Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 242, P. 154332 - 154332
Published: Jan. 21, 2023
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: Feb. 17, 2023
Abstract Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease progression leads to joint deformity and associated loss of function, which significantly impacts the quality life for sufferers adds losses in labor force. In past few decades, RA has attracted increased attention from researchers, abnormal signaling pathways are a very important research field diagnosis treatment RA, provides evidence understanding this complex disease developing novel RA-linked intervention targets. The current review intends provide comprehensive overview including general introduction disease, historical events, epidemiology, risk factors, pathological process, highlight primary progress various molecular mechanisms, genetic epigenetic summarize most recent developments identifying new inhibitors treating RA. therapeutic interventions approved drugs, clinical pre-clinical cutting-edge technologies. These will hopefully drive strategically targeted therapies hope ideas options future.
Language: Английский
Citations
217
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(5), P. 2871 - 2871
Published: March 6, 2022
Rheumatoid arthritis (RA) is an inflammatory disease characterized by a variety of symptoms and pathologies often presenting with polyarthritis. The primary symptom in the initial stage joint swelling due to synovitis. With progression, cartilage bone are affected cause deformities. Advanced osteoarticular destruction deformation can irreversible physical disabilities. Physical disabilities not only deteriorate patients’ quality life but also have substantial medical economic effects on society. Therefore, prevention progression important task. Recent studies progressively improved our understanding molecular mechanism which synovitis caused immune disorders results activation osteoclasts; activated osteoclasts turn para-articular osteoporosis. In this paper, we review mechanisms metabolism under physiological RA conditions, describe therapeutic intervention against bone.
Language: Английский
Citations
84
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Feb. 9, 2023
Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation, pannus formation, and bone cartilage damage. It has a high disability rate. The hypoxic microenvironment of RA joints can cause reactive oxygen species (ROS) accumulation mitochondrial damage, which not only affect the metabolic processes immune cells pathological changes in fibroblastic but also upregulate expression several inflammatory pathways, ultimately promoting inflammation. Additionally, ROS damage are involved angiogenesis destruction, thereby accelerating progression. In this review, we highlighted effects on response, angiogenesis, RA. summarized therapies that target or mitochondria to relieve symptoms discuss gaps research existing controversies, hoping provide new ideas for area insights targeted drug development
Language: Английский
Citations
65
Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 39, P. 102178 - 102178
Published: July 1, 2024
Inflammatory arthritis is a growing worldwide concern, afflicting millions of individuals and leading to depreciating quality life, significant morbidity, subsequent healthcare burden. Conventional therapies for inflammatory often hold limitations, including systemic cross-reactivities, side effects, inadequate management inflammation. Therefore, "Smart" stimuli-responsive biomaterials are materialized as promising theranostic approaches management. These designed specific external internal stimulation, enabling the sustained release bioactive therapeutic agents during local or administration. Stimuli-responsive allow precise spatiotemporal control over drug release, minimizing exposure, reducing off-target real-time monitoring pathological conditions, driving potential breakthrough in managing arthritis. Owing this prominence, review article expounds on emerging prospects targeting molecular signatures associated with intricately elicit minimal no contradictory effects. In addition, application these disease progression multi-stimuli-responsive comprehended show progress diagnosis treatment. This "single-platted" comprehensive acquaintance clinical-based outcomes navigates microenvironment, proposing an optimistic avenue personalized effective minimized
Language: Английский
Citations
19
Interdisciplinary Rehabilitation / Rehabilitacion Interdisciplinaria, Journal Year: 2024, Volume and Issue: 4, P. 76 - 76
Published: Jan. 11, 2024
Rheumatoid arthritis (RA) is a chronic, autoimmune, and systemic inflammatory disease that mainly affects diarthrodial joints. Its global prevalence 0,5-1 % in adults, increasing to 5 women over 55 years old. RA reduces the quality of life expectancy by 3-10 years, due associated cardiovascular diseases. Current treatment based on initiating early disease-modifying therapy with goal suppressing inflammation, inducing remission, preventing joint damage, improving functionality. Antirheumatic medications include non-steroidal anti-inflammatory drugs, glucocorticoids, non-biological immunosuppressants like methotrexate, biological immunomodulators such as anti-TNF or anti-interleukins, which have shown high clinical effectiveness. However, there individual variability therapeutic response, adverse effects, loss efficacy time. This study conducted systematic literature review following PRISMA methodology. The search was performed PubMed, Scopus, Web Science, using MESH terms keywords related rheumatoid arthritis, treatments, effectiveness, prognostic factors. Studies published between 2015-2022 were included, ultimately selecting 30 articles met eligibility criteria. objective this compile synthesize available evidence currently used therapies for factors success, most frequently reported complications effects. results contribute enhancing strategies, considering personalized approach each patient's needs.
Language: Английский
Citations
17
Best Practice & Research Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown, P. 102036 - 102036
Published: Feb. 1, 2025
Language: Английский
Citations
2
Biology, Journal Year: 2023, Volume and Issue: 12(5), P. 694 - 694
Published: May 9, 2023
Macrophages are a type of immune cell distributed throughout all tissues an organism. Allograft inflammatory factor 1 (AIF1) is calcium-binding protein linked to the activation macrophages. AIF1 key intracellular signaling molecule that participates in phagocytosis, membrane ruffling and F-actin polymerization. Moreover, it has several type-specific functions. plays important roles development diseases: kidney disease, rheumatoid arthritis, cancer, cardiovascular diseases, metabolic diseases neurological disorders, transplants. In this review, we present comprehensive review known structure, functions role diseases.
Language: Английский
Citations
30
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Aug. 9, 2023
Frequent use of hormones and drugs may be associated with side-effects. Recent studies have shown that probiotics effects on the prevention treatment immune-related diseases. Limosilactobacillus reuteri ( L. ) had regulatory intestinal microbiota, host epithelial cells, immune cytokines, antibodies (Ab), toll-like receptors (TLRs), tryptophan (Try) metabolism, antioxidant enzymes, expression related genes, exhibits antibacterial anti-inflammatory effects, leading to alleviation disease symptoms. Although specific composition cell-free supernatant (CFS) has not been clarified, its efficacy in animal models drawn increased attention potential use. This review summarizes flora regulation, discusses feasibility application atopic dermatitis (AD), asthma, necrotizing enterocolitis (NEC), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), provides insights for
Language: Английский
Citations
26
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(9), P. 1286 - 1286
Published: Sept. 12, 2023
The p38 mitogen-activated protein kinase (p38-MAPK) is a crucial signaling pathway closely involved in several physiological and cellular functions, including cell cycle, apoptosis, gene expression, responses to stress stimuli. It also plays central role inflammation immunity. Owing disparate p38-MAPK it has thus far formed an elusive drug target with failed clinical trials inflammatory diseases due challenges hepatotoxicity, cardiac toxicity, lack of efficacy, tachyphylaxis, which brief initial improvement rapid disease rebound. To overcome these limitations, downstream antagonism the MAPK-activated (MAPKAPK, known as MK2) blockade demonstrated potential abrogate without prior recognized toxicities. Such MK2 inhibition (MK2i) associated robust suppression key pro-inflammatory cytokines, TNFα IL-6 others experimental systems vitro. Considering this recent evidence regarding MK2i arthritis, we revisit discuss literature encompassing inhibitors focus on pathway. We then highlight how novel strategies, although encouraging pre-clinical arena, may either show for efficacy or emergent human data from different settings.
Language: Английский
Citations
26
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 208, P. 115300 - 115300
Published: March 26, 2024
Language: Английский
Citations
11