The Journal of Physical Chemistry B,
Journal Year:
2023,
Volume and Issue:
127(3), P. 600 - 615
Published: Jan. 13, 2023
The
onset
of
amyloidogenic
diseases
is
associated
with
the
misfolding
and
aggregation
proteins.
Despite
extensive
research,
no
effective
therapeutics
are
yet
available
to
treat
these
chronic
degenerative
diseases.
Targeting
disease-specific
proteins
regarded
as
a
promising
new
approach
In
past
few
years,
rapid
progress
in
this
field
has
been
made
vitro,
vivo,
silico
generate
potential
drug
candidates,
ranging
from
small
molecules
polymers
nanoparticles.
Small
molecular
probes,
mostly
those
derived
natural
sources,
have
particular
interest
among
amyloid
inhibitors.
Here,
we
summarize
some
most
important
probes
which
can
inhibit
Aβ,
hIAPP,
α-syn
peptides
discuss
how
their
binding
efficacy
preference
for
vary
structure
conformation.
This
provides
comprehensive
idea
crucial
factors
should
be
incorporated
into
future
design
novel
candidates
useful
treatment
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(8), P. 1628 - 1628
Published: Aug. 17, 2023
Alzheimer’s
disease
(AD)
is
a
brain
disorder
that
progressively
undermines
memory
and
thinking
skills
by
affecting
the
hippocampus
entorhinal
cortex.
The
main
histopathological
hallmarks
of
AD
are
presence
abnormal
protein
aggregates
(Aβ
tau),
synaptic
dysfunction,
aberrant
proteostasis,
cytoskeletal
abnormalities,
altered
energy
homeostasis,
DNA
RNA
defects,
inflammation,
neuronal
cell
death.
However,
oxidative
stress
or
damage
also
evident
commonly
overlooked
considered
consequence
advancement
dementia
symptoms.
control
onset
linked
to
activity
amyloid-β
peptide,
which
may
serve
as
both
antioxidant
pro-oxidant
molecules.
Furthermore,
correlated
with
proteins,
nucleic
acids,
lipids
in
vulnerable
populations,
ultimately
lead
death
through
different
molecular
mechanisms.
By
recognizing
an
integral
feature
AD,
alternative
therapeutic
preventive
interventions
developed
tested
potential
complementary
therapies
for
this
devastating
neurodegenerative
disease.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 22
Published: April 11, 2022
Alzheimer’s
disease
(AD)
is
a
common
neurodegenerative
brain
disorder
that
causes
cellular
response
alterations,
such
as
impaired
cholinergic
mechanism,
amyloid-beta
(Aβ)
AD
aggregation,
neuroinflammation,
and
several
other
pathways.
still
the
most
prevalent
form
of
dementia
affects
many
individuals
across
globe.
The
exact
cause
obscure.
There
are
yet
no
effective
medications
for
halting,
preventing,
or
curing
AD’s
progress.
Plenty
natural
products
isolated
from
sources
analyzed
in
preclinical
clinical
settings
neuroprotective
effects
preventing
treating
AD.
In
addition,
their
derivatives
have
been
promising
Natural
bioactive
compounds
play
an
active
modulatory
role
pathological
molecular
mechanisms
development.
This
review
focuses
on
plant
demonstrated
activities
maybe
to
treat
prevent
this
article
summarizes
literature
pertaining
agents
treatment
Rapid
metabolism,
nonspecific
targeting,
low
solubility,
lack
BBB
permeability,
limited
bioavailability
shortcomings
molecules
We
can
use
nanotechnology
nanocarriers
based
different
types
approaches.
Pharmaceuticals,
Journal Year:
2022,
Volume and Issue:
15(4), P. 408 - 408
Published: March 27, 2022
Thymoquinone
(TQ)
possesses
anticonvulsant,
antianxiety,
antidepressant,
and
antipsychotic
properties.
It
could
be
utilized
to
treat
drug
misuse
or
dependence,
those
with
memory
cognitive
impairment.
TQ
protects
brain
cells
from
oxidative
stress,
which
is
especially
pronounced
in
memory-related
regions.
exhibits
antineurotoxin
characteristics,
implying
its
role
preventing
neurodegenerative
disorders
such
as
Alzheimer's
disease
Parkinson's
disease.
TQ's
antioxidant
anti-inflammatory
properties
protect
damage
inflammation.
Glutamate
can
trigger
cell
death
by
causing
mitochondrial
malfunction
the
formation
of
reactive
oxygen
species
(ROS).
Reduction
ROS
production
explain
effects
neuroinflammation.
help
prevent
glutamate-induced
apoptosis
suppressing
malfunction.
Several
studies
have
demonstrated
inhibiting
Toll-like
receptors
(TLRs)
some
inflammatory
mediators,
leading
reduced
inflammation
neurotoxicity.
did
not
show
any
signs
dopaminergic
neuron
loss
after
treatment
various
animals.
has
been
shown
clinical
block
acetylcholinesterase
(AChE)
activity,
increases
acetylcholine
(ACh).
As
a
result,
fresh
memories
are
programmed
preserve
effects.
Treatment
linked
better
outcomes
decreased
side
than
other
drugs.
Journal of Personalized Medicine,
Journal Year:
2022,
Volume and Issue:
12(9), P. 1515 - 1515
Published: Sept. 15, 2022
Alzheimer's
disease
(AD)
is
a
neurodegenerative
characterized
by
tangle-shaped
accumulation
of
beta-amyloid
peptide
fragments
and
Tau
protein
in
brain
neurons.
The
pathophysiological
mechanism
involves
the
presence
Aβ-amyloid
peptide,
protein,
oxidative
stress,
an
exacerbated
neuro-inflammatory
response.
This
review
aims
to
offer
updated
compendium
most
recent
promising
advances
AD
treatment
through
administration
phytochemicals.
literature
survey
was
carried
out
electronic
search
following
specialized
databases
PubMed/Medline,
Embase,
TRIP
database,
Google
Scholar,
Wiley,
Web
Science
regarding
published
works
that
included
molecular
mechanisms
signaling
pathways
targeted
phytochemicals
various
experimental
models
vitro
vivo.
results
studies
showed
use
against
has
gained
relevance
due
their
antioxidant,
anti-neuroinflammatory,
anti-amyloid,
anti-hyperphosphorylation
properties
protein.
Some
bioactive
compounds
from
plants
have
been
shown
ability
prevent
stop
progression
Alzheimer's.
Frontiers in Neuroscience,
Journal Year:
2022,
Volume and Issue:
16
Published: May 16, 2022
The
current
scientific
community
is
facing
a
daunting
challenge
to
unravel
reliable
natural
compounds
with
realistic
potential
treat
neurological
disorders
such
as
Alzheimer’s
disease
(AD).
reported
compounds/drugs
mostly
synthetic
deemed
the
reliability
and
therapeutic
largely
due
their
complexity
off-target
issues.
products
from
nutraceutical
emerge
viable
preventive
therapeutics
fill
huge
gap
in
treating
disorders.
Considering
that
multifactorial
disease,
offer
advantage
of
multitarget
approach,
tagging
different
molecular
sites
human
brain,
compared
single-target
activity
most
drugs
so
far
used
disease.
A
wide
range
plant
extracts
phytochemicals
possess
includes
curcumin,
resveratrol,
epigallocatechin-3-gallate,
morin,
delphinidins,
quercetin,
luteolin,
oleocanthal,
other
huperzine
A,
limonoids,
azaphilones.
Reported
targets
these
include
inhibition
acetylcholinesterase,
amyloid
senile
plaques,
oxidation
products,
inflammatory
pathways,
specific
brain
receptors,
etc.
We
tenaciously
aimed
review
in-depth
applications
against
special
focus
on
diversity
medicinal
plants
phytocompounds
mechanism
action
pathologies.
strongly
believe
phytoconstituents
alone
or
combination
would
be
effective
treatments
lesser
side
effects
currently
available
treatments.
Brain Sciences,
Journal Year:
2023,
Volume and Issue:
13(1), P. 145 - 145
Published: Jan. 14, 2023
Neurodegenerative
diseases
(ND)
include
a
wide
range
of
conditions
that
result
from
progressive
damage
to
the
neurons.
Alzheimer's
disease
(AD)
is
one
most
common
NDs,
and
neuroinflammation
oxidative
stress
(OS)
are
major
factors
in
development
progression
disease.
Many
naturally
occurring
phytochemical
compounds
exhibit
antioxidant
anti-inflammatory
activities
with
potential
neuroprotective
effects.
Several
plant
species,
including
Alpinia
katsumadai
conchigera,
contain
cardamonin
(CD).
CD
(2',4'-dihydroxy-6'methoxychalcone)
has
many
therapeutic
properties,
anticancer,
anti-inflammatory,
antioxidant,
antiviral,
antibiotic
activities.
potent
compound
can
reduce
OS
modulate
inflammatory
processes
play
significant
part
developing
neurodegenerative
diseases.
been
shown
variety
signaling
molecules
involved
ND,
transcription
(NF-kB
STAT3),
cytokines
(TNF-α,
IL-1,
IL-6),
enzymes
(COX-2,
MMP-9,
ALDH1),
other
proteins
genes
(Bcl-2,
XIAP,
cyclin
D1).
Additionally,
effectively
modulates
miRNA
levels
autophagy-related
CD-protective
mechanisms
against
neurodegeneration.
In
summary,
this
review
provides
mechanistic
insights
into
CD's
ability
modify
multiple
stress-antioxidant
system
pathways,
Nrf2,
neuroinflammation.
it
points
possible
preventive
utilization
diseases,
specifically
AD.
