Breast Cancer Treatment Using the Magneto-Hyperthermia Technique Associated with Omega-3 Polyunsaturated Fatty Acids’ Supplementation and Physical Training

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 310 - 310

Published: Feb. 22, 2024

Breast cancer (BC) presents a growing global concern, mainly for the female population of working age. Their pathophysiology shows challenges when attempting to ensure conventional treatment efficacy without adverse effects. This study aimed evaluate magneto-hyperthermia (MHT) therapy associated with supplementation omega-3 polyunsaturated fatty acid (w-3 PUFA) and engagement in physical training (PT) triple-negative BC (TNBC) model. First, we assessed physicochemical properties iron oxide nanoparticles (ION) biological conditions, as well their heating potential MHT therapy. Then, bioluminescence (BLI) evaluation best tumor growth conditions TNBC model (the quantity implanted cells time), (5 consecutive days) previous administration 8 weeks w-3 PUFA PT, was carried out. The results showed good stability ION using 300 Gauss 420 kHz. In model, adequate observed after 14 days 2 × 106 implantation by BLI. There delay animals that received PT significant decrease MHT. pioneering combination approach (MHT, omega-3, exercise) positive effect on reduction demonstrated promise pre-clinical clinical studies future.

Language: Английский

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Effects of a 6-Month Rowing Training Program in Breast Cancer Survivors

Published: March 15, 2024

The purpose of this longitudinal study was to determine the effects a rowing training program on physical fitness and body composition in female breast cancer survivors (56.78 ± 6.38 years). Over six months, participants (n=40) performed two sessions per week for an average 75 minutes, com-bining resistance muscle strength exercises with rowing. To evaluate impact program, tests anthropometric measurements were carried out before after protocol. results show statis-tically significant improvements measures such as weight (-1.84 kg), BMI (-0.7 kg/m2), hip (-3.24 cm) waist circumference (-2.45 cm). In addition, variables associated also improved including leg (3.04 cm), dominant handgrip (4.24 kgf), non-dominant (3.49 aerobic endurance (78.35 m) flexibility (3.96 We can therefore conclude that rowing-based exercise is effective strategy improve type population, yielding both basic capacity variables, es-sential factors better health quality life.

Language: Английский

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Mutant RAS-driven Secretome Causes Skeletal Muscle Defects in Breast Cancer

Cancer Research Communications, Journal Year: 2024, Volume and Issue: 4(5), P. 1282 - 1295

Published: April 23, 2024

Cancer-induced skeletal muscle defects differ in severity between individuals with the same cancer type. Cancer subtype-specific genomic aberrations are suggested to mediate these differences, but experimental validation studies very limited. We utilized three different breast patient-derived xenograft (PDX) models correlate subtype defects. PDXs were derived from brain metastasis of triple-negative (TNBC), estrogen receptor-positive/progesterone receptor-positive (ER+/PR+) primary a BRCA2-mutation carrier, and pleural effusion an ER+/PR- cancer. While impaired function as measured through rotarod performance reduced levels circulating and/or miR-486 common across all PDXs, only TNBC-derived PDX activated phospho-p38 muscle. To further extend results, we generated transformed variants human epithelial cells healthy donors using HRASG12V or PIK3CAH1047R mutant oncogenes. Mutations RAS oncogene its modulators found approximately 37% metastatic cancers, which is often associated Although both oncogenes adenocarcinomas NSG mice, HRASG12V-derived tumors caused affecting performance, contraction force, miR-486, Pax7, pAKT, p53 Circulating chemokine CXCL1 elevated animals containing mutation. Because pathway 19% evaluating context particularly mutations, may accelerate development therapeutic modalities overcome cancer-induced systemic effects.

Language: Английский

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Fixed-Seat Rowing versus Sliding-Seat Rowing: Effects on Physical Fitness in Breast Cancer Survivors

Cancers, Journal Year: 2024, Volume and Issue: 16(12), P. 2207 - 2207

Published: June 13, 2024

This study aimed to analyze the effects of a team rowing-based training program on physical fitness and anthropometric parameters in female breast cancer survivors (n = 40; 56.78 ± 6.38 years). The participants were divided into two groups: one rowed fixed-seat rowing (FSR) boats 20; 56.35 4.89 years), other sliding-seat (SSR) 57.20 7.7 Both groups engaged 75 min sessions per week for 24 weeks. Significant improvements observed both terms weight (FSR: −1.93 kg, SSR: −1.75 kg), body mass index −0.73 kg/m2, −0.67 kg/m2), waist circumference −2.83 cm, −3.66 cm), hip −2.02 −2.88 cm). Muscle strength improved lower extremities (jump test: FSR: 2.99 3.11 cm) upper (dominant: 4.13 kgf, 4.34 kgf; non-dominant: 3.67 3.32 kgf). Aerobic capacity also improved, with SSR group showing greater increase 63.05 m, 93.65 m). Flexibility tests revealed better results dominant (SSR: 1.75 cm vs. −5.55 non-dominant limbs 1.72 −3.81 These findings suggest that type modality can influence outcomes, superior compared FSR group.

Language: Английский

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Effects of Rowing on Cardiac Function in Breast Cancer Survivors

Published: July 2, 2024

This longitudinal study aimed to analyze the effects of a team rowing-based training program on physical fitness and anthropometric parameters in female breast cancer survivors (n=40; 56.78±6.38 years). Participants were divided into two groups: one rowed fixed seat rowing (FSR) boats (n=20; 56.35±4.89 years) other sliding (SSR) 57.20±7.7 Both groups engaged 75-minute sessions per week for 24 weeks. Significant improvements observed both resting heart rate (FSR: -10.65 bpm; SSR: -8.45 bpm), at beginning 6-minute walk test (6MWT) -10.7 -11.25 end -13.85 -20.35 bpm). Blood pressure improved significantly diastolic blood -12.35 mmHg; -19.25 mmHg) systolic -13 -16.95 mmHg). Additionally, increased distance covered 6MWT +63.05 m; +93.65 m). These results suggest that is viable safe activity survivors, improving cardiac function, pressure, cardiorespiratory capacity, particularly boats.

Language: Английский

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Impact of Physical Exercise on Quality of Life, Self-Esteem, and Depression in Breast Cancer Survivors: A Pilot Study

Onco, Journal Year: 2024, Volume and Issue: 4(3), P. 207 - 216

Published: Aug. 22, 2024

Controlled study designs usually report that physical exercise improves the health of women living with breast cancer. However, many these are not sufficiently active to experience benefits exercise. The main objective was analyze effect a program on quality life, self-esteem, and depression in cancer survivors. Thirteen participants (46.54 ± 6.31 years old) completed intervention. Three patient-reported questionnaires were used: Supplementary Questionnaire Breast Cancer Module (QLQ-BR23), Beck Depression Inventory (BDI), Rosenberg Self-Esteem Scale (RSES). All had significantly improved self-esteem (p = 0.004). Although there no statistically significant changes depression, notable decrease scores (6.39 4.75 vs. 5.00 4.75; p 0.080). Regarding improvements observed “future perspectives” 0.047) “arm symptoms” 0.015). No noted other variables. Our results suggest is an effective strategy positively affects survivors’ life self-esteem. reinforce need for community-based programs Healthcare professionals should promote improve outcomes before, during, after treatment.

Language: Английский

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Mechanistic Insights and Therapeutic Applications of Hinokitiol in Inflammation, Antimicrobial Therapy, and Cancer

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 13, P. 100527 - 100527

Published: Oct. 12, 2024

Language: Английский

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Exercise improves the outcome of anticancer treatment with ultrasound-hyperthermia-enhanced nanochemotherapy and autophagy inhibitor

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(7), P. e0288380 - e0288380

Published: July 12, 2023

It has been shown that exercise a direct impact on tumor growth along with functional improvement. Previous studies have decreases the risk of cancer recurrence across various types cancer. was indicated stimulates immune system to fight study demonstrated pulsed-wave ultrasound hyperthermia (pUH) combined PEGylated liposomal doxorubicin (PLD) and chloroquine (CQ) inhibits 4T1 tumors delays their recurrence. In this study, we investigated if combinatorial treatment high-intensity interval training (HIIT) pUH-enhanced PLD delivery CQ improved outcome. The mouse experiment composed three groups, HIIT+PLD+pUH+CQ group, PLD+pUH+CQ control group. group received 6 weeks HIIT (15 min per day, 5 days week) before implantation. Seven later, they therapy (10 mg/kg) + pUH (3 MHz, 50% duty cycle, 0.65 W/cm 2 , 15min) (50 mg/kg daily). Results showed significantly reduced volumes brought about longer survival tumor-bearing mice than did. Blood cell components were analyzed neutrophil reticulocytes decreased while lymphocytes increased after exercise.

Language: Английский

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Load-velocity Relationship of the Bench Press Exercise is not Affected by Breast Cancer Surgery and Adjuvant Therapy

International Journal of Sports Medicine, Journal Year: 2023, Volume and Issue: 45(02), P. 110 - 115

Published: Nov. 13, 2023

We examined the effect of breast cancer surgery and adjuvant therapy on relationship between bar velocity relative intensity (load-velocity [L-V] relationship) bench press (BP) exercise. Twenty-two survivors (age: 48.0±8.2 yr., strength: 0.40±0.08) completed a loading test up to one-repetition maximum (1RM) in BP using lightweight carbon bar. General individual relationships (%1RM) mean propulsive (MPV) were studied. Furthermore, (MPV

Language: Английский

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Vateria indica (Linn) resin based ointment for the topical treatment of Radiation-Induced burns in cancer patients

Journal of King Saud University - Science, Journal Year: 2023, Volume and Issue: 35(5), P. 102659 - 102659

Published: March 28, 2023

Cancer patients undergoing radiation-therapy (RT) suffer from many side-effects like dermatitis and mucositis. A simple economical effective treatment for this condition required the preparation of an ointment to alleviate dermatological damage radiation burns. Emphasis was laid upon finding indigenous natural product therapy but fully authenticated by a thorough study under pharmacological guidelines. An prepared using resin Sarja rasa (Ayurveda)/Vellaikungiliyam (Siddha)/Raal (Unani). correlation between topical in RT cellular dimensions established. To circumvent poor quality controls or species contamination found commercial sources it felt important locate source its botanical authentication. The particle size present ascertained scanning electron microscopy (SEM). obtained incising tapping V. indica L. tree which potentially possess wound-healing has anti-sarcomic properties. This seminal carried out with permission ethics committee, targeting affected head neck cancers. aspect complete exclusion microbial interference commonly indigenous, home-made some preparations. Therefore, samples were microbiologically monitored ensure absolute thereafter, stability studies also conducted. remarkable change observed terms decrease severity symptoms shorter duration healing when compared control group.

Language: Английский

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