Cancer
cells
are
very
diverse
but
mostly
share
a
common
metabolic
property:
they
strongly
glycolytic
even
though
oxygen
is
available.
Herein,
the
abnormalities
of
cancer
interpreted
as
modifications
electric
currents
in
redox
reactions.
A
lower
current
electron
transport
chain,
an
increase
concentration
reduced
cofactors
and
partial
reversal
tricarboxylic
acid
cycle
physical
characteristics
several
forms
cancer.
The
existence
short-circuits
between
oxidative
branches
reductive
network
argue
favor
electronic
approach
nanoscopic
scale.
These
changes
flows
induce
pseudo-hypoxia
Warburg
effect
through
succinate
production
divert
electrons
from
to
biosynthetic
pathways.
This
new
look
at
may
have
potential
therapeutic
applications.
Function,
Journal Year:
2024,
Volume and Issue:
5(3)
Published: Jan. 1, 2024
Abstract
The
Warburg
Effect
is
a
longstanding
enigma
in
cancer
biology.
Despite
the
passage
of
100
yr
since
its
discovery,
and
accumulation
vast
body
research
on
subject,
no
convincing
biochemical
explanation
has
been
given
for
original
observations
aerobic
glycolysis
cell
metabolism.
Here,
we
have
worked
out
first-principles
quantitative
analysis
problem
from
principles
stoichiometry
available
electron
balance.
results
interpreted
using
Nath’s
unified
theory
energy
coupling
adenosine
triphosphate
(ATP)
synthesis,
data
colleagues
analyzed
this
new
perspective.
Use
biomass
yield
based
ATP
per
unit
substrate
consumed,
${{Y}_{X/S}}\
ATP$,
or
Nath-Warburg
number,
NaWa
shown
to
excellently
model
with
very
small
standard
deviation
values,
without
employing
additional
fitted
adjustable
parameters.
Based
analysis,
novel
conservative
mechanism
utilization,
recycling
other
key
metabolites
(eg,
lactate)
proposed.
offers
fresh
insights
into
metabolic
symbiosis
within
and/or
among
proliferating
cells.
fundamental
understanding
gained
our
approach
should
help
catalyzing
development
more
efficient
metabolism-targeting
anticancer
drugs.
Journal of Proteome Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 4, 2025
Identifying
novel
biomarkers
is
crucial
for
early
detection
of
colorectal
cancer
(CRC).
Saliva,
as
a
noninvasive
sample,
holds
promise
CRC
detection.
Here,
we
used
Olink
proteomics
and
untargeted
metabolomics
to
analyze
saliva
samples
from
patients
healthy
controls
with
the
aim
identifying
candidate
in
saliva.
Univariate
multivariate
analyses
revealed
16
differentially
expressed
proteins
(DEPs)
40
accumulated
metabolites
(DAMs).
Pathway
enrichment
showed
DEPs
were
mainly
involved
transcriptional
dysregulation,
Toll-like
receptor
signaling,
chemokine
signaling.
Metabolomics
analysis
highlighted
significant
changes
amino
acid
metabolites,
particularly
pathways
such
arginine
biosynthesis,
histidine
metabolism,
cysteine
methionine
metabolism.
Random
forest
ELISA
validation
identified
four
potential
biomarkers:
succinate,
l-methionine,
GZMB,
MMP12.
A
combined
protein-metabolite
diagnostic
model
was
developed
using
logistic
regression,
achieving
an
area
under
curve
0.933
(95%
CI:
0.871-0.996)
discovery
cohort
0.969
0.918-1.000)
cohort,
effectively
distinguishing
individuals.
In
conclusion,
our
study
validated
panel
saliva-based
that
could
improve
screening
provide
new
insights
into
clinical
diagnosis.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(5), P. 960 - 960
Published: Feb. 27, 2024
Non-coding
RNAs
provide
new
opportunities
to
identify
biomarkers
that
properly
classify
cancer
patients.
Here,
we
study
the
biomarker
status
of
mitochondrial
long
non-coding
RNAs,
MDL1
and
MDL1AS.
Expression
these
genes
was
studied
in
public
transcriptomic
databases.
In
addition,
a
cohort
69
locally
advanced
rectal
(LARC)
patients
with
follow-up
more
than
5
years
used
determine
prognostic
value
markers.
Furthermore,
cell
lines
colorectal
(HCT116)
breast
(MDA-MB-231)
carcinoma
were
employed
effects
downregulating
MDL1AS
vitro.
(but
not
MDL1)
significantly
different
tumor
cells
surrounding
tissue
tumor-type-specific
context.
Both
accurate
for
5-year
survival
LARC
(p
=
0.040
p
0.007,
respectively)
promising
areas
under
curve
ROC
analyses
(0.820
0.930,
respectively).
downregulation
reduced
respiration
both
lines.
this
produced
decrease
growth
migration
on
cells,
but
reverse
cells.
summary,
can
be
as
reliable
LARC,
expression
provides
relevant
information
diagnosis
cancers.
Genes & Nutrition,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: May 27, 2024
Mitochondrial
respiration
complexes
play
a
crucial
function.
As
result,
dysfunction
or
change
is
intimately
associated
with
many
different
diseases,
among
them
cancer.
The
epigenetic,
evolutionary,
and
metabolic
effects
of
mitochondrial
complex
IΙ
are
the
primary
concerns
our
review.
Provides
novel
insight
into
vital
role
naringenin
(NAR)
as
an
intriguing
flavonoid
phytochemical
in
cancer
treatment.
NAR
significant
that
member
flavanone
group
polyphenols
mostly
present
citrus
fruits,
such
grapefruits,
well
other
fruits
vegetables,
like
tomatoes
cherries,
foods
produced
from
medicinal
herbs.
evidence
now
available
indicates
NAR,
herbal
remedy,
has
pharmacological
qualities
anti-cancer
effects.
Through
variety
mechanisms,
including
induction
apoptosis,
cell
cycle
arrest,
restriction
angiogenesis,
modulation
several
signaling
pathways,
prevents
growth
However,
hydrophobic
crystalline
structure
primarily
responsible
for
its
instability,
limited
oral
bioavailability,
water
solubility.
Furthermore,
there
no
targeting
high
rate
breakdown
acidic
environment.
These
shortcomings
barriers
to
efficient
medical
application.
Improvement
ΙΙ
by
loading
it
on
chitosan
nanoparticles
promising
strategy.
Advances in Redox Research,
Journal Year:
2023,
Volume and Issue:
10, P. 100087 - 100087
Published: Nov. 30, 2023
Cancer
cells
are
very
diverse
but
mostly
share
a
common
metabolic
property:
they
strongly
glycolytic
even
though
oxygen
is
available.
Herein,
the
abnormalities
of
cancer
interpreted
as
modifications
electric
currents
in
redox
reactions.
A
lower
current
electron
transport
chain,
an
increase
concentration
reduced
cofactors
and
partial
reversal
tricarboxylic
acid
cycle
physical
characteristics
several
forms
cancer.
The
existence
short-circuits
between
oxidative
branches
reductive
network
argue
favor
electronic
approach
nanoscopic
scale.
These
changes
flows
induce
pseudo-hypoxia
Warburg
effect
through
succinate
production
divert
electrons
from
to
biosynthetic
pathways.
This
new
look
at
may
have
potential
therapeutic
applications.
PLoS ONE,
Journal Year:
2023,
Volume and Issue:
18(12), P. e0296038 - e0296038
Published: Dec. 20, 2023
The
24B_1
small
non-coding
RNA
molecule
has
been
identified
in
Escherichia
coli
after
induction
of
Shiga
toxin-converting
bacteriophage
Φ24B.
In
this
work,
we
focused
on
its
direct
role
during
phage
and
bacterial
host
development.
We
observed
that
many
aspects,
sRNA
resembles
herpesviral
microRNAs.
Similar
to
microRNAs,
the
mature
is
a
short
molecule,
consisting
just
20
nucleotides.
It
generated
by
cleaving
80-nt
long
precursor
transcript,
likely
it
undergoes
multi-step
maturation
process
which
Hfq
protein
plays
an
important
role,
as
confirmed
demonstration
binding
precursor,
but
not
form.
Moreover,
significant
maintaining
prophage
state
reprogramming
host's
energy
metabolism.
proved
overproduction
causes
opposite
physiological
effects
mutant
devoid
gene,
thus,
favors
lysogenic
pathway.
Furthermore,
overrepresentation
significantly
increases
efficiency
expression
genes
coding
for
proteins
CI,
CII,
CIII
are
engaged
maintenance
prophage.
seems
through
mRNA
sdhB
succinate
dehydrogenase
subunit,
alters
central
carbon
metabolism
drop
ATP
intracellular
level.
Interestingly,
similar
effect,
called
Warburg
switch,
caused
microRNAs
cancer
cells.
advantage
effect
still
unclear,
however,
was
proposed
cells,
all
rapidly
dividing
adopted
convert
nutrients
such
glucose
glutamine
faster
more
efficiently
into
biomass.
availability
essential
building
blocks,
nucleotides,
amino
acids,
lipids,
crucial
effective
cell
proliferation
turn
stay
state.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(7), P. 757 - 757
Published: June 22, 2024
Despite
advancements
in
therapeutic
strategies,
the
development
of
drug
resistance
and
metastasis
remains
a
serious
concern
for
efficacy
chemotherapy
against
colorectal
cancer
(CRC).
We
have
previously
demonstrated
that
low
expression
ribosomal
protein
uL3
positively
correlates
with
chemoresistance
CRC
patients.
Here,
we
loss
increased
metastatic
capacity
cells
chick
embryos.
Metabolomic
analysis
revealed
large
perturbations
amino
acid
glutathione
metabolism
resistant
uL3-silenced
cells,
indicating
silencing
dramatically
triggered
redox
metabolic
reprogramming.
RNA-Seq
data
notable
dysregulation
108
genes
related
to
ferroptosis
Solute
Carrier
Family
7
Member
11
(SLC7A11)
is
one
most
dysregulated
genes;
its
mRNA
stability
negatively
regulated
by
uL3,
inversely
correlated
levels.
Inhibition
SLC7A11
erastin
impaired
cell
survival
inducing
ferroptosis.
Of
interest,
combined
treatment
plus
enhanced
chemotherapeutic
sensitivity
erastin.
The
antimetastatic
potential
strategy
was
evaluated
Overall,
our
study
sheds
light
on
uL3-mediated
provides
evidence
novel
approach,
induce
ferroptosis,
establishing
individualized
therapy
examining
p53,
profiles
tumors.
Cancer & Metabolism,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Dec. 23, 2024
Heterozygosity
for
loss-of-function
alleles
of
the
genes
encoding
four
subunits
succinate
dehydrogenase
(SDHA,
SDHB,
SDHC,
SDHD),
as
well
SDHAF2
assembly
factor
predispose
affected
individuals
to
pheochromocytoma
and
paraganglioma
(PPGL),
two
rare
neuroendocrine
tumors
that
arise
from
neural
crest-derived
paraganglia.
Tumorigenesis
results
loss
remaining
functional
SDHx
gene
copy,
leading
a
cell
with
no
SDH
defective
tricarboxylic
acid
(TCA)
cycle.
It
is
believed
subsequent
accumulation
competitively
inhibits
multiple
dioxygenase
enzymes
normally
suppress
hypoxic
signaling
demethylate
histones
DNA,
ultimately
increased
expression
involved
in
angiogenesis
proliferation.
Why
selectively
tumorigenic
cells
remains
poorly
understood.
In
absence
SDH-loss
tumor-derived
models,
cellular
burden
have
been
investigated
through
conditional
knockouts
pre-existing
murine
or
human
lines
varying
degrees
clinical
relevance.
Here
we
characterize
available
lines,
immortalized
adrenally-derived
premature
chromaffin
vs.
fibroblasts,
at
level
detail
beyond
currently
reported
literature
intention
laying
foundation
future
investigations
into
adaptive
pathways
vulnerabilities
cells.
We
report
different
mechanistic
phenotypic
manifestations
subunit
presented
contexts.
These
findings
highlight
similarities
differences
response
between
models.
show
display
more
severe
morphological
mitochondrial
alterations,
yet
are
unique
preserving
residual
Complex
I
function,
perhaps
allowing
them
better
tolerate
loss,
thus
making
closer
model
PPGL
relative
fibroblasts.(281
words).
