Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

Journal of Biomedical Science, Journal Year: 2021, Volume and Issue: 28(1)

Published: April 13, 2021

Abstract Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy because of their high immunomodulation ability, tropism towards inflamed and injured tissues, easy access isolation. Currently, there more than 1200 registered MSC clinical trials globally. However, lack standardized methods to characterize cell safety, efficacy, biodistribution dramatically hinders the progress utility in practice. In this review, we summarize current state MSC-based therapy, focusing on systemic safety MSCs. MSC-associated risks tumor initiation promotion underlying mechanisms these discussed. addition, methodology pharmacokinetics pharmacodynamics therapies addressed. Better understanding MSCs will facilitate future applications precision medicine using stem cells.

Language: Английский

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Quaternary Ammonium Compounds: A Chemical Class of Emerging Concern

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(20), P. 7645 - 7665

Published: May 9, 2023

Quaternary ammonium compounds (QACs), a large class of chemicals that includes high production volume substances, have been used for decades as antimicrobials, preservatives, and antistatic agents other functions in cleaning, disinfecting, personal care products, durable consumer goods. QAC use has accelerated response to the COVID-19 pandemic banning 19 antimicrobials from several products by US Food Drug Administration 2016. Studies conducted before after onset indicate increased human exposure QACs. Environmental releases these also increased. Emerging information on adverse environmental health impacts QACs is motivating reconsideration risks benefits across life cycle their production, use, disposal. This work presents critical review literature scientific perspective developed multidisciplinary, multi-institutional team authors academia, governmental, nonprofit organizations. The evaluates currently available ecological profile identifies multiple areas potential concern. Adverse effects include acute chronic toxicity susceptible aquatic organisms, with concentrations some approaching levels Suspected or known outcomes dermal respiratory effects, developmental reproductive toxicity, disruption metabolic function such lipid homeostasis, impairment mitochondrial function. QACs' role antimicrobial resistance demonstrated. In regulatory system, how managed depends it used, example pesticides products. can result same receiving different degrees scrutiny depending agency regulating it. Further, Protection Agency's current method grouping based structure, first proposed 1988, insufficient address wide range chemistries, toxicities, scenarios. Consequently, exposures common mixtures sources remain largely unassessed. Some restrictions implemented elsewhere, primarily focused Assessing posed hampered vast structural diversity lack quantitative data majority compounds. important gaps provides research policy recommendations preserving utility chemistries while seeking limit effects.

Language: Английский

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Obesity II: Establishing causal links between chemical exposures and obesity

Biochemical Pharmacology, Journal Year: 2022, Volume and Issue: 199, P. 115015 - 115015

Published: April 5, 2022

Language: Английский

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Mitochondrial-Targeting Near-Infrared Fluorescent Probe for Visualizing Viscosity in Drug-Induced Cells and a Fatty Liver Mouse Model

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 94(12), P. 5069 - 5074

Published: March 14, 2022

Mitochondria, as "cell energy stations", are involved in the regulation of various cell functions. Recent investigations revealed that mitochondrial dysfunction can cause an intracellular viscosity mutation, a process is associated with increasing number diseases not curable or manageable. However, conventional viscometers cannot be used to monitor changes living cells and vivo. In order cater complex biological environment, we present chemical toolbox, MI-BP-CC, employs N,N-diethyl double bonds sensitive sites for based on TICT mechanism (twisted intramolecular charge transfer) fatter liver mice. MI-BP-CC features good targeting near-infrared emission. Surprisingly, presence viscosity, probe exhibited ultrasensitive model detection showing red fluorescence signal from silent "off" state "on". More importantly, utilizing satisfactory performance have successfully visualized increased under pathological models Parkinson's (PD) fatty We anticipate these findings will provide convenient efficient tool understand physiological functions more biosystems.

Language: Английский

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Mitochondria-targeted BODIPY dyes for small molecule recognition, bio-imaging and photodynamic therapy

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(8), P. 3976 - 4019

Published: Jan. 1, 2024

This review focuses on the design strategy, spectroscopic characteristics, and functionalization of mitochondrion-targeted BODIPY dyes, providing an overview these dyes for bioimaging photodynamic therapy.

Language: Английский

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Cellular ROS and Antioxidants: Physiological and Pathological Role

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 602 - 602

Published: May 14, 2024

Reactive oxygen species (ROS) are highly reactive derivatives that include free radicals such as superoxide anion radical (O2•−) and hydroxyl (HO•), well non-radical molecules hydrogen peroxide (H2O2), peroxynitrite (ONOO−), hypochlorous acid (HOCl) [...]

Language: Английский

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Rational Design of MMP-Independent Near-Infrared Fluorescent Probes for Accurately Monitoring Mitochondrial Viscosity

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(19), P. 7611 - 7619

Published: May 3, 2023

Mitochondrial viscosity affects metabolite diffusion and mitochondrial metabolism is associated with many diseases. However, the accuracy of mitochondria-targeting fluorescent probes in measuring unsatisfactory because these can diffuse from mitochondria during mitophagy a decreased membrane potential (MMP). To avoid this problem, by incorporating different alkyl side chains into dihydroxanthene fluorophores (denoted as DHX), we developed six near-infrared (NIR) for accurate detection viscosity, sensitivity to targeting anchoring capability increased increasing chain length. Among them, DHX-V-C12 had highly selective response variations minimum interference polarity, pH, other biologically relevant species. Furthermore, was used monitor changes HeLa cells treated ionophores (nystatin, monensin) or under starvation conditions. We hope that strategy based on length will be general analytes, enabling study functions.

Language: Английский

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Pharmacological approaches to enhance mitochondrial biogenesis: focus on PGC-1Α, AMPK, and SIRT1 in cellular health

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 28, 2025

Language: Английский

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A dual-targeted organelles SO2 specific probe for bioimaging in related diseases and food analysis

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 433, P. 133750 - 133750

Published: Nov. 23, 2021

Language: Английский

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Ferroptosis in Different Pathological Contexts Seen through the Eyes of Mitochondria

Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)

Published: Jan. 1, 2021

Ferroptosis is a recently described form of regulated cell death characterized by intracellular iron accumulation and severe lipid peroxidation due to an impaired cysteine-glutathione-glutathione peroxidase 4 antioxidant defence axis. One the hallmarks ferroptosis specific morphological phenotype extensive ultrastructural changes mitochondria. Increasing evidence suggests that mitochondria play significant role in induction execution ferroptosis. The present review summarizes existing knowledge about mitochondrial impact on different pathological states, primarily cancer, cardiovascular diseases, neurodegenerative diseases. Additionally, we highlight pathologies which ferroptosis/mitochondria relation remains be investigated, where process has been confirmed (such as liver- kidney-related pathologies) those not studied yet, such diabetes. We will bring attention avenues could followed future research, based use mitochondria-targeted approaches anti- proferroptotic strategies directed improvement development novel therapeutic strategies.

Language: Английский

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