The major histocompatibility complex participates in Parkinson’s disease DOI Creative Commons

Rou Gu,

Jianyu Pan, Maher Un Nisa Awan

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107168 - 107168

Published: April 5, 2024

Parkinson's disease (PD) is a common neurodegenerative characterized by progressive loss of dopaminergic neurons in the substantia nigra and aggregation alpha-synuclein (α-syn). The central nervous system (CNS) has previously been considered as an immune-privileged area. However, studies have shown that immune responses are involved PD. major histocompatibility complex (MHC) presents antigens from Antigen-presenting cells(APCs) to T lymphocytes, will be induced. MHCs expressed microglia, astrocytes, neurons. Single nucleotide polymorphisms MHC related risk aggregated α-syn triggers expression activating glia cells. CD4+ CD8+ lymphocytes microglia activation detected brains PD patients. In addiction further increase blood-brain barrier (BBB) permeability cell infiltration Thus, through participating inflammatory responses.

Language: Английский

Alpha Synuclein: Neurodegeneration and Inflammation DOI Open Access
Gianluigi Forloni

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5914 - 5914

Published: March 21, 2023

Alpha-Synuclein (α-Syn) is one of the most important molecules involved in pathogenesis Parkinson’s disease and related disorders, synucleinopathies, but also several other neurodegenerative disorders with a more elusive role. This review analyzes activities α-Syn, different conformational states, monomeric, oligomeric fibrils, relation to neuronal dysfunction. The damage induced by α-Syn various conformers will be analyzed its capacity spread intracellular aggregation seeds prion-like mechanism. In view prominent role inflammation virtually all activity illustrated considering influence on glial reactivity. We others have described interaction between general cerebral dysfunctional α-Syn. Differences microglia astrocyte activation been observed when vivo presence oligomers has combined lasting peripheral inflammatory effect. reactivity was amplified, while astrocytes were damaged double stimulus, opening new perspectives for control synucleinopathies. Starting from our studies experimental models, we extended perspective find useful pointers orient future research potential therapeutic strategies disorders.

Language: Английский

Citations

66
Role of α-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson’s disease DOI

Qiankun Lv,

Kang‐Xin Tao,

Xiaobo Wang

et al.

Inflammation Research, Journal Year: 2023, Volume and Issue: 72(3), P. 443 - 462

Published: Jan. 4, 2023

Language: Английский

Citations

55
Dysbiosis of the gut microbiota and its effect on α-synuclein and prion protein misfolding: consequences for neurodegeneration DOI Creative Commons

Nasir Uddin Mahbub,

Md Minarul Islam, Seong‐Tshool Hong

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 16, 2024

Abnormal behavior of α-synuclein and prion proteins is the hallmark Parkinson’s disease (PD) illnesses, respectively, being complex neurological disorders. A primary cause protein aggregation, brain injury, cognitive loss in illnesses misfolding normal cellular (PrP C ) into an infectious form Sc ). Aggregation causes disruptions processes (PD), leading to dopamine-producing neurons motor symptoms. Alteration composition or activity gut microbes may weaken intestinal barrier make it possible for prions go from brain. The gut-brain axis linked neuroinflammation; metabolites produced by microbiota affect aggregation α-synuclein, regulate inflammation immunological responses, influence course neurotoxicity proteins, even if their targets are distinct proteins. This thorough analysis explores interactions that exist between neurodegenerative particularly involvement microbiota, a collection bacteria, archaea, fungi, viruses etc., various becoming increasingly recognized. microbiome influences neuroinflammation, neurotransmitter synthesis, mitochondrial function, integrity through axis, which contributes development progression disease. review delves molecular mechanisms underlie these relationships, emphasizing effects microbial such as bacterial lipopolysaccharides (LPS), short-chain fatty acids (SCFAs) regulating functioning. Additionally, looks at how environmental dietary decisions whether they could be risk factors illnesses. study concludes highlighting critical role plays It also provides promising direction future research treatment approaches. People afflicted difficult ailments find hope new preventive therapeutic approaches diseases better understood.

Language: Английский

Citations

19
The Molecular Mechanisms of the Relationship between Insulin Resistance and Parkinson’s Disease Pathogenesis DOI Open Access
Viviana A. Ruiz‐Pozo, Rafael Tamayo‐Trujillo, Santiago Cadena-Ullauri

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(16), P. 3585 - 3585

Published: Aug. 15, 2023

Parkinson’s disease (PD) is a degenerative condition resulting from the loss of dopaminergic neurons. This neuronal leads to motor and non-motor neurological symptoms. Most PD cases are idiopathic, no cure available. Recently, it has been proposed that insulin resistance (IR) could be central factor in development. IR associated with neuropathological features like α-synuclein aggregation, loss, neuroinflammation, mitochondrial dysfunction, autophagy. These related impaired metabolism, death, aggravation Moreover, pharmacological options involve signaling improvement non-dopaminergic strategies have under drugs prevent metabolic pathways involved damage. All these approaches improve outcomes. Also, new biomarker identification may allow for an earlier diagnosis high-risk individuals. review describes main implicated development involving IR. presents several therapeutic directed at used treatment. The understanding molecular mechanisms neurodegenerative enhance diagnosis.

Language: Английский

Citations

34
The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review DOI Open Access

Bombonica Gabriela Dogaru,

Constantin Munteanu

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 12555 - 12555

Published: Aug. 8, 2023

This review explores the emerging role of hydrogen sulfide (H

Language: Английский

Citations

25
Salivary Biomarkers for Parkinson’s Disease: A Systematic Review with Meta-Analysis DOI Creative Commons
Kacper Nijakowski,

Wojciech Owecki,

Jakub Jankowski

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(4), P. 340 - 340

Published: Feb. 14, 2024

Parkinson’s Disease (PD) is a common neurodegenerative disease which manifests with motor features, such as bradykinesia, resting tremor, rigidity, and postural instability. Using the non-invasive technique of saliva collection, we designed systematic review to answer question “Are salivary biomarkers reliable for diagnosis Disease?”. Following inclusion exclusion criteria, 30 studies were included in this (according PRISMA statement guidelines). Mostly proteins reported potential saliva. Based on meta-analysis, PD patients, levels total alpha-synuclein significantly decreased, those oligomeric increased. Also, according pooled AUC, heme oxygenase-1 demonstrated significant predictive value saliva-based diagnosis. In conclusion, some biomarkers, especially alpha-synuclein, can be altered could reliably useful early differentiating other synucleopathies.

Language: Английский

Citations

10
Porous Materials for Early Diagnosis of Neurodegenerative Diseases DOI Creative Commons
Payam Arghavani, Hossein Daneshgar, Soheil Sojdeh

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Abstract Neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease, present formidable challenges in modern medicine due to their complex pathologies the absence of curative treatments. Despite advances symptomatic management, early diagnosis remains essential for mitigating progression improving patient outcomes. Traditional diagnostic methods, such as MRI, PET, cerebrospinal fluid biomarker analysis, are often inadequate detection these diseases. Emerging porous materials, including metal–organic frameworks (MOFs), covalent–organic (COFs), MXene, zeolites, silicon, offer promising new approaches neurodegenerative These characterized by highly tunable physicochemical properties, have potential capture concentrate disease‐specific biomarkers amyloid‐beta (Aβ), tau protein, alpha‐synuclein (α‐Syn). The integration materials into advanced biosensors real‐time holds promise revolutionizing neurodiagnostic, enabling non‐invasive, sensitive, specific platforms. Furthermore, incorporation artificial intelligence (AI) machine learning (ML) techniques analysis sensor data enhances accuracy allows more efficient interpretation profiles. AI ML can optimize feature selection, improve pattern recognition, facilitate prediction progression, making them indispensable tools personalized medicine. This review explores diagnostics, emphasizing design, functionality, synergistic role advancing clinical applications.

Language: Английский

Citations

2
The roles of intrinsically disordered proteins in neurodegeneration DOI Creative Commons
Kagistia Hana Utami, Satoru Morimoto, Yasue Mitsukura

et al.

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2025, Volume and Issue: unknown, P. 130772 - 130772

Published: Feb. 1, 2025

Language: Английский

Citations

2
Versatile Copper-Chalcogenide-Based Nanoparticles for the Treatment of Brain Diseases DOI Creative Commons
Shuyang Xie,

Hualong Liu,

Ke Yang

et al.

Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

2
α-synuclein and tau: interactions, cross-seeding, and the redefinition of synucleinopathies as complex proteinopathies DOI Creative Commons
Francisco J. Padilla-Godínez,

Eunice Ruth Vázquez-García,

María Isabel Trujillo-Villagrán

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: March 27, 2025

Neurodegenerative diseases are characterized by protein aggregation and overlapping pathologies, challenging traditional classifications highlighting shared underlying mechanisms. Parkinson’s disease related synucleinopathies, including Lewy body dementia multiple system atrophy, highlight the interplay between α-synuclein tau, two key proteins implicated in these disorders. Recent studies reveal that tau co-aggregate, interact synergistically, propagate via prion-like mechanisms, exacerbating neuronal dysfunction. This review examines physiological roles pathological transitions of α-synuclein, emphasizing their microtubule dynamics, synaptic regulation, structural heterogeneity aggregates. Evidence from post-mortem brains, transgenic models, proteomic analyses underscores significance soluble oligomers as primary neurotoxic species explores diverse molecular composition bodies glial cytoplasmic inclusions. The co-localization influenced genetic factors post-translational modifications, offers insights into mechanisms across synucleinopathies tauopathies. These findings advocate for integrated therapeutic strategies targeting cross-seeding proteostatic disruption while preserving roles. By framing neurodegeneration a collapse networks rather than isolated proteinopathies, this work proposes paradigm shift toward understanding treating complex neurodegenerative

Language: Английский

Citations

2