International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12171 - 12171
Published: Nov. 13, 2024
The
treatment
of
diabetic
wounds
is
impaired
by
the
intricate
nature
diabetes
and
its
associated
complications,
necessitating
novel
strategies.
utilization
mesenchymal
stem/stromal
cells
(MSCs)
as
a
therapeutic
modality
for
chronic
recalcitrant
in
patients
an
active
area
investigation
aimed
at
enhancing
potential
covering
tissue
regeneration.
threat
posed
to
patient
their
environment
presence
foot
ulcer
(DFU)
so
significant
that
any
additional
approach
opens
new
pathways
halt
progression
local
changes,
which
subsequently
lead
generalized
inflammatory
process,
offers
chance
reduce
risk
amputation
or
even
death.
This
article
explores
MSCs
treatment,
examining
mechanisms
action,
clinical
application
challenges,
future
directions
research
therapy.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(1), P. 378 - 378
Published: Jan. 4, 2025
Diabetic
retinopathy
(DR)
is
a
complication
of
diabetes,
characterized
by
progressive
microvascular
dysfunction
that
can
result
in
vision
loss.
Chronic
hyperglycemia
drives
oxidative
stress,
endothelial
dysfunction,
and
inflammation,
leading
to
retinal
damage
complications
such
as
neovascularization.
Current
treatments,
including
anti-VEGF
agents,
have
limitations,
necessitating
the
exploration
alternative
therapeutic
strategies.
Fractalkine
(CX3CL1),
chemokine
with
dual
roles
membrane-bound
adhesion
molecule
soluble
chemoattractant,
has
emerged
potential
target.
Its
receptor,
CX3CR1,
expressed
on
immune
cells
mediates
processes
cell
recruitment
microglial
activation
through
intracellular
signaling
pathways.
In
DR,
fractalkine
plays
critical
angiogenesis,
neuroprotection,
balancing
tissue
repair.
elevated
levels
are
associated
inflammation
dysfunction.
Experimental
studies
suggest
deficiency
exacerbates
severity
diabetic
(DR),
whereas
exogenous
appears
reduce
neuronal
damage.
However,
its
role
pathological
angiogenesis
within
DR
remains
unclear
warrants
further
investigation.
Preclinical
evidence
indicates
may
hold
potential,
particularly
mitigating
injury
early-stage
DR.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
170, P. 116051 - 116051
Published: Dec. 28, 2023
Diabetes
mellitus
is
a
widespread
metabolic
disorder
with
increasing
incidence
worldwide,
posing
considerable
threat
to
human
health
because
of
its
complications.
Therefore,
cost-effective
antidiabetic
drugs
minimal
side
effects
are
urgently
needed.
Dioscin,
naturally
occurring
compound,
helps
reduce
the
complications
diabetes
by
regulating
glucose
and
lipid
metabolism,
protecting
islet
β
cells,
improving
insulin
resistance,
inhibiting
oxidative
stress
inflammatory
response.
Plant-derived
dioscin
reduces
risk
toxicity
associated
chemically
synthesized
drugs.
It
promising
option
for
treating
preventive
therapeutic
effects,
which
may
be
attributed
variety
underlying
mechanisms.
However,
data
compiled
current
studies
preliminary.
Information
about
molecular
mechanism
remains
limited,
no
high-quality
experiments
clinical
trials
testing
safety
efficacy
have
been
conducted.
As
resource
research
in
this
area,
review
expected
provide
systematic
framework
application
treatment
Life,
Journal Year:
2023,
Volume and Issue:
13(9), P. 1831 - 1831
Published: Aug. 29, 2023
Diabetes
poses
a
significant
global
health
challenge,
necessitating
innovative
therapeutic
strategies.
Natural
products
and
their
derivatives
have
emerged
as
promising
candidates
for
diabetes
management
due
to
diverse
compositions
pharmacological
effects.
Algae,
in
particular,
garnered
attention
potential
source
of
bioactive
compounds
with
anti-diabetic
properties.
This
review
offers
comprehensive
overview
algae-derived
natural
management,
highlighting
recent
developments
future
prospects.
It
underscores
the
pivotal
role
care
delves
into
diversity
algae,
constituents,
underlying
mechanisms
efficacy.
Noteworthy
algal
substantial
are
briefly
elucidated,
along
specific
contributions
addressing
distinct
aspects
diabetes.
The
challenges
limitations
inherent
utilizing
algae
interventions
examined,
accompanied
by
strategic
recommendations
optimizing
effectiveness.
By
these
considerations,
this
aims
chart
course
research
refining
algae-based
approaches.
Leveraging
multifaceted
activities
chemical
components
holds
promise
pursuit
novel
antidiabetic
treatments.
Through
continued
fine-tuning
interventions,
burden
could
be
mitigated,
ultimately
leading
enhanced
patient
outcomes.
Drug Discovery Today,
Journal Year:
2023,
Volume and Issue:
28(11), P. 103757 - 103757
Published: Aug. 30, 2023
The
complement
system
is
involved
in
the
pathogenesis
of
several
ocular
diseases,
providing
a
rationale
for
investigation
complement-targeting
therapeutics
these
conditions.
Dry
age-related
macular
degeneration,
as
characterised
by
geographic
atrophy
(GA),
currently
most
active
area
research
therapeutics,
with
C3
inhibitor
approved
United
States
earlier
this
year
marking
first
therapy
GA.
This
review
discusses
role
disease,
provides
an
overview
agents
under
development
conditions,
and
reflects
on
lessons
that
can
be
learned
from
preclinical
investigations
clinical
trials
conducted
field
to
date.
Diabetes
and
its
complications
are
a
global
health
burden,
necessitating
novel
therapeutic
approaches.
Natural
products
derivatives
gaining
attention
as
potential
agents
for
managing
diabetes
due
to
their
diverse
constituents
pharmacological
activities.
Algae,
in
particular,
offer
promising
bioactive
compounds
with
antidiabetic
properties.
This
review
provides
an
overview
of
natural
derived
from
algae
management,
including
advancements
future
prospects.
It
highlights
the
significance
diabetes,
explores
algae's
diversity,
compounds,
mechanisms
action.
The
challenges,
limitations,
strategies
optimizing
algae-based
interventions
discussed,
alongside
research
directions.
Algae's
multifaceted
activities
chemical
make
them
attractive
developing
therapeutics.
Further
optimization
have
address
burden
improve
patient
outcomes.
