Unveiling the dynamics of gut microbial interactions: a review of dietary impact and precision nutrition in gastrointestinal health

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: May 30, 2024

The human microbiome, a dynamic ecosystem within the gastrointestinal tract, plays pivotal role in shaping overall health. This review delves into six interconnected sections, unraveling intricate relationship between diet, gut microbiota, and their profound impact on dance of nutrients orchestrates complex symphony, influencing digestive processes susceptibility to disorders. Emphasizing bidirectional communication brain, Brain-Gut Axis section highlights crucial dietary choices physical, mental, emotional well-being. Autoimmune diseases, particularly those manifesting reveal delicate balance disrupted by microbiome imbalances. Strategies for reconciling microbes through diets, precision nutrition, clinical indications showcase promising avenues managing distress revolutionizing healthcare. From Low-FODMAP diet neuro-gut interventions, these strategies provide holistic understanding gut’s world. Precision as groundbreaking discipline, holds transformative potential tailoring recommendations individual microbiota compositions, reshaping landscape Recent advancements indications, including exact probiotics, fecal transplantation, signify new era where actively participates therapeutic strategies. As takes center stage healthcare, paradigm shift toward personalized effective treatments disorders emerges, reflecting symbiotic body its microbial companions.

Language: Английский

---

Gut Microbiota Alteration and Its Modulation with Probiotics in Celiac Disease

Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2638 - 2638

Published: Sept. 26, 2023

Celiac disease (CD) is a chronic inflammation of the small intestine triggered by gluten ingestion in genetically predisposed people. Recent literature studies highlight possible role gut microbiota pathogenesis this disease. The complex community microorganisms that can interact with innate and adaptative immune systems. A condition dysbiosis, which refers to an alteration composition function human microbiota, lead dysregulated response. This may contribute triggering intolerance, favoring development and/or progression CD susceptible patients. Interestingly, on children adults showed different microbiome profile fecal samples, degree “activity” for From point view, our review aimed collect discuss modern evidence about its modulation probiotics, future indications management patients affected CD.

Language: Английский

---

How the Microbiota May Affect Celiac Disease and What We Can Do

Nutrients, Journal Year: 2024, Volume and Issue: 16(12), P. 1882 - 1882

Published: June 14, 2024

Celiac disease (CeD) is an autoimmune with a strong association human leukocyte antigen (HLA), characterized by the production of specific autoantibodies and immune-mediated enterocyte killing. CeD unique condition, as it only one in which environmental trigger known: gluten, storage protein present wheat, barley, rye. How when loss tolerance intestinal mucosa to gluten occurs still unknown. This event, through activation adaptive immune responses, enhances epithelial cell death, increases permeability barrier, induces secretion pro-inflammatory cytokines, resulting transition from genetic predisposition actual onset disease. While role gastrointestinal infections possible has been considered on basis mechanism mimicry, more likely alternative appears involve complex disruption microbiota ecosystem triggered infections, rather than effect single pathogen mucosal homeostasis. Several lines evidence show existence dysbiosis that precedes genetically at-risk subjects, protective bacterial elements both epigenetically functionally can influence response epithelium leading tolerance. We have conducted literature review order summarize current knowledge about part unraveled accompanies some exciting new data how this might be prevented and/or counteracted. The search was PubMed.gov time frame 2010 March 2024 utilizing terms "celiac microbiota", microbiome", probiotics" restricting following article types: Clinical Trials, Meta-Analysis, Review, Systematic Review. A total 364 papers were identified reviewed. main conclusions outlined follows: (1) quantitative qualitative changes gut clearly documented patients; (2) microbiota's extensive variable interactions enterocytes, viral pathogens even combine impact inflammatory tolerance, ultimately affecting pathogenesis, progression, clinical expression CeD; (3) gluten-free diet fails restore eubiosis digestive tract patients, also negatively affects microbial homeostasis; (4) tools allowing targeted therapy, such use probiotics (a good example being precision like novel strain B. vulgatus (20220303-A2) begin potential applications.

Language: Английский

---

Important denominator between autoimmune comorbidities: a review of class II HLA, autoimmune disease, and the gut

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 26, 2023

Human leukocyte antigen (HLA) genes are associated with more diseases than any other region of the genome. Highly polymorphic HLA produce variable haplotypes that specifically correlated pathogenically different autoimmunities. Despite differing etiologies, however, many autoimmune disorders share same risk-associated often resulting in comorbidity. This shared risk remains an unanswered question field. Yet, several groups have revealed links between gut microbial community composition and diseases. Autoimmunity is frequently dysbiosis, loss barrier function permeability tight junctions, which increases class II expression levels thus further influences microbiome. However, autoimmune-risk-associated connected to dysbiosis long before autoimmunity even begins. review evaluates current research on HLA-microbiome-autoimmunity triplex proposes pre-autoimmune bacterial important determinant comorbidities systemic inflammation as a common denominator.

Language: Английский

---

Gut microbiota in celiac disease

Annals of Gastroenterology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Celiac disease (CD) is an autoimmune gastrointestinal triggered by dietary gluten, occurring in genetically predisposed individuals.Currently, a gluten-free diet the only current evidenced-based treatment for CD.With growing prevalence of this condition worldwide, adjuvant therapies are needed.We understand that there several factors influence pathogenesis condition.There complex interplay between genetics, environmental triggers, immune system and gut microbiota.Recently, has been focus on significance microbiota autoimmune-based conditions.In particular, much research involving role microbial flora CD.Here, mini-review, we highlight importance symbiotic relationship with host, introduce key development intestinal early colonization, ultimately explore its CD.

Language: Английский

---

Fecal microbiota transplantation in autoimmune diseases – An extensive paper on a pathogenetic therapy

Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: 23(7-8), P. 103541 - 103541

Published: April 7, 2024

Language: Английский

---

Lactiplantibacillus plantarum Moderating Effect on Autoimmune Celiac Disease Triggers

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Language: Английский

---

Gut dysbiosis: cause or consequence of intestinal inflammation in celiac disease?

Expert Review of Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: March 26, 2025

Celiac disease (CeD) is an immune-mediated condition that occurs in genetically predisposed individuals ingesting gluten. It characterized by enteropathy leading to both gastrointestinal and extra-intestinal symptoms. The prevalence of CeD has increased world-wide. Evidence suggests genetic predisposition exposure gluten are necessary but not sufficient for onset, implying other unknown factors at play its pathogenesis. This review summarizes the current knowledge on contribution gut microbiota pathogenesis, aiming address question whether it cause or consequence celiac enteropathy. We reviewed literature (studies published PubMed database between 2007 2023), linking dysbiosis CeD, focusing specifically prospective birth cohorts' studies discussing how multi-omics artificial intelligence (AI) could transform diagnosis a personalized medicine approach. A multi-omic approach will allow better clarification pivotal role microbiome epigenetically triggering Further, combination results with AI would pave way improved identification new therapeutic interventions.

Language: Английский

---

Microbial-derived peptidases are altered in celiac disease, non-celiac gluten sensitivity, and functional dyspepsia: a systematic review and re-analysis of the duodenal microbiome

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: May 9, 2025

Dietary gluten triggers symptoms in patients with gluten-related disorders (GRDs) including celiac disease (CeD), non-celiac sensitivity (NCGS), and subsets of functional dyspepsia (FD). The gastrointestinal microbiota is altered these when compared to healthy individuals. As the crucial for hydrolysis gluten, we hypothesized that capacity digest reduced conditions. We systematically reviewed re-analyzed published datasets compare microbiomes GRD identify signals explaining responses. A systematic search five databases was conducted studies where CeD, NCGS, or FD analyzed by 16S rRNA amplicon shotgun metagenomic sequencing control populations. Where available, raw duodenal sequence data were a consistent bioinformatic pipeline. Thirty articles met inclusion criteria this review. Microbiota diversity metrics not impacted diseases; however, genera Streptococcus, Neisseria, Lactobacillus commonly patients. Re-analysis possible included but did any differentially abundant taxa. Predicted analysis microbiome revealed peptidases aminopeptidase, proline iminopeptidase, Xaa-Pro dipeptidase are FD, respectively. These microbial-derived hydrolyze bonds proline-rich peptides. While GRDs differ from controls, no distinct phenotype links them. However, alterations predicted produce gluten-hydrolyzing enzymes suggest inappropriate digestion impacts host responses dietary findings have implications therapeutic management GRDs, as treatment gluten-degrading tailored probiotics could improve outcomes enhancing into non-reactive

Language: Английский

---

The importance of gut microbiome in the perinatal period

European Journal of Pediatrics, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Language: Английский

---