Oxidative Stress in Breast Cancer: A Biochemical Map of Reactive Oxygen Species Production
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(5), P. 4646 - 4687
Published: May 13, 2024
This
review
systematizes
information
about
the
metabolic
features
of
breast
cancer
directly
related
to
oxidative
stress.
It
has
been
shown
those
redox
changes
occur
at
all
levels
and
affect
many
regulatory
systems
in
human
body.
The
biochemical
processes
occurring
are
described,
ranging
from
nonspecific,
first
glance,
strictly
hormone-induced
reactions,
genetic
epigenetic
regulation,
which
allows
for
a
broader
deeper
understanding
principles
oncogenesis,
as
well
maintaining
viability
cells
mammary
gland.
Specific
pathways
activation
stress
have
studied
response
overproduction
hormones
estrogens,
specific
ways
reduce
its
negative
impact
described.
diversity
participants
that
trigger
reactions
different
sides
is
considered
more
fully:
glycolytic
activity
cancer,
nature
consumption
amino
acids
metals.
role
metals
discussed
detail.
They
can
act
both
co-factors
direct
stress,
since
they
either
mechanism
lipid
peroxidation
or
capable
activating
signaling
tumorigenesis.
Special
attention
paid
regulation
tumors.
A
complex
cascade
mechanisms
explained,
made
it
possible
reconsider
existing
opinion
triggers
launching
oncological
process,
survival
their
ability
localize.
Language: Английский
Breast Cancer: Extracellular Matrix and Microbiome Interactions
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(13), P. 7226 - 7226
Published: June 30, 2024
Breast
cancer
represents
the
most
prevalent
form
of
and
leading
cause
cancer-related
mortality
among
females
worldwide.
It
has
been
reported
that
several
risk
factors
contribute
to
appearance
progression
this
disease.
Despite
advancements
in
breast
treatment,
a
significant
portion
patients
with
distant
metastases
still
experiences
no
cure.
The
extracellular
matrix
potential
target
for
enhanced
serum
biomarkers
cancer.
Furthermore,
degradation
epithelial–mesenchymal
transition
constitute
primary
stages
local
invasion
during
tumorigenesis.
Additionally,
microbiome
influence
on
diverse
physiological
processes.
is
emerging
microbial
dysbiosis
element
development
various
cancers,
including
Thus,
better
understanding
interactions
could
provide
novel
alternatives
treatment
management.
In
review,
we
summarize
current
evidence
regarding
intricate
relationship
between
microbiome.
We
discuss
arising
associations
future
perspectives
field.
Language: Английский