Role of Oxidative Stress in the Occurrence, Development, and Treatment of Breast Cancer

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 104 - 104

Published: Jan. 17, 2025

Breast cancer is one of the most prevalent cancers worldwide. Recent studies have increasingly emphasized role oxidative stress in initiation and progression breast cancer. This article reviews how imbalance influences occurrence advancement cancer, elucidating intricate mechanisms through which reactive oxygen species (ROS) operate this context their potential therapeutic applications. By highlighting these critical insights, review aims to enhance our understanding as a target for innovative strategies management

Language: Английский

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Nanoconjugate Carrying pH-Responsive Transferrin Receptor-Targeted Hesperetin Triggers Triple-Negative Breast Cancer Cell Death through Oxidative Attack and Assemblage of Pro-Apoptotic Proteins

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(11), P. 7556 - 7573

Published: Nov. 6, 2024

Triple-negative breast cancer (TNBC) is recognized as a major aggressive subtype of due to its expeditious worsening growth, extensive metastatic capability, and recalcitrance standard current treatments. Hesperetin (HSP), natural bioflavonoid from citrus fruits, demonstrates pronounced anticancer efficacy, but hydrophobicity limits clinical development. The present study reports the fabrication biocompatible pH-responsive transferrin (TF) receptor-targeted HSP-loaded poly(lactic-co-glycolic acid) (PLGA) nanobioconjugate (PLGA-HSP-TF NPs) exploration in vitro vivo antineoplastic potential. PLGA nanoparticles (NPs), PLGA-HSP NPs, PLGA-HSP-TF NPs were synthesized characterized by DLS, FTIR, FE-SEM, 1H NMR spectroscopy. stability release profile inspected, efficacy was scrutinized terms cytotoxicity, oxidative stress apoptosis biomarkers, cell cycle arrest. In tumor regression host survival studies executed Ehrlich ascites carcinoma (EAC) cell-bearing Swiss albino mice. drug uptake highly stable accomplished effectively MDA-MB-231 cells showed pH-dependent intracellular HSP, which generated excessive reactive oxygen species (ROS) that led assault TNBC cells. This elevated ROS dropped mitochondrial membrane potential triggered apoptosis-mediated death arresting at G0/G1 phase. Furthermore, unveiled significant compared free HSP with minimum toxicity dose 20 mg/kg body weight. divulges may be an astounding nanocandidate for triple-negative therapy.

Language: Английский

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Diet quality and cardiometabolic health in breast cancer survivors: the Pathways Study

Breast Cancer Research and Treatment, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Metabolomic Profiling of Disease Progression Following Radiotherapy for Breast Cancer

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 891 - 891

Published: March 5, 2025

This study aims to explore metabolic biomarkers and pathways in breast cancer prognosis. We performed a global post-radiotherapy (RT) urinary metabolomic analysis of 120 patients: 60 progression-free (PF) patients as the reference with progressive disease (PD: recurrence, second primary, metastasis, or death). UPLC-MS/MS (Metabolon Inc.) identified 1742 biochemicals (1258 known 484 unknown structures). Following normalization osmolality, log transformation, imputation missing values, Welch's two-sample t-test was used identify that differed between PF PD groups. Data visualization were MetaboAnalyst. Metabolic significantly groups following: amino acid metabolism, including phenylalanine, tyrosine, tryptophan biosynthesis (impact value (IV) = 1.00; p 0.0007); histidine metabolism (IV 0.60; < 0.0001); arginine proline 0.70; 0.0035). Metabolites carbohydrate glucose (p 0.0197), sedoheptulose 0.0115), carboxymethyl lysine 0.0098), elevated PD. Gamma-glutamyl acids, myo-inositol, oxidative stress biomarkers, 7-Hydroxyindole Sulfate sulfate, who died ≤ 0.05). Amino emerged key pathway progression, while metabolites also showed potential utility for progression. These findings demonstrate applications metabolomics identifying targets predicting

Language: Английский

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Effects of low-power red laser and blue LED on oxidative stress and cell death in human breast cancer cells

Laser Physics Letters, Journal Year: 2025, Volume and Issue: 22(5), P. 055601 - 055601

Published: April 28, 2025

Abstract Breast cancer is the most common type of in women worldwide. Several factors, such as reactive oxygen species (ROS) are involved pathophysiology cancer. At low levels, ROS could act signaling molecules, but at high cause oxidative damages and programmed cell death. Photobiomodulation (PBM) comes from interaction photoacceptors with photons emitted by low-power lasers light-emitting diodes (LEDs), which leaves to releasing ROS. PBM induce apoptosis increasing level cells. However, there few data on effects breast cells, blue light simultaneous red necrosis Thus, this study aimed evaluate ROS, levels human cultures after exposure laser LED. MCF-7 MDA-MB-231 cells were irradiated a (69 J cm −2 , 0.77 W ) LED (482 5.35 ), alone or combination, apoptosis, evaluated flow cytometry. The results showed that therapeutic alters death rates This indicates redox status process be considered for development alternative treat control

Language: Английский

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Role of oxeiptosis in disease mechanisms and therapeutic opportunities

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

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Deciphering the Regulatory Potential of Antioxidant and Electron-Shuttling Bioactive Compounds in Oolong Tea

Biology, Journal Year: 2025, Volume and Issue: 14(5), P. 487 - 487

Published: April 28, 2025

OT has gained attention for its high polyphenol content and therapeutic potential. To elucidate this further, study investigated the electron-shuttling bioactive compounds of evaluated their effect on dysregulated breast cancer (BC) genes. extracts were obtained via solvent extraction (SE) supercritical fluid (SFE), followed by in vitro assays. Phytochemical analysis revealed that ethanol-extracted (OTL-E) had highest polyphenol, flavonoid, tannin contents, correlating with strong antioxidant activity, while water-extracted (OTL-W) exhibited greater bioelectricity-stimulating properties microbial fuel cells (MFC), confirmed cyclic voltammetry (CV). Based phytochemical analyses, SE displayed a better technique isolating compared to SFE. In silico approaches through network pharmacology, molecular docking dynamics simulations polyphenols ortho- or para-dihydroxyl groups targeted BC proteins involved kinase signaling, apoptosis, hormone receptor pathways. Luteolin binding affinities MAPK1 PIK3CA free energy (ΔG) -9.1 -8.4 kcal/mol, respectively. Trajectory-based analyses enthalpy-favored ligand-induced conformational changes these oncoproteins, altering function development. These findings suggest potential as chemopreventive agent, warranting further vivo validation.

Language: Английский

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The metabolism-immunity axis in Immune thrombocytopenia: from energy regulation to targeted therapy

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107803 - 107803

Published: May 1, 2025

Language: Английский

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Polysaccharides extracted from tucum-do-cerrado fruits (Bactris setosa Mart) have antineoplastic effects in mice while preserving hepatic gluconeogenesis

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134590 - 134590

Published: Aug. 9, 2024

Language: Английский

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In Silico Analysis of Non-Conventional Oxidative Stress-Related Enzymes and Their Potential Relationship with Carcinogenesis

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1279 - 1279

Published: Oct. 23, 2024

Carcinogenesis is driven by complex molecular events, often involving key enzymes that regulate oxidative stress (OS). While classical such as SOD, catalase, and GPx have been extensively studied, other, non-classical stress-related (OSRE) may play critical roles in cancer progression. We aimed to explore the role of OSRE involved an OS scenario assess their potential contribution carcinogenesis some most prevalent types. Through data mining bioinformatic analysis gene protein expression mutation data, we identified with altered mutations across Functional pathways EGFR, MT-ND, GST, PLCG2, PRDX6, SRC, JAK2 were investigated. Our findings reveal traditionally considered peripheral significant tumor Those contribute initiation progression, well be hallmarks, EMT invasion, proliferation, ROS production. In addition, like SRC found dual both promoting generation being modulated OS. also interact oncogenic signaling pathways, including Wnt/β-catenin JAK2/STAT3, linking them aggressiveness therapeutic resistance. Future research should focus on translating these into clinical applications, development novel inhibitors or drugs targeting enzymes.

Language: Английский

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