Bridging the Gap: Immune Checkpoint Inhibitor as an Option in the Management of Advanced and Recurrent Cervical Cancer in Sub-Saharan Africa DOI Open Access
Izuchukwu F. Okpalanwaka,

Francis I Anazodo,

Zimuzor L Chike-Aliozor

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Cervical cancer remains a leading cause of cancer-related mortality in women low and middle-income countries despite efforts to improve prevention standard-of-care interventions. Sub-Saharan Africa (SSA) leads the numbers for global cervical incidence mortality, with majority diagnosed late stage malignancy. Although death rate has been on decline last two decades owing advancements screening treatment options, SSA not declined very much. Chemotherapy choice without meeting expected survival outcomes these patients, having advanced diseases at diagnosis. Immune checkpoint inhibitors have recently shown clinical promise improving patients integrated into guidelines most high-income countries, which helped further reduce cancer. However, many are yet fully benefit from using immune In this review, we discuss challenges hindering effective use possible solutions.

Language: Английский

Interplay between LncRNAs and microRNAs in Breast Cancer DOI Open Access
Heidi Schwarzenbach,

Peter B. Gahan

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8095 - 8095

Published: April 30, 2023

(1) Although long noncoding RNAs (lncRNAs) are known to be precursors of microRNAs (miRNAs), they frequently act as competing endogoneous (ceRNAs), yet still their interplay with miRNA is not well known. However, interaction miRNAs may result in the modulation action. (2) To determine contribution these RNA molecules tumor resistance chemotherapeutic drugs, it essential consider only oncogenic and suppressive function but also impact lncRNAs on miRNAs. Therefore, we performed an extensive search different databases including PubMed. (3) The present study concerns between regulatory post-transcriptional network drugs used treatment breast cancer. (4) Consideration this improve for new circumvent chemoresistance.

Language: Английский

Citations

27
Mapping the function of MicroRNAs as a critical regulator of tumor-immune cell communication in breast cancer and potential treatment strategies DOI Creative Commons

Aimi Syamima Abdul Manap,

Aini Athirah Wisham,

Fei Wen Wong

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: April 25, 2024

Among women, breast cancer ranks as the most prevalent form of cancer, and presence metastases significantly reduces prognosis diminishes overall survival rates. Gaining insights into biological mechanisms governing conversion cells, their subsequent spread to other areas body, immune system’s monitoring tumor growth will contribute advancement more efficient targeted therapies. MicroRNAs (miRNAs) play a critical role in interaction between cells facilitating cells’ evasion system promoting progression. Additionally, miRNAs also influence metastasis formation, including establishment metastatic sites transformation migratory phenotypes. Specifically, dysregulated expression these genes has been associated with abnormal oncogenes suppressor genes, thereby development. This study aims provide concise overview significance function focusing on involvement suppressors antitumor response formation. Furthermore, hold tremendous potential targets for gene therapy due ability modulate specific pathways that can either promote or suppress carcinogenesis. perspective highlights latest strategies developed miRNA-based

Language: Английский

Citations

9
Synergistic Immunoregulation: harnessing CircRNAs and PiRNAs to Amplify PD-1/PD-L1 Inhibition Therapy DOI Creative Commons
Rui Han, Xiwu Rao, Huiling Zhou

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 4803 - 4834

Published: May 1, 2024

Abstract: The utilization of PD-1/PD-L1 inhibitors marks a significant advancement in cancer therapy. However, the efficacy monotherapy is still disappointing substantial subset patients, necessitating exploration combinational strategies. Emerging from promising results KEYNOTE-942 trial, RNA-based therapies, particularly circRNAs and piRNAs, have distinguished themselves as innovative sensitizers to immune checkpoint (ICIs). These non-coding RNAs, notable for their stability specificity, were once underrecognized but are now known crucial roles regulating PD-L1 expression bolstering anti-cancer immunity. Our manuscript offers comprehensive analysis selected elucidating immunomodulatory effects mechanisms, thus underscoring potential ICIs enhancers. In conjunction with recent Nobel Prize-awarded advancements mRNA vaccine technology, our review highlights transformative implications these findings treatment. We also discuss prospects piRNAs future therapeutic applications research. This study pioneers synergistic application novel augment inhibition therapy, demonstrating unique modulating responses. offer groundbreaking approach enhancing immunotherapy, opening new avenues treatment abstract aims encapsulate essence research burgeoning role RNAs encouraging further investigation into this field. Keywords: CircRNA, piwi-RNA, blockade, immunotherapy sensitizer, combination therapy

Language: Английский

Citations

8
The integrative genomic and functional immunological analyses of colorectal cancer initiating cells to modulate stemness properties and the susceptibility to immune responses DOI Creative Commons
Issam Tout, Salim Bougarn, Mohammed Toufiq

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 17, 2025

Colorectal cancer (CRC) initiating cells (CICs) possess self-renewal capabilities and are pivotal in tumor recurrence resistance to conventional therapies, including immunotherapy. The mechanisms underlying their interaction with immune remain unclear. We conducted a multi-omics analysis—encompassing DNA methylation, total RNA sequencing, microRNAs (miRNAs; N = 800) profiling on primary CICs differentiated cell lines, autologous pairs. Functional immunological assays were performed assess the impact of miRNA modulation. exhibited distinct methylation patterns, transcriptomic profiles, expressions compared (p < 0.05 or 0.01). Notably, miRNA-15a -196a implicated regulating tumorigenic pathways, such as epithelial-to-mesenchymal transition (EMT), TGF-β signaling, transfection mimics led downregulation oncogenic EMT markers (CRKL, lncRNA SOX2-OT, JUNB, SMAD3) pathway, resulting significant reduction vitro proliferation tumorigenicity migration zebrafish xenograft model. Additionally, enhanced expression antigen processing machinery decreased checkpoints (PD-L1, PD-L2, CTLA-4) immunosuppressive cytokines (IL-4). co-culture HLA-matched lymphocytes overexpressing miRNA-15a, elicited robust tumor-specific responses, characterized by shift toward central effector memory T phenotypes prevented terminal differentiation exhaustion. combination modulation Indoleamine 2,3-dioxygenase blockade immunomodulating agents further potentiated these effects. Our study demonstrates that not only suppresses properties but also enhances visibility system upregulating presentation reducing immunomodulatory molecules. These findings suggest combining epigenetic holds promise for overcoming treatment CRC.

Language: Английский

Citations

0
Investigation the immunotherapeutic potential of miR-4477a targeting PD-1/PD-L1 in breast cancer cell line using a CD8+ co-culture model DOI
Yasin Tülüce, Sedat Köstekci, Fuat Karakuş

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: March 19, 2025

Language: Английский

Citations

0
Targeting tumor-associated macrophages with nanocarrier-based treatment for breast cancer: A step toward developing innovative anti-cancer therapeutics DOI Creative Commons
Ghazala Muteeb, Doaa S. R. Khafaga,

Manar T El-Morsy

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(18), P. e37217 - e37217

Published: Aug. 30, 2024

Language: Английский

Citations

3
Next-Cell Hypothesis: Mechanism of Obesity-Associated Carcinogenesis DOI
Ayşe Başak Engin, Atilla Engin

Advances in experimental medicine and biology, Journal Year: 2024, Volume and Issue: unknown, P. 727 - 766

Published: Jan. 1, 2024

Language: Английский

Citations

1
Allele‐specific micro‐RNA‐mediated regulation of ADAM33 in childhood allergic asthma DOI
Xiang Wen, Juan Zhou, Heping Fang

et al.

Respirology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Abstract Background and Objective A disintegrin metalloprotease 33 (ADAM33) is associated with asthma susceptibility, its genetic variations impact susceptibility disease severity. However, the mechanisms remain unclear. This study aimed to investigate ADAM33 single nucleotide polymorphisms (SNPs) in childhood explore their regulatory mechanisms. Methods Eleven selected SNPs were genotyped identified association susceptibility. In validation cohort, we measured plasma sADAM33 levels compared them severity among children different SNP genotypes. Computational predictions miRNAs targeting SNP, of on miRNA regulation was confirmed using a dual luciferase reporter system. Finally, validated role expression an vitro model upregulated expression. Results Only rs3918400 allergic exhibited higher levels. Among asthmatic children, those CT/TT genotype had levels, poorer control, more severe airway hyper‐responsiveness, lower FEV 1 % dust mite‐specific IgE activity CC genotype. miR‐3928‐5p bound strongly C allele effectively reduced protein cells. binding affinity T weaker, resulting diminished negative Conclusion The affects by miR‐3928‐5p, potentially participating complex interplay processes related

Language: Английский

Citations

1
Multiple Genetic Polymorphisms within microRNA Targets and Homologous microRNA-Binding Sites: Two More Factors Influencing microRNA-Mediated Regulation of Gene Expression DOI Creative Commons

Miruna Giurgiu,

Robert F. Kaltenbach,

Franziska Ahrend

et al.

IntechOpen eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 14, 2023

miRNA-mRNA interaction depends on multiple factors such as 3’UTR isoforms, the cell and tissue-specific expression levels of RNA-binding proteins, sequence context around mRNA target site, other mechanisms. Genetic polymorphisms within miRNAs their sites appear to be among most important ones because they influence mode outcome universally irreversibly. SNP disruption binding sites, well conformational changes preventing access miRNA its are adopted credible mechanistic explanations SNP-mediated effects. The occurrence SNPs same miRNA-binding site implies combinatorial action. presence repetitive (homologous) for may both enhance targeting provide backup instead one disrupted by SNP, thus rescuing functionality. While being underexplored, genetic homologous considered additional influencing miRNA-mediated regulation gene expression.

Language: Английский

Citations

3
Evaluation of MMP-13 and Micro RNA-138 as prognostic biomarkers for breast cancer in Egyptian women patients DOI
Hossam M. El‐Masry, Sally M. Khadrawy, Mahmoud M. Kamel

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 253, P. 155045 - 155045

Published: Dec. 27, 2023

Language: Английский

Citations

1