Cytokine-Mediated Crosstalk Between Keratinocytes and T Cells in Atopic Dermatitis

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: April 7, 2022

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by barrier dysfunction, dysregulated immune response, and dysbiosis with increased Staphylococcus aureus colonization. Infiltration of various T helper cell subsets into lesional subsequent cytokine release are hallmark AD. Release cytokines both cells keratinocytes plays key role in inflammation drives many AD features. This review aims to discuss cytokine-mediated crosstalk between pathogenesis the potential impact virulence factors produced on these interactions.

Language: Английский

---

The Role of TSLP in Atopic Dermatitis: From Pathogenetic Molecule to Therapeutical Target

Mediators of Inflammation, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 8

Published: April 15, 2023

Atopic dermatitis (AD) is a kind of chronic skin disease with inflammatory infiltration, characterized by barrier dysfunction, immune response dysregulation, and dysbiosis. Thymic stromal lymphopoietin (TSLP) acts as regulator response, positively associated AD deterioration. Mainly secreted keratinocytes, TSLP interacts multiple cells (including dendritic cells, T mast cells), following induction Th2-oriented during the pathogenesis AD. This article primarily focuses on biological function, relationship between different cell populations, treatments targeting TSLP.

Language: Английский

---

The Role of the Microbiota in the Pathogenesis and Treatment of Atopic Dermatitis—A Literature Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6539 - 6539

Published: June 13, 2024

Atopic dermatitis (AD) is a chronic inflammatory skin condition with high prevalence worldwide. AD pathogenesis complex and consists of immune system dysregulation impaired barrier, influenced by genetic environmental factors. The purpose the review to show interplay between atopic microbiota. Human microbiota plays an important role in course disease. Dysbiosis factor contributing development diseases, including dermatitis. gut can influence composition microbiota, strengthening barrier regulating response via involvement bacterial metabolites, particularly short-chain fatty acids, signaling pathways gut–skin axis. be modulated antibiotic intake, dietary adjustments, hygiene, living conditions. One promising strategies for modulating probiotics. This offers summary how influences treatment AD, highlighting aspects that warrant additional investigation.

Language: Английский

---

Therapeutic effects elicited by the probiotic Lacticaseibacillusrhamnosus GG in children with atopic dermatitis. The results of the ProPAD trial

Pediatric Allergy and Immunology, Journal Year: 2022, Volume and Issue: 33(8)

Published: Aug. 1, 2022

Abstract Background Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting up to 20% of the pediatric population associated with alteration and gut microbiome. Probiotics have been proposed for AD treatment. The ProPAD study aimed investigate therapeutic effects probiotic Lacticaseibacillus rhamnosus GG (LGG) in children AD. Methods In total, 100 patients aged 6–36 months were enrolled randomized, double‐blind, controlled trial receive placebo (Group A) or LGG (1 x 10 CFU/daily) B) 12 weeks. primary outcome was evaluation efficacy supplementation on severity comparing Scoring Dermatitis (SCORAD) index at baseline (T0) 12‐week (T12). A reduction ≥8.7 points SCORAD considered as minimum clinically important difference (MCID). secondary outcomes 4‐week (T16) after end treatment, number days without rescue medications, changes Infant Quality Of Life questionnaire (IDQOL), microbiome structure function, structure. Results rate subjects achieving MCID T12 T16 higher Group B ( p < .05), remained .05)The medications B. IDQOL improved .05). beneficial modulation observed only patients. Conclusions could be useful adjunctive therapy quality life paralleled

Language: Английский

---

Lignin-Based Antioxidant Hydrogel Patch for the Management of Atopic Dermatitis by Mitigating Oxidative Stress in the Skin

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(26), P. 33135 - 33148

Published: June 20, 2024

Atopic dermatitis (AD), a chronic skin condition characterized by itching, redness, and inflammation, is closely associated with heightened levels of endogenous reactive oxygen species (ROS) in the skin. ROS can contribute to onset progression AD through oxidative stress, which leads release proinflammatory cytokines, T-cell differentiation, exacerbation symptoms. In this study, we aim develop therapeutic antioxidant hydrogel patch for potential treatment using lignin, biomass waste material. Lignin contains polyphenol groups that enable it scavenge exhibit properties. The lignin patches, possessing optimized mechanical properties control cross-linker ratio, demonstrated high ROS-scavenging capabilities. Furthermore, excellent biocompatibility skin, exhibiting beneficial protecting human keratinocytes under conditions. When applied an mouse model, effectively reduced epidermal thickness inflamed regions, decreased mast cell infiltration, regulated inflammatory cytokine levels. These findings collectively suggest serves as managing modulating stress its ability.

Language: Английский

---

Identification of a cytokine profile in serum and cerebrospinal fluid of pediatric and adult spinal muscular atrophy patients and its modulation upon nusinersen treatment

Frontiers in Cellular Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Aug. 11, 2022

Background and objectives Multisystem involvement in spinal muscular atrophy (SMA) is gaining prominence since different therapeutic options are emerging, making the way for new SMA phenotypes consequent challenges clinical care. Defective immune organs have been found preclinical models of SMA, suggesting an system disease. However, state patients has not investigated so far. Here, we aimed to evaluate innate adaptive immunity pattern type 1 3 patients, before after nusinersen treatment. Methods Twenty one pediatric 1, 2, 12 adult 2 were included this single-center retrospective study. A Bio-Plex Pro-Human Cytokine 13-plex Immunoassay was used measure cytokines serum cerebrospinal fluid (CSF) study cohort 6 months therapy with nusinersen. Results We detected a significant increase IL-1β, IL-4, IL-6, IL-10, IFN-γ, IL-17A, IL-22, IL-23, IL-31, IL-33, at baseline, compared reference ranges healthy controls. Pediatric showed also TNF-α IL-17F levels baseline. Il-22, IL-33 decreased when decrease INF-γ, IL-17A CSF both displayed detectable all no differences treatment Notably, higher baseline expression IL-23 correlated worse motor function outcome patients. Moreover, treatment, presenting IL-10 concentration better Hammersmith Functional Motor Scale Expanded (HFMSE) score. Discussion show inflammatory signature that reduced upon SMN2 modulating presence mediators CSF. Our findings enhance knowledge potential implications.

Language: Английский

---

Environmental Exposures may Hold the Key; Impact of Air Pollution, Greenness, and Rural/Farm Lifestyle on Allergic Outcomes

Current Allergy and Asthma Reports, Journal Year: 2023, Volume and Issue: 23(2), P. 77 - 91

Published: Jan. 7, 2023

Language: Английский

---

Exploring the Potential of IL-4 and IL-13 Plasma Levels as Biomarkers in Atopic Dermatitis

Life, Journal Year: 2024, Volume and Issue: 14(3), P. 352 - 352

Published: March 7, 2024

Atopic dermatitis (AD) is a persistent inflammatory skin condition that impacts individuals of various age groups, including both children and adults. Its pathophysiology involves allergens penetrating disrupted epidermal barrier, triggering the dermal cells to produce pro-inflammatory cytokines eliciting T-cell-mediated immune response. Notably, interleukins (ILs), particularly interleukin 4 (IL-4) 13 (IL-13), play key role in AD pathogenesis. Therapies directed at mechanisms, Dupilumab, have demonstrated notable effectiveness enhancing lesions, alleviating subjective symptoms, improving overall quality life for with AD. Despite therapeutic advances, assessing severity remains challenging. The commonly used tools, such as SCORAD DLQI scores, rely on patient responses. Paraclinically, search universal biomarkers continues, efforts identify reliable indicators reflecting disease treatment Various biomarkers, Th2-related chemokines cytokines, been explored, but none gained recognition routine clinical use. This study aims investigate dynamics plasma levels IL-4 IL-13 during Dupilumab establish correlations between these ILs severity, measured using scores. ultimate endpoint determine whether can serve their correlation patient-reported feelings activity potentially influencing inclusion or exclusion diagnostic elements practice.

Language: Английский

---

Infectious factors in atopic dermatitis, pharmaceutical possibilities (systematic literature review)

Russian Journal of Clinical Dermatology and Venereology, Journal Year: 2025, Volume and Issue: 24(1), P. 7 - 7

Published: Feb. 25, 2025

Patients, who suffered from atopic dermatitis (AD), are diagnosed with bacterial and viral diseases significantly more often in a severe form. Objective. To analyze the results of researches on infectious factors possibilities pharmaceutical impact patients AD. Material methods. Search for articles was carried out PubMed, Scopus, Google Scholar, E-library scientific databases by following keywords: diseases, dermatitis, immune responses. Results. Systemic responses basis pathogenic relationship between AD diseases. Atopic march includes bronchial asthma, allergic rhinoconjunctivitis and/or food intolerance. In adulthood, may be manifested eczematous lesions hands’ skin contact dermatitis. Epithelial barrier damage, increased concentrations Th2/Th22 cytokines, reduced levels antimicrobial peptides, decreased diversity, prevalence pathogens, as well use immunosuppressive agents therapy components pathogenesis sensibilization pathology. Staphylococcus aureus is detected 70—90% cases foci bacteriological techniques, whereby some have predominantly methicillin-resistant S. aureus. A frequent presence human papilloma virus, reduction microbial diversity colonies Malassezia fungi noted. Patients higher visceral organs (streptococcal pharyngitis, upper lower respiratory tract infections, recurrent otitis, varicella disease urinary esophagitis gastritis). Conclusion. associated morbidity both most etiology, that should considered therapeutic diagnostic algorithms.

Language: Английский

---

Saccharomyces boulardii (CNCM I-745) ameliorates Ovalbumin-induced atopic dermatitis by modulating the NF-κB signaling in skin and colon

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Feb. 26, 2025

Language: Английский

---