An Overview of 1,2,3-triazole-Containing Hybrids and Their Potential Anticholinesterase Activities

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(2), P. 179 - 179

Published: Jan. 24, 2023

Acetylcholine (ACh) neurotransmitter of the cholinergic system in brain is involved learning, memory, stress responses, and cognitive functioning. It hydrolyzed into choline acetic acid by two key cholinesterase enzymes, viz., acetylcholinesterase (AChE) butyrylcholinesterase (BuChE). A loss or degeneration neurons that leads to a reduction ACh levels considered significant contributing factor development neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD). Numerous studies have shown inhibitors can raise level and, therefore, enhance people’s quality life, at very least, it temporarily lessen symptoms NDs. 1,2,3-triazole, five-membered heterocyclic ring, privileged moiety, is, central scaffold, capable interacting with variety receptors enzymes exhibit broad range important biological activities. Recently, has been clubbed other pharmacophoric fragments/molecules hope obtaining potent selective AChE and/or BuChE inhibitors. The present updated review succinctly summarizes different synthetic strategies used synthesize 1,2,3-triazole moiety. also highlights anticholinesterase potential various di/trihybrids reported past seven years (2015–2022), including rationale for hybridization an emphasis on their structural features optimization treat

Language: Английский

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The fate of heterogeneous catalysis & click chemistry for 1,2,3-triazoles: Nobel prize in chemistry 2022

Catalysis Communications, Journal Year: 2023, Volume and Issue: 176, P. 106629 - 106629

Published: Feb. 23, 2023

The demand for environmental friendly methodologies had shifted the approach of scientific community using easy and green reaction conditions instead hazardous harsh conditions. One suggested approaches, use catalyst remained prime choice free reaction. difficulty in separation homogeneous from product increased attention chemists heterogeneous catalysts. present review summarizes some recent important developments catalysis "click reaction" obtaining 1,2,3-triazoles via Cu-catalyzed 1,3-dipolar azide-alkyne cycloaddition (CuAAC). A vast collection papers is efficiently grouped into two significant classes to increase readability language. Firstly, CuAAC reactions, secondly, other metal-catalyzed (MAAC) reactions are discussed. further sub-classes Cu(I)-nanoparticle catalyzed (Cu-NPs-AAC) simple Cu(I)-catalyzed (CuAAC) reactions. In most cases, formation 1,4-disubstituted 1,2,3-triazoles, as reported, was conveniently presented with help colored schemes.

Language: Английский

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Chiral metal-organic frameworks and their composites as stationary phases for liquid chromatography chiral separation: A minireview

Journal of Chromatography A, Journal Year: 2023, Volume and Issue: 1700, P. 464032 - 464032

Published: April 28, 2023

Language: Английский

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Click modified bis-appended Schiff base 1,2,3-triazole chemosensor for detection of Pb(II)ion and computational studies

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1288, P. 135666 - 135666

Published: April 29, 2023

Language: Английский

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Adsorption and photocatalytic applications of porphyrin-based materials for environmental separation processes: A review

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 908, P. 168293 - 168293

Published: Nov. 4, 2023

Language: Английский

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The recent development of β‐cyclodextrin‐based catalysts system in click reactions: A review

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 38(3)

Published: Jan. 18, 2024

A significant challenge for scientists today is to design green and eco‐friendly catalysts based on chemistry with high catalytic performance recycling properties. Many studies have aimed address environmental issues by developing chemical processes that reduce the production of harmful substances. β‐Cyclodextrin (β‐CD), a class cyclic oligomers, has garnered considerable attention in recent decades. It been utilized as alternative catalyst various organic conversions, demonstrating satisfactory activity improved efficiency reactions. The availability, non‐toxicity, low cost, renewability, transformations are several benefits cyclodextrins attracted interest from research groups worldwide. click reaction well‐known its selectivity producing 1,2,3‐triazoles medicinal activities. This involves aryl/alkyl halides, alkynes, NaN 3 under ambient conditions generate necessary scaffolds called 1,2,3‐triazoles. Therefore, finding approaches synthesizing great interest. In decades, advancements made metal‐catalyzed reactions synthesize 1,2,3‐triazole derivatives. Carolyn Bertozzi, Morten Meldal, Barry Sharpless were awarded Nobel Prize Chemistry 2022 their contributions foundations bio‐orthogonal chemistry. transition, reactions, using modified β‐CD derivatives particularly advantageous because valuable properties ability form inclusion complexes different metals. review focuses catalyzed β‐CD‐based prepare triazoles. Using biodegradable method safe, sustainable, eco‐friendly. provided access essential pharmaceutical products exhibits diverse biological specific purpose this summarize application systems

Language: Английский

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Recent progress of metal–organic framework-based nanozymes with oxidoreductase-like activity

The Analyst, Journal Year: 2024, Volume and Issue: 149(5), P. 1416 - 1435

Published: Jan. 1, 2024

The research progress of MOF-based nanozymes with oxidoreductase-like activity.

Language: Английский

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Application of Functionalized Zn-Based Metal–Organic Frameworks (Zn-MOFs) with CuO in Heterocycle Synthesis via Azide–Alkyne Cycloaddition

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(11), P. 4898 - 4914

Published: Jan. 31, 2024

The main goal of this article is to discuss the expansion click chemistry. A new catalyst composed CuO nanoparticles embedded in Zn-MOF with ligand 2,4,6-tris(4-carboxyphenoxy)-1,3,5-triazine (H3L) presented. incorporation into structure led desirable morphology and catalytic properties. designed was evaluated for its role multicomponent reaction copper-catalyzed azide–alkyne cycloaddition (CuAAC) preparation triazole rings 80–91% yield. demonstrated an appealing architecture exhibited robustness, high efficiency, environmental friendliness. Characterization performed using various techniques, including Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission microscopes (TEM), high-resolution (HRTEM), X-ray photoelectron (XPS), energy-dispersive (EDX), elemental mapping, diffraction (XRD). results suggest that novel has potential be a valuable tool development synthetic approaches wide range applications.

Language: Английский

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Recent advances in Cu-BTC MOF-based engineered materials for the photocatalytic treatment of pharmaceutical wastewater towards environmental remediation

RSC Sustainability, Journal Year: 2023, Volume and Issue: 1(8), P. 1952 - 1961

Published: Jan. 1, 2023

Cu-MOF has gained attention due to its exceptional thermal stability, large surface area and pore volume. This review summarizes advantages covering synthesis, reactivity applications in removing toxic pharmaceutical residues from wastewater.

Language: Английский

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Green synthesis of 1,4-disubstituted 1,2,3-triazoles: a sustainable approach

Green Chemistry, Journal Year: 2023, Volume and Issue: 26(4), P. 1725 - 1769

Published: Dec. 27, 2023

The synthesis of 1,4-disubstituted 1,2,3-triazoles, showcasing advancements in sustainable methodologies, emphasizing green solvents, catalysts, and innovative technologies, while addressing associated challenges future prospects.

Language: Английский

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