Regenerative Engineering and Translational Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: April 11, 2025
Language: Английский
Nature Medicine, Journal Year: 2023, Volume and Issue: 29(8), P. 2121 - 2132
Published: July 6, 2023
Language: Английский
Citations
221
Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)
Published: June 4, 2024
Abstract Pancreatic cancer is a major cause of cancer-related death, but despondently, the outlook and prognosis for this resistant type tumor have remained grim long time. Currently, it extremely challenging to prevent or detect early enough effective treatment because patients rarely exhibit symptoms there are no reliable indicators detection. Most advanced spreading that difficult treat, treatments like chemotherapy radiotherapy can only slightly prolong their life by few months. Immunotherapy has revolutionized pancreatic cancer, yet its effectiveness limited tumor's immunosuppressive hard-to-reach microenvironment. First, article explains microenvironment highlights wide range immunotherapy options, including therapies involving oncolytic viruses, modified T cells (T-cell receptor [TCR]-engineered chimeric antigen [CAR] T-cell therapy), CAR natural killer cell therapy, cytokine-induced cells, immune checkpoint inhibitors, immunomodulators, vaccines, strategies targeting myeloid in context contemporary knowledge future trends. Lastly, discusses main challenges ahead immunotherapy.
Language: Английский
Citations
38
Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)
Published: Jan. 15, 2025
As one of the three major malignant tumors in women, morbidity endometrial cancer is second only to that cervical and increasing yearly. Its etiological mechanism not clear, risk factors are numerous common closely related obesity, hypertension, diabetes, etc. The gut microbiota has many strains, which play a considerable part normal digestion absorption human body regulation immune response. In last few years, research on been unprecedentedly popular, it confirmed correlates with occurrence development all kinds benign diseases. this article, effects its metabolites reviewed, application prevention, diagnosis treatment explored.
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(18), P. 10479 - 10479
Published: Sept. 9, 2022
In recent years, interest in natural products such as alternative sources of pharmaceuticals for numerous chronic diseases, including tumors, has been renewed. Propolis, a product collected by honeybees, and polyphenolic/flavonoid propolis-related components modulate all steps the cancer progression process. Anticancer activity propolis its compounds relies on various mechanisms: cell-cycle arrest attenuation cells proliferation, reduction number stem cells, induction apoptosis, modulation oncogene signaling pathways, inhibition matrix metalloproteinases, prevention metastasis, anti-angiogenesis, anti-inflammatory effects accompanied tumor microenvironment (by modifying macrophage activation polarization), epigenetic regulation, antiviral bactericidal activities, gut microbiota, chemotherapy-induced deleterious side effects. Ingredients from also ”sensitize“ to chemotherapeutic agents, likely blocking transcription factor nuclear kappa-light-chain-enhancer activated B (NF-κB). this review, we summarize current knowledge related flavonoids other polyphenolic growth metastasizing ability, discuss possible molecular cellular mechanisms involved inflammatory pathways processes that affect survival, invasion, angiogenesis, metastasis tumor.
Language: Английский
Citations
61
Cancers, Journal Year: 2023, Volume and Issue: 15(4), P. 1061 - 1061
Published: Feb. 7, 2023
Several epidemiological and clinical studies have suggested a relationship between obstructive sleep apnea (OSA) higher incidence or severity of cancer. This appears to be dependent on myriad factors. These include non-modifiable factors, such as age gender; modifiable preventable specific comorbidities (especially obesity), the use particular treatments, and, above all, histological type location Heterogeneity in OSA cancer is also related influences intermittent hypoxemia (a hallmark feature OSA), among others, metabolism microenvironment different types tumoral cells. The hypoxia inducible transcription factor (HIF-1α), molecule activated expressed situations hypoxemia, seems key enabling variety pathophysiological mechanisms that are becoming increasingly better recognized. appear operationally involved via alterations cellular functions (mainly involving immune system) molecular functions, by inducing modifications microbiome. This, turn, may individually collectively increase risk cancer, which then, further modulated genetic susceptibility individual. Here, we provide an updated brief review pathways been identified could explain We identify future challenges need overcome this intriguing field research.
Language: Английский
Citations
27
Cells, Journal Year: 2024, Volume and Issue: 13(17), P. 1437 - 1437
Published: Aug. 27, 2024
The gut microbiota plays an essential role in maintaining immune homeostasis and influencing the landscape within tumor microenvironment. This review aims to elucidate interactions between dynamics, with a focus on colorectal cancer (CRC). spans foundational concepts of immuno-microbial interplay, factors microbiome composition, evidence linking immunotherapy outcomes. Gut modulates anti-cancer immunity through several mechanisms, including enhancement surveillance modulation inflammatory responses. Specific microbial species their metabolic byproducts can significantly influence efficacy immunotherapies. Furthermore, diversity correlates clinical outcomes CRC, suggesting potential as valuable biomarker for predicting response immunotherapy. Conclusions: Understanding relationship responses offers novel therapeutic strategies development. not only influences natural history treatment CRC but also serves critical modulator activity. Further exploration into microbiome's could enhance effectiveness existing treatments guide development new modalities.
Language: Английский
Citations
12
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9463 - 9463
Published: Aug. 30, 2024
Colorectal cancer (CRC) represents a significant global health burden, with high incidence and mortality rates worldwide. Recent progress in research highlights the distinct clinical molecular characteristics of colon versus rectal cancers, underscoring tumor location's importance treatment approaches. This article provides comprehensive review our current understanding CRC epidemiology, risk factors, pathogenesis, management strategies. We also present intricate cellular architecture colonic crypts their roles intestinal homeostasis. carcinogenesis multistep processes are described, covering conventional adenoma-carcinoma sequence, alternative serrated pathways, influential Vogelstein model, which proposes sequential
Language: Английский
Citations
9
Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 13, 2025
Language: Английский
Citations
1
Cancers, Journal Year: 2023, Volume and Issue: 15(7), P. 2101 - 2101
Published: March 31, 2023
Cancer immunotherapy is a treatment modality that aims to stimulate the anti-tumor immunity of host elicit favorable clinical outcomes. Immune checkpoint inhibitors (ICIs) gained traction due lasting effects and better tolerance in patients carrying solid tumors comparison conventional treatment. However, significant portion may present primary or acquired resistance (non-responders), thus, they have limited therapeutic Resistance ICIs can be derived from host-related, tumor-intrinsic, environmental factors. Recent studies suggest correlation gut microbiota with response as well incidence adverse events. Currently, preclinical aim elucidate unique microbial signatures related ICI immunity, employing metagenomics and/or multi-omics. Decoding this complex relationship provide basis for manipulating malleable structure enhance success. Here, we delve into factors affecting ICIs, focusing on intricate microbiome–immunity interplay. Additionally, review discuss future trends directions promising field.
Language: Английский
Citations
21
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: April 19, 2023
Alopecia areata (AA) is a non-scarring hair loss disorder caused by autoimmunity. The immune collapse of the follicle, where interferon-gamma (IFN-γ) and CD8+ T cells accumulate, key factor in AA. However, exact functional mechanism remains unclear. Therefore, AA treatment has poor efficacy maintenance high relapse rate after drug withdrawal. Recent studies show that immune-related molecules affect These communicate through autocrine paracrine signals. Various cytokines, chemokines growth factors mediate this crosstalk. In addition, adipose-derived stem (ADSCs), gut microbiota, follicle melanocytes, non-coding RNAs specific regulatory have crucial roles intercellular communication without clear cause, suggesting potential new targets for therapy. This review discusses latest research on possible pathogenesis therapeutic
Language: Английский
Citations
21