaging appearances, worse prognosis, complications compared to other locations sarcoma. Commonly, primarily present as large masses, progressively encasing adjacent structures, causing mass effect, complications. diagnosis is often challenging, these tumors may be overlooked; however, failure recognize characteristics leads a prognosis for patients. Surgery only recognized curative treatment, but anatomical constraints retroperitoneum limit ability achieve wide resection margins; therefore, high rate recurrence, require long-term follow-up. The radiologist has an important role in RPS, definition their extent, Specific knowledge main findings required reach early diagnosis, and, ultimately, guarantee best patient management. This article provides overview current regarding cross-sectional features patients presenting tips tricks improve RPS.

Language: Английский

Citations

13
Surgical Principles of Primary Retroperitoneal Sarcoma in the Era of Personalized Treatment: A Review of the Frontline Extended Surgery DOI Open Access
Paula Muñoz,

Pedro Bretcha-Boix,

Vicente Artigas

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(17), P. 4091 - 4091

Published: Aug. 24, 2022

Surgery is the key treatment in retroperitoneal sarcoma (RPS), as completeness of resection most important prognostic factor related to treatment. Compartmental surgery/frontline extended approach based on soft-tissue surgical principles, and involves resecting adjacent viscera achieve a wide negative margin. This associated with improved local control survival. surgery must be tailored tumor histology, localization, patient performance status. We herein present review compartmental covering oncological technical basis, describing each subtype localization retroperitoneum.

Language: Английский

Citations

18
Dedifferentiated liposarcoma with extensive cystic change causing significant diagnostic challenges: report of two cases and review of the literature DOI Creative Commons
Viola Katharina Vetter, Përparim Limani, Falko Ensle

et al.

Diagnostic Pathology, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 27, 2025

Retroperitoneal dedifferentiated liposarcoma is a rare, aggressive malignancy, characterized by high rates of recurrences and the potential for metastasis. On imaging, these tumors typically present as solid mass with lipomatous non-lipomatous components. Cystic changes liposarcomas exceedingly rare might pose significant diagnostic challenges, only few cases reported in literature. We here two retroperitoneal cystic presentation female patients aged 51 62 years. Imaging revealed large perinephric masses measuring up to 13.0 cm 16.1 cm, respectively, calcifications cyst wall observed second case. Differential diagnoses included echinococcosis, mesenchymal neoplasms, benign lesions (e.g. endometrial cyst). Both underwent upfront compartmental en-bloc surgical resection tumor kidney after multidisciplinary board (MDT) discussion. Macroscopically, were adherent but sharply demarcated from kidney. Histological examination first case small component well-differentiated (WDLPS) adjacent non-lipogenic sarcoma prominent whirling pattern, compatible dedifferentiation. The demonstrated spindle cell neoplasm osteosarcomatous heterologous differentiation. MDM2 amplification was confirmed both molecular testing. No long-term follow-up data available either patient. In conclusion, highlight importance recognizing unusual extensive liposarcoma, which can complicate work-up.

Language: Английский

Citations

0
A New ROCK Band for Diaphragmatic Reconstruction in Retroperitoneal Sarcoma Surgery DOI Creative Commons
Ferdinando Cananzi,

Vittoria Perano,

Stefania De Mola

et al.

Journal of Surgical Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

ABSTRACT Introduction Complete surgical resection is the mainstay of treatment for retroperitoneal sarcomas (RPS). For primary well‐differentiated liposarcomas and dedifferentiated liposarcomas, aggressive en‐bloc adjacent organs crucial local control. Diaphragmatic may be necessary in left‐sided RPS cases. While closure defects usually possible, large require alternative methods such as prosthetic reconstruction. Methods We developed an innovative technique reconstructing diaphragmatic after using a rectangular polytetrafluoroethylene band called ROCK (robust organic composite kinetic restoration diaphragm). This involves fixing folded to prevertebral fascia diaphragm ensure tension‐free while preserving function. The study analyzed patients treated with this at IRCCS‐Humanitas Research Hospital from January December 2023. Results Four underwent left median age was 56.5 years, male/female ratio 1/3. Median tumor size 24.5 cm, operative time 409.5 min. There were no band‐related complications, hernias, or respiratory failures. Conclusions provides safe, effective, adaptable method reconstruction resection, improving anatomical functional outcomes. Larger studies are needed validation.

Language: Английский

Citations

0
Impact of Fragmented Care on Retroperitoneal Sarcomas DOI

Denise L Wong,

Jordan Fredette,

Jill S. Hasler

et al.

The American Journal of Surgery, Journal Year: 2025, Volume and Issue: unknown, P. 116319 - 116319

Published: March 1, 2025

Language: Английский

Citations

0
Significant Predictors of Postoperative Morbidity After Radical Resection of Retroperitoneal Sarcoma in a Tertiary Center DOI
Claudia Di Prata,

Benjamin Renouf,

Dimitri Tzanis

et al.

Annals of Surgical Oncology, Journal Year: 2023, Volume and Issue: 30(7), P. 4515 - 4526

Published: May 9, 2023

Language: Английский

Citations

8
Retroperitoneal leiomyosarcoma DOI

Hana Dittrichová,

Pavel Hánek,

Klára Havlová

et al.

Urologie pro praxi, Journal Year: 2024, Volume and Issue: 25(4), P. 233 - 236

Published: Nov. 25, 2024

Prezentujeme kazuistiku 69letého muže, u něhož byl při ultrazvukovém vyšetření urotraktu náhodně zachycen suspektní 30mm útvar v oblasti levé nadledviny, na základě zobrazovacích nebylo možné vyloučit maligní potenciál nálezu. Pacient indikován k levostranné adrenalektomii, histologickým nálezem středně diferencovaný ohraničený leiomyosarkom, nadledvina byla bez infiltrace. známek generalizace, doporučení multidisciplinárního onkologického týmu je zařazen do sledování, kontrolní restagingové CT proběhlo šest měsíců od výkonu s negativním nálezem.

Citations

3
Treatment Pathways and Prognosis in Advanced Sarcoma with Peritoneal Sarcomatosis DOI Open Access

Fabian Klingler,

Hany Ashmawy, Lena Häberle

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(4), P. 1340 - 1340

Published: Feb. 20, 2023

Sarcomas represent a heterogeneous group of mesenchymal malignancies that most commonly occur in the extremities, retroperitoneum, and head neck. Intra-abdominal manifestations are rare prove particularly difficult to treat when peritoneal sarcomatosis is present. Because overall poor prognosis disease, tailored approach surgical management essential achieve satisfactory outcomes with limited morbidity. We present perioperative long-term 19 cases sarcoma treated surgically at our hospital. Treatment pathways were reviewed clinical follow-up was performed. Patient characteristics, medical history, tumor subtype, approach, hospital stay, complications, follow-up, survival (OS) assessed. Our patients 9 women 10 men median age 45.9 years (18–88) 30 months (0–200). In cases, either discovered during surgery or procedure performed palliative intent from beginning. The these very should consider variety factors tailor an for each patient. Sharing experiences will help increase knowledge about this disease provide insight into future cases.

Language: Английский

Citations

8
Comparing Multivisceral Resection with Tumor-only Resection of Liposarcoma Using the Win Ratio DOI Creative Commons
Leva Gorji,

Melica Nikahd,

Amblessed Onuma

et al.

Annals of Surgical Oncology, Journal Year: 2024, Volume and Issue: 31(5), P. 3389 - 3396

Published: Feb. 12, 2024

Abstract Background Multivisceral resection of retroperitoneal liposarcoma (LPS) is associated with increased morbidity and may not confer a survival benefit compared tumor-only (TO) resection. We both approaches using novel statistical method called the “win ratio” (WR). Methods Patients who underwent LPS from 2004 to 2015 were identified National Cancer Database. was defined as removal primary site in addition other organs. The WR calculated based on hierarchy postoperative outcomes: 30-day 90-day mortality, long-term survival, severe complication. Results Among 958 patients (multivisceral 634, TO 324) resection, median age 63 years (interquartile range [IQR] 54–71) follow-up 51 months (IQR 30–86). There no difference among versus multivisceral matched cohort (WR 0.82, 95% confidence interval [CI] 0.61–1.10). In aged 72–90 years, those had 36% lower odds winning undergoing 0.64, CI 0.40–0.98). A subgroup analysis classified having adjacent tumor involvement at time surgery revealed that 33% 0.67, 0.45–0.99). Conclusions Based win-ratio assessments hierarchical composite endpoint, without improved outcomes. This supports rationale for less invasive select patients, especially older patients.

Language: Английский

Citations

2