Obstetrics & Gynecology Science,
Journal Year:
2023,
Volume and Issue:
66(5), P. 347 - 363
Published: June 28, 2023
Nowadays,
polycystic
ovary
syndrome
(PCOS)
and
cognitive
dysfunction
are
major
health
problems
among
female.
This
narrative
review
aimed
to
investigate
in
female
with
PCOS.
English
Persian
articles
published
PubMed,
Scopus,
Web
of
Science,
Google
Scholar,
PsycINFO,
Scientific
Information
Database,
Cochrane
Database
Systematic
Reviews
until
May
2022
were
searched.
Sixteen
studies
involving
850
PCOS
974
controls
assessed.
In
these
studies,
the
association
between
biochemical
factors
symptoms
memory,
attention,
executive
functioning,
information
processing
speed,
visuospatial
skills
was
evaluated.
The
literature
revealed
possible
changes
study
summarized
different
aspects
function
due
medication,
psychological
(mood
disorders
caused
by
disease
complications),
markers,
such
as
metabolic
sex
hormone
abnormalities.
Considering
existing
scientific
gap
regarding
possibility
complications
PCOS,
further
biological
should
be
conducted
evaluate
potential
mechanisms
involved.
Journal of Applied Toxicology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 19, 2025
ABSTRACT
Hair
relaxers
are
predominantly
used
by
Black
women
in
the
United
States.
It
has
been
recently
suggested
that
exposure
to
potential
endocrine‐disrupting
compounds
from
use
of
these
products
may
be
associated
with
development
gynecological
and
breast
cancers
anatomically
relevant
nonmalignancies.
We
conducted
a
systematic
literature
review
using
PubMed
identify
original
studies
reporting
measures
association
between
hair
relaxer
adverse
outcomes,
focusing
specifically
on
A
total
1382
were
initially
identified,
after
consideration
exclusion
inclusion
criteria,
final
set
consisted
seven
cohort
one
case–control
study.
The
overall
findings
suggest
States
do
not
experience
an
increased
risk
cancer,
ovarian
or
uterine
cancer
due
relaxers.
One
study
found
statistically
significant
leiomyomata,
but
there
no
other
identified
support
findings.
None
characterized
chemical
constituents
From
epidemiologic
perspective,
weight
evidence
does
hypothesis
is
factor
for
US
women.
Heliyon,
Journal Year:
2025,
Volume and Issue:
11(4), P. e42582 - e42582
Published: Feb. 1, 2025
Menstrual
disorders
(MDs),
including
premenstrual
syndrome,
amenorrhea,
and
dysmenorrhea,
affect
women
globally.
Dioscorea
alata
L.,
a
traditional
yam
species,
has
been
used
medicinally,
but
its
potential
in
treating
MDs
remains
understudied.
This
study
employs
network
pharmacology
approach
to
examine
the
effects
of
D.
alata's
secondary
metabolites
on
via
multi-target
mechanisms.
Compounds
were
identified
from
literature
PubChem,
while
disease-related
targets
gathered
GeneCards,
DisGeNET,
CTD
databases.
Swiss
target
prediction
was
link
compounds
targets.
A
protein-protein
interaction
(PPI)
constructed
using
STRING,
Gene
Ontology
(GO)
KEGG
enrichment
analyses
conducted
predict
functional
pathways.
Eighteen
bioactive
120
therapeutic
specific
identified.
analysis
revealed
20
significant
pathways
related
menstrual
disturbances.
Among
targets,
TNF
α,
PPARG,
ESR1,
AKT1
highlighted
as
key
Molecular
docking
showed
strong
interactions
between
Daidzein
Diosgenin
Alatanin
AKT1,
PPARG.
The
findings
suggest
that
compounds,
such
Diosgenin,
Daidzein,
Genistin,
Cycloartane,
Alatanin,
could
modulate
involved
ovarian
follicle
formation,
hormone
regulation,
estrogen
receptor
signaling,
stress-activated
MAP
kinase
pathway.
provides
new
insights
into
for
disorders,
supporting
further
investigation
development.
Psychoneuroendocrinology,
Journal Year:
2024,
Volume and Issue:
166, P. 107070 - 107070
Published: May 9, 2024
Estrogen
is
a
group
of
hormones
that
collaborate
with
the
nervous
system
to
impact
overall
well-being
all
genders.
It
influences
many
processes,
including
those
occurring
in
central
system,
affecting
learning
and
memory,
playing
roles
neurodegenerative
diseases
mental
disorders.
The
hormone's
action
mediated
by
specific
receptors.
Significant
classical
estrogen
receptors,
ERα
ERβ,
various
were
known
since
years,
but
after
identifying
structurally
locationally
distinct
receptor,
G
protein-coupled
receptor
(GPER),
its
role
human
physiology
pathophysiology
was
investigated.
This
review
compiles
GPER-related
information,
highlighting
on
homeostasis
diseases,
while
putting
special
attention
functions
dysfunctions
this
neurobiology
biobehavioral
processes.
Understanding
modulation
possibilities
essential
for
therapy,
as
disruptions
receptors
can
lead
or
disorders,
irrespective
correct
levels.
We
conclude
studies
GPER
have
potential
develop
therapies
regulate
positively
health.
Journal of Pathology Informatics,
Journal Year:
2024,
Volume and Issue:
15, P. 100380 - 100380
Published: April 29, 2024
Endometrial
CD138+
plasma
cells
serve
as
a
diagnostic
biomarker
for
endometrial
inflammation,
and
their
elevated
occurrence
correlates
positively
with
adverse
pregnancy
outcomes.
Infertility-related
conditions
like
polycystic
ovary
syndrome
(PCOS)
recurrent
implantation
failure
(RIF)
are
closely
associated
systemic
local
chronic
inflammatory
status,
wherein
cell
accumulation
could
also
contribute
to
pathology.
Current
methods
quantifying
typically
involve
laborious
time-consuming
microscopic
assessments
of
only
few
random
areas
from
slide.
These
have
limitations
in
accurately
representing
the
entire
slide
susceptible
significant
biases
arising
intra-
interobserver
variations.
Implementing
artificial
intelligence
(AI)
identification
enhance
accuracy,
reproducibility,
reliability
analysis.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(11), P. 9280 - 9280
Published: May 25, 2023
Estrogen
receptor
alpha
(ERα)
is
widely
expressed
in
reproductive
organs,
but
also
non-reproductive
tissues
of
females
and
males.
There
evidence
that
lipocalin
2
(LCN2),
which
has
diverse
immunological
metabolic
functions,
regulated
by
ERα
adipose
tissue.
However,
many
other
tissues,
the
impact
on
LCN2
expression
not
been
studied
yet.
Therefore,
we
used
an
Esr1-deficient
mouse
strain
analyzed
(ovary,
testes)
(kidney,
spleen,
liver,
lung)
both
sexes.
Tissues
collected
from
adult
wild-type
(WT)
animals
were
immunohistochemistry,
Western
blot
analysis,
RT-qPCR
for
Lcn2
expression.
In
only
minor
genotype-
or
sex-specific
differences
detected.
contrast,
significant
observed
tissues.
Particularly,
there
was
a
strong
increase
ovaries
when
compared
to
WTs.
summary,
found
inverse
correlation
between
presence
testes
ovaries.
Our
results
provide
important
basis
better
understand
regulation
context
hormones
health
disease.
Journal of Animal Physiology and Animal Nutrition,
Journal Year:
2023,
Volume and Issue:
108(1), P. 1 - 12
Published: June 28, 2023
Abstract
Buffalo
cows
play
a
vital
role
in
milk
and
meat
production;
however,
they
are
characterised
by
several
reproductive
disorders.
Feeding
diets
with
high
oestrogenic
activity
may
be
disrupting
factor.
This
study
aimed
to
evaluate
the
effects
of
feeding
roughages
different
on
performance
early
postpartum
buffalo
cows.
A
total
30
were
equally
stratified
into
two
experimental
groups
fed
either
Trifolium
alexandrinum
(Berseem
clover,
phytoestrogenic
roughage)
or
corn
silage
(nonoestrogenic
for
90
consecutive
days.
After
35
days
from
beginning
treatments,
both
synchronized
oestrus
using
double
i.m.
injection
2
mL
prostaglandin
F
2α
,
11
apart,
subsequently,
overt
signs
observed
recorded.
Moreover,
ovarian
structures,
numbers
sizes
follicles
corpora
lutea,
ultrasonography
examined
at
day—12
(represents
Day
treatment),
0
(day
oestrus)
after
oestrous
synchronization
(mid‐luteal
phase).
Pregnancy
was
diagnosed
postinsemination.
Blood
serum
samples
analysed
progesterone
(P
4
),
estradiol
(E
tumor
necrosis
factor
(TNF‐α),
interlukein‐1β
(IL‐1β)
nitric
oxide
(NO).
The
liquid
chromatography‐analysis
showed
abundance
isoflavones
Berseem
about
58
times
higher
concentration
than
that
group.
During
period,
all
size
categories
clover
group
No
significant
difference
lutea
between
groups,
but
lower
(
p
<
0.05)
diameter
corpus
luteum
had
overall
concentrations
blood
E
IL‐1β
TNF‐α,
P
those
recorded
Oestrous
rate,
onset
time
duration
not
significantly
affected
treatment.
conception
rate
reduced
compared
In
conclusion,
roughage
such
as
can
negatively
affect
loss
seems
associated
inadequate
luteal
function
during
pregnancy.
Environmental Science & Technology,
Journal Year:
2023,
Volume and Issue:
57(50), P. 21327 - 21336
Published: Dec. 7, 2023
Exposure
to
environmental
endocrine-disrupting
chemicals
(EDCs)
can
cause
extensive
health
issues.
However,
specific
EDCs
remain
elusive.
This
work
aimed
at
performing
nontargeted
identification
of
estrogen
receptor
α
(ERα)-active
compounds
using
an
ERα
protein
affinity
assay
combined
with
high-resolution
mass
spectrometry
in
the
source
and
drinking
water
sampled
from
major
rivers
China.
Fifty-one
potential
ERα-active
across
13
categories
were
identified.
For
first
time,
diisodecyl
phenyl
phosphate
was
found
have
antiestrogenic
activity,
three
(galaxolidone,
bensulfuron
methyl,
UV234)
plausible
ligands.
Among
51
identified
compounds,
12
detected
aquatic
environment
for
concentration
N-phenyl-2-naphthylamine,
a
widely
used
antioxidant
rubber
products,
up
1469
1190
ng/L
water,
respectively.
study
demonstrated
widespread
presence
known
unknown
estrogenic
pollutants
that
serve
as
key
sources
China
low
removal
efficiency
these
treatment
plants.
