Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13
Published: April 14, 2023
EDITORIAL article Front. Cell. Infect. Microbiol., 14 April 2023Sec. Virus and Host Volume 13 - 2023 | https://doi.org/10.3389/fcimb.2023.1198392
Language: Английский
Diagnostics, Journal Year: 2024, Volume and Issue: 14(3), P. 244 - 244
Published: Jan. 24, 2024
(1) Background: COVID-19 was responsible for the latest pandemic, shaking and reshaping healthcare systems worldwide. Its late clinical manifestations make it linger in medical memory as a debilitating illness over extended periods. (2) Methods: recent literature systematically analyzed to categorize examine symptomatology pathophysiology of Long COVID across various bodily systems, including pulmonary, cardiovascular, gastrointestinal, neuropsychiatric, dermatological, renal, hematological, endocrinological aspects. (3) Results: The review outlines diverse multiple emphasizing its complexity challenges diagnosis treatment. Factors such pre-existing conditions, initial severity, vaccination status, gender, age were identified influential manifestation persistence symptoms. This condition is highlighted disease capable enduring an period presenting new symptoms time. (4) Conclusions: emerges with intricate multi-systemic involvement, complicating findings underscore necessity nuanced understanding effectively manage address evolving nature this
Language: Английский
Citations
8
Biomedicines, Journal Year: 2023, Volume and Issue: 11(5), P. 1302 - 1302
Published: April 27, 2023
Accumulating evidence implicates obesity as a risk factor for increased severity of disease outcomes in patients infected with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Obesity is associated adipose tissue dysfunction, which not only predisposes individuals to metabolic complications, but also substantially contributes low-grade systemic inflammation, altered immune cell composition, and compromised function. This seems impact the susceptibility outcome diseases caused by viruses, obese people appear more vulnerable developing infections they recover later from infectious than normal-weight individuals. Based on these findings, efforts identify suitable diagnostic prognostic markers Coronavirus 2019 (COVID-19) predict have been made. includes analysis cytokines secreted tissues (adipokines), multiple regulatory functions body; instance, modulating insulin sensitivity, blood pressure, lipid metabolism, appetite, fertility. Most relevant context viral infections, adipokines influence number, consequences overall activity Hence, circulating levels diverse SARS-CoV-2 considered reveal COVID-19 markers. review article summarizes findings aimed correlate progression COVID-19. Several studies provided insights chemerin, adiponectin, leptin, resistin, galectin-3 SARS-CoV-2-infected patients, while limited information yet available apelin visfatin Altogether, current points at resistin being value disease.
Language: Английский
Citations
16
Advanced Science, Journal Year: 2023, Volume and Issue: 11(8)
Published: Dec. 28, 2023
Infectious diseases are increasingly recognized as a major threat worldwide due to the rise of antimicrobial resistance and emergence novel pathogens. In vitro models that can adequately mimic in vivo gastrointestinal physiology high demand elucidate mechanisms behind pathogen infectivity, aid design effective preventive therapeutic interventions. There exists trade-off between simple throughput those more complex physiologically relevant. The complexity model used shall be guided by biological question addressed. This review provides an overview structure function intestine developed emulate this. Conventional discussed addition emerging which employ engineering principles equip them with necessary advanced monitoring capabilities for intestinal host-pathogen interrogation. Limitations current future perspectives on field presented.
Language: Английский
Citations
15
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(13), P. 3977 - 3977
Published: July 8, 2024
In recent years, remarkable strides have been made in the management of gastrointestinal disorders, transforming landscape patient care and outcomes. This article explores latest breakthroughs field, encompassing innovative diagnostic techniques, personalized treatment approaches, novel therapeutic interventions. Additionally, this emphasizes use precision medicine tailored to individual genetic microbiome profiles, application artificial intelligence disease prediction monitoring. review highlights dynamic progress managing conditions such as inflammatory bowel disease, gastroesophageal reflux irritable syndrome, cancers. By delving into these advancements, we offer a glimpse promising future gastroenterology, where multidisciplinary collaborations cutting-edge technologies converge provide more effective, patient-centric solutions for individuals grappling with disorders.
Language: Английский
Citations
6
Renal Replacement Therapy, Journal Year: 2025, Volume and Issue: 11(1)
Published: Jan. 10, 2025
Abstract Background Coronavirus disease 2019 (COVID-19) is known to deteriorate nutrition in the general population. However, influence of COVID-19 on nutritional status patients undergoing maintenance hemodialysis remains unclear. Methods A retrospective study was conducted a hospital that had an outbreak severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. diagnosed using antigen test, and subjects were divided into control groups. Data body mass index, biochemistry measurements, geriatric risk index (GNRI), functional oral intake scale, collected from medical records. generalized linear mixed model used analyze interaction time × group for these parameters between two Results The included 28 participants, 16 whom belonged group. There no significant differences baseline characteristics, except serum creatinine level, among In group, 63% exhibited anorexia 50% experienced vomiting/nausea. Nutritional support or dietary consultations provided nine patients. Significant declines observed albumin total iron binding capacity, energy intake, GNRI recovered within 1 month following resolution Conclusions deteriorated hemodialysis. More proactive may help maintain during infection could lead better prognosis.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 13, 2025
Language: Английский
Citations
0
Vaccine, Journal Year: 2025, Volume and Issue: 53, P. 127078 - 127078
Published: April 1, 2025
The COVID-19 pandemic underscored the importance of advancing technologies that enable rapid development and distribution more effective vaccines when required. Since SARS-CoV-2 enters body through nasal mucosa, optimising induction secretory IgA (sIgA) production, a key component mucosal immune response, is essential. It has long been known sIgA occurs vaccine administered surfaces responses initiated at one site can influence activity other surfaces. Consequently, we propose an oral formulation (Vacform) comprising immunomodulator CL097, TLR7/8 agonist, spike protein, both encapsulated within glucan particles (GPs). studies demonstrated Vacform induced ROS production in RAW 264.7 cells but not human neutrophils. concentrations tested did induce NO cells. While stimulated TNF-α IL-6 mouse spleen cells, this effect was observed Finally, proliferation PBMCs. Thus, its immunomodulatory properties were evident specific under certain vitro conditions. subsequently vaccination studies. C57BL/6 mice initially immunized subcutaneously, followed by two boosts with every weeks. elicited both, humoral (serum IgG sIgA) cellular responses. A balanced Th1/Th2/Th17 profile observed. In conclusion, GPs:CL097 adjuvant system shows promise for eliciting robust against provides foundation future on dose-response optimization challenge models.
Language: Английский
Citations
0
COVID, Journal Year: 2025, Volume and Issue: 5(4), P. 58 - 58
Published: April 18, 2025
SARS-CoV-2 has been identified in multiple organs and fluids, including the liver peritoneal fluid. Gastrointestinal symptoms, such as abdominal pain, diarrhea, nausea, vomiting, can exacerbate COVID-19 outcomes by contributing to complications, like acid–base imbalances cardiovascular dysfunction, particularly patients with pre-existing conditions. We report three cases of cirrhotic detected their ascitic fluid review relevant literature on virus’s presence clinical significance These findings underscore diagnostic prognostic challenges managing chronic disease highlight need for further research clarify viral dissemination mechanisms optimize protective measures healthcare workers during surgical procedures.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14800 - 14800
Published: Sept. 30, 2023
Since the emergence of coronavirus disease 2019 (COVID-19) pandemic, many lives have been tragically lost to severe infections. The COVID-19 impact extends beyond respiratory system, affecting various organs and functions. In cases, it can progress acute distress syndrome (ARDS) multi-organ failure, often fueled by an excessive immune response known as a cytokine storm. Mesenchymal stem cells (MSCs) considerable potential because they mitigate inflammation, modulate responses, promote tissue regeneration. Accumulating evidence underscores efficacy safety MSCs in treating ARDS. Nonetheless, critical aspects, such optimal routes MSC administration, appropriate dosage, treatment intervals, management extrapulmonary complications, pediatric applications, warrant further exploration. These research avenues hold promise for enriching our understanding refining application confronting multifaceted challenges posed COVID-19.
Language: Английский
Citations
9
Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)
Published: March 27, 2024
Abstract The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is the cause of coronavirus disease 2019 (COVID-19); a distress that has emerged from city Wuhan, Hubei province, China during December 2019. COVID-19 currently major global health problem and now spread to most countries in world. profoundly impacted human activities worldwide. Genetic mutation one essential characteristics viruses. They do so adapt their host or move another one. Viral genetic mutations have high potentiality impact as these grant viruses unique unpredicted characteristics. difficulty predicting viral significant obstacle field. Evidence indicates SARS-CoV-2 variety genomic diversity with obvious clinical consequences implications. In this review, we comprehensively summarized discussed available knowledge regarding outbreaks fundamental focus on role proteins progression. We also implications variants how they affect severity hinder vaccine development. Finally, provided massive phylogenetic analysis spike gene 214 isolates different geographical regions all over world associated
Language: Английский
Citations
3