Journal of Stomatology Oral and Maxillofacial Surgery, Journal Year: 2024, Volume and Issue: unknown, P. 102139 - 102139
Published: Nov. 1, 2024
Language: Английский
European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)
Published: Jan. 5, 2024
This review article explores the dynamic field of radiopharmaceuticals, where innovative developments arise from combining radioisotopes and pharmaceuticals, opening up exciting therapeutic possibilities. The in-depth exploration covers targeted drug delivery, delving into passive targeting through enhanced permeability retention, as well active using ligand-receptor strategies. also discusses stimulus-responsive release systems, which orchestrate controlled release, enhancing precision effectiveness. A significant focus is placed on crucial role radiopharmaceuticals in medical imaging theranostics, highlighting their contribution to diagnostic accuracy image-guided curative interventions. emphasizes safety considerations strategies for mitigating side effects, providing valuable insights addressing challenges achieving precise delivery. Looking ahead, nanoparticle formulations cutting-edge innovations next-generation showcasing potential applications. Real-world examples are presented case studies, including use radiolabelled antibodies solid tumors, peptide receptor radionuclide therapy neuroendocrine intricate management bone metastases. concluding perspective envisions future trajectory anticipating a harmonious integration medicine artificial intelligence. vision foresees an era aligns seamlessly with scientific advancements, ushering new epoch marked by fusion resonance visionary progress.
Language: Английский
Citations
51
Biomedicines, Journal Year: 2024, Volume and Issue: 12(1), P. 183 - 183
Published: Jan. 15, 2024
The management of metastatic cancer is complicated by chemotherapy resistance. This manuscript provides a comprehensive academic review strategies to overcome resistance in cancer. presents background information on cells, highlighting its clinical significance and the current challenges associated with using treat delves into molecular mechanisms underlying subsequent sections. It discusses genetic alterations, mutations, epigenetic modifications that contribute development Additionally, role altered drug metabolism efflux mechanisms, as well activation survival pathways evasion cell death, are explored detail. thoroughly examined, covering various approaches have shown promise. These include combination therapy approaches, targeted therapies, immunotherapeutic strategies, repurposing existing drugs. Each strategy discussed terms rationale potential effectiveness. Strategies for early detection monitoring resistance, rational design vis-a-vis personalized medicine predictive biomarkers guiding treatment decisions, importance lifestyle supportive therapies improving outcomes discussed. Lastly, outlines implications strategies. insights ongoing trials emerging address cells. also explores opportunities translating laboratory findings practice identifies future directions novel therapeutic avenues. detailed analysis emphasizes understanding range addressing this critical issue treating
Language: Английский
Citations
35
Archivos de Bronconeumología, Journal Year: 2024, Volume and Issue: 60, P. S46 - S58
Published: May 6, 2024
Language: Английский
Citations
8
Cellular Signalling, Journal Year: 2024, Volume and Issue: 122, P. 111329 - 111329
Published: Aug. 5, 2024
Language: Английский
Citations
8
World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(8), P. 863 - 880
Published: Feb. 26, 2024
The development and progression of gastric cancer (GC) are closely linked to the nutritional status patients. Although immunotherapy has been demonstrated be clinically effective, relationships sarcopenia myosteatosis with use immune checkpoint inhibitors (ICIs) in patients remain characterized.
Language: Английский
Citations
5
BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)
Published: May 3, 2024
Abstract Radiotherapy is a mainstay of cancer treatment. The clinical response to radiotherapy heterogeneous, from complete early progression. Recent studies have explored the importance patient characteristics in radiotherapy. In this editorial, we invite contributions for BMC Cancer collection articles titled ‘Advances personalized radiotherapy’ towards improvement treatment response.
Language: Английский
Citations
5
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Feb. 24, 2024
The human protein-coding gene ITGB1 (Integrin 1), also known as CD29, has a length of 58048 base pairs. Integrin family's most prevalent subunit, it participates in the transmission numerous intracellular signaling pathways. A thorough examination ITGB1's functions malignancies, however, is inadequate and many their relationships to onset development cancers remain unknown. In this work, we examined role 33 cancers. Finally, multi-platform analysis revealed that three malignancies had significantly altered expression tumor tissues comparison normal tissues. addition, was discovered through survival stand-alone prognostic factor number linked immune cell infiltration colon cancer, according an investigation pan-cancer. co-expression research, showed positive connection with majority proliferation EMT indicators, indicating may have essential function controlling cancer metastasis proliferation. Our pan-cancer gives evidence favor further into its oncogenic various types.
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3355 - 3355
Published: March 15, 2024
DNA damage is induced by both endogenous and exogenous factors. Repair of double-strand break (DSB), a serious that threatens genome stability, decreases with senescence. However, the molecular mechanisms underlying decline in repair capacity during senescence remain unclear. We performed immunofluorescence staining for phosphorylated histone H2AX (γ-H2AX) normal human fetal lung fibroblasts skin different ages after chronic irradiation (total dose, 1 Gy; dose rate, Gy/day) to investigate effect cellular organismal aging on DSB repair. Accumulation DSBs was observed aging, probably caused delayed Importantly, formation γ-H2AX foci, an early event repair, aging. These results suggest delay focus might overall Interestingly, immediate foci suppressed cells senescence-associated heterochromatin (SAHF). To relationship between SAHF, we used LiCl relax SAHFs, followed irradiation. demonstrated rescued associated This indicates SAHF interferes inhibits radiation-induced DSB. Our therapeutic targeting SAHFs have potential resolve dysfunction
Language: Английский
Citations
4
Oral Oncology, Journal Year: 2024, Volume and Issue: 158, P. 106982 - 106982
Published: Aug. 16, 2024
Language: Английский
Citations
4
Journal of Radiation Research and Applied Sciences, Journal Year: 2024, Volume and Issue: 17(2), P. 100937 - 100937
Published: April 26, 2024
Malignant tumors comprise cancer cells and their surrounding tumor microenvironment (TME). This environment includes cellular non-cellular components that collectively form a sophisticated network contributing to cell survival, progression, immune evasion, resistance treatment. Recent findings have shown TME act as protective "fortress," effectively shielding from the impact of radiation. review provides comprehensive overview our current knowledge how reinforces radiotherapy. Furthermore, it outlines growing body evidence preclinical clinical studies regarding influence in fostering radioresistance. Additionally, explores potential targeting various amplify responses radiation settings, delves into associated challenges future perspectives this rapidly evolving field.
Language: Английский
Citations
2