Engineered protein-based materials for tissue repair: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 303, P. 140674 - 140674

Published: Feb. 3, 2025

Language: Английский

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Xanthium strumarium/gelatin methacryloyl based hydrogels with anti-inflammatory and antioxidant properties for diabetic wound healing via akt/mtor pathway

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 300, P. 140186 - 140186

Published: Jan. 27, 2025

Language: Английский

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Dual physiological responsive structural color hydrogel particles for wound repair

Bioactive Materials, Journal Year: 2025, Volume and Issue: 46, P. 494 - 502

Published: Jan. 7, 2025

Language: Английский

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Tongue Prick Bionic Angularly Adjustable Microneedles for Enhanced Scarless Wound Healing

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Abstract High‐tension site wounds are frequently accompanied by challenges associated with hypertrophic scarring. The key to achieving scar‐free healing is the creation of a mechanical environment conducive skin regeneration. Herein, simple rolling punctures utilized on angle transform molds develop cat tongue prick bionic angle‐adjustable microneedles (TPMNs) maintain firm grip periwound skin, thereby reducing tissue tension. integration TPMNs triboelectric nanogenerators (TENGs) enables excellent conductive and properties. system can provide stable spatial electric field around wound promote cell migration. As microfluid reaches TPMNs, self‐driving force enhanced unique design control flow rate. Sufficient evidence has shown that expedite contraction regeneration while concurrently scar formation in mouse trauma model experiments. innovative TPMNs‐TENGs synergistically provides highly functional platform for tension relief, which suitable treatment this study potentially extends construction regulation smart wearable devices.

Language: Английский

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Advances in Mussel Adhesion Proteins and Mussel-Inspired Material Electrospun Nanofibers for Their Application in Wound Repair

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Mussel refers to a marine organism with strong adhesive properties, and it secretes mussel adhesion protein (MAP). The most vital feature of MAP is the abundance 3,4-dihydroxyphenylalanine (DOPA) group lysine, which have antimicrobial, anti-inflammatory, antioxidant, cell adhesion-promoting properties can accelerate wound healing. Polydopamine (PDA) currently widely used mussel-inspired material characterized by good adhesion, biocompatibility, biodegradability. It mediate various interactions form functional coatings on cell-material surfaces. Nanofibers based materials been exerting role in repair, while there no comprehensive review presenting them. This Review introduces structure MAPs their mechanisms materials. Second, functionalized modification inspired electrospun nanofibers application repair. Finally, future development direction coping strategies are discussed. Moreover, this offer novel for repair bring about new breakthroughs innovations tissue engineering regenerative medicine.

Language: Английский

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A highly transparent dopamine-copolymerized hydrogel with enhanced ROS-scavenging and tissue-adhesive properties for chronic diabetic wounds

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Electrospinning and electrospun nanofibers: From academic research to industrial production

Progress in Materials Science, Journal Year: 2025, Volume and Issue: unknown, P. 101494 - 101494

Published: April 1, 2025

Language: Английский

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Dual-Responsive Antibacterial Hydrogel Patch for Chronic-Infected Wound Healing

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(11), P. 7283 - 7297

Published: Oct. 17, 2024

Bacterial infections in chronic wounds, such as bedsores and diabetic ulcers, present significant healthcare challenges. Excessive antibiotic use leads to drug resistance lacks precision for targeted wound treatment. Our study introduces an innovative solution: a near-infrared (NIR) pH dual-responsive hydrogel patch incorporating regenerated silk fibroin (RSF) molybdenum dioxide (MoO

Language: Английский

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Bioactive Nanoparticle‐Embedded Micro/Nanofibrous Dressing with Improved Angiogenesis and Immunoregulation for Facilitating Burn Wound Healing

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract In the context of severe burn injuries, presence excessive reactive oxygen species (ROS), prolonged microbial infection, and compromised angiogenesis can contribute to metabolic reprogramming macrophages, resulting in a dysregulated inflammatory response that hinders healing process. this study, cerium oxide nanoparticles (CeNPs) are encapsulated within silk fibroin‐poly(e‐caprolactone) polymer create an electrospun PSF/CeNPs nanofiber membrane (PSF/membrane). This is further modified through addition angiopoietin‐1 mimetic peptide, QHREDGS, formation QPSF/CeNPs (QHREDGS membrane). vitro assessments revealed displayed intended ability regulate ROS levels, favorable biocompatibility with cells, promoted endothelial cell attachment growth, exhibited anti‐inflammatory properties modulation macrophage phenotypes from M1 M2, as well pro‐angiogenetic antibacterial effects. vivo, dressing demonstrated acceleration wound healing, promotion angiogenesis, downregulation factors, enhancement collagen deposition. bioactive shows potential clinical therapy for promoting regeneration both acute chronically damaged skin tissue.

Language: Английский

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Piezoelectric Electrospun Fibrous Scaffold: A Gas Pedal for Skin Wound Healing

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106526 - 106526

Published: Dec. 1, 2024

Language: Английский

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