Gut microbiome’s causal role in head and neck cancer: findings from mendelian randomization DOI Creative Commons
Meng Lian,

Minghong Sun,

Boxuan Han

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 19, 2024

The gut microbiome (GM) has been implicated in cancer pathogenesis and treatment, including head neck cancers (HNC). However, the specific microbial compositions influencing HNC underlying mechanisms remain largely unknown.

Language: Английский

Obesity-Associated Colorectal Cancer DOI Open Access
Lucía G. Gutiérrez, Omar Motiño, Daniel Barriuso

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8836 - 8836

Published: Aug. 14, 2024

Colorectal cancer (CRC) affects approximately 2 million people worldwide. Obesity is the major risk factor for CRC. In addition, obesity contributes to a chronic inflammatory stage that enhances tumor progression through secretion of proinflammatory cytokines. addition an increased response, obesity-associated presents accrued molecular factors related characteristics, such as genome instability, sustained cell proliferation, telomere dysfunctions, angiogenesis, and microbial alteration, among others. Despite evidence accumulated over last few years, treatments CRC do not differ from in normal-weight individuals. this review, we summarize current knowledge on cancer, including its epidemiology, factors, treatments. Finally, enumerate possible new therapeutic targets may improve conditions obese patients. key development CRC, resulting reversal should be considered strategy improving antineoplastic therapies.

Language: Английский

Citations

2
Circulating Bacterial DNA in Colorectal Cancer Patients: The Potential Role of <em>Fusobacterium nucleatum</em> DOI Open Access
Ioannis Koliarakis, Ilias Lagkouvardos,

Konstantinos Vogiatzoglou

et al.

Published: July 17, 2024

Dysbiosis, as reflected by the altered composition of microbiome favoring pathogenic species, is a major contributor to colorectal cancer (CRC) development, which could lead bacterial translocation into bloodstream. This study aimed evaluate presence circulated DNA (cbDNA) in CRC patients, with or without surgical removal primary tumor. In total, 100 participants enrolled this prospective clinicolaboratory study, equally divided four groups; healthy controls (Group 1), patients non-metastatic tumor 2), metastatic surgically excised 3) non-excised 4) extracted from peripheral blood was analyzed using PCR specific primers targeting 16S rRNA, Escherichia coli (E. coli), and Fusobacterium nucleatum (F. nucleatum). Only detection F. significantly higher Group 4 compared 1 (p &lt; 0.001), 2 = 0.023) 3 0.023). The association cbDNA other clinical parameters co-morbidities also evaluated. These results highlighted importance role an intratumoral oncomicrobe associated CRC.

Language: Английский

Citations

1
Circulating Bacterial DNA in Colorectal Cancer Patients: The Potential Role of Fusobacterium nucleatum DOI Open Access
Ioannis Koliarakis, Ilias Lagkouvardos,

Konstantinos Vogiatzoglou

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 9025 - 9025

Published: Aug. 20, 2024

Intestinal dysbiosis is a major contributor to colorectal cancer (CRC) development, leading bacterial translocation into the bloodstream. This study aimed evaluate presence of circulated DNA (cbDNA) in CRC patients (

Language: Английский

Citations

1
Gut microbiome’s causal role in head and neck cancer: findings from mendelian randomization DOI Creative Commons
Meng Lian,

Minghong Sun,

Boxuan Han

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 19, 2024

The gut microbiome (GM) has been implicated in cancer pathogenesis and treatment, including head neck cancers (HNC). However, the specific microbial compositions influencing HNC underlying mechanisms remain largely unknown.

Language: Английский

Citations

0