Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 226, P. 116399 - 116399
Published: June 27, 2024
Language: Английский
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(8), P. 2042 - 2042
Published: July 29, 2023
Exosome-based drug delivery is emerging as a promising field with the potential to revolutionize therapeutic interventions. Exosomes, which are small extracellular vesicles released by various cell types, have attracted significant attention due their unique properties and natural ability transport bioactive molecules. These nano-sized vesicles, ranging in size from 30 150 nm, can effectively variety of cargoes, including proteins, nucleic acids, lipids. Compared traditional systems, exosomes exhibit biocompatibility, low immunogenicity, reduced toxicity. In addition, be designed tailored improve targeting efficiency, cargo loading capacity, stability, paving way for personalized medicine precision therapy. However, despite exosome-based delivery, its clinical application remains challenging limitations exosome isolation purification, efficiency insufficient targeted rapid elimination circulation. This comprehensive review focuses on transition bench clinic, highlighting key aspects, such structure biogenesis, methods, surface engineering techniques, applications. It also discusses challenges prospects this field.
Language: Английский
Citations
78
Molecular Therapy, Journal Year: 2024, Volume and Issue: 32(9), P. 2939 - 2949
Published: Feb. 27, 2024
Language: Английский
Citations
38
Biomedicines, Journal Year: 2024, Volume and Issue: 12(1), P. 123 - 123
Published: Jan. 7, 2024
Lung cancer demands innovative approaches for early detection and targeted treatment. In addressing this urgent need, exosomes play a pivotal role in revolutionizing both the treatment of lung cancer. Their remarkable capacity to encapsulate diverse range biomolecules, traverse biological barriers, be engineered with specific targeting molecules makes them highly promising diagnostic markers precise drug delivery cells. Furthermore, an in-depth analysis exosomal content biogenesis offers crucial insights into molecular profile tumors. This knowledge holds significant potential development therapies strategies Despite notable progress field, challenges standardization cargo loading persist. Collaborative research efforts are imperative maximize advance field precision medicine benefit patients.
Language: Английский
Citations
26
Small, Journal Year: 2024, Volume and Issue: 20(35)
Published: May 1, 2024
Abstract Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotechnology to augment traditional vaccine efficacy. This review comprehensively examines the current state‐of‐the‐art nanovaccine development, elucidating innovative strategies and technologies employed their design. It explores both preclinical clinical advancements, emphasizing key studies demonstrating potential elicit robust anti‐tumor immune responses. The study encompasses various facets, including integrating biomaterial‐based nanocarriers for antigen delivery, adjuvant selection, impact of nanoscale properties on performance. Detailed insights into complex interplay between tumor microenvironment responses are provided, highlighting challenges opportunities optimizing therapeutic outcomes. Additionally, presents thorough analysis ongoing trials, presenting snapshot landscape. By curating latest scientific findings developments, this aims serve as comprehensive resource researchers clinicians engaged advancing immunotherapy. Integrating design holds immense promise revolutionizing treatment paradigms, provides timely update evolving landscape nanovaccines.
Language: Английский
Citations
24
International Journal of Oral Science, Journal Year: 2024, Volume and Issue: 16(1)
Published: Jan. 15, 2024
Abstract Oral diseases, such as periodontitis, salivary gland and oral cancers, significantly challenge health conditions due to their detrimental effects on patient’s digestive functions, pronunciation, esthetic demands. Delayed diagnosis non-targeted treatment profoundly influence patients’ prognosis quality of life. The exploration innovative approaches for early detection precise represents a promising frontier in medicine. Exosomes, which are characterized nanometer-sized extracellular vesicles, secreted by virtually all types cells. As the research continues, complex roles these intracellular-derived vesicles biological processes have gradually unfolded. Exosomes attracted attention valuable diagnostic therapeutic tools ability transfer abundant cargos intricate involvement multiple cellular functions. In this review, we provide an overview recent applications exosomes within field focusing inflammation-related bone diseases squamous cell carcinomas. We characterize exosome alterations demonstrate potential biomarkers diagnosis, highlighting indicators diseases. also summarize targeted therapy proposed future directions use clinical treatment.
Language: Английский
Citations
23
Materials Advances, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
The pursuit of effective drug delivery systems is critical in advancing cancer therapies, particularly the realms chemotherapy, radiotherapy and immunotherapy.
Language: Английский
Citations
2
Bioengineering, Journal Year: 2025, Volume and Issue: 12(1), P. 92 - 92
Published: Jan. 20, 2025
Critical limb ischemia (CLI) poses a substantial and intricate challenge in vascular medicine, necessitating the development of innovative therapeutic strategies to address its multifaceted pathophysiology. Conventional revascularization approaches often fail adequately complexity CLI, identification alternative methodologies. This review explores uncharted territory beyond traditional therapies, focusing on potential two distinct yet interrelated entities: cell-derived extracellular vesicles (EVs) artificial nanovesicles. Cell-derived EVs are small membranous structures naturally released by cells, nanovesicles artificially engineered nanosized vesicles. Both these represent promising avenues for intervention. They act as carriers bioactive cargo, including proteins, nucleic acids, lipids, that can modulate cellular responses associated with ischemic tissue repair angiogenesis. also assesses evolving landscape CLI through unique perspective The spans spectrum from early preclinical investigations latest translational advancements, providing comprehensive overview current state research this emerging field. These groundbreaking vesicle therapies hold immense revolutionizing treatment paradigms.
Language: Английский
Citations
2
ACS Omega, Journal Year: 2023, Volume and Issue: 8(46), P. 43374 - 43387
Published: Nov. 9, 2023
Exosomes are nanoscale vesicles secreted by living cells that have similar membrane composition to parental and carry a variety of proteins, lipids, nucleic acids. Therefore, exosomes certain biological activities play an important role in intercellular communication. On the basis its potential as carrier for drug delivery systems, been engineered compensate shortage natural through various engineering strategies improving efficiency, enhancing targeting tissues organs, extending circulating half-life exosomes. This review focuses on loading drugs different strategies, discussions exosome surface modification summarizes advantages disadvantages strategies. In addition, this provides overview recent applications number refractory relapsable diseases. has provide reference further research development
Language: Английский
Citations
35
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(6), P. 709 - 709
Published: May 24, 2024
Of all the numerous nanosized extracellular vesicles released by a cell, endosomal-originated exosomes are increasingly recognized as potential therapeutics, owing to their inherent stability, low immunogenicity, and targeted delivery capabilities. This review critically evaluates transformative of exosome-based modalities across pharmaceutical precision medicine landscapes. Because precise biomolecular cargo delivery, posited ideal candidates in drug enhancing regenerative strategies, advancing diagnostic technologies. Despite significant market growth projections exosome therapy, its utilization is encumbered substantial scientific regulatory challenges. These include lack universally accepted protocols for isolation complexities associated with navigating environment, particularly guidelines set forth U.S. Food Drug Administration (FDA). presents comprehensive overview current research trajectories aimed at addressing these impediments discusses prospective advancements that could substantiate clinical translation exosomal therapies. By providing analysis both capabilities hurdles therapeutic applications, this article aims inform direct future paradigms, thereby fostering integration systems into mainstream practice.
Language: Английский
Citations
15
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 2241 - 2264
Published: March 1, 2024
Abstract: Recently, gene therapy has become a subject of considerable research and been widely evaluated in various disease models. Though it is considered as stand-alone agent for COVID-19 vaccination, still suffering from the following drawbacks during its translation bench to bedside: high sensitivity exogenous nucleic acids enzymatic degradation; severe side effects induced either by or components formulation; difficulty cross barriers before reaching therapeutic target. Therefore, successful application therapy, safe reliable transport vector urgently needed. Extracellular vesicles (EVs) are ideal candidate delivery drugs owing their low immunogenicity, good biocompatibility toxicity. To better understand properties EVs advantages drug vehicles, this review covers origin methods generation, well common isolation purification research, with pros cons discussed. Meanwhile, engineering also highlighted. In addition, paper presents progress EVs-mediated microRNAs, small interfering RNAs, messenger plasmids, antisense oligonucleotides. We believe will provide theoretical basis development drugs. Keywords: extracellular vesicles, system,
Language: Английский
Citations
12