Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 7, 2024
Brazilin
is
the
main
compound
in
Caesalpinia
sappan
and
Haematoxylum
braziletto
,
which
identified
as
a
homoisoflavonoid
based
on
its
molecular
structure.
These
plants
are
traditionally
used
an
anti-inflammatory
to
treat
fever,
hemorrhage,
rheumatism,
skin
problems,
diabetes,
cardiovascular
diseases.
Recently,
brazilin
has
increased
interest
cancer
studies.
Several
findings
have
shown
that
cytotoxic
effects
colorectal
cancer,
breast
lung
multiple
myeloma,
osteosarcoma,
cervical
bladder
carcinoma,
also
other
cancers,
along
with
numerous
facts
about
possible
mechanisms
will
be
discussed.
Besides
flavonoid
content,
able
chelate
metal
ions.
A
study
proved
could
antituberculosis
agent
ability
iron.
This
iron-chelating
of
all
studies
discussed
this
review
lead
us
statement
that,
future,
potency
chemo-preventive
anticancer
agent.
The
article
aimed
determine
mechanism
pathogenesis
cancer.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(23), P. 8367 - 8367
Published: Nov. 30, 2022
Natural
products
have
been
an
invaluable
and
useful
source
of
anticancer
agents
over
the
years.
Several
compounds
synthesized
from
natural
by
modifying
their
structures
or
using
naturally
occurring
as
building
blocks
in
synthesis
these
for
various
purposes
different
fields,
such
biology,
medicine,
engineering.
Multiple
modern
costly
treatments
applied
to
combat
cancer
limit
its
lethality,
but
results
are
not
significantly
refreshing.
products,
which
a
significant
new
therapeutic
drugs,
currently
being
investigated
potential
cytotoxic
shown
positive
trend
preclinical
research
prompted
numerous
innovative
strategies
order
expedite
clinical
research.
becoming
increasingly
important
drug
discovery
due
high
molecular
diversity
novel
biofunctionality.
Furthermore,
can
provide
superior
efficacy
safety
unique
properties.
The
objective
current
review
is
overview
emergence
treatment
prevention
cancer,
chemosensitizers,
immunotherapeutics,
combinatorial
therapies
with
other
formulations
mechanisms
underlying
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(4), P. 3643 - 3643
Published: Feb. 11, 2023
Breast
cancer
(BC)
is
one
of
the
most
widely
diagnosed
cancers
and
a
leading
cause
death
among
women
worldwide.
Globally,
BC
second
frequent
first
gynecological
one,
affecting
with
relatively
low
case-mortality
rate.
Surgery,
radiotherapy,
chemotherapy
are
main
treatments
for
BC,
even
though
latter
often
not
aways
successful
because
common
side
effects
damage
caused
to
healthy
tissues
organs.
Aggressive
metastatic
BCs
difficult
treat,
thus
new
studies
needed
in
order
find
therapies
strategies
managing
these
diseases.
In
this
review,
we
intend
give
an
overview
field,
presenting
data
from
literature
concerning
classification
drugs
used
therapy
treatment
BCs,
along
clinical
studies.
Biologics,
Journal Year:
2024,
Volume and Issue:
Volume 18, P. 229 - 255
Published: Sept. 1, 2024
Natural
products
have
proven
to
be
promising
anti-cancer
agents
due
their
diverse
chemical
structures
and
bioactivity.This
review
examines
central
role
in
cancer
treatment,
focusing
on
mechanisms
of
action
therapeutic
benefits.Medicinal
plants
contain
bioactive
compounds,
such
as
flavonoids,
alkaloids,
terpenoids
polyphenols,
which
exhibit
various
anticancer
properties.These
compounds
induce
apoptosis,
inhibit
cell
proliferation
cycle
progression,
interfere
with
microtubule
formation,
act
topoisomerase
targets,
angiogenesis,
modulate
key
signaling
pathways,
improve
the
tumor
microenvironment,
reverse
drug
resistance
activate
immune
cells.Herbal
drugs
offer
advantages,
particularly
selective
toxicity
against
cells,
reducing
adverse
side
effects
associated
conventional
chemotherapy.Recent
studies
clinical
trials
highlight
benefits
herbal
medicines
alleviating
effects,
improving
tolerance
chemotherapy
occurrence
synergistic
treatments.For
example,
medicine
SH003
was
found
safe
potentially
effective
treatment
solid
cancers,
while
Fucoidan
showed
anti-inflammatory
properties
that
are
beneficial
for
patients
advanced
cancer.The
current
research
landscape
is
extensive.Numerous
investigating
efficacy,
safety
cancers
lung,
prostate,
breast
hepatocellular
carcinoma.Promising
developments
include
polypharmacological
approach,
combination
therapies,
immunomodulation
improvement
quality
life.However,
there
still
challenges
development
use
natural
drugs,
need
further
into
action,
possible
interactions
optimal
dosage.Standardizing
extracts,
bioavailability
delivery,
overcoming
regulatory
acceptance
hurdles
critical
issues
addressed.Nonetheless,
warrant
investigation
development.Multidisciplinary
collaboration
essential
advance
therapy
integrate
these
mainstream
treatment.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(24), P. 15765 - 15765
Published: Dec. 12, 2022
Cancer
is
one
of
the
deadliest
non
communicable
diseases.
Numerous
anticancer
medications
have
been
developed
to
target
molecular
pathways
driving
cancer.
However,
there
has
no
discernible
increase
in
overall
survival
rate
cancer
patients.
Therefore,
innovative
chemo-preventive
techniques
and
agents
are
required
supplement
standard
treatments
boost
their
efficacy.
Fruits
vegetables
should
be
tapped
into
as
a
source
compounds
that
can
serve
therapy.
Phytochemicals
play
an
important
role
sources
new
medication
treatment.
Some
synthetic
natural
chemicals
effective
for
chemoprevention,
i.e.,
use
exogenous
medicine
inhibit
or
impede
tumor
development.
They
help
regulate
linked
development
spread
enhance
antioxidant
status,
inactivating
carcinogens,
suppressing
proliferation,
inducing
cell
cycle
arrest
death,
regulating
immune
system.
While
focusing
on
four
main
categories
plant-based
agents,
epipodophyllotoxin,
camptothecin
derivatives,
taxane
diterpenoids,
vinca
alkaloids
mode
action,
we
review
effects
phytochemicals,
like
quercetin,
curcumin,
piperine,
epigallocatechin
gallate
(EGCG),
gingerol.
We
examine
different
signaling
associated
with
how
inflammation
key
mechanism
growth.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6651 - 6651
Published: April 2, 2023
Cancer
development
is
associated
with
the
deregulation
of
various
cell
signaling
pathways
brought
on
by
certain
genetic
and
epigenetic
alterations.
Therefore,
novel
therapeutic
strategies
have
been
developed
to
target
those
pathways.
The
phosphoinositide
3-kinase
(PI3K)/protein
kinase
B
(Akt)/mammalian
rapamycin
(mTOR)
(PI3K/Akt/mTOR)
pathway
one
major
deregulated
in
types
cancer.
Several
anticancer
drug
candidates
are
currently
being
investigated
preclinical
and/or
clinical
studies
this
pathway.
Natural
bioactive
compounds
provide
an
excellent
source
for
development.
Curcumin
plumbagin
two
potential
that
shown
PI3K/Akt/mTOR
individually.
However,
their
combinatorial
effect
cancer
cells
still
unknown.
This
study
aims
investigate
synergistic
these
employing
a
sequential
molecular
docking
dynamics
(MD)
analysis.
An
increase
binding
affinity
decrease
inhibition
constant
observed
when
curcumin
were
subjected
against
key
proteins
PI3K,
Akt,
mTOR.
MD
simulations
mechanics
combined
generalized
Born
surface
area
(MM-GBSA)
analyses
validated
proteins'
more
stable
conformation
interacting
combination.
indicates
role
possible
dose
advantage
used
findings
pave
way
further
investigation
vitro
vivo
models.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(14), P. 3585 - 3585
Published: July 12, 2023
Radiotherapy
is
an
important
cancer
treatment.
However,
in
addition
to
killing
tumor
cells,
radiotherapy
causes
damage
the
surrounding
cells
and
toxic
normal
tissues.
Therefore,
effective
radioprotective
agent
that
prevents
deleterious
effects
of
ionizing
radiation
required.
Numerous
synthetic
substances
have
been
shown
clear
effects.
most
these
not
translated
for
use
clinical
applications
due
their
high
toxicity
side
Many
medicinal
plants
exhibit
various
biological
activities,
including
antioxidant,
anti-inflammatory,
anticancer
activities.
In
recent
years,
new
agents
obtained
from
natural
products
investigated
by
radioprotection
researchers,
abundance
sources,
efficiency,
low
toxicity.
this
review,
we
summarize
mechanisms
underlying
products,
ROS
scavenging,
promotion
DNA
repair,
anti-inflammatory
effects,
inhibition
cell
death
signaling
pathways.
addition,
systematically
review
with
properties,
polyphenols,
polysaccharides,
alkaloids,
saponins.
Specifically,
discuss
polyphenols
apigenin,
genistein,
epigallocatechin
gallate,
quercetin,
resveratrol,
curcumin;
polysaccharides
astragalus,
schisandra,
Hohenbuehelia
serotina;
saponins
ginsenosides
acanthopanax
senticosus;
alkaloids
matrine,
ligustrazine,
β-carboline.
further
optimization
through
structural
modification,
improved
extraction
purification
methods,
trials
are
needed
before
translation.
With
a
deeper
understanding
involved
development
high-throughput
screening
could
become
promising
novel
agents.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(4), P. 680 - 680
Published: Feb. 6, 2024
In
recent
years,
the
emergence
of
cancer
drug
resistance
has
been
one
crucial
tumor
hallmarks
that
are
supported
by
level
genetic
heterogeneity
and
complexities
at
cellular
levels.
Oxidative
stress,
immune
evasion,
metabolic
reprogramming,
overexpression
ABC
transporters,
stemness
among
several
key
contributing
molecular
response
mechanisms.
Topo-active
drugs,
e.g.,
doxorubicin
topotecan,
clinically
active
utilized
extensively
against
a
wide
variety
human
tumors
often
result
in
development
failure
to
therapy.
Thus,
there
is
an
urgent
need
for
incremental
comprehensive
understanding
mechanisms
specifically
context
topo-active
drugs.
This
review
delves
into
intricate
mechanistic
aspects
these
intracellular
extracellular
explores
use
potential
combinatorial
approaches
utilizing
various
drugs
inhibitors
pathways
involved
resistance.
We
believe
this
will
help
guide
basic
scientists,
pre-clinicians,
clinicians,
policymakers
toward
holistic
interdisciplinary
strategies
transcend
resistance,
renewing
optimism
ongoing
battle
cancer.
Bulletin of the National Research Centre/Bulletin of the National Research Center,
Journal Year:
2024,
Volume and Issue:
48(1)
Published: Jan. 5, 2024
Abstract
Background
The
second
most
common
cancer
in
the
world
is
breast
cancer.
Chemotherapy
used
to
treat
cancer,
but
instances
of
multidrug
resistance,
targets
that
are
not
selective,
and
physicochemical
issues
raise
doubts
about
its
efficacy.
So,
exploration
chemopreventive
agents
from
efficient
natural
sources
has
been
required.
chia
quinoa
seeds
have
health-promoting
activities
include
cardio-protective,
antidiabetic,
anticancer
effects.
Given
paramount
importance
their
oils
potential
bioactivities,
this
work
aimed
assess
repressive
effect
oil
nanocapsules
against
mammary
tumors
rats.
Rat
models
chemically
induced
were
gavaged
with
for
one
month.
was
studied
by
quantifying
TNF-α,
assessing
gene
expression
proto-oncogenes
(PIK3CA
MYC)
using
qRT-PCR,
analyzing
cell
cycle
tissue.
Results
studies
clarified
inhibition
response
associated
a
reduction
TNF-α
levels,
proliferation
capability,
motivation
apoptosis.
Furthermore,
nanocapsule
management
repressed
activation
MYC
PIK3CA
genes.
As
well
as
modulated
liver
enzymes
kidney
function
alterations
tumor
animals.
Meanwhile,
both
oils'
do
an
impact
on
kidneys
healthy
Conclusions
findings
indicate
safe
can
reduce
growth,
suggesting
therapeutic
target
treatment.
