The role of polyphenols in the prevention and treatment of cancer DOI Creative Commons

Aleksandra Szypuła,

Beniamin Michalik,

Iwona Galasińska

et al.

Journal of Education Health and Sport, Journal Year: 2024, Volume and Issue: 59, P. 126 - 144

Published: Feb. 13, 2024

Introduction: Polyphenolic compounds are widespread in nature, contained large quantities especially fruits, vegetables, cereals and nuts. In recent years numerous attempts have been made to characterize their biological effects, with particular emphasis on protective potential against the development of chronic diseases, including cancer. Purpose study: The aim study was collect analyze publications use polyphenols prevention treatment cancer, breast colon prostate cancer lung - four most common cancers Polish population. Material methods: A review literature available PubMed performed using various combinations keywords: 'polyphenols' + 'cancer', 'oncology', ‘polyphenols’ ‘chemoprevention’, ‘chemotherapy’, 'lung cancer', 'breast ‘colorectal cancer’, 'prostate cancer'/'prostate gland cancer'. Results: analysis collected allows conclude that exert multidirectional anticancer effect through antioxidant, antiproliferative, anti-inflammatory, immunomodulatory prosenescence activity. This has demonstrated, among others, relation cellular models colorectal cervical cancer. Polyphenols also reduce side effects associated conventional therapies increase effectiveness. Conclusions: both as independent components complex regimens chemopreventive potentially chemotherapeutic effects. By influencing stages carcinogenesis initiation, promotion progression they constitute a promising direction for new, more effective forms therapy

Language: Английский

Enhancing the Bioavailability of Resveratrol: Combine It, Derivatize It, or Encapsulate It? DOI Creative Commons
Mohamed Salla, Nadine Karaki,

Belal El Kaderi

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 569 - 569

Published: April 22, 2024

Overcoming the limited bioavailability and extensive metabolism of effective in vitro drugs remains a challenge that limits translation promising into clinical trials. Resveratrol, despite its well-reported therapeutic benefits, is not metabolically stable thus has been utilized as an drug. This because it needs to be consumed large amounts overcome burdens conversion less metabolites. Herein, we summarize more relevant approaches modify resveratrol, aiming increase biological efficacy. We discuss combination therapies, derivatization, use resveratrol nanoparticles. Interestingly, with established chemotherapeutic shown effects on colon cancer (with oxaliplatin), liver cisplatin, 5-FU), gastric doxorubicin). On other hand, derivatizing including hydroxylation, amination, amidation, imidation, methoxylation, prenylation, halogenation, glycosylation, oligomerization, differentially modifies could used for preferential outcomes. Moreover, encapsulation allows trapping within different forms shells targeted therapy. Depending nanoparticle used, can enhance solubility absorption, increasing These include polymers, metals, solid lipids, nanoparticles have preclinical results, adding “hype” research resveratrol. review provides platform compare allow directed better treatment options

Language: Английский

Citations

24
Plant Foods and Their Bioactives as Dietary Enhancers for Colon Cancer Treatment with 5-Fluorouracil DOI
Zhongming Yang, Carlos L. Céspedes, Zhongguo Yang

et al.

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 50

Published: Jan. 4, 2025

Cancer is the world's second most common cause of death, with colon cancer (CC) ranking third in prevalence and cancer-related fatalities. CC originates or rectum influenced by genetic mutations, lifestyle, diet. Although chemotherapy, especially 5-fluorouracil (5-FU), fundamental to treatment has improved patient survival, its benefits are often limited significant side effects emerging drug resistance. Recently, plant-based foods have drawn interest research for their natural bioactive compounds relatively low toxicity. Certain plant not only exhibit anti-cancer activity but may also boost effectiveness 5-FU while reducing adverse effects. Despite evidence suggesting a synergistic effect between 5-FU, this area remains fragmented. This review consolidates current on including fruits, vegetables, legumes, tea bioactives treatment. Besides, it explores mechanisms through which these enhance efficacy reduce effects, evaluates clinical application prospects, identifies challenges future directions. comprehensive analysis aims provide scientific foundation integrated CC, highlighting potential enhancing chemotherapy associated toxicities.

Language: Английский

Citations

6
Natural polyphenols: A protective approach to reduce colorectal cancer DOI Creative Commons
Joel Okpoghono, Endurance Fegor Isoje, Ufuoma Augustina Igbuku

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e32390 - e32390

Published: June 1, 2024

A form of cancer that affects the rectum or colon (large intestine) is called colorectal (CRC). The main risk factors for CRC include dietary, lifestyle, and environmental variables. Currently natural polyphenols have demonstrated impressive anticarcinogenic capabilities.

Language: Английский

Citations

11
Unlocking the potential of Berberine: Advancing cancer therapy through chemosensitization and combination treatments DOI
Anjana Sajeev,

Bethsebie Sailo,

Jyothsna Unnikrishnan

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 597, P. 217019 - 217019

Published: June 5, 2024

Language: Английский

Citations

6
A perspective on emerging therapies in metastatic colorectal cancer: Focusing on molecular medicine and drug resistance DOI
Anggraeni Endah Kusumaningrum,

Sarce Makaba,

Eyhab Ali

et al.

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(1)

Published: Jan. 1, 2024

Abstract The majority of cancer cases are colorectal cancer, which is also the second largest cause cancer‐related deaths worldwide. Metastasis leading death for patients with cancer. Metastatic incidence on rise due to a tiny percentage tumors developing resistant medicines despite advances in treatment tactics. Cutting‐edge targeted medications now go‐to option customized and all‐encompassing CRC care. Specifically, multitarget kinase inhibitors, antivascular endothelial growth factors, epidermal factor receptors widely used clinical practice CRC‐targeted treatments. Rare targets metastatic becoming more well‐known developments precision diagnostics extensive use second‐generation sequencing technology. These include KRAS mutation, BRAF V600E HER2 overexpression/amplification, MSI‐H/dMMR. Incorporating certain into trials has significantly increased patient survival rates, opening new avenues bringing fresh viewpoints treating focused therapies change how treated, giving hope better results. markers can transform individualize therapy regimens. They could open door precisely effective medicines, improving outcomes quality life. fast‐growing body knowledge regarding molecular biology latest gene directly responsible this advancement.

Language: Английский

Citations

4
Resveratrol and p53: How are they involved in CRC plasticity and apoptosis? DOI Creative Commons
Aranka Brockmueller, Constanze Buhrmann, Amir Reza Moravejolahkami

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: 66, P. 181 - 195

Published: Jan. 6, 2024

Colorectal cancer (CRC), which is mainly caused by epigenetic and lifestyle factors, very often associated with functional plasticity during its development. In addition, the malignant of CRC cells underscores one their survival abilities to functionally adapt specific stresses, including inflammation, that occur carcinogenesis. This leads generation various subsets phenotypic diversity promotes epithelial-mesenchymal transition (EMT), formation cell stem (CSC) metabolic reprogramming. can enhance differentiation facilitate tumorigenic potential, drug resistance metastasis. The tumor protein p53 acts as central suppressors carcinogenesis regulating target genes, whose proteins are involved in cells, autophagy, cycle, apoptosis, DNA repair. aim this review summarize latest published research on resveratrol's effect prevention CRC, regulatory actions, specifically pathway, treatment options. Resveratrol, a naturally occurring polyphenol, potent inducer variety tumor-controlling. However, underlying mechanisms linking signaling pathway anti-plasticity resveratrol still poorly understood. Therefore, discusses novel relationships between anti-cellular plasticity/heterogeneity, pro-apoptosis modulation oncogenesis, crucial prevents changes leading migration resistance, thus improving ongoing CRC.

Language: Английский

Citations

4
Dynamic interplay of nuclear receptors in tumor cell plasticity and drug resistance: Shifting gears in malignant transformations and applications in cancer therapeutics DOI
Bandari BharathwajChetty, Anjana Sajeev, Ravichandran Vishwa

et al.

Cancer and Metastasis Reviews, Journal Year: 2024, Volume and Issue: 43(1), P. 321 - 362

Published: March 1, 2024

Language: Английский

Citations

4
The Role of Natural Products from Herbal Medicine in TLR4 Signaling for Colorectal Cancer Treatment DOI Creative Commons
Yan Luo,

Guochen Zhang,

Chao Hu

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(12), P. 2727 - 2727

Published: June 7, 2024

The toll-like receptor 4 (TLR4) signaling pathway constitutes an intricate network of protein interactions primarily involved in inflammation and cancer. This triggers intracellular cascades, modulating transcription factors that regulate gene expression related to immunity malignancy. Previous studies showed colon cancer patients with low TLR4 exhibit extended survival times the holds a significant role CRC pathogenesis. In recent years, traditional Chinese medicines (TCMs) have garnered substantial attention as alternative therapeutic modality for CRC, due their multifaceted composition ability target multiple pathways. Emerging evidence indicates specific TCM products, such andrographolide, rosmarinic acid, baicalin, etc., potential impede development through pathway. Here, we review biochemical processes natural products from TCMs affecting sheds light on treatment strategies utilizing inhibitors which contributes advancement research accelerates clinical integration into treatment.

Language: Английский

Citations

4
Synergistic Mechanisms of Selected Polyphenols in Overcoming Chemoresistance and Enhancing Chemosensitivity in Colorectal Cancer DOI Creative Commons
Kha Wai Hon, Rakesh Naidu

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 815 - 815

Published: July 7, 2024

Colorectal cancer (CRC) is a leading cause of deaths worldwide. Despite significant advances in medical treatment, chemotherapy as monotherapy can lead to substantial side effects and chemoresistance. This underscores the need for therapeutic approaches that are not only pharmacologically safe but also modulate multiple potent signaling pathways sensitize cells overcome resistance standard drugs. In recent years, scientists have been searching natural compounds be used chemosensitizers addition conventional medications synergistic treatment CRC. Polyphenols represent diverse group target induce anti-cancer effects. Additionally, polyphenols shown work synergistically with chemotherapeutics other cells. review aims provide comprehensive insight into mechanisms selected CRC Further research clinical trials warranted fully harness combined or improving outcomes.

Language: Английский

Citations

4
Prominent Naturally Derived Oxidative-Stress-Targeting Drugs and Their Applications in Cancer Treatment DOI Creative Commons

Eunsun Lee,

Dongki Yang,

Jeong Hee Hong

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 49 - 49

Published: Jan. 3, 2025

The relationship between oxidative stress and cancer has been extensively studied highlighted, along with its role in various aspects of angiogenesis. modulation levels the adaptive mechanisms systems are attractive research themes for developing anti-cancer strategies. Reactive oxygen species (ROS) involved pathophysiological processes play crucial roles DNA damage Although cells have developed defense against stress, excessive ROS production proposed as an strategy to induce cellular apoptosis. In particular, natural-source-based antioxidants identified effective cancers, delivery platforms enhance their efficacy. this review, we highlighted components (plumbagin, quercetin, resveratrol, curcumin, xanthatin, carvacrol, telmisartan, sulforaphane) that modulate recent targeting used increase application drugs diverse action. Further, summarized actual doses effects these drug candidates systems. Overall, review provides beneficial expanding cancer-targeting fields addressing limited applications types.

Language: Английский

Citations

0