Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: March 13, 2025
Language: Английский
Best Practice & Research Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown, P. 102036 - 102036
Published: Feb. 1, 2025
Language: Английский
Citations
1
Proteoglycan Research, Journal Year: 2025, Volume and Issue: 3(1)
Published: Jan. 1, 2025
ABSTRACT Alterations in glycoconjugate profiles are thought to promote changes cell‐to‐cell and cell‐to‐intracellular extracellular scaffold interactions human disease. The nearly unlimited number of “glycoforms” that may exist nature difficult study due glycosylation modifications being associated with non‐genome coded posttranscription post‐translation processes. Specific products generated by dependent on concentration sub‐cellular locations glycan synthesis processing enzymes. An indirect “high‐throughput” approach is characterize enzymes (hydrolases transferases) single cell sequencing all types tissue diseases. We previously identified TMEM230 as an endoplasmic reticulum (ER) protein regulates NOTCH glycoprotein receptor ligand signaling zebrafish blood vessel formation destructive remodeling capacities diverse including fibroblast, phagocytic immune system cells patients cancer or granulomatous systemic vasculitis autoimmune disorder. represents a paradigm mediated signal transduction supports the role modifications. ER initiates earliest steps synthesis, sorting, trafficking. As remodeling, Notch hallmarks disorders, we investigated whether aberrant expression was also rheumatoid arthritis (RA). In this current study, analysis supported downregulated synovial RA while were predominantly upregulated. contrast, upregulated high‐grade compared low‐grade gliomas it N‐linked (GlcNAc), glycosaminoglycan expression. Our collective results support glycan/glycoconjugate aggressive gliomas. therefore be therapeutic target marker for clinical treatment induced autoimmunity disorders cancer.
Language: Английский
Citations
1
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(9), P. 1286 - 1286
Published: Sept. 12, 2023
The p38 mitogen-activated protein kinase (p38-MAPK) is a crucial signaling pathway closely involved in several physiological and cellular functions, including cell cycle, apoptosis, gene expression, responses to stress stimuli. It also plays central role inflammation immunity. Owing disparate p38-MAPK it has thus far formed an elusive drug target with failed clinical trials inflammatory diseases due challenges hepatotoxicity, cardiac toxicity, lack of efficacy, tachyphylaxis, which brief initial improvement rapid disease rebound. To overcome these limitations, downstream antagonism the MAPK-activated (MAPKAPK, known as MK2) blockade demonstrated potential abrogate without prior recognized toxicities. Such MK2 inhibition (MK2i) associated robust suppression key pro-inflammatory cytokines, TNFα IL-6 others experimental systems vitro. Considering this recent evidence regarding MK2i arthritis, we revisit discuss literature encompassing inhibitors focus on pathway. We then highlight how novel strategies, although encouraging pre-clinical arena, may either show for efficacy or emergent human data from different settings.
Language: Английский
Citations
21
Life Sciences, Journal Year: 2023, Volume and Issue: 336, P. 122322 - 122322
Published: Dec. 1, 2023
Language: Английский
Citations
16
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 431 - 431
Published: March 28, 2024
Methotrexate (MTX) is the first drug of choice to treat several diseases, including rheumatoid arthritis. However, its administration accompanied by severe side effects, most commonly hepatotoxicity. Hence, alternative therapies with a lower toxicity and fewer effects are needed. This study aimed investigate antioxidant hepatoprotective silibinin (SIL, natural agent) against MTX-induced hepatotoxicity in an adjuvant-induced arthritis (AIA) rat model. Arthritic rats were treated SIL (100 mg/kg) and/or methotrexate (2 mg/kg). Non-arthritic rats, arthritic untreated who received vehicle followed parallel. alleviated systemic consequences restoring lost weight, decreasing erythrocyte sedimentation rate, ameliorating joint damage, which was evident both micro- macroscopically. Additionally, prevented histopathological alterations liver significantly reduced damage caused MTX AIA, as shown decrease markers (ALT AST). Furthermore, relieved oxidative stress induced AIA tissue lipid peroxidation (MDA) levels enhancing defense system (GSH levels; catalase superoxide dismutase (SOD) activities). In conclusion, our results suggest that potent agent rats. It markedly attenuated progression severity disease eased improving pro-oxidant/antioxidant balance.
Language: Английский
Citations
6
Molecules, Journal Year: 2021, Volume and Issue: 27(1), P. 78 - 78
Published: Dec. 23, 2021
Callicarpalongissima has been used as a Yao folk medicine to treat arthritis for years in China, although its active anti-arthritic moieties have not clarified so far. In this study, two natural phenolic diterpenoids with anti-rheumatoid (RA) effects, rosmanol and carnosol, isolated from the medicinal plant were reported on first time. type II collagen-induced DBA/1 mice, both (40 mg/kg/d) carnosol alone alleviated RA symptoms, such swelling, redness, synovitis; decreased index score; downregulated serum pro-inflammatory cytokine levels of interleukin 6 (IL-6), monocyte chemotactic protein 1 (MCP-1), tumor necrosis factor α (TNF-α). Additionally, they blocked activation Toll-like receptor 4 (TLR4)/nuclear κB (NF-κB)/c-Jun N-terminal kinase (JNK) p38 mitogen-activated (MAPK) pathways. Of particular interest was that when combination (20 mg/kg/d each), anti-RA effect inhibitory activity TLR4/NF-κB/MAPK pathway significantly enhanced. The results demonstrated synergistically by inhibiting inflammation through regulating pathway, meaning potential be developed into novel, safe combinations treatment RA.
Language: Английский
Citations
37
Molecules, Journal Year: 2023, Volume and Issue: 28(6), P. 2483 - 2483
Published: March 8, 2023
Rheumatoid arthritis (RA) is a chronic and autoimmune disease characterized by inflammation, dysfunction, cartilage bone destruction. In this review, we summarized the available reports on protective effects of Ganoderma lucidum polysaccharides (GLP) RA in terms anti-inflammatory, immunomodulatory, anti-angiogenic osteoprotective effects. Firstly, GLP inhibits synovial fibroblast (RASF) proliferation migration, modulates pro- anti-inflammatory cytokines reduces inflammation. Secondly, regulates differentiation antigen-presenting cells such as dendritic cells, phagocytosis mononuclear macrophages nature killer (NK) ratio M1, M2 related inflammatory cytokines. addition, produced activities balancing humoral cellular immunity, regulating immunoglobulin production, modulating T B lymphocyte proliferative responses cytokine release, exhibiting immunomodulatory Thirdly, angiogenesis through direct inhibition vascular endothelial cell induction death indirect growth factor (VEGF) production cells. Finally, can inhibit matrix metalloproteinases promote osteoblast formation, exerting articular cartilage. It suggested that may be promising agent for treatment RA.
Language: Английский
Citations
15
Inflammopharmacology, Journal Year: 2023, Volume and Issue: 31(4), P. 1577 - 1588
Published: June 19, 2023
Language: Английский
Citations
13
Aging and Disease, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Rheumatoid arthritis (RA), a prevalent chronic disease, poses significant treatment challenges, including side effects and high costs of conventional therapies. This heightens interest in natural, over-the-counter (OTC) anti-inflammatory supplements as potential adjunctive treatments. Given their roles mitigating inflammation oxidative stress, key factors RA pathogenesis, these could offer valuable therapeutic adjunctive. Our review addresses this emerging area, providing insights into the efficacy safety management. Methods: observational studies, systematic reviews, meta-analyses on over past 10 years. Relevant articles were reviewed, data was synthesized.
Language: Английский
Citations
5
Apmis, Journal Year: 2024, Volume and Issue: 132(6), P. 382 - 415
Published: March 12, 2024
Rheumatoid arthritis (RA) is a multifaceted autoimmune disorder characterized by chronic inflammation and joint destruction. Recent research has elucidated the intricate interplay between gut microbiota RA pathogenesis, underscoring role of microbiota‐derived metabolites as pivotal contributors to disease development progression. The human microbiota, comprising vast array microorganisms their metabolic byproducts, plays crucial in maintaining immune homeostasis. Dysbiosis this microbial community been linked numerous disorders, including RA. Microbiota‐derived metabolites, such short‐chain fatty acids (SCFAs), tryptophan derivatives, Trimethylamine‐N‐oxide (TMAO), bile acids, peptidoglycan, lipopolysaccharide (LPS), exhibit immunomodulatory properties that can either exacerbate or ameliorate Mechanistically, these influence cell differentiation, cytokine production, barrier integrity, collectively shaping milieu. This review highlights recent advances understanding crosstalk pathogenesis also discusses potential specific trigger suppress autoimmunity, shedding light on molecular interactions with cells signaling pathways. Additionally, explores translational aspects diagnostic prognostic tools Furthermore, challenges prospects translating findings into clinical practice are critically examined.
Language: Английский
Citations
5