Microplastics: A threat to Fetoplacental unit and Reproductive systems

Toxicology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 101938 - 101938

Published: Jan. 1, 2025

Language: Английский

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Mixtures of polystyrene micro and nanoplastics affects fat and glucose metabolism in 3T3-L1 adipocytes and zebrafish larvae

NanoImpact, Journal Year: 2025, Volume and Issue: unknown, P. 100549 - 100549

Published: Feb. 1, 2025

Language: Английский

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Hepatotoxic Effects of Environmentally Relevant Concentrations of Polystyrene Microplastics on Senescent Zebrafish (Danio rerio): Patterns of Stress Response and Metabolomic Alterations

Aquatic Toxicology, Journal Year: 2025, Volume and Issue: 279, P. 107252 - 107252

Published: Jan. 16, 2025

Language: Английский

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Organ-specific accumulation and toxicity analysis of orally administered polyethylene terephthalate microplastics

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 24, 2025

Microplastics (MPs), plastic particles with a diameter of < 5 mm, are intentionally produced or formed by the breakdown variety larger plastics. Polyethylene terephthalate (PET) is common source MPs and PET-MPs prevalent in environment. Owing to their persistence, can enter ecosystems, air, food sources, posing significant health risks. This study aimed investigate toxicological effects vivo accumulation smaller than 10 µm. To track biodistribution, fluorescently labeled were prepared. Particle size morphology confirmed using physical chemical characterization. Following oral administration ICR (CD-1®) outbred mice, occurred predominantly lungs, as IVIS spectrum CT analysis ex imaging. Toxicity assays revealed development granulomatous inflammation lungs at medium high doses, indicating concentration-dependent response. The recorded no-observed-adverse-effect levels 1.75 mg/kg for males 7 females. highlights potential induce persistent respiratory tissues reveals need further research support regulatory standards long-term MP exposure.

Language: Английский

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Investigating the Epigenetic Effects of Polystyrene Nanoplastic Exposure in Bluegill (Lepomis macrochirus) Epithelial Cells Using Methylation-Sensitive AFLPs

Microplastics, Journal Year: 2025, Volume and Issue: 4(1), P. 10 - 10

Published: Feb. 27, 2025

Microplastics, remnants of macroplastics that have broken down to fragments smaller than 5 mm, and nanoplastics, even further sizes < 1 μm, are pervasive in aquatic ecosystems. These plastic particles consumed by microscopic organisms, leading bioaccumulation up trophic levels. The accumulation the organismal gut can result various repercussions, including cellular contamination genomic modifications such as DNA methylation. While methylation has been studied teleost fishes, impact nanoplastic exposure on this process any species remains largely unexplored. This study delves into uncharted territory, investigating due within genome cultured bluegill BF-2 cells (Lepomis macrochirus) using methylation-sensitive AFLPs. state was analyzed through capillary gel analysis electropherograms. Differential occurred between several control experimental groups exposure; however, these differences were not dose- or time-dependent. results could suggest higher dosages times nanoplastics do increased levels congruence with dosage time; rather, only presence is enough cause changes.

Language: Английский

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Trending Physico-Chemical Characteristics of Microplastics (MPs) and Nano-plastics (NPs) in Different Physical Environments and Their Role in Various Emerging Environmental Issues: A Review

Published: Jan. 1, 2025

Language: Английский

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Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2837 - 2837

Published: March 21, 2025

There is a significant, rather than just anecdotal, connection between the liver and eyes. This evident in noticeable cases such as jaundice, where sclera has yellow tint. But this can be seen through even more subtle indicators, molecules known hepatokines. relationship not merely anecdotal; some studies, it referred to “liver–eye axis”. Ubiquitous environmental contaminants, microplastics (MPs), enter bloodstream human body conjunctival sac, nasolacrimal duct, upper respiratory tract mucosa. Once absorbed, these substances accumulate various organs cause harm. Toxic from surface of eye lead local oxidative damage by inducing apoptosis corneal cells, irregularly shaped microparticles exacerbate effect. Even other toxicants ocular may absorbed into distributed throughout body. Environmental toxicology presents challenge because many pollutants same route that used certain medications. Previous research indicated accumulation MPs play major role development chronic disease humans. It crucial investigate whether buildup potential fibrosis, or simply consequence conditions cirrhosis portal hypertension.

Language: Английский

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Developing a feasible fast-track testing method for developmental neurotoxicity studies: alternative model for risk assessment of micro- and nanoplastics

Frontiers in Toxicology, Journal Year: 2025, Volume and Issue: 7

Published: April 15, 2025

Micro- and nanoplastics (MNPs) are widespread environmental pollutants that pose significant health risks. They originate from industrial processes, consumer products, degradation, inducing oxidative stress through cellular dysfunctions such as membrane interaction, internalization, mitochondrial damage, inflammation, metal ion leaching, impaired antioxidant defense. Despite increasing evidence of their toxicity—particularly developmental neurotoxicity (DNT) impairment—our understanding remains limited due to the high costs animal studies, which reduce overall size experimental data. This underscores urgent need for alternative test methods cost-effective, rapid, translational. review examines new approach methodologies (NAMs) DNT assessment, addressing ethical, financial, translational limitations models. NAMs integrate three complementary non-animal models enhance conventional testing. First, zebrafish provide organismal insights into behavioral neurodevelopmental outcomes at minimal cost. Second, neuronal organoids replicate human-specific processes in a 3D system, offering mechanistic insights. Lastly, human cell lines enable high-throughput screening, integrating findings organoid studies. Establishing paradigm testing is crucial faster more efficient toxicity risk assessments, ultimately protecting public health. Standardizing gaining regulatory acceptance will improve predictive accuracy broaden application toxicology. Advancing these essential risks MNP exposure while promoting ethical sustainable research practices.

Language: Английский

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From Cradle to Grave: Microplastics—A Dangerous Legacy for Future Generations

Environments, Journal Year: 2024, Volume and Issue: 11(12), P. 263 - 263

Published: Nov. 22, 2024

Microplastics have become a ubiquitous pollutant that permeates every aspect of our environment—from the oceans to soil elementary foundations human life. New findings demonstrate microplastic particles not only pose latent threat adult populations, but also play serious role even before birth during fetal stages development. Exposure microplastics early childhood is another source risk almost impossible prevent. This comprehensive review examines multiple aspects associated with development, detailing mechanisms by which these enter body, their bioaccumulation in tissues throughout life and inevitable re-entry into different ecosystems after death.

Language: Английский

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Assessing the toxicological impact of PET-MPs exposure on IVDD: Insights from network toxicology and molecular docking

Journal of Environmental Management, Journal Year: 2024, Volume and Issue: 373, P. 123830 - 123830

Published: Dec. 29, 2024

Language: Английский

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