Deleted Journal, Journal Year: 2023, Volume and Issue: 1(1), P. 27 - 33
Published: Dec. 21, 2023
Studies have shown that mycelial polysaccharides can regulate the body's resistance to inflammation in different ways, this paper briefly describes how extraction of reduce impact on performance mycelium, as well some mechanism resistance. In order provide a theoretical basis for helping become good anti-inflammatory drugs.
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129682 - 129682
Published: Jan. 22, 2024
Language: Английский
Citations
22
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140645 - 140645
Published: Feb. 1, 2025
Language: Английский
Citations
1
New Zealand Journal of Botany, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 85
Published: July 22, 2024
Ganoderma, a genus of mushrooms known for its long history medicinal use, has gained increasing attention in recent years due to potential health benefits. This review delves into the bioactive compounds found Ganoderma and elucidates intricate mechanisms underlying immunomodulatory anti-tumour activities. The diverse health-promoting effects can be attributed decadent array compounds, notably polysaccharides, triterpenoids, which play pivotal role. ability mushroom modulate immune system, enhancing activity cells, such as natural killer cells macrophages, is central focus. Furthermore, we explore how exerts through induction apoptosis, inhibition angiogenesis, interference with various signalling pathways critical cancer cell growth metastasis. As research this area continues evolve, comprehensive understanding supplement role promoting well-being emerging, offering promising avenues further investigation application healthcare.
Language: Английский
Citations
6
Carbohydrate Polymer Technologies and Applications, Journal Year: 2024, Volume and Issue: 7, P. 100526 - 100526
Published: June 1, 2024
Functional polysaccharides are characterized by functional and structural biomolecules, which play a dual role, both as nutrient molecules providing energy signalling involved in intercellular communications. There increasing evidences showing that possess beneficial effects for treating chronic diseases, such cancer, cardiovascular disease, etc, but its mechanism of action remains imprecision. Additionally, due to the limitations precision detection methods complexity their structures, metabolic kinetics behaviours or bioavailability polysaccharides, interaction between it entering systemic circulation target cells have been conundrum faced researcher. This review summarized latest advances efficacy diseases structure-activity relationship, absorption behaviours, specific cellular receptors so understand mechanisms bioactivities. is expected provide new insights paves way application.
Language: Английский
Citations
5
Veterinary World, Journal Year: 2025, Volume and Issue: unknown, P. 582 - 597
Published: March 1, 2025
Background and Aim: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent joint inflammation systemic immune dysregulation. The current pharmacological treatments, primarily synthetic drugs, often present adverse effects long-term toxicity. This study explores the therapeutic potential of Coprinus comatus nanogels as novel herbal formulation with antiarthritic anti-inflammatory properties in Complete Freund’s Adjuvant (CFA)-induced rat model RA. aims to evaluate efficacy C. reducing pro-inflammatory cytokine levels, antibody production, paw edema, indices assess their safer alternative conventional RA therapies. Materials Methods: Twenty-four male Wistar rats were randomized into six groups: Healthy control, negative control (CFA-induced without treatment), positive (sodium diclofenac 0.012 g/mL), three treatment groups (TG1, TG2, TG3) receiving 250, 500, 750 mg/kg nanogels, respectively. Oral treatments administered for 30 days. Pro-inflammatory cytokines (tumor necrosis factor-alpha [TNF-α], interleukin [IL]-6, IL-1β), antibodies (immunoglobulin [Ig]G, IgE), cyclooxygenase-2 (COX-2) enzyme activity, measured using enzyme-linked immunosorbent assay standard methods. Statistical analyses conducted one-way analysis variance. Results: dose significantly reduced TNF-α (17.71%), IL-1β (19.83%), IgE (23.91%) levels. 250 exhibited highest reductions IL-6 (30.88%) COX-2 (16.54%) TGs demonstrated 27.75% reduction edema 45.45% indices. Key bioactive compounds contributing these included flavonoids, polyphenols, triterpenoids, β-glucans. Conclusion: promising properties, suggesting an Further studies are recommended explore safety clinical applicability human management. Keywords: anti-inflammatory, comatus, reduction, medicine, rheumatoid arthritis.
Language: Английский
Citations
0
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: April 26, 2024
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a critical tumor suppressor protein that regulates various biological processes such as cell proliferation, apoptosis, inflammatory responses by controlling the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PI3K/AKT) signaling pathway. PTEN plays crucial role in pathogenesis of rheumatoid arthritis (RA). Loss may contribute to survival, pro-inflammatory cytokine release fibroblast-like synoviocytes (FLS). Also, persistent PI3K increases myeloid cells' osteoclastic potential, enhancing localized bone destruction. Recent studies have shown expression synovial lining RA patients with aggressive FLS minimal. Experimental upregulation could reduce damage caused RA. Nonetheless, complete comprehension aberrant drives progression its interactions other molecules remains elusive. This review dedicated promoting thorough understanding mechanisms aims furnish pertinent theoretical support for forthcoming endeavors both basic clinical research within this domain.
Language: Английский
Citations
4
Food & medicine homology., Journal Year: 2024, Volume and Issue: 2(1), P. 9420040 - 9420040
Published: Sept. 18, 2024
Language: Английский
Citations
4
Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105990 - 105990
Published: Jan. 1, 2025
Language: Английский
Citations
0
Reference series in phytochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23
Published: Jan. 1, 2025
Language: Английский
Citations
0
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: March 28, 2025
Wound healing remains a global challenge for clinical and experimental research. Hydrogels prepared from natural polysaccharides show great potential in the wound process. In this study, novel hydrogels (G-GLP) were using oxidized Ganoderma lucidum (OGLPs) carboxymethyl chitosan via Schiff base reaction, which did not require addition of any chemical cross-linking agent. The showed excellent mechanical properties biocompatibility. Moreover, superior hemostatic performance mouse liver trauma tail amputation models. Importantly, G-GLP improved inflammation by promoting polarization macrophage M2 subtype, inhibiting M1 subtype reducing intracellular levels reactive oxygen species. vivo experiments demonstrated that accelerated total defect model blood vessel repair collagen deposition. These results demonstrate has as an effective dressing.
Language: Английский
Citations
0