Physical exercise as a friend not a foe in acute kidney diseases through immune system modulation

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 20, 2023

Regular and moderate exercise is being used for therapeutic purposes in treating several diseases, including cancer, cardiovascular arthritis, even chronic kidney diseases (CKDs). Conversely, extenuating physical has long been pointed out as one of the sources acute injury (AKI) due to its severe impact on body's physiology. AKI development associated with increased tubular necrosis, which initiates a cascade inflammatory responses. The latter involves cytokine production, immune cell (macrophages, lymphocytes, neutrophils, among others) activation, oxidative stress. can induce prolonged fibrosis stimulation, leading CKD development. need alternative treatments still relevant issue. In this context arises question whether moderate, not extenuating, could, some level, prevent AKI. Several studies have shown that help reduce tissue damage increase functional recovery kidneys after an injury. particular, system be modulated by exercise, better from different pathologies. review, we aimed explore role trigger AKI, but modulator inflammatory/immune prevention or scenarios. induced ischemia reperfusion, sepsis, diabetes, antibiotics, chemotherapy, regular and/or could modulate toward more regulatory response, presenting, general, anti-inflammatory profile. Exercise was diminish stress, markers (caspase-3, lactate dehydrogenase, nitric oxide), cytokines (interleukin (IL)-1b, IL-6, IL-8, tumor necrosis factor-α (TNF-α)), lymphocytes suppressive phenotype, decrease factor-β (TGF-β), Thus, it creates environment less damage, hypoxia, apoptosis, fibrosis. conclusion, practice system, favoring profile prevents occurrence assists Moderate should considered patients complementary therapy.

Language: Английский

---

The Role of the Complement System in the Pathogenesis of Infectious Forms of Hemolytic Uremic Syndrome

Biomolecules, Journal Year: 2023, Volume and Issue: 14(1), P. 39 - 39

Published: Dec. 27, 2023

Hemolytic uremic syndrome (HUS) is an acute disease and the most common cause of childhood renal failure. HUS characterized by a triad symptoms: microangiopathic hemolytic anemia, thrombocytopenia, kidney injury. In cases, occurs as result infection caused Shiga toxin-producing microbes: hemorrhagic Escherichia coli Shigella dysenteriae type 1. They account for up to 90% all cases HUS. The remaining 10% grouped under general term atypical represent heterogeneous group diseases with similar clinical signs. Emerging evidence suggests that in addition E. S. 1, variety bacterial viral infections can development particular, infectious act main aHUS recurrence. pathogenesis based on congenital or acquired defects complement system. This review presents summarized data from recent studies, suggesting dysregulation key pathogenetic factor various types infection-induced Separate links system are considered, damage which during lead hyperactivation following microvascular endothelial injury

Language: Английский

---

Anti-Inflammatory Benefits of Vitamin D and Its Analogues against Glomerulosclerosis and Kidney Diseases

Sclerosis, Journal Year: 2024, Volume and Issue: 2(3), P. 217 - 265

Published: Aug. 26, 2024

Apart from the significant progress scientific community has made during last few decades, inflammation-mediated kidney-related diseases like chronic and diabetic kidney (CKD DKD) glomerulosclerosis still continue to raise mortality rates. Recently, conventional therapeutic interventions have been put aside, since natural vitamin D-derived treatment gained attention offered several promising outcomes. Within this article, utilization of D its analogues as potential toward diseases, due their anti-inflammatory, antioxidant anti-fibrotic activity, is outlined. Vitamin including calcitriol, paricalcitol 22-oxacalcitriol previously explored for such applications, but hidden yet be further elucidated. Several clinical trials demonstrated that analogues’ supplementation correlated with inflammatory signaling oxidative stress regulation, immunity/metabolism augmentation subsequently, healthcare-related infections’ prevention, results these are thoroughly evaluated. The highlighted research outcomes urge study on a plethora view fully clarify substantial anti-inflammatory constituents renal diseases-related health-promoting properties in many kidney-associated healthcare complications infections.

Language: Английский

---

Analysis of seasonal H3N2 influenza virus epidemic characteristics and whole genome features in Jining City from 2018 to 2023

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(8)

Published: Aug. 1, 2024

Seasonal H3N2 influenza virus, known for its rapid evolution, poses a serious threat to human health. This study focuses on analyzing the virus trends in Jining City (2018-2023) and understanding evolving nature of strains. Data influenza-like cases were gathered from City's sentinel hospitals: First People's Hospital Rencheng Maternal Child Health Hospital, using Chinese Influenza Surveillance Information System. Over period 2018 2023, 7844 throat swab specimens assessed real-time fluorescence quantitative PCR nucleic acid detection. For positive seasonal isolation was followed by whole genome sequencing. Evolutionary trees built eight gene segments, protein variation analysis performed. From represented 6.99% (237 299/3 397 247) outpatient visits, peaking December January. detected 15.67% (1229/7844) cases, primarily February. Notably, no found 2020-2021 season. Full sequencing conducted 70 strains, revealing distinct evolutionary branches across seasons. Significant antigenic site variations HA noted. No resistance mutations inhibitors found, but some strains exhibited PA, NS1, PA-X, PB1-F2. saw significant shifts 2022-2023 evolution. Sustained vigilance is imperative vaccine updates antiviral selection.

Language: Английский

---

Emerging Insights Into Necroptosis: Implications for Renal Health and Diseases

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 16, 2023

Necroptosis is a regulated form of cell death that has gained increasing attention in recent years. It plays significant role various physiological and pathological processes, including renal health disease. This review article provides an overview necroptosis as pathway explores its implications physiology diseases. The molecular signaling pathways involved necroptosis, the key players such receptor-interacting protein kinases (RIPKs) mixed lineage kinase domain-like (MLKL), are discussed detail. crosstalk between other pathways, particularly apoptosis, explored to understand interplay these processes cells. In normal conditions, been found play crucial development tissue homeostasis. However, dysregulated can contribute damage, inflammation, fibrosis highlights involvement acute kidney injury, chronic disease, transplant rejection, elucidating underlying pathophysiological mechanisms consequences. therapeutic targeting diseases emerging area interest. Current strategies modulate inhibition mediators regulators, here. Additionally, potential targets inhibitors along with preclinical clinical studies exploring their efficacy, reviewed.

Language: Английский

---

Proteomic analysis of laser captured tubular tissues reveals complement activation and mitochondrial dysfunction in autoimmune related kidney diseases

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 20, 2024

Autoimmune related kidney diseases (ARKDs), including minimal change nephropathy (MCN), membranous (MN), IgA (IgAN), and lupus nephritis (LN), significantly affect renal function. These are characterized by the formation of local immune complexes subsequent activation complement system, leading to damage proteinuria. Despite known patterns glomerular injury, specific molecular mechanisms that contribute tubular across ARKDs remain underexplored. Laser capture microdissection liquid chromatography-tandem mass spectrometry (LC-MS/MS) were used conduct a comparative proteomic analysis tissues from formalin-fixed paraffin-embedded samples. The cohort comprised 10 normal controls (NC), 5 MCN, 4 MN, 17 IgAN, 21 LN patients. Clinical parameters histopathological assessments integrated with findings comprehensively investigate underlying pathogenic processes. evaluation indicated significant damage, as reflected elevated urinary protein levels reduced plasma albumin in patients ARKD. Histological analyses confirmed varying degrees deposition complexes. Proteomic identified changes expression, particularly components (C3, C4A, C4B, C8G, CFB, SERPINA1) mitochondrial proteins (ATP5F1E ATP5PD), highlighting common alterations system ARKDs. suggest novel complement-mitochondrial-epithelial-mesenchymal transition (EMT) pathway axis contributes Notably, CFB ARKD revealed, implicating it therapeutic target. This study underscores importance dysfunction pathogenesis ARKDs, proposes potential target inhibit mitigate damage. Future research should validate complement-mitochondrial-EMT explore effects inhibitors alleviating progression.

Language: Английский

---

Strobilanthes sarcorrhiza root phenolic extract prevent diabetic nephropathy in mice by regulating NF-κB/IL-1β signaling and glycerophospholipid metabolism

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2024, Volume and Issue: 253, P. 116534 - 116534

Published: Oct. 20, 2024

Language: Английский

---

Interplay between periodontitis and chronic kidney disease

Nature Reviews Nephrology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Language: Английский

---

Farnesol Inhibits PI3 Kinase Signaling and Inflammatory Gene Expression in Primary Human Renal Epithelial Cells

Biomedicines, Journal Year: 2023, Volume and Issue: 11(12), P. 3322 - 3322

Published: Dec. 15, 2023

Chronic inflammation and elevated cytokine levels are closely associated with the progression of chronic kidney disease (CKD), which is responsible for manifestation numerous complications mortality. In addition to conventional CKD therapies, possibility using natural compounds anti-inflammatory potential has attracted widespread attention in scientific research. This study aimed effects a oil compound, farnesol, primary human renal proximal tubule epithelial cell (RPTEC) culture. Farnesol was encapsulated lipid-based small unilamellar vesicles (SUVs) overcome its insolubility culture medium. The attachment empty farnesol-loaded (farnesol-SUVs) examined BODIPY, fluorescent dye hydrophobic properties. Next, we used multiple protein, RNA, protein phosphorylation arrays investigate impact farnesol on inflammatory signaling RPTECs. results indicated that inhibits TNF-α/IL-1β-induced PI3 kinase p85 subunit subsequent transcriptional activation genes TNFRSF9, CD27, TNFRSF8, DR6, FAS, IL-7, CCL2. Therefore, may be promising compound treating CKD.

Language: Английский

---

Tripterygium wilfordii Hook.f induced kidney injury through mediating inflammation via PI3K-Akt/HIF-1/TNF signaling pathway: A study of network toxicology and molecular docking

Medicine, Journal Year: 2024, Volume and Issue: 103(6), P. e36968 - e36968

Published: Feb. 9, 2024

We intend to explore potential mechanisms of Tripterygium wilfordii Hook.f (TwHF) induced kidney injury (KI) using the methods network toxicology and molecular docking. determined TwHF compounds with its targets KI targets, obtained after intersecting KI. Then we conducted protein-protein interaction (PPI) network, gene expression analysis, ontology (GO) function Kyoto encyclopedia genes genomes (KEGG) pathway enrichment analysis mechanism TwHF-induced Finally docking verify core toxic targets. 12 62 PPI GO unveiled key biological process suggested might be associated inflammation, immune response, hypoxia as well oxidative stress. KEGG indicated PI3K-Akt signaling pathway, HIF-1 TNF were pathways Molecular showed that binding energy was all less than −6.5 kcal/mol verified screening ability pharmacology provided evidence for modifying structure. Through study, induce activate progress renal mediate via accelerate inflammatory processes, also a theoretical basis structure supported follow-up research.

Language: Английский

---