Neurotropic virus infection and neurodegenerative diseases: Potential roles of autophagy pathway

CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 30(6)

Published: Dec. 11, 2023

Abstract Neurodegenerative diseases (NDs) constitute a group of disorders characterized by the progressive deterioration nervous system functionality. Currently, precise etiological factors responsible for NDs remain incompletely elucidated, although it is probable that combination aging, genetic predisposition, and environmental stressors participate in this process. Accumulating evidence indicates viral infections, especially neurotropic viruses, can contribute to onset progression NDs. In review, emerging supporting association between infection summarized, how autophagy pathway mediated cause pathological aggregation cellular proteins associated with various discussed. Furthermore, autophagy‐related genes (ARGs) involved Herpes simplex virus (HSV‐1) are analyzed, whether these could link HSV‐1 Elucidating mechanisms underlying critical developing targeted therapeutic approaches prevent slow

Language: Английский

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Synthesis, In Vitro Biological Investigation, and In Silico Analysis of Pyrazole-Based Derivatives as Multi-target Agents

Egyptian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 0(0), P. 0 - 0

Published: May 3, 2023

The diseases-related complications and causes are threaded.Accordingly, the preparation of one drug with multiple targets is very pressing.In this context, three series pyrazole-based derivatives 7a-c, 9a-c, 11a-c were designed synthesized by using 5-amino-pyrazoles 3a-c as starting materials.The structures various products characterized devices (elemental analysis spectral tools).The biological activities pyrazolebased estimated antioxidant, anti-diabetic, anti-Alzheimer, anti-arthritic.The estimation results showed that two 7c 11a displayed powerful activities.In silico (physicochemical, drug-likeness, toxicity properties) was performed.This research could be valuable for exploration targets.

Language: Английский

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Bidirectional two-sample Mendelian randomization analysis identifies causal associations between oxidative stress and Parkinson’s disease

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: July 4, 2024

Background Observational studies have shown that oxidative stress (OS) is associated with Parkinson’s disease (PD). However, whether such observations reflect cause–effect remains largely unknown. To test this, we performed a two-sample bidirectional Mendelian randomization (MR) analysis to investigate the causal-effects between OS biomarkers and PD. Methods We selected summary statistics data for single-nucleotide polymorphisms (SNPs) catalase ( n = 13), glutathione peroxidases 12), superoxide dismutase vitamin A 7), C 10), E B12 8), folate 14), copper 6), Zinc iron 23) levels, corresponding PD from International Parkinson Disease Genomics Consortium (IPDGC, 33,674 cases 449,056 controls). Inverse-variance weighted (IVW) MR analyses were conducted estimate associations of Reverse was further predict causal effects on above biomarkers. Results As PD, IVW method suggested (Zn) levels significantly (OR 1.107, 95% CI 1.013–1.211; p 0.025), which consistent results median analyses. Moreover, remained robust in sensitivity analysis. there no significant catalase, peroxidases, dismutase, A, C, E, B12, folate, copper, or OS, our reverse also did not support effect liability OS. Conclusion The study supported Zn These findings may inform prevention strategies interventions directed toward

Language: Английский

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The neurobiological effects of senescence on dopaminergic system: A comprehensive review

Journal of Chemical Neuroanatomy, Journal Year: 2024, Volume and Issue: 137, P. 102415 - 102415

Published: March 22, 2024

Language: Английский

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Interplay Between Oxidative Stress, Autophagy and the Endocannabinoid System in Neurodegenerative Diseases: Role of the Nrf2- p62/SQSTM1 Pathway and Nutraceutical Activation

Published: June 6, 2024

The onset of neurodegenerative diseases involves a complex interplay pathological mecha-nisms, including protein aggregation, oxidative stress, impaired autophagy. This review focuses on the intricate connection between stress and autophagy in disor-ders, highlighting as pivotal disease pathogenesis. Reactive oxygen species (ROS) play dual roles cellular homeostasis regulation, with disruptions redox sig-naling contributing to neurodegeneration. activation Nrf2 pathway represents criti-cal antioxidant mechanism, while maintains by degrading al-tered cell components. interaction p62/SQSTM1, Keap1 forms regulatory essential for response, whose dysregulation leads aggregate accumulation. Targeting Nrf2-p62/SQSTM1 holds promise thera-peutic intervention, mitigating preserving functions. Additionally, explores potential synergy endocannabinoid system signal-ing neuroprotection. Further research is needed elucidate involved molecular mecha-nisms develop effective therapeutic strategies against

Language: Английский

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Oxidative stress, neuroinflammation, and the blood-brain barrier biomarkers on the brain response to spaceflight

Life Sciences in Space Research, Journal Year: 2024, Volume and Issue: 43, P. 22 - 28

Published: Aug. 8, 2024

Prolonged spaceflight can induce physiologic and pathologic abnormalities in the central nervous system (CNS). Our knowledge of adaptive and/or detrimental effects on structure function is limited. Substantial effort has been devoted to identifying developing reliable indicators characterize predict CNS injury dysfunction associated with prolonged exposure major components space environment including microgravity, physiological/psychological stress, radiation from galactic cosmic rays (GCR) solar particle events (SPEs) outside low earth orbit (LEO). The blood-brain barrier (BBB) a semi-permeable membrane that essential maintain homeostasis brain microenvironment. Oxidative stress or other environmental stressors may disrupt BBB integrity increase permeability leading immune cell infiltration undesirable neuroinflammation. focus this review article damage rodent human studies. We will highlight potential biomarkers for damage, site-specific circulating neuroinflammatory factors, structural parenchyma proteins, neuroimaging tools evaluation. These help understand risks travel are also critical novel countermeasure development mitigate flight risk astronaut performances.

Language: Английский

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Physical Activity Regulates and Mediates the Signaling Pathway and Pathophysiological Mechanisms of the Neuroinflammation and Neurodegenerative

Asian Journal of Sports Medicine, Journal Year: 2024, Volume and Issue: 15(4)

Published: Oct. 23, 2024

Context: The correlation between neuroinflammation and neurodegenerative disorders has been extensively documented. Elevated levels of inflammatory cytokines in the bloodstream have demonstrated to impair memory function heighten susceptibility disorders. Furthermore, elevated quantities reactive oxygen species (ROS) body, known as oxidative stress, exacerbate illnesses negatively affect learning memory. Neuroprotection prevents neuronal cell death by intervening blocking pathogenetic process that leads cellular malfunction death. Methods: We evaluated several studies WEB SCIENCE, SCOPUS, PubMed. we identified central genes signaling pathways associated with neurogenesis, neural system, neuroplasticity through data mining, a literature review artificial intelligence, an in-silico study. Results: Physical exercise (PE) benefits various physiological systems, including nervous system. beneficial impacts physical activity on cognitive performance, well-being, safeguarding neurons against different brain injuries are research PE is powerful non-pharmacological intervention enhances function, memory, while decreasing likelihood developing Additionally, engaging moderate does not result extreme fatigue impact reducing inflammation promoting antioxidant effects. According hormesis theory, inactivity overtraining can decrease function. Conclusions: In summary, combination aerobic exercise, HIIT, resistance training, performed at appropriate intensities, most for neuroprotection health. Regular engagement these activities help mitigate risk diseases enhance overall

Language: Английский

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Exploring the key parameters for indoor light intervention in treating neurodegenerative diseases: A systematic review

Building and Environment, Journal Year: 2024, Volume and Issue: 258, P. 111587 - 111587

Published: April 27, 2024

Language: Английский

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Comparison of Machine Learning Methods for Predicting 3-Year Survival in Elderly Esophageal squamous cancer Patients Based on Oxidative Stress

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 29, 2024

Background There is currently a lack of machine learning model studies exploring the relationship between oxidative stress score (OSS) and prognosis elderly Esophageal squamous cancer(ESCC) patients. MethodsThis study included ESCC patients who underwent curative resection surgery from January 2013 to December 2020. Machine strategies including decision tree (DT), random forest (RF), support vector (SVM) were employed construct predictive for 3-year overall survival (OS) elder base on OSS. ResultsPatients divided into derivation cohort validation cohort, consisted 340 145 patients, respectively. 8 important features which most factors influencing OS (pathological N stage, pathological T tumor histological type, vascular invasion, CEA, OSS, CA 19-9, amount bleeding) in training RF, DT SVM. In RF exhibited highest performance with an AUC 0.975(0.962-0.987), while 0.784(0.739-0.830) SVM 0.879(0.843-0.916). external showed similar trend . Conclusion The clinical prediction constructed based OSS can effectively predict after surgery.

Language: Английский

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Allocryptopine Attenuates Inflammatory Responses in Microglial Cells Via TLR4-Dependent NF-κB and p38 MAPK Pathways

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Language: Английский

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