Chemical characterization, anticancer, antioxidant and anti-obesity activities with molecular docking studies of Pleurotus ostreatus biomass exposed to moist heat

Journal of Food Measurement & Characterization, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

---

Unveiling the in vitro activity of extracted Euphorbia trigona via Supercritical Fluid Extraction against pathogenic yeasts, obesity, cancer, and its wound healing properties

Bioresources and Bioprocessing, Journal Year: 2025, Volume and Issue: 12(1)

Published: April 4, 2025

Abstract Natural products of plant origin are being explored as safe alternatives for illness management. Their extraction processes play a crucial role in determining their phytochemical and pharmacological properties. In this context, Euphorbia trigona was extracted using Supercritical Fluid Extraction with CO 2 (SFE-CO ) at two operating temperatures: 20 °C 40 °C. Phytochemical characterization performed via HPLC, along anti-yeast evaluation the well diffusion method, anticancer assessment MTT assay, wound healing analysis scratch anti-obesity through lipase assay E. extract. The results indicated that SFE-CO greater quantity (0.198 g) than (0.156 g). Several compounds, such rosmarinic acid, gallic daidzein, ellagic naringenin, ferulic were identified high concentrations 10,034.29, 1,800.33, 750.22, 748.11, 462.15, 207.05 µg/mL, respectively, extract obtained °C, compared to High inhibition zones 24 ± 1.5, 0.5, 23 0.33 mm recorded against C. albicans , tropicalis G. candidum from Moreover, exhibited lower MIC MFC values tested yeasts efficacy ultrastructure examined severely affected by A IC 50 (98.87 1.26 µg/mL) (333.87 1.8 cancer cells (A431). closure level 84.08% while it 71.27% Lipase inhibited 15.77 28.14 respectively. Molecular docking acid is suitable inhibitor yeasts. Graphical

Language: Английский

---

Therapeutic potential of anti-cancer compounds from African medicinal plants: From in vitro studies to clinical applications

Journal of Phytomolecules and Pharmacology, Journal Year: 2025, Volume and Issue: 4(1), P. 20 - 38

Published: April 30, 2025

Language: Английский

---

Acute and sub-chronic toxicity studies of an aqueous extract of the leaves of Macaranga heterophylla Müll. Arg. (Euphorbiaceae) in Sprague-Dawley rats

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119941 - 119941

Published: May 1, 2025

Language: Английский

---

METABOLITES PROFILING AND THE ANTIBACTERIAL ACTIVITY OF ETHANOL LEAF EXTRACT OF JATROPHA CURCA

FUDMA Journal of Sciences, Journal Year: 2025, Volume and Issue: 9, P. 72 - 78

Published: April 27, 2025

The current study was carried out to screen and assess the antibacterial activity of Jatropha curcas ethanol leaf extracts against some bacteria isolated from oral cavity students Federal University Dutsin-Ma (FUDMA), Katsina State, Nigeria. A fresh plant collected, air dried, homogenized extracted using 95% Ethanol. total twenty (20) samples were collected sterile swab sticks process microbiological standard techniques, bacterial species blood agar confirmed Gram’s staining biochemical tests. preliminary phytochemical screening performed techniques. existence components J. extract (FTIR GCMS). cactus tested for well diffusion method. Phytochemical analysis gave positive results alkaloids, Cardiac glycosides, Saponins, Tannins Terpenoids. Octadecanoic acid 2,3-dihydroxypropyl ester (C21H42O4) found as prominent phytoconstituent in which probably contributed effect extract. Streptococcus Species S. aureus common pathogens. showed promising with an inhibitory zone (20mm) at 25 mg/ml (18mm) Staphylococcus aureus, respectively. In conclusion could be a good candidate agent development both gram negative strains of.bacterial.

Language: Английский

---

Naturally Occurring Nor-Steroids and Their Design and Pharmaceutical Application

Published: April 16, 2024

The main focus of this review is to introduce readers the fascinating class lipid molecules known as norsteroids, exploring their distribution across various biotopes and biological activities. provides an in-depth analysis modified steroids, including A, B, C, D-norsteroids, each characterized by distinct structural alterations. These modifications, which range from removal specific methyl groups changes in steroid core, result unique molecular architectures that significantly impact activity therapeutic potential. discussion on D-norsteroids sheds light configurations how these modifications influence pharmacological properties. also presents examples natural sources produce a diverse array steroids with structures, aforementioned D-nor variants. compounds, sourced marine organisms like sponges, soft corals starfish, well terrestrial entities such plants, fungi, bacteria. exploration encompasses biosynthesis, ecological significance, potential medical applications, highlighting crucial area interest pharmacology product chemistry. emphasizes importance researching for drug development, particularly addressing diseases where conventional medications are inadequate or conditions lacking sufficient options. Examples norsteroid synthesis provided illustrate practical applications research.

Language: Английский

---

Naturally Occurring Norsteroids and Their Design and Pharmaceutical Application

Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 1021 - 1021

Published: May 6, 2024

The main focus of this review is to introduce readers the fascinating class lipid molecules known as norsteroids, exploring their distribution across various biotopes and biological activities. provides an in-depth analysis modified steroids, including A, B, C, D-norsteroids, each characterized by distinct structural alterations. These modifications, which range from removal specific methyl groups changes in steroid core, result unique molecular architectures that significantly impact activity therapeutic potential. discussion on D-norsteroids sheds light configurations how these modifications influence pharmacological properties. also presents examples natural sources produce a diverse array steroids with structures, aforementioned D-nor variants. compounds are sourced marine organisms like sponges, soft corals, starfish, well terrestrial entities such plants, fungi, bacteria. exploration encompasses biosynthesis, ecological significance, potential medical applications, highlighting crucial area interest pharmacology product chemistry. emphasizes importance researching for drug development, particularly addressing diseases where conventional medications inadequate or conditions lacking sufficient options. Examples norsteroid synthesis provided illustrate practical applications research.

Language: Английский

---

Antioxidant and cytotoxic effects of <i>Chrozophora rottleri</i> fruit ethanol extract

International Journal of Pharmaceutical Sciences and Drug Research, Journal Year: 2024, Volume and Issue: unknown, P. 586 - 591

Published: July 30, 2024

Liver cancer, particularly hepatocellular carcinoma (HCC), occurs from liver cell abnormalities, influenced by factors such viral hepatitis, obesity toxins and drugs. Non-Alcoholic Fatty Disease (NAFLD) exacerbates disorders globally, marked fat accumulation, whereas fibrosis raises cancer risk in NAFLD Alcohol-Induced (ALD). Herbal medicine gains attraction for health, offering hepatoprotective benefits. Medicinal plant metabolites, polyphenols, display antioxidative effects, possibly suppressing development. This work focuses on evaluating the possible antioxidant cytotoxic effects of Chrozophora rottleri fruit ethanol extract (CRFEE) using in-vitro experiments. The capacity CRFEE was examined hydroxyl radical nitric oxide scavenging revealed considerable efficacy against both radicals, radicals 48.25% with an IC50 35.08±1.62 μg/ml 49.35% 307.44±2.28 μg/ml. Notably, displayed better efficiency compared to standard antioxidant, butylated toluene (BHT), neutralizing radicals. Additionally, cytotoxicity MTT test HepG-2 line cultures. had strong detrimental cells, higher dosages resulting a major loss viability. value determined 63±0.08μg/mL, suggesting its reducing proliferation. results demonstrate substantial activity cells (HepG-2 line). bioactive chemicals contained show potential future pharmaceutical applications, underscoring relevance natural-based research therapy necessity further exploration vivo.

Language: Английский

---

Anticancer potential of essential oils from Croton L. species (Euphorbiaceae): A comprehensive review of ethnomedicinal, pharmacological, phytochemical, and toxicological evidence

South African Journal of Botany, Journal Year: 2024, Volume and Issue: 175, P. 180 - 192

Published: Oct. 18, 2024

Language: Английский

---

Study design of herbal medicine clinical trials: a descriptive analysis of published studies investigating the effects of herbal medicinal products on human participants

BMC Complementary Medicine and Therapies, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 8, 2024

Abstract Background Increasing global interest in natural therapies has led to a rise the use of herbal medicines for managing various ailments. However, concerns about scientific evaluation have prompted study aiming assess design medicine clinical trials. This aimed provide descriptive overview design, characteristics, and methodologies contemporary Materials methods The reviewed trials published between 2019 2022 five electronic databases: PubMed, Embase, Web Sciences, Scopus, Cochrane Library. Data extraction included intervention details, outcome measures, trial phases, blinding, other relevant information, with analyses presented. term ‘herbal medicines’ this refers herbs, materials, preparations, finished products containing active ingredients from plant parts or their combinations. Results Out initially identified 5,918 records, 1,517 articles were eligible inclusion study. majority conducted Asian countries, covering range diseases. A randomized, double-blind, parallel 1:1 allocation ratio was frequently employed, along common placebos across all phases. Capsules most dosage form. median number human participants varied ranging 50 Phase 1 240 4. Conclusions analysis observed that employed designs, widespread placebo. Our observations provided valuable insights into evolving landscape

Language: Английский

---