Bidirectional association between breast cancer and dementia: a systematic review and meta-analysis of observational studies

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e18888 - e18888

Published: Jan. 31, 2025

Cognitive decline following cancer treatment can vary from mild cognitive impairment to severe dementia. However, there is inconsistent evidence regarding the relationship between breast survivors and their risk of developing This meta-analysis aims consolidate observational studies explore bidirectional association dementia risk. We conducted a comprehensive search using medical subject headings (MeSH) keywords across PubMed, Cochrane Library, Embase databases identify cohort, case-control, cross-sectional examining link Statistical analysis was performed Stata version 14.0, with random effects model employed account for heterogeneity. Publication bias assessed funnel plots Egger's test. included 13 total 346,051 participants, up June 20, 2024. Of these, seven investigated among patients cancer, revealing lower [OR = 0.56, 95% CI [0.27-1.18], I2 99.1%, P 0.128]. Similarly, explored in individuals dementia, showing as well 0.79, [0.51-1.22], 94.5%, 0.290]. Our findings indicate that less likely lead similarly low associated cancer. These insights are crucial clinicians guiding prevention monitoring neurodegenerative conditions

Language: Английский

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$$\mathcal {B}\text {rain}{\mathcal{M}\mathcal{N}}\text {et}$$: a unified neural network architecture for brain image classification

Network Modeling Analysis in Health Informatics and Bioinformatics, Journal Year: 2024, Volume and Issue: 13(1)

Published: March 22, 2024

Language: Английский

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Effects of physical and psychological multimorbidity on the risk of dementia: multinational prospective cohorts and a meta-analysis

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 27, 2024

Language: Английский

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Neurocognition and mean radiotherapy dose to vulnerable brain structures: new organs at risk?

Radiation Oncology, Journal Year: 2023, Volume and Issue: 18(1)

Published: Aug. 11, 2023

Children with brain tumors are at high risk of neurocognitive decline after radiotherapy (RT). However, there is a lack studies on how RT doses to organs (OARs) impacts neurocognition. The aim this study was examine dose-risk relationships for mean dose different structures important networks. We explored previously established OARs and potentially new OARs.A sample 44 pediatric tumor survivors who had received proton and/or photon were included. Correlations between IQ analyzed. Previously cochleae, optic chiasm, nerve, pituitary gland, hypothalamus, hippocampus pons. Potential RT-induced cerebellum, vermis thalamus.Mean correlated several subtests. Higher pons lower performance particularly full-scale (FIQ), Perceptual Reasoning (PRI), Working Memory (WMI) Processing Speed Index (PSI). processing speed working memory. For those receiving whole (WBRT), higher the gland memory.A correlation found subtests in potential OARs. Thus, validated constraints vulnerable structures, parsimonious approach planning should be considered preserve

Language: Английский

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Alzheimer Disease and Related Dementia Following Hormone-Modulating Therapy in Patients With Breast Cancer

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(7), P. e2422493 - e2422493

Published: July 16, 2024

Importance Hormone-modulating therapy (HMT) is a widely accepted treatment for hormone receptor–positive breast cancer, although its cognitive effects, including potential link to Alzheimer disease and related dementias (ADRD), remain understudied. Objective To investigate the association between HMT cancer risk of developing ADRD in women aged 65 years or older. Design, Setting, Participants This cohort study used comprehensive dataset from Surveillance, Epidemiology, End Results (SEER)–Medicare linked database identify patients who did not receive within 3 after initial diagnosis assessed their later life. Individuals with preexisting receiving before were excluded. was performed June 2022 through January 2024. Exposure Receipt HMT. Main Outcomes Measures Risk associated HMT; associations age, self-identified race, type. measured using hazard ratios (HRs) 95% CIs adjusted confounders such as demographic, sociocultural, clinical variables. Among 18 808 older diagnosed 2007 2009 (1266 Black [6.7%], 16 526 White [87.9%], 1016 other [5.4%]), 12 356 (65.7%) received diagnosis, while 6452 (34.3%) not. The most common age group both samples 75 79 (HMT, 2721 [22.0%]; no HMT, 1469 [22.8%]), majority groups 10 904 [88.3%]; 5622 [87.1%]). During an average follow-up, 2926 (23.7%) users 1802 (27.9%) non-HMT developed ADRD. 7% lower relative overall (HR, 0.93; CI, 0.88-0.98; P = .005). decreased varied by race. reduction greatest 74 0.76; 0.62-0.92). among 0.81; 0.67-0.98). Women had 11% 0.89; 0.81-0.97), but disappeared 0.96; 0.90-1.02). Other races showed significant Age- race-based also Conclusions Relevance In this retrospective study, protection against newly cancer; decrease relatively greater under years, protective effect diminished race women. When deciding use more, clinicians should consider type decisions.

Language: Английский

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Increased Risk of Alzheimer’s Disease in Patients with Head and Neck Cancer

Cancers, Journal Year: 2023, Volume and Issue: 15(23), P. 5516 - 5516

Published: Nov. 22, 2023

Patients with head and neck cancer (HNC) often experience cognitive impairment. However, the relationship between Alzheimer's disease (AD) remains unclear. We aimed to elucidate patients HNC their subsequent AD development. This retrospective study used data from a nationwide representative cohort sample, Korean National Health Insurance Service Cohort. The group was defined based on presence of diagnostic codes for (C00-C14 C30-C32). After matching independent variables propensity score 4:1, total 2304 people without 576 were enrolled in this study. Hazard ratios (HRs) incidence (per 1000 person-years) 95% confidence intervals (CIs) calculated. 14.92 9.77 non-cancer patients. Additionally, found have higher risk developing compared group. Female middle-aged had events other subgroups. Surprisingly, during observation period, relatively high within first year after diagnosis. In conclusion, our suggests that are positively correlated.

Language: Английский

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Interaction of water soluble phthalocyanine compounds with parallel and hybrid G-quadruplex DNA molecules

Polyhedron, Journal Year: 2023, Volume and Issue: 238, P. 116413 - 116413

Published: April 13, 2023

Language: Английский

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BrainMNet: A Unified Neural Network Architecture for Brain Image Classification

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 10, 2024

Abstract In brain-related diseases, including Brain Tumours and Alzheimer's, accurate timely diagnosis is crucial for effective medical intervention. Current state-of-the-art (SOTA) approaches in imaging predominantly focus on diagnosing a single brain disease at time. However, recent research has uncovered intricate connections between various realizing that treating one condition may lead to the development of others. Consequently, there growing need diagnostic systems addressing multiple diseases. Designing separate models different however, can impose substantial overhead. To tackle this challenge, our paper introduces BrainMNet, an innovative neural network architecture explicitly tailored classifying images. The primary objective propose single, robust framework capable spectrum comprehensively validates BrainMNet's efficacy, specifically tumours Alzheimer's disease. Remarkably, proposed model workflow surpasses current SOTA methods, demonstrating enhancement accuracy precision. Furthermore, it maintains balanced performance across classes tumour dataset, emphasizing versatility precise diagnosis. BrainMNet undergoes ablation study optimize its choice optimal optimizer, data growth analysis verifies small datasets, simulating real-life scenarios where progressively increases over Thus, signifies significant stride toward unified solution diverse

Language: Английский

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Comorbidities in patients with vascular dementia and Alzheimer's disease with Neuropsychiatric symptoms

Geriatric Nursing, Journal Year: 2024, Volume and Issue: 57, P. 217 - 223

Published: May 1, 2024

Language: Английский

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Balance and strength measures are associated with incident dementia in older men

Aging and Health Research, Journal Year: 2024, Volume and Issue: 4(3), P. 100199 - 100199

Published: July 28, 2024

As people age the risk of dementia increases. Balance and strength deteriorate with ageing, but their associations are not clear. We aimed to determine relationships balance performance incident in Health Men Study (HIMS) cohort. used wave 4 HIMS as baseline for analyses (2011–2013), following 1261 men until December 2017 via data linkage dementia. was measured using a modified Outcome Measure Elder Rehabilitation (mBOOMER) Score knee extension test. Cox proportional hazards regression used, adjusting sociodemographic health data. Strength scores were analysed non-linearly restricted cubic splines. 13.7% diagnosed over mean period 4.7 (SD 1.5) years. Higher mBOOMER associated reduced dementia, greater changes at higher (9 vs 8: HR 0.80, 95% CI 0.73–0.88; 12 11: 0.49, 0.36–0.68). lower limb occurring scores, plateauing around 25 kg (5 4: 0.93, 0.89–0.98; 24: 0.99, 0.95–1.03). This study demonstrated non-linear association better both likelihood These results raise hypothesis that strategies improve could reduce incidence older men.

Language: Английский

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