Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
167, P. 115522 - 115522
Published: Sept. 25, 2023
Renal
cell
carcinoma
(RCC)
is
one
of
the
top
ten
malignancies
and
tumor-related
causes
death
worldwide.
The
most
common
histologic
subtype
kidney
renal
clear
(KIRC),
accounting
for
approximately
75%
all
RCC
cases.
Early
resection
considered
basic
treatment
patients
with
KIRC.
However,
30%
these
experience
recurrence
post-operation.
Cuproptosis,
an
autonomous
mechanism
controlling
death,
encompasses
various
molecular
mechanisms
multiple
cellular
metabolic
pathways.
These
pathways
mainly
include
copper
signaling
pathways,
mitochondrial
metabolism
lipoic
acid
pathway
Recent
evidence
shows
that
cuproptosis
identified
as
a
key
modality
plays
meaningful
role
in
tumor
progression.
there
no
published
systematic
review
summarizes
correlation
between
KIRC,
despite
fact
investigations
on
pathogenesis
KIRC
have
increased
past
years.
Researchers
discovered
exogenous
infusion
accelerates
dysfunction
suppresses
cells
by
inducing
cuproptosis.
levels
tricarboxylic
cycle
proteins,
protein,
copper,
ferredoxin
1
(FDX1)
were
dysregulated
cells,
prognosis
high
FDX1
expression
better
than
low
expression.
Cuproptosis
played
indispensable
regulation
microenvironment
features,
progression,
long-term
In
this
review,
we
summarized
systemic
processes
copper-related
highlighting
potential
targets
related
to
treatment.
Immunological Reviews,
Journal Year:
2023,
Volume and Issue:
321(1), P. 211 - 227
Published: Sept. 16, 2023
Summary
Copper
is
an
essential
nutrient
for
maintaining
enzyme
activity
and
transcription
factor
function.
Excess
copper
results
in
the
aggregation
of
lipoylated
dihydrolipoamide
S‐acetyltransferase
(DLAT),
which
correlates
to
mitochondrial
tricarboxylic
acid
(TCA)
cycle,
resulting
proteotoxic
stress
eliciting
a
novel
cell
death
modality:
cuproptosis.
Cuproptosis
exerts
indispensable
role
cancer
progression,
considered
promising
strategy
therapy.
Cancer
immunotherapy
has
gained
extensive
attention
owing
breakthroughs
immune
checkpoint
blockade;
furthermore,
cuproptosis
strongly
connected
modulation
antitumor
immunity.
Thus,
thorough
recognition
concerning
mechanisms
involved
metabolism
may
facilitate
improvement
management.
This
review
outlines
cellular
molecular
characteristics
links
regulated
modality
with
human
cancers.
We
also
current
knowledge
on
complex
effects
immunity
response.
Furthermore,
potential
agents
that
elicit
pathways
are
summarized.
Lastly,
we
discuss
influence
induction
tumor
microenvironment
as
well
challenges
adding
regulators
therapeutic
strategies
beyond
traditional
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: July 26, 2023
Copper
is
an
essential
micronutrient
that
plays
a
critical
role
in
many
physiological
processes.
However,
excessive
copper
accumulation
cancer
cells
has
been
linked
to
tumor
growth
and
metastasis.
This
review
article
explores
the
potential
of
targeting
metabolism
as
promising
strategy
for
treatment.
Excessive
associated
with
By
disrupting
homeostasis
inducing
cell
death
through
copper-dependent
mechanisms
(cuproplasia
cuprotosis,
respectively),
therapies
can
be
developed
improved
efficacy
reduced
side
effects.
The
discusses
biological
processes,
such
angiogenesis,
immune
response,
redox
homeostasis.
Various
approaches
treatment
are
examined,
including
use
enzymes,
copper-based
compounds,
cuprotosis-related
genes
or
proteins.
also
strategies
like
chelation
therapy
nanotechnology
targeted
delivery
copper-targeting
agents.
understanding
intricate
network
cuprotosis
its
interactions
microenvironment
system,
new
targets
identified,
leading
outcomes.
Overall,
this
comprehensive
highlights
significant
effective
approach
treatment,
while
providing
valuable
insights
into
current
state
research
field.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 19, 2024
Background
Myocardial
infarction
(MI)
caused
by
severe
coronary
artery
disease
has
high
incidence
and
mortality
rates,
making
its
prevention
treatment
a
central
challenging
aspect
of
clinical
work
for
cardiovascular
practitioners.
Recently,
researchers
have
turned
their
attention
to
novel
mechanism
cell
death
Cu
2+
,
cuproptosis.
Methods
This
study
integrated
data
from
three
MI-related
bulk
datasets
downloaded
the
Gene
Expression
Omnibus
(GEO)
database,
identified
16
differentially
expressed
genes
(DEGs)
related
cuproptosis
taking
intersection
6378
DEGs
obtained
differential
analysis
with
49
cuproptosis-related
genes.
Four
hub
genes,
Dbt,
Dlat,
Ube2d1
Ube2d3,
were
screened
out
through
random
forest
Lasso
analysis.
In
group,
showed
low
expression,
while
Ube2d3
exhibited
expression.
Results
Focusing
on
subsequent
functional
studies,
we
confirmed
expression
in
MI
group
qRT-PCR
Western
Blot
detection
after
successful
construction
mouse
model
left
anterior
descending
(LAD)
ligation,
further
clarified
correlation
development
detecting
levels
proteins.
Moreover,
vitro
experiments,
was
be
highly
oxygen-glucose
deprivation
(OGD)-treated
cardiomyocytes
AC16.
order
clarify
role
knocked
down
OGD-treated
AC16
cells,
Ube2d3’s
promoting
hypoxia
damage
cells
inducing
cuproptosis,
as
evidenced
MTT,
TUNEL,
LDH
release
Conclusion
summary,
our
findings
indicate
that
regulates
affect
progression
MI.
Journal of Cancer Research and Clinical Oncology,
Journal Year:
2024,
Volume and Issue:
150(6)
Published: June 4, 2024
Abstract
Background
Butyrate
is
a
common
short-chain
fatty
acids
(SCFA),
and
it
has
been
demonstrated
to
regulate
the
development
of
breast
cancer
(BC),
while
underlying
mechanism
still
unreported.
Methods
Gas
chromatography
was
used
measure
amounts
SCFA
(acetate,
propionate,
butyrate)
in
feces.
Cell
viability
measured
by
CCK-8
assay.
The
wound
healing
assay
cell
migration,
transwell
invasion.
levels
protein
gene
were
determined
western
blot
RT-qPCR
assay,
respectively.
Results
lower
faecal
samples
from
BC
patients
compared
control
samples.
In
cellular
experiments,
butyrate
significantly
suppressed
viability,
migration
invasion
T47D
dose-dependent
manner.
animal
effectively
impeded
growth
tumors.
Toll
like
receptor
4
(TLR4)
highly
expressed
tumors
patients.
inhibited
expression
TLR4.
addition,
promoted
cuproptosis-related
genes
including
PDXK
(pyridoxal
kinase)
SLC25A28
(solute
carrier
family
25
member
28),
which
lowly
Importantly,
overexpression
TLR4
can
reverses
promotion
prevention
malignant
biological
behaviors
cells.
Conclusion
summary,
inhibits
facilitating
through
inhibition
Our
investigation
first
identified
connection
among
butyrate,
progression.
These
findings
may
provide
novel
target
for
treatment
BC.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 5, 2025
Abstract
This
study
aims
to
screen
and
identify
microRNA
(miRNA)
expression
profiles
across
different
stages
of
prostate
cancer
(PCa)
benign
prostatic
hyperplasia
(BPH)
using
high-throughput
sequencing.
The
seeks
determine
whether
specific
miRNAs
show
consistent
differential
various
PCa,
with
the
goal
identifying
potential
biomarkers
relevant
disease
progression.
In
this
study,
a
total
12
specimens
PCa
BPH
were
collected
from
September
2021
June
2022
in
Second
Affiliated
Hospital
Nanchang
University,
330,006,
P.R.
China
(including
3
early
localized
tumor,
local
invasion,
distant
metastasis
tumor
BPH).
profile
miRNA
was
screened
by
sequencing
technology,
differentially
expressed
between
each
group
bioinformatics
analysis.
Further
targeted
site
analysis
GO
enrichment
KEGG
miRNA-derived
genes
performed
on
above
miRNAs.
Finally,
hsa-miR-6715b-3p
tissues
verified
qRT-PCR
assay.
A
1526
identified
through
By
comparing
groups,
228
identified,
100
upregulated
128
downregulated.
Additionally,
69
novel
predicted.
results
showed
that
highly
compared
tissues.
presents
preliminary
investigation
identifies
as
promising
biomarker
for
Our
findings
validate
high
highlight
its
role
critical
oncogenic
pathways.
These
provide
theoretical
foundation
further
functional
studies
explore
clinical
utility
therapy
resistance
progression,
contributing
growing
knowledge
miRNA-based
PCa.
