Life Sciences, Journal Year: 2024, Volume and Issue: 354, P. 122979 - 122979
Published: Aug. 13, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6971 - 6971
Published: June 26, 2024
The gut microbiota is a diverse bacterial community consisting of approximately 2000 species, predominantly from five phyla: Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, and Verrucomicrobia. microbiota's species create distinct compounds that impact the host's health, including well-known short-chain fatty acids. These are produced through breakdown dietary fibers fermentation undigested carbohydrates by intestinal microbiota. main acids consist acetate, propionate, butyrate. concentration butyrate in mammalian intestines varies depending on diet. Its functions use as an energy source, cell differentiation, reduction inflammatory process intestine, defense against oxidative stress. It also plays epigenetic role histone deacetylases, thus helping to reduce risk colon cancer. Finally, affects gut-brain axis crossing brain-blood barrier, making it crucial determine right concentrations for both local peripheral effects. In recent years, there has been significant amount attention given polyphenols promoting human health. Polyphenols play roles protecting health can produce fermentation. This paper aims summarize information key summits related negative correlation between diversity chronic diseases guide future research determining specific activity carry out these vital functions.
Language: Английский
Citations
14
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116420 - 116420
Published: March 11, 2024
Gut microbiome alterations are associated with various cancers including brain tumours such as glioma and glioblastoma. The gut communicates the via a bidirectional pathway known gut-brain axis (GBA) which is essential for maintaining homeostasis. microbiota produces many metabolites short chain fatty acids (SCFAs) amino glutamate, glutamine, arginine tryptophan. Through modulation of these able to regulate several functions cells, immune cells tumour DNA methylation, mitochondrial function, aryl hydrocarbon receptor (AhR), T-cell proliferation, autophagy even apoptosis. Here, we summarise current findings on respect cancers, an area research that widely overlooked. Several studies investigated relationship between tumours. However, it remains unclear whether variation cause or product cancer. Subsequently, biomarker panel was constructed use predictive, prognostic diagnostic tool multiple glioblastoma multiforme (GBM). This review further presents intratumoural microbiome, fascinating microenvironment within possible treatment target can be manipulated maximise effectiveness personalised therapy. Studies utilising therapeutic strategy necessary accurately assess clinical cancers.
Language: Английский
Citations
11
Microorganisms, Journal Year: 2024, Volume and Issue: 12(4), P. 634 - 634
Published: March 22, 2024
The bidirectional relationship between the gut microbiota and nervous system is known as microbiota-gut-brain axis (MGBA). MGBA controls complex interactions brain, enteric system, gut-associated immune neuroendocrine systems, regulating key physiological functions such response, sleep, emotions mood, food intake, intestinal functions. Psychobiotics are considered tools with potential to modulate through preventive, adjunctive, or curative approaches, but their specific mechanisms of action on many aspects health yet be characterized. This narrative review perspectives article highlights paradigms needing attention scope probiotics applications in human increases, a growing body evidence supporting systemic beneficial effects. However, there limitations overcome before establishing extent which we can incorporate management neuropsychiatric disorders. Although this uses term general manner, it remains important study at strain level most cases.
Language: Английский
Citations
11
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5782 - 5782
Published: May 26, 2024
Nowadays, depressive disorder is spreading rapidly all over the world. Therefore, attention to studies of pathogenesis disease in order find novel ways early diagnosis and treatment increasing among scientific medical communities. Special drawn a biomarker therapeutic strategy through microbiota–gut–brain axis. It known that symbiotic interactions between gut microbes host can affect mental health. The review analyzes mechanisms action microbiota on pathophysiology depression. possibility using knowledge about taxonomic composition metabolic profile patients with depression select gene compositions (metagenomic signature) as biomarkers evaluated. use silico technologies (machine learning) for based given. Alternative approaches are being considered by balancing microbial dietary modifications additives, namely probiotics, postbiotics (including vesicles) prebiotics psychobiotics, fecal transplantation. bacterium Faecalibacterium prausnitzii under consideration promising new-generation probiotic auxiliary diagnostic analysis conducted this may be useful clinical practice pharmacology.
Language: Английский
Citations
8
NeuroMolecular Medicine, Journal Year: 2025, Volume and Issue: 27(1)
Published: Jan. 16, 2025
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 808 - 808
Published: Jan. 18, 2025
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social communication and interaction, alongside repetitive behaviors, atypical sensory-motor patterns. The growing prevalence of ASD has driven substantial advancements research aimed at understanding its etiology, preventing onset, mitigating impact. This ongoing effort necessitates continuous updates to the body knowledge identification previously unexplored factors. present study addresses this need examining roles nutrition, oxidative stress, trace elements pathophysiology ASD. In review, an overview provided key dietary recommendations for individuals with ASD, including gluten-free casein-free (GFCF) diets, ketogenic diets (KDs), other nutritional interventions. Furthermore, it explores involvement stress highlights significance maintaining neuropsychiatric health. impact these factors on molecular cellular mechanisms was discussed, therapeutic strategies their efficacy managing
Language: Английский
Citations
1
Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 558 - 558
Published: Jan. 31, 2025
Alzheimer’s disease (AD) is the most common form of dementia and characterized by memory impairment that significantly interferes with daily life. Therapeutic options for AD substantively modify progression remain a critical unmet need. In this regard, gut microbiota crucial in maintaining human health regulating metabolism immune responses, increasing evidence suggests probiotics, particularly beneficial bacteria, can enhance cognitive functions. Recent studies have highlighted positive effects Bifidobacterium breve MCC1274 (B. MCC1274) on individuals mild (MCI) schizophrenia. Additionally, oral supplementation B. has been shown to effectively prevent decline AppNL–G–F mice. relation pathology, found reduce amyloid-β (Aβ) accumulation tau phosphorylation both wild-type (WT) It also decreases microglial activation increases levels synaptic proteins. review, we examine AD, exploring potential mechanisms action how probiotic strain may aid preventing or treating disease. Furthermore, discuss broader implications improving overall host provide insights into future research directions promising therapy.
Language: Английский
Citations
1
Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 270 - 270
Published: Feb. 12, 2025
The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.
Language: Английский
Citations
1
Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(12), P. 4667 - 4687
Published: Aug. 14, 2023
The blood–brain barrier (BBB) impairment plays a crucial role in the pathological processes of aging-accompanied neurological diseases (AAND). Meanwhile, circadian rhythms disruption and gut microbiota dysbiosis are associated with increased morbidity accelerated aging population. Importantly, also known to induce generation toxic metabolites pro-inflammatory cytokines, resulting BBB integrity. Collectively, this provides new perspective for exploring relationship among rhythms, microbes, diseases. In review, we focus on recent advances interplay between rhythm disturbances dysbiosis, their potential roles that occurs AAND. Based existing literature, discuss propose mechanisms underlying damage induced by dysregulated microbiota, which would serve as basis developing interventions protect population through targeting exploiting its links treating
Language: Английский
Citations
22
Neuroscience Bulletin, Journal Year: 2023, Volume and Issue: 40(4), P. 500 - 516
Published: Sept. 27, 2023
Parkinson's disease (PD) is a complicated neurodegenerative disease, characterized by the accumulation of α-synuclein (α-syn) in Lewy bodies and neurites, massive loss midbrain dopamine neurons. Increasing evidence suggests that gut microbiota microbial metabolites are involved development PD. Among these, short-chain fatty acids (SCFAs), most abundant metabolites, have been proven to play key role brain-gut communication. In this review, we analyze SCFAs pathology PD from multiple dimensions summarize alterations patients as well their correlation with motor non-motor symptoms. Future research should focus on further elucidating neuroinflammation, developing novel strategies employing derivatives treat
Language: Английский
Citations
22