lncRNA Biomarkers of Glioblastoma Multiforme

Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 932 - 932

Published: April 23, 2024

Long noncoding RNAs (lncRNAs) are RNA molecules of 200 nucleotides or more in length that not translated into proteins. Their expression is tissue-specific, with the vast majority involved regulation cellular processes and functions. Many human diseases, including cancer, have been shown to be associated deregulated lncRNAs, rendering them potential therapeutic targets biomarkers for differential diagnosis. The lncRNAs nervous system varies different cell types, implicated mechanisms neurons glia, effects on development functioning brain. Reports also a link between changes lncRNA etiopathogenesis brain neoplasia, glioblastoma multiforme (GBM). GBM an aggressive variant cancer unfavourable prognosis median survival 14-16 months. It considered brain-specific disease highly invasive malignant cells spreading throughout neural tissue, impeding complete resection, leading post-surgery recurrences, which prime cause mortality. early diagnosis could improve treatment extend survival, profiling biological fluids promising detection neoplastic at their initial stages effective interventions. This review presents systematic overview GBM-associated deregulation focus fingerprints patients' blood.

Language: Английский

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LncRNAs: the art of being influential without protein

Trends in Plant Science, Journal Year: 2024, Volume and Issue: 29(7), P. 770 - 785

Published: Feb. 16, 2024

The plant long noncoding (lnc)RNA field is on the brink of transitioning from large-scale identification lncRNAs to their functional characterization. Due cross-kingdom conservation interaction types and molecular functions, there much be learned mammalian lncRNA research. Here, we discuss different processes involving regulation chromatin splicing. Furthermore, interactome, which includes proteins, other RNAs, DNA. We explore how functionalities could reflected in similar pathways plants hypothesize that several breakthroughs research lead discovery novel functions. Expanding our knowledge biological role multiple applications paves way for future agricultural applications.

Language: Английский

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Delving Into lncRNA‐Mediated Regulation of Autophagy‐Associated Signaling Pathways in the Context of Breast Cancer

Cell Biology International, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Breast cancer is a multifaceted and prevalent malignancy, impacting considerable proportion of women globally. Numerous signaling pathways intricately regulate cellular functions such as growth, proliferation, survival. Among the various regulators, lncRNAs have emerged significant players despite their inability to encode proteins. An expanding body literature underscores pivotal roles play in biology, particularly context breast cancer. Autophagy, process dedicated degradation recycling components, now recognized crucial factor initiation progression. The interplay between lncRNAs, pathways, autophagy pathophysiology remains an active area investigation. Researchers identified specific that are dysregulated patients, influencing modulation key pathways. Using experimental methodologies bioinformatics approaches, multiple been elucidated, providing deeper insights into contributions pathogenesis metastatic processes. In summary, pathophysiological landscape characterized by complex interactions involving lncRNA-mediated autophagy. This understanding paves way for identifying novel therapeutic targets, prognostic markers, diagnostic ultimately contributing improved treatment outcomes management.

Language: Английский

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Pulmonary Hypertension: Molecular Mechanisms and Clinical Studies

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: March 1, 2025

Pulmonary hypertension (PH) stands as a tumor paradigm cardiovascular disease marked by hyperproliferation of cells and vascular remodeling, culminating in heart failure. Complex genetic epigenetic mechanisms collectively contribute to the disruption pulmonary homeostasis. In recent years, advancements research technology have identified numerous gene deletions mutations, addition bone morphogenetic protein receptor type 2, that are closely associated with remodeling process PH. Additionally, modifications such RNA methylation, DNA histone modification, noncoding RNAs been shown precisely regulate PH molecular networks cell-type-specific manner, emerging potential biomarkers therapeutic targets. This review summarizes analyzes roles currently genes factors PH, emphasizing pivotal role long ncRNAs its regulation. it examines current clinical preclinical therapies for targeting these explores new treatment strategies.

Language: Английский

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Circulating non-coding RNA biomarkers of endocrine tumours

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: 20(10), P. 600 - 614

Published: June 17, 2024

Language: Английский

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Exploring the enigma: history, present, and future of long non-coding RNAs in cancer

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 7, 2024

Abstract Long noncoding RNAs (lncRNAs), which are more than 200 nucleotides in length and do not encode proteins, play crucial roles governing gene expression at both the transcriptional posttranscriptional levels. These molecules demonstrate specific patterns various tissues developmental stages, suggesting their involvement numerous processes diseases, notably cancer. Despite widespread acknowledgment growing enthusiasm surrounding potential as diagnostic prognostic biomarkers, precise mechanisms through lncRNAs function remain inadequately understood. A few have been studied depth, providing valuable insights into biological activities emerging functional themes mechanistic models. However, extent to mammalian genome is transcribed transcripts still a matter of debate. This review synthesizes our current understanding lncRNA biogenesis, genomic contexts, multifaceted tumorigenesis, highlighting cancer-targeted therapy. By exploring historical perspectives alongside recent breakthroughs, we aim illuminate diverse reflect on broader implications study for evolution function, well advancing clinical applications.

Language: Английский

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Non-coding RNAs in the pathogenesis of Alzheimer’s disease: β-amyloid aggregation, Tau phosphorylation and neuroinflammation

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Jan. 31, 2025

Language: Английский

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The interplay of p16INK4a and non-coding RNAs: bridging cellular senescence, aging, and cancer

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 5, 2025

Language: Английский

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Disease‐Associated Risk Variants and Expression Levels of the lncRNA, CDKN2B‐AS1, Are Associated With the Progression of HCC

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(6)

Published: March 1, 2025

ABSTRACT The most susceptible loci of hepatocellular carcinoma (HCC) identified by genome‐wide association studies are located in non‐coding regions. antisense RNA at the INK4 locus (ANRIL), also known as cyclin‐dependent kinase inhibitor 2B 1 (CDKN2B‐AS1), is a long (lnc)RNA situated within and to genes encoding CDKN2A/B on chromosome 9p21.3. Single‐nucleotide polymorphisms (SNPs) CDKN2B‐AS1 associated with several cancer types, but their impacts HCC remain unclear. In this study, we investigated effects SNPs both susceptibility its clinicopathological development. Five SNP loci—rs564398 (T/C), rs1333048 (A/C), rs1537373 (G/T), rs2151280 (A/G) rs8181047 (G/A)—were analysed using TaqMan allelic discrimination assay for genotyping cohort 810 patients 1190 healthy controls. Under dominant model, least one minor C‐allele rs564398 showed lower risk liver cirrhosis (odds ratio (OR) = 0.677). Additionally, GT + TT genotype had reduced developing large tumours (T3 T4) advanced clinical stages (III/IV), particularly male population (OR 0.644 0.679). Furthermore, data from Cancer Genome Atlas revealed that expression levels were elevated tissues compared normal correlated T stages, high histological grades poor prognoses. Our findings suggest polymorphic variants may influence development progression Taiwanese population.

Language: Английский

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Long noncoding RNA antisense noncoding RNA in the INK4 locus as a diagnostic and prognostic biomarker in acute myeloid leukemia

The Egyptian Journal of Haematology, Journal Year: 2025, Volume and Issue: 50(1), P. 146 - 157

Published: Jan. 1, 2025

Abstract Background In acute myeloid leukemia (AML), long non coding RNAs (lncRNAs) may serve as prognostic indicators. The precise significance of lncRNAs for the prognosis AML is still unknown. Objective present study aims to assess possible diagnostic and impact antisense noncoding RNA in INK4 locus (ANRIL) patients. Patients methods This included 60 patients recently diagnosed with South Egypt Cancer Institute (SECI) 30 healthy individuals matched age sex a control. Molecular testing was conducted detect expression ANRIL gene, analysis carried out using real-time PCR. Results patient’s median gene significantly higher compared control group’s ( P <0.001). Outcome based on level showed poorer overall survival high group (6 months) than low (11 months). Also, shorter disease-free (5.5 (9 Conclusion upregulated studied patients, it correlated poor outcomes decreased survival. LncRNA play role pathophysiology course AML, providing fresh insight into potential use biomarker or therapeutic target AML.

Language: Английский

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