The Involvement of Polyamines Catabolism in the Crosstalk between Neurons and Astrocytes in Neurodegeneration

Biomedicines, Journal Year: 2022, Volume and Issue: 10(7), P. 1756 - 1756

Published: July 21, 2022

In mammalian cells, the content of polyamines is tightly regulated. Polyamines, including spermine, spermidine and putrescine, are involved in many cellular processes. Spermine oxidase specifically oxidizes its deregulated activity has been reported to be linked brain pathologies involving neuron damage. a neuromodulator number ionotropic glutamate receptors types ion channels. this respect, Dach-SMOX mouse model overexpressing spermine neocortex neurons was revealed chronic oxidative stress, excitotoxicity neuronal Reactive astrocytosis, excitotoxic loss susceptibility seizure discussed here. This genetic would help researchers understand linkage between polyamine dysregulation neurodegeneration unveil roles crosstalk astrocytes neuroprotection or neurodegeneration.

Language: Английский

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Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades

Journal of Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 65(6), P. 4727 - 4751

Published: March 4, 2022

By replacing a phenolic ring of (E)-resveratrol with an 1,3,4-oxadiazol-2(3H)-one heterocycle, new resveratrol-based multitarget-directed ligands (MTDLs) were obtained. They evaluated in several assays related to oxidative stress and inflammation (monoamine oxidases, nuclear erythroid 2-related factor, quinone reductase-2, oxygen radical trapping) then experiments increasing complexity (neurogenic properties neuroprotection vs okadaic acid). 5-[(E)-2-(4-Methoxyphenyl)ethenyl]-3-(prop-2-yn-1-yl)-1,3,4-oxadiazol-2(3H)-one (4e) showed well-balanced MTDL profile: cellular activation the NRF2-ARE pathway (CD = 9.83 μM), selective inhibition both hMAO-B QR2 (IC50s 8.05 0.57 best ability promote hippocampal neurogenesis. It good drug-like profile (positive vitro central nervous system permeability, physiological solubility, no glutathione conjugation, lack PAINS or Lipinski alerts) exerted neuroprotective antioxidant actions acute chronic Alzheimer models using tissues. Thus, 4e is interesting that could stimulate defensive regenerative pathways block early events neurodegenerative cascades.

Language: Английский

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Modulating endoplasmic reticulum stress in APP/PS1 mice by Gomisin B and Osthole in Bushen-Yizhi formula: Synergistic effects and therapeutic implications for Alzheimer's disease

Phytomedicine, Journal Year: 2023, Volume and Issue: 119, P. 155023 - 155023

Published: Aug. 12, 2023

Language: Английский

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Intermittent theta burst stimulation attenuates oxidative stress and reactive astrogliosis in the streptozotocin-induced model of Alzheimer’s disease-like pathology

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: May 18, 2023

Intracerebroventricularly (icv) injected streptozotocin (STZ) is a widely used model for sporadic Alzheimer's disease (sAD)-like pathology, marked by oxidative stress-mediated pathological progression. Intermittent theta burst stimulation (iTBS) noninvasive technique brain activity with the ability to induce long-term potentiation-like plasticity and represents promising treatment several neurological diseases, including AD. The present study aims investigate effect of iTBS protocol on animal STZ-induced sAD-like pathology in context antioxidant, anti-inflammatory, anti-amyloidogenic effects cortex, striatum, hippocampus, cerebellum.Male Wistar rats were divided into four experimental groups: control (icv normal saline solution), STZ STZ-3 mg/kg), + (STZ subjected protocol), Placebo animals placebo noise artifact). Biochemical assays immunofluorescence microscopy evaluate functional structural changes.The icv administration induces stress attenuates antioxidative capacity all examined regions. significantly reduced nitrosative parameters. Also, decreased Aβ-1-42 APP levels. enhances reported as elevated its enzymatic non-enzymatic components. In addition, BDNF expression attenuated astrogliosis confirmed GFAP+/VIM+/C3+ cell reactivity hippocampus.Our results provide evidence beneficial applied attenuating stress, increasing antioxidant decreasing reactive STZ-administrated rats.

Language: Английский

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Age-related pathophysiological alterations in molecular stress markers and key modulators of hypoxia

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 90, P. 102022 - 102022

Published: July 23, 2023

Language: Английский

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