Alantolactone induces concurrent apoptosis and GSDME-dependent pyroptosis of anaplastic thyroid cancer through ROS mitochondria-dependent caspase pathway

Phytomedicine, Journal Year: 2022, Volume and Issue: 108, P. 154528 - 154528

Published: Oct. 27, 2022

Language: Английский

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Structures, Sources, Identification/Quantification Methods, Health Benefits, Bioaccessibility, and Products of Isorhamnetin Glycosides as Phytonutrients

Nutrients, Journal Year: 2023, Volume and Issue: 15(8), P. 1947 - 1947

Published: April 18, 2023

In recent years, people have tended to consume phytonutrients and nutrients in their daily diets. Isorhamnetin glycosides (IGs) are an essential class of flavonoids derived from dietary medicinal plants such as Opuntia ficus-indica, Hippophae rhamnoides, Ginkgo biloba. This review summarizes the structures, sources, quantitative qualitative analysis technologies, health benefits, bioaccessibility, marketed products IGs. Routine innovative assay methods, IR, TLC, NMR, UV, MS, HPLC, UPLC, HSCCC, been widely used for characterization quantification All therapeutic effects IGs discovered date collected discussed this study, with emphasis on relevant mechanisms health-promoting effects. exhibit diverse biological activities against cancer, diabetes, hepatic diseases, obesity, thrombosis. They exert through multiple networks underlying molecular signaling pathways. Owing these could be utilized make foods functional foods. higher bioaccessibility plasma concentrations longer average residence time blood than aglycones. Overall, very promising excellent application potential.

Language: Английский

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Chronic unpredictable stress exposure disrupts testicular function by modulating germ cell-junctional dynamics and Nrf2/HO-1/IKKβ/NF-κB pathway

Reproductive Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 108845 - 108845

Published: Jan. 1, 2025

Language: Английский

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Investigating the proliferative inhibition of HepG2 cells by exosome-like nanovesicles derived from Centella asiatica extract through metabolomics

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116855 - 116855

Published: June 7, 2024

Nano-particles demonstrating excellent anticancer properties have gradually found application in cancer therapy. However, their widespread use is impeded by potential toxicity, high cost, and the complexity of preparation process. In this study, we achieved exosome-like Centella asiatica-derived nanovesicles (ADNVs) through a straightforward juicing high-speed centrifugation We employed transmission electron microscopy nanoparticle flow cytometry to characterize morphology, diameter, stability ADNVs. evaluated vitro effects ADNVs using Cell Counting Kit-8 apoptosis assays. Through sequencing bicinchoninic acid protein analysis, discovered abundant presence proteins microRNAs These can target various diseases such as infection. Furthermore, demonstrated effective internalization HepG2 cells, resulting an increase reactive oxygen species levels, mitochondrial damage, cell cycle arrest at G1 phase, apoptosis. Finally, analyzed changes cellular metabolites post-treatment metabolomics techniques. Our findings indicated that primarily influence metabolic pathways amino metabolism lipid biosynthesis, which are closely associated with treatment. results demonstrate utility agents.

Language: Английский

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Nanoparticles for cancer therapy: a review of influencing factors and evaluation methods for biosafety

Clinical & Translational Oncology, Journal Year: 2023, Volume and Issue: 25(7), P. 2043 - 2055

Published: Feb. 19, 2023

Language: Английский

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Metal-organic framework-encapsulated dihydroartemisinin nanoparticles induces apoptotic cell death in ovarian cancer by blocking ROMO1-mediated ROS production

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: June 29, 2023

Dihydroartemisinin (DHA), a natural product derived from the herbal medicine Artemisia annua, is recently used as novel anti-cancer agent. However, some intrinsic disadvantages limit its potential for clinical management of cancer patients, such poor water solubility and low bioavailability. Nowadays, nanoscale drug delivery system emerges hopeful platform improve treatment. Accordingly, metal-organic framework (MOF) based on zeolitic imidazolate framework-8 was designed synthesized to carry DHA in core (ZIF-DHA). Contrast with free DHA, these prepared ZIF-DHA nanoparticles (NPs) displayed preferable anti-tumor therapeutic activity several ovarian cells accompanied suppressed production cellular reactive oxygen species (ROS) induced apoptotic cell death. 4D-FastDIA-based mass spectrometry technology indicated that down-regulated modulator 1 (ROMO1) might be regarded targets NPs. Overexpression ROMO1 significantly reversed ROS-generation by ZIF-DHA, well pro-apoptosis effects. Taken together, our study elucidated highlighted framework-8-based MOF treat cancer. Our findings suggested NPs could an attractive strategy

Language: Английский

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KSHV hijacks FoxO1 to promote cell proliferation and cellular transformation by antagonizing oxidative stress

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(3)

Published: March 1, 2023

Abstract Reactive oxygen species (ROS) are a group of highly short‐lived molecules that control diverse behaviors cells. Normal cells maintain ROS balance to ensure their functions. Because oncogenic stress, cancer often have excessive ROS, also known as oxidative which counteracted by enhanced antioxidant systems redox homeostasis. Kaposi's sarcoma‐associated herpesvirus (KSHV) is an virus associated with sarcoma (KS), manifests hyper inflammation and stress the hallmarks. We previously shown can disrupt KSHV latency inducing viral lytic replication, leading cell death. Paradoxically, most KS tumor latently infected in inflammatory microenvironment, part due activation alternative complement TLR4 pathways, indicating existence defense system In this study, we show upregulates genes, including SOD2 CAT hijacking forkhead box protein O1 (FoxO1), intracellular level. Moreover, fine‐tuned level KSHV‐transformed essential for survival. Consequently, extremely sensitive exogenous insult such treatment low hydrogen peroxide (H 2 O ). Either chemical inhibition or knockdown FoxO1 short interfering RNAs decreases expression genes subsequently increases cells, resulting proliferation colony formation soft agar. Mechanistically, KSHV‐encoded microRNAs vFLIP upregulate activating NF‐κB pathway. These results reveal novel mechanism counteracts upregulating FoxO1, KSHV‐induced cellular transformation. Therefore, might be potential therapeutic target KSHV‐related malignancies.

Language: Английский

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Involvement of GSK-3β, NF-κB, PPARγ, and apoptosis in amlodipine's anticancer effect in BALB/c mice

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 117298 - 117298

Published: March 1, 2025

Language: Английский

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A β-glucosidase extracted from walnut (Juglans regia L.) green husk induces human hepatoma cell apoptosis via ROS-mediated p53 and NF-κB pathway

Food Science and Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: May 10, 2025

Language: Английский

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Impact of antioxidant supplementation during in vitro culture of ovarian preantral follicles: A review

Theriogenology, Journal Year: 2023, Volume and Issue: 207, P. 110 - 122

Published: May 27, 2023

Language: Английский

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