The Use of Stem Cells as a Potential Treatment Method for Selected Neurodegenerative Diseases: Review

Cellular and Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 43(6), P. 2643 - 2673

Published: April 7, 2023

Stem cells have been the subject of research for years due to their enormous therapeutic potential. Most neurological diseases such as multiple sclerosis (MS), amyotrophic lateral (ALS), Alzheimer's disease (AD), Parkinson's (PD), and Huntington's (HD) are incurable or very difficult treat. Therefore new therapies sought in which autologous stem used. They often patient's only hope recovery slowing down progress symptoms. The most important conclusions arise after analyzing literature on use neurodegenerative diseases. effectiveness MSC cell therapy has confirmed ALS HD therapy. slow progression show early promising signs efficacy. In HD, they reduced huntingtin (Htt) aggregation stimulation endogenous neurogenesis. MS with hematopoietic (HSCs) inducted significant recalibration pro-inflammatory immunoregulatory components immune system. iPSC allow accurate PD modeling. patient-specific therefore minimize risk rejection and, long-term observation, did not form any tumors brain. Extracellular vesicles derived from bone marrow mesenchymal stromal (BM-MSC-EVs) Human adipose-derived stromal/stem (hASCs) widely used treat AD. Due reduction Aβ42 deposits increasing survival neurons, improve memory learning abilities. Despite many animal models clinical trial studies, still needs be refined increase its human body.

Language: Английский

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Advances in clinical translation of stem cell-based therapy in neurological diseases

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Stem cell-based therapies have raised considerable interest to develop regenerative treatment for neurological disorders with high disability. In this review, we focus on recent preclinical and clinical evidence of stem cell therapy in the degenerative diseases discuss different types, delivery routes biodistribution therapy. addition, advances mechanistic insights therapy, including functional replacement by exogenous cells, immunomodulation paracrine effects are also demonstrated. Finally, highlight adjunction approaches that has been implemented augment their reparative function, survival migration target specific tissue, preconditioning, genetical engineering, co-transplantation combined

Language: Английский

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Clinical trials using dental stem cells: 2022 update

World Journal of Stem Cells, Journal Year: 2023, Volume and Issue: 15(3), P. 31 - 51

Published: March 22, 2023

For nearly 20 years, dental stem cells (DSCs) have been successfully isolated from mature/immature teeth and surrounding tissue, including pulp of permanent exfoliated deciduous teeth, periodontal ligaments, follicles, gingival apical papilla. They several properties (such as self-renewal, multidirectional differentiation, immunomodulation) exhibit enormous potential for clinical applications. To date, many articles trials using DSCs reported the treatment pulpitis, periapical lesions, periodontitis, cleft lip palate, acute ischemic stroke, so on, DSC-based therapies obtained satisfactory effects in most trials. In these studies, no adverse events were reported, which suggested safety therapy. this review, we outline characteristics summarize their therapies. Meanwhile, also present current limitations perspectives therapy harvesting inflamed applying DSC-conditioned medium/DSC-derived extracellular vesicles, expanding-free strategies) to provide a theoretical basis

Language: Английский

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Huntington’s Disease Drug Development: A Phase 3 Pipeline Analysis

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(11), P. 1513 - 1513

Published: Oct. 24, 2023

Huntington’s Disease (HD) is a severely debilitating neurodegenerative disorder in which sufferers exhibit different combinations of movement disorders, dementia, and behavioral or psychiatric abnormalities. The result trinucleotide repeat expansion mutation that inherited an autosomal dominant manner. While there currently no treatment to alter the course HD, are medications lessen abnormal symptoms. ClinicalTrials.gov was searched identify drugs have completed phase III drug trials for HD. described were further limited interventional studies recruiting, active not completed. In addition, all must posted update within past year. PubMed used gather information on these studies. Of nine clinical met criteria, eight involved following drugs: metformin, dextromethorphan/quinidine, deutetrabenazine, valbenazine, Cellavita pridopidine, SAGE-718, RO7234292 (RG6042). treatments, four already FDA approved. This systematic review provides resource summarizes present therapies treating this devastating condition United States.

Language: Английский

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Brain-Derived Neurotrophic Factor Dysregulation as an Essential Pathological Feature in Huntington’s Disease: Mechanisms and Potential Therapeutics

Biomedicines, Journal Year: 2023, Volume and Issue: 11(8), P. 2275 - 2275

Published: Aug. 16, 2023

Brain-derived neurotrophic factor (BDNF) is a major neurotrophin whose loss or interruption well established to have numerous intersections with the pathogenesis of progressive neurological disorders. There perhaps no greater example disease resulting from dysregulation BDNF signaling than Huntington’s (HD)—an inherited neurodegenerative disorder characterized by motor, psychiatric, and cognitive impairments associated basal ganglia dysfunction ultimate death striatal projection neurons. Investigation collection mechanisms leading in HD highlights this neurotrophin’s importance neuronal viability calls attention opportunities for therapeutic interventions. Using electronic database searches existing forthcoming research, we constructed literature review overarching goal exploring diverse set molecular events that trigger within HD. We highlighted research investigated these preclinical models connected studies those evaluating similar endpoints human subjects. also included special focus on growing body detailing key transcriptomic epigenetic alterations affect abundance Finally, offer critical evaluation proposed neurotrophin-directed therapies assessed clinical trials seeking correct expression individuals.

Language: Английский

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Advances in Gene and Cellular Therapeutic Approaches for Huntington’s Disease

Protein & Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 9, 2024

Abstract Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by the abnormal expansion of CAG trinucleotide repeats in Huntingtin gene (HTT) located on chromosome 4. It transmitted autosomal dominant manner and characterized motor dysfunction, cognitive decline, emotional disturbances. To date, there are no curative treatments for HD have been developed; current therapeutic approaches focus symptom relief comprehensive care through coordinated pharmacological nonpharmacological methods to manage diverse phenotypes disease. International clinical guidelines treatment continually being revised effort enhance within a multidisciplinary framework. Additionally, innovative cell therapy strategies actively researched developed address complexities improve outcomes. This review endeavours elucidate emerging HD, offering detailed insight into looking forward future paradigms. Considering complexity underlying mechanisms driving synergistic strategy that integrates various factors—such as distinct types, epigenetic patterns, genetic components, cerebral microenvironment—may significantly In future, we eagerly anticipate ongoing innovations interdisciplinary research will bring profound advancements refinements HD.

Language: Английский

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Age-Related Neurodegenerative Diseases: A Stem Cell’s Perspective

Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 347 - 347

Published: Feb. 27, 2025

Neurodegenerative diseases encompass a number of very heterogeneous disorders, primarily characterized by neuronal loss and concomitant decline in neurological function. Examples this type clinical condition are Alzheimer's Disease, Parkinson's Huntington's Disease Amyotrophic Lateral Sclerosis. Age has been identified as major risk the etiology these which explains their increased incidence developed countries. Unfortunately, despite continued intensive efforts, no cure yet found for any diseases; reliable markers that allow an early diagnosis disease identification key molecular events leading to onset progression lacking. Altered adult neurogenesis appears precede appearance severe symptoms. Given scarcity human samples considerable differences with model species, increasingly complex stem-cell-based models being developed. These shedding light on alterations contribute development, facilitating new targets providing screening platform testing candidate drugs. Moreover, secretome other promising features cell types explored, use them replacement cells high plasticity or co-adjuvant therapy combinatorial treatments.

Language: Английский

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Human striatal progenitor cells that contain inducible safeguards and overexpress BDNF rescue Huntington’s disease phenotypes in R6/2 mice

Molecular Therapy — Methods & Clinical Development, Journal Year: 2025, Volume and Issue: 33(1), P. 101415 - 101415

Published: Jan. 22, 2025

Language: Английский

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A Bibliometric Analysis of Research on the Role of BDNF in Depression and Treatment

Biomolecules, Journal Year: 2022, Volume and Issue: 12(10), P. 1464 - 1464

Published: Oct. 12, 2022

Brain-derived neurotrophic factor (BDNF), as the most widely distributed and studied in mammalian brain, plays a key role depression mechanisms of action for antidepressants. Currently, there is large number studies on BDNF pathogenesis therapeutic mechanism depression. The quantity quality these studies, however, are unknown. To give beginners quicker introduction to this research topic, we therefore performed bibliometric analysis. A total 5300 publications were included. We obtained topic from Web Science database, variety bibliographic elements collected, including annual publications, authors, countries/regions, institutions, journals, keywords. Moreover, found that oxidative stress neuroinflammation hotspots field very recent years. Collectively, study provides comprehensive summary analysis its treatment offers meaningful values topic.

Language: Английский

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The Importance of Stem Cells Isolated from Human Dental Pulp and Exfoliated Deciduous Teeth as Therapeutic Approach in Nervous System Pathologies

Cells, Journal Year: 2023, Volume and Issue: 12(13), P. 1686 - 1686

Published: June 22, 2023

Despite decades of research, no therapies are available to halt or slow down the course neuro-degenerative disorders. Most drugs developed fight neurodegeneration aimed alleviate symptoms, but none has proven adequate in altering pathologies. Cell therapy emerged as an intriguing alternative classical pharmacological approach. consists transplantation stem cells that can be obtained from various embryonal and adult tissues. Whereas former holds notable ethical issue, somatic without major concerns. However, most cells, such those derived bone marrow, committed toward mesodermal lineage, hence need reprogrammed induce differentiation into neurons. The discovery neural crest dental pulp, both adults' molar baby teeth (dental pulp human exfoliated deciduous teeth, respectively) prompted researchers investigate their utility nervous system In this review, we recapitulate advancements on application these preclinical models neurodegenerative diseases, highlighting differences analogies maintenance, differentiation, potential clinical application.

Language: Английский

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