Advances in Blood Biomarkers for Alzheimer’s Disease: Ultra-Sensitive Detection Technologies and Impact on Clinical Diagnosis DOI Open Access
Yi Zhang,

Kefan Bi,

Linfu Zhou

et al.

Degenerative Neurological and Neuromuscular Disease, Journal Year: 2024, Volume and Issue: Volume 14, P. 85 - 102

Published: July 1, 2024

Abstract: Alzheimer's disease has escalated into a critical public health concern, marked by its neurodegenerative nature that progressively diminishes cognitive abilities. Recognized as continuously advancing and presently incurable condition, AD underscores the necessity for early-stage diagnosis interventions aimed at delaying decline in mental function. Despite proven efficacy of cerebrospinal fluid positron emission tomography diagnosing AD, their broader utility is constrained significant costs invasive these procedures. Consequently, innovation blood biomarkers such Amyloid-beta, phosphorylated-tau, total-tau et al, distinguished high sensitivity, minimal invasiveness, accessibility, cost-efficiency, emerges promising avenue diagnosis. The advent ultra-sensitive detection methodologies, including single-molecule enzyme-linked immunosorbent assay immunoprecipitation-mass spectrometry, revolutionized plasma biomarkers, supplanting previous low-sensitivity techniques. This rapid advancement technology facilitates more accurate quantification pathological brain proteins AD-associated bloodstream. manuscript meticulously reviews landscape current research on immunological markers anchored National Institute Aging—Alzheimer's Association AT(N) framework. It highlights selection forefront technologies now integral to assessing markers. Additionally, this review examines crucial pre-analytical processing steps samples significantly impact outcomes addresses practical challenges faced during clinical testing. These discussions are enhancing our comprehension refining diagnostic precision using blood-based biomarkers. aims shed light potential avenues improvement techniques employed detecting investigating thereby contributing field research. Keywords: disease, blood, technologies,

Language: Английский

Phenyl salicylate induces neurotoxicity and early Alzheimer's disease-like symptoms through ndrg1-regulated myelin damage, increasing bace1 in zebrafish DOI

Siyu Liu,

Xiao‐Mei Li, Shuping Jiao

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 965, P. 178664 - 178664

Published: Feb. 1, 2025

Language: Английский

Citations

1
Behavioral and histological study on the neuroprotective effect of thymoquinone on the cerebellum in AlCl3-induced neurotoxicity in rats through modulation of oxidative stress, apoptosis, and autophagy DOI

Amira I. Shrief,

Dina S Elshenawy,

Ahmed E. Elsukary

et al.

Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)

Published: Feb. 6, 2025

Language: Английский

Citations

1
Decreased water exchange rate across the blood–brain barrier throughout the Alzheimer's disease continuum: Evidence from Chinese data DOI Creative Commons
Guanqun Chen, Hui Li, Xingfeng Shao

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(3)

Published: March 1, 2025

Abstract INTRODUCTION Water exchange rate (Kw) across the blood–brain barrier (BBB) is used in magnetic resonance imaging (MRI) techniques to evaluate BBB functionality. Variations Kw Alzheimer's disease (AD) continuum remain uncertain. METHODS The study encompassed 38 cognitively normal individuals without AD biomarkers (CN_A–), 30 (CN_A+), and 31 impaired (CI_A+) with positive biomarkers. Participants underwent clinical assessments, MRI/positron emission tomography scans, assays of plasma RESULTS Significantly lower was observed multiple brain regions throughout continuum. This alteration correlated neuropsychological performance. Elevated levels phosphorylated tau 217 intensified inverse relationship between integration Kw, volume, demonstrated potential distinguishing stages within DISCUSSION Consistently evident may act as a diagnostic tool for early screening. Highlights Observations revealed decline water continuum, notably hippocampus, parahippocampal gyrus, deep nuclei during preclinical stage AD. Strong correlations were established various biomarkers, well performance Interaction (p‐tau)217 hippocampus linked executive function, indicating combined detrimental impact on cognitive abilities stemming from both blood—brain p‐tau 217. use biomarkers—neurofilament light chain glial fibrillary acidic protein—demonstrated

Language: Английский

Citations

1
Central autonomic network dysfunction and plasma Alzheimer’s disease biomarkers in older adults DOI Creative Commons
Trevor Lohman, Arunima Kapoor, Allison C Engstrom

et al.

Alzheimer s Research & Therapy, Journal Year: 2024, Volume and Issue: 16(1)

Published: June 8, 2024

Higher order regulation of autonomic function is maintained by the coordinated activity specific cortical and subcortical brain regions, collectively referred to as central network (CAN). Autonomic changes are frequently observed in Alzheimer's disease (AD) dementia, but no studies date have investigated whether plasma AD biomarkers associated with CAN functional connectivity at risk older adults.

Language: Английский

Citations

8
Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures for asymptomatic and symptomatic Alzheimer’s disease. DOI Creative Commons
Carlos Cruchaga, Muhammad Ali, Yuanyuan Shen

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 16, 2024

Abstract Changes in Amyloid-β (A), hyperphosphorylated Tau (T) brain and cerebrospinal fluid (CSF) precedes AD symptoms, making CSF proteome a potential avenue to understand the pathophysiology facilitate reliable diagnostics therapies. Using AT framework three-stage study design (discovery, replication, meta-analysis), we identified 2,173 proteins dysregulated AD, that were further validated third totally independent cohort. Machine learning was implemented create validate highly accurate replicable (AUC>0.90) models predict biomarker positivity clinical status. These can also identify people will convert those cases with faster progression. The associated cluster four different protein pseudo-trajectories groups spanning continuum enrichment specific pathways including neuronal death, apoptosis tau phosphorylation (early stages), microglia dysregulation endolysosomal dysfuncton(mid-stages), plasticity longevity (mid-stages) late microglia-neuron crosstalk (late stages).

Language: Английский

Citations

6
Repositioning of baricitinib for management of memory impairment in ovariectomized/D-galactose treated rats: A potential role of JAK2/STAT3-PI3K/AKT/mTOR signaling pathway DOI
Merhan O. Hindam, Lamiaa A. Ahmed, Nesrine S. El Sayed

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 351, P. 122838 - 122838

Published: June 17, 2024

Language: Английский

Citations

6
Circulating small extracellular vesicles in Alzheimer’s disease: a case–control study of neuro-inflammation and synaptic dysfunction DOI Creative Commons

Rishabh Singh,

Sanskriti Rai,

Prahalad Singh Bharti

et al.

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 20, 2024

Abstract Background Alzheimer’s disease (AD) is a neurodegenerative characterized by Aβ plaques and neurofibrillary tangles. Chronic inflammation synaptic dysfunction lead to progression cognitive decline. Small extracellular vesicles (sEVs) are implicated in AD facilitating the spread of pathological proteins inflammatory cytokines. This study investigates neuroinflammation protein markers plasma-derived sEVs (PsEVs), their association with Amyloid-β tau pathologies, correlation progression. Methods A total 90 [AD = 35, mild impairment (MCI) 25, healthy age-matched controls (AMC) 30] participants were recruited. PsEVs isolated using chemical precipitation method, morphology was transmission electron microscopy. Using nanoparticle tracking analysis, size concentration determined. Antibody-based validation done CD63, CD81, TSG101, L1CAM antibodies. Synaptic evaluated synaptophysin, TNF-α, IL-1β, GFAP AD-specific markers, amyloid-β (1–42), p-Tau examined within Western blot ELISA. Results Our findings reveal higher concentrations MCI compared AMC ( p < 0.0001). (1–42) expression significantly elevated AMC. We could also differentiate between MCI. Similarly, PsEVs-derived exhibited AMC, which further increased AD. Synaptophysin downregulated from 0.047) whereas showed The neuropsychological tests (which included for integrity, neuroinflammation, pathology) performed our study. number correlates dysfunction, neuroinflammation. Conclusions Elevated PsEVs, upregulated show high diagnostic accuracy synaptophysin neuroinflammatory patients suggest potential degeneration These support PsEV-associated biomarkers diagnosis highlight

Language: Английский

Citations

6
A systematic review of the neuropathology and memory decline induced by monosodium glutamate in the Alzheimer’s disease-like animal model DOI Creative Commons

Singh S. Ankul,

Lakshmi Chandran,

Anuragh Singh

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 24, 2023

This systematic review analyzes monosodium glutamate (MSG) in the Alzheimer’s disease-like condition to enhance translational research. Our seeks understand how MSG affects brain and causes degenerative disorders. Due significant preclinical data linking toxicity disease lack of a comprehensive or meta-analysis, we initiated study on MSG’s potential link. We searched PubMed, ScienceDirect, ProQuest, DOAJ, Scopus for animal research English language papers without time constraints. used PRISMA-P framework PICO technique collect population, intervention exposure, comparison, result data. It was registered PROSPERO as CRD42022371502. affected mice’s exploratory behaviors short-term working memory. The brain, hippocampus, cerebellar tissue demonstrated neuronal injury-related histological histomorphometric changes. A total 70% MSG-treated mice had poor nesting behavior. treated also more hyperphosphorylated tau protein their cortical hippocampus neurons. Glutamate glutamine levels increased with MSG, dose-dependent mixed horizontal locomotor, grooming, anxiety responses reduced. treatment significantly decreased phospho-CREB levels, supporting idea that neurons were harmed, despite CREB mRNA expression. High doses drastically lower serum serotonin levels. In conclusion, showed AD-like pathology, atrophy, memory impairment. Further longer span deeper behavioral characterization is needed. Systematic registration : https://www.crd.york.ac.uk/prospero/ , identifier [CRD42022371502].

Language: Английский

Citations

14
The seeds of its regulation: Natural antisense transcripts as single-gene control switches in neurodegenerative disorders DOI
Debomoy K. Lahiri, Bryan Maloney, Ruizhi Wang

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102336 - 102336

Published: May 11, 2024

Language: Английский

Citations

5
Aging, sex, metabolic and life experience factors: Contributions to neuro-inflammaging in Alzheimer’s disease research DOI Creative Commons

Pasindu Hansana Singhaarachchi,

Péter Antal, Frédéric Calon

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 162, P. 105724 - 105724

Published: May 16, 2024

Alzheimer's disease (AD) is prevalent around the world, yet our understanding of still very limited. Recent work suggests that cornerstone AD may include inflammation accompanies it. Failure a normal pro-inflammatory immune response to resolve lead persistent central contributes unsuccessful clearance amyloid-beta plaques as they form, neuronal death, and ultimately cognitive decline. Individual metabolic, dietary (lipid) profiles can differentially regulate this inflammatory process with aging, obesity, poor diet, early life stress other factors contributing greater risk developing AD. Here, we integrate evidence for interface between these factors, how contribute brain milieu. In particular, discuss importance appropriate polyunsaturated fatty acids (PUFA) in diet metabolism specialised pro-resolving mediators (SPMs); raising possibility strategies improve outlook.

Language: Английский

Citations

5