Polyploidy in Cancer: Causal Mechanisms, Cancer-Specific Consequences, and Emerging Treatments DOI Open Access
Patrick Conway,

Jonathan Dao,

Dmytro Kovalskyy

et al.

Molecular Cancer Therapeutics, Journal Year: 2024, Volume and Issue: 23(5), P. 638 - 647

Published: Feb. 5, 2024

Abstract Drug resistance is the major determinant for metastatic disease and fatalities, across all cancers. Depending on tissue of origin therapeutic course, a variety biological mechanisms can support sustain drug resistance. Although genetic mutations gene silencing through epigenetic are culprits in targeted therapy, efflux polyploidization more global that prevail broad range pathologies, response to treatments. There an unmet need identify patients at risk polyploidy, understand underlying polyploidization, develop strategies predict, limit, reverse polyploidy thus enhancing efficacy standard-of-care therapy improve better outcomes. This literature review provides overview cancer offers perspective patient monitoring actionable therapy.

Language: Английский

Navigating the ERK1/2 MAPK Cascade DOI Creative Commons
Ana Martín-Vega, Melanie H. Cobb

Biomolecules, Journal Year: 2023, Volume and Issue: 13(10), P. 1555 - 1555

Published: Oct. 20, 2023

The RAS-ERK pathway is a fundamental signaling cascade crucial for many biological processes including proliferation, cell cycle control, growth, and survival; common across all types. Notably, ERK1/2 are implicated in specific context-dependent manner as stem cells pancreatic β-cells. Alterations the different components of this result dysregulation effector kinases which communicate with hundreds substrates. Aberrant activation contributes to range disorders, cancer. This review provides an overview structure, activation, regulation, mutational frequency tiers cascade; particular focus on ERK1/2. We highlight importance scaffold proteins that contribute kinase localization coordinate interaction dynamics substrates, activators, inhibitors. Additionally, we explore innovative therapeutic approaches emphasizing promising avenues field.

Language: Английский

Citations

43
Cell Cycle Progression and Synchronization: An Overview DOI
Zhixiang Wang

Methods in molecular biology, Journal Year: 2022, Volume and Issue: unknown, P. 3 - 23

Published: Jan. 1, 2022

Language: Английский

Citations

65
An Overview of the Role of MicroRNAs on Carcinogenesis: A Focus on Cell Cycle, Angiogenesis and Metastasis DOI Open Access
Leonel Pekarek,

Diego Torres‐Carranza,

Oscar Fraile‐Martínez

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7268 - 7268

Published: April 14, 2023

In recent years, the importance of epigenetic markers in carcinogenesis different malignant neoplasms has been demonstrated, also demonstrating their utility for understanding metastatic spread and tumor progression cancer patients. Among biomarkers, microRNAs represent a set non-coding RNAs that regulate gene expression, having involved wide variety neoplasia acting oncogenic pathways. Both overexpression downregulation complex interaction with various genes whose ultimate consequence is increased cell proliferation, invasion driver markers. It should be noted current clinical practice, even though combination shown to useful by authors at diagnostic prognostic levels, there are no kits can used initial approach or assess recurrences oncological diseases. Previous works have cited as critical role several carcinogenic mechanisms, ranging from cycle alterations angiogenesis mechanisms distant dissemination. Indeed, specific seem tightly modulation components related these processes. For instance, cyclins cyclin-dependent kinases, transcription factors, signaling molecules angiogenic/antiangiogenic products, among others, recognized targets types cancer. Therefore, purpose this article describe main implications alterations, metastasis angiogenesis, trying summarize involvement carcinogenesis.

Language: Английский

Citations

37
A literature review: mechanisms of antitumor pharmacological action of leonurine alkaloid DOI Creative Commons
Qiang Cao, Qi Wang, Xinyan Wu

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 25, 2023

Leonurine refers to the desiccated aerial portion of a plant in Labiatae family. The primary bioactive constituent is an alkaloid, alkaloid (Leo), renowned for its substantial therapeutic efficacy treatment gynecological disorders, addition broad-spectrum antineoplastic capabilities. Over recent years, pharmacodynamic mechanisms Leo have garnered escalating scholarly interest. exhibits anticancer potential by means array mechanisms, encompassing inhibition neoplastic cell proliferation, induction both apoptosis and autophagy, containment oncogenic invasion migration. key signal transduction pathways implicated these processes include Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL), Phosphoinositide3-Kinase/Serine/Threonine Protein Kinase (PI3K/AKT), Signal Transducer Activator Transcription 3 (STAT3), Mitogen-Activated Protein/Extracellular Signal-Regulated (MAP/ERK). This paper commences with exploration principal cellular behaviors influenced associated pathways, thereby scrutinizing sequence events. intention offer theoretical reinforcement elucidation more profound underpinning Leo's correlating pharmaceutical development.

Language: Английский

Citations

24
The impact of the BCR-ABL oncogene in the pathology and treatment of chronic myeloid leukemia DOI Creative Commons
Mohamed El‐Tanani, Hamdi Nsairat, Ismail Matalka

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 254, P. 155161 - 155161

Published: Jan. 22, 2024

Chronic Myeloid Leukemia (CML) is characterized by chromosomal aberrations involving the fusion of BCR and ABL genes on chromosome 22, resulting from a reciprocal translocation between chromosomes 9 22. This gives rise to oncogenic BCR-ABL, an aberrant tyrosine kinase identified as Abl protein. The protein intricately regulates cell cycle phosphorylating residues through diverse signaling pathways. In CML, BCR-ABL disrupts first exon Abl, leading sustained activation resistance deactivation mechanisms. Pharmacological interventions, such imatinib, effectively target BCR-ABL's activity binding near active site, disrupting ATP binding, inhibiting downstream phosphorylation. Nevertheless, emergence resistance, often attributed cap structure mutations, poses challenge imatinib efficacy. Current research endeavours are directed towards overcoming investigating innovative therapeutic strategies. article offers comprehensive analysis structural attributes emphasizing its pivotal role biomarker in CML. It underscores imperative for ongoing refine treatment modalities enhance overall outcomes managing

Language: Английский

Citations

15
Skeletal muscle regeneration with 3D bioprinted hyaluronate/gelatin hydrogels incorporating MXene nanoparticles DOI

Hyo Jung Jo,

Moon Sung Kang, Hye Jin Heo

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130696 - 130696

Published: March 6, 2024

Language: Английский

Citations

15
NIR‐Responsive Multifunctional Artificial Skin for Regenerative Wound Healing DOI
Yiyue Hong, Mengyang Wang, D.J. Hu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: May 30, 2024

Abstract Efficient wound repair with skin appendage regeneration following severe trauma poses a challenge due to the scarcity of grafts and decreased drug effectiveness in protease‐rich microenvironments. Here, multifunctional artificial (NIR‐mFAS) photothermal‐triggered delivery capabilities is designed actively comprehensively improve regenerative potential full‐thickness wounds. The antibacterial chitosan/silk fibroin hydrogel matrix skin, cross‐linked by electrostatic interactions, effectively encapsulates sustains release epidermal growth factor (EGF) accelerate re‐epithelialization neovascularization promoting migration proliferation cells. Subsequently, photothermal responsive polydopamine nanoparticles (PDA‐NPs) dispersed enable precise control over BMP4 under irradiation 1064 nm NIR, thereby inhibiting scarring reducing myofibroblasts during proliferative stage. Importantly, concurrent controlled CHIR99021 can modulate cell fate inducing conversion into dermal papilla‐like cells, leading hair follicle sebaceous gland regeneration. NIR‐mFAS functions as an advanced system for achieving high‐quality healing offers smart therapeutic approach that be applied other treatments requiring coordinated multiple pharmacological agents.

Language: Английский

Citations

10
Role of spindle assembly checkpoint proteins in gametogenesis and embryogenesis DOI Creative Commons

Renju Pun,

Brian J. North

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 22, 2025

The spindle assembly checkpoint (SAC) is a surveillance mechanism that prevents uneven segregation of sister chromatids between daughter cells during anaphase. This essential regulatory aneuploidy which can lead to various congenital defects observed in newborns. Many studies have been carried out elucidate the role proteins involved SAC as well function gametogenesis and embryogenesis. In this review, we discuss regulating both meiotic mitotic cell division along with several factors influence strength species. Finally, outline consequences their absence or insufficiency on proper embryogenesis vivo .

Language: Английский

Citations

1
Exploring the reproductive exposure risks of phthalates and organophosphates in atmospheric particulate matter based on quantitative structure-activity relationships and network toxicology models DOI
Ke Gao,

Kai Hua,

Shiyuan Wang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137395 - 137395

Published: Jan. 1, 2025

Language: Английский

Citations

1
LncRNA-ANRIL regulates CDKN2A to promote malignant proliferation of Kasumi-1 cells DOI Creative Commons
Jianxia Xu, Jingxin Zhang, Chengsi Zhang

et al.

Cell Division, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 28, 2025

This study aimed to investigate the regulatory effects of long non-coding RNA-ANRIL on CDKN2A in cell cycle Kasumi-1 cells and elucidate underlying molecular mechanisms. ANRIL expression levels were quantified using RT-qPCR peripheral blood samples from acute myeloid leukemia (AML) patients. knockdown efficiency was validated via RT-qPCR, distribution analyzed flow cytometry. Cell proliferation assays conducted with CCK-8 following palbociclib treatment downregulation. RNA immunoprecipitation (RIP) identified potential ANRIL-associated targets, while western blotting assessed GSK3β/β-catenin/cyclin D1 signaling components related proteins. markedly overexpressed AML patient samples. Knockdown led G1 phase arrest accompanied by reduced CDK2/4/6 cyclin protein levels, upregulation induced opposite effect. Palbociclib for 24 h 48 elevated population suppressed expression, demonstrating its ability counteract ANRIL-driven progression. Downregulation also GSK3β/β-catenin pathway, reducing whereas reactivated this axis. Co-transfection experiments showed that simultaneous suppression overexpression attenuated ANRIL's stimulatory RIP analysis confirmed a physical interaction between CDKN2A. Furthermore, downregulation inhibited reversed pathway activation mediated upregulation. facilitates survival modulating activate pathway.

Language: Английский

Citations

1