American Journal of Cancer Research, Journal Year: 2024, Volume and Issue: 14(8), P. 4096 - 4111
Published: Jan. 1, 2024
VMA21 has been shown to be dysregulated in a number of cancers. However, no study yet explored whether is involved the regulation triple-negative breast cancer (TNBC), especially from level immune escape.
Language: Английский
Journal of Cellular Physiology, Journal Year: 2025, Volume and Issue: 240(4)
Published: April 1, 2025
ABSTRACT Glioma cells exhibit high invasiveness and have the ability to evade surgical resection, radiotherapy, chemotherapy, which are major factors contributing challenges in effective treatment recurrence. The ubiquitin‐proteasome system (UPS) plays a crucial role posttranslational modification, significantly aggressive progression of glioblastoma (GBM). This study identified E3 ubiquitin ligase CBLB as abnormally regulated component UPS GBM, noting its significant downregulation compared normal brain tissue negative correlation with malignant phenotypes poor prognosis. Experimental studies, both vitro vivo, shown that can inhibit migration invasion GBM cells. Mechanistically, directly interacts MAP3K9 through RING domain, leading K48‐K63‐linked polyubiquitination at Lys 193 site, thereby promoting proteasomal‐mediated degradation. suppresses MAPK‐P38 pathway activation. identifies tumor suppressor modulates signaling by degradation MAP3K9, offering new therapeutic approach for treatment.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: May 5, 2025
Language: Английский
Citations
0
Cellular and Molecular Life Sciences, Journal Year: 2025, Volume and Issue: 82(1)
Published: May 14, 2025
Abstract The post-translational modification and stability regulation of RIG-I play critical roles in promoting IFN-I production maintaining immune homeostasis. In this study, we found that ubiquitin-specific peptidase 1 (USP1) promotes protein through deubiquitination, which turn enhances antiviral immunity the inflammatory cytokines, inhibits replication influenza virus MDCK cells. contrast, USP1 knockdown inhibited deubiquitination RIG-I, decreased level, significantly increased titer. Meanwhile, inhibition expression did not have a significant effect on proliferation cells, suggesting could be used as target gene to establish vaccine-producing cell line. above results provide more comprehensive understanding function response mechanism, theoretical methodological basis for screening genes artificial establishment high-yield lines vaccine production.
Language: Английский
Citations
0
Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)
Published: May 17, 2025
The therapeutic options for patients with advanced endometrial carcinoma (EC) were still limited and the prognosis remained unfavorable. F-box leucine-rich repeat protein 18 (FBXL18), belonging to family, was frequently altered in human cancer, while its functional role underlying mechanisms EC largely unexplored. expression of FBXL18 tissues cells explored using data mining strategies further experiments. Multiple vitro assays, including CCK-8, colony formation, wound healing, Transwell invasion performed assess function on cell proliferation, migration, invasion. Bioinformatic analyses, western blot, qRT-PCR, Co-immunoprecipitation ubiquitination assays employed identify downstream pathway direct substrate FBXL18. highly expressed lines, high had poor clinical outcome. Loss- gain-of-function showed that silencing suppressed invasion, overexpressing caused opposite effects. Mechanistically, could physically interacted DUSP16, a dual specificity phosphatase, leading degradation, thus activating JNK signaling pathway. Upregulation DUSP16 alleviated overexpression-induced activation pathway, reversed overexpression-mediated enhanced capacities In summary, our study showcased elevated expression, prognostic prediction performance, malignant tumor-promoting EC. novel this phenotype are promotes degradation activates JNK/c-JUN facilitate progression.
Language: Английский
Citations
0
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: March 15, 2024
SKP2 (S-phase kinase-associated protein 2) is a member of the F-box family substrate-recognition subunits in SCF ubiquitin-protein ligase complexes. It associated with ubiquitin-mediated degradation mammalian cell cycle components and other target proteins involved progression, signal transduction, transcription. Being an oncogene solid tumors hematological malignancies, it frequently drug resistance poor disease outcomes. In current review, we discussed novel role different malignancies. Further, performed limited in-silico analysis to establish involvement few publicly available cancer datasets. Interestingly, our study identified Skp2 expression be altered cancer-specific manner. While was found overexpressed several types, showed down-regulation SKP2. Our review provides evidence for developing inhibitors We also investigated effect status on survival progression. addition, miRNA its families regulating explored. Subsequently, predicted common miRNAs against genes by using miRNA-predication tools. Finally, approaches future prospective gene drugs miRNA-based therapeutics applications translational research.
Language: Английский
Citations
3
BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)
Published: July 25, 2024
Leukemia, a type of blood cell cancer, is categorized by the white cells affected (lymphocytes or myeloid cells) and disease progression (acute chronic). In 2020, it ranked 15th among most diagnosed cancers 11th in cancer-related deaths globally, with 474,519 new cases 311,594 (GLOBOCAN2020). Research into leukemia's development mechanisms may lead to treatments. Ubiquitin-specific proteases (USPs), family deubiquitinating enzymes, play critical roles various biological processes, both tumor-suppressive oncogenic functions, though comprehensive understanding still needed.
Language: Английский
Citations
3
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: March 18, 2024
T cells play critical role in multiple immune processes including antigen response, tumor immunity, inflammation, self-tolerance maintenance and autoimmune diseases et. Fetal liver or bone marrow-derived thymus-seeding progenitors (TSPs) settle thymus undergo cell-lineage commitment, proliferation, cell receptor (TCR) rearrangement, thymic selections driven by microenvironment composed of epithelial (TEC), dendritic (DC), macrophage B cells, thus generating with diverse TCR repertoire immunocompetent but not self-reactive. Additionally, some self-reactive thymocytes give rise to Treg the help TEC DC, serving for tolerance. The sequential fate decision, selection during development establishment are tightly regulated ensure proper response without reaction. There remarkable progresses understanding regulatory mechanisms regarding ubiquitination past few years, which holds great potential further therapeutic interventions immune-related diseases.
Language: Английский
Citations
2
Clinical and Molecular Hepatology, Journal Year: 2024, Volume and Issue: unknown
Published: July 23, 2024
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12191 - 12191
Published: Nov. 13, 2024
Erythropoietin-producing hepatocellular A2 (EphA2) is a member of the Eph tyrosine kinase receptor family that has been linked to various biological processes. In tumors, EphA2 overexpression associated with noncanonical pathway activation, tumor progression, and poor prognosis, which emphasized its importance as marker malignancy. Studies on numerous cancer models have highlighted EphA2’s dual often contradictory action, can be attributed EphA2′s interactions involving multiple pathways different ligands, well heterogeneity microenvironment. this review, we summarize main mechanisms underlying dysregulation in cancer, highlighting molecular complexity. Then, analyze therapies developed over time counteract action. We discuss limitations described approaches, emphasizing fact goal new options high specificity without losing therapeutic efficacy. For reason, immunotherapy or emerging field targeted protein degradation proteolysis-targeting chimeras (PROTACs) may represent promising solution based deeper understanding sustaining oncogenic activity.
Language: Английский
Citations
2
Cancer Letters, Journal Year: 2024, Volume and Issue: 611, P. 217409 - 217409
Published: Dec. 21, 2024
Language: Английский
Citations
2