The Role of Gut Microbiota and Gut–Brain Interplay in Selected Diseases of the Central Nervous System DOI Open Access
Julia Doroszkiewicz, Magdalena Groblewska, Barbara Mroczko

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(18), P. 10028 - 10028

Published: Sept. 17, 2021

The gut microbiome has attracted increasing attention from researchers in recent years. microbiota can have a specific and complex cross-talk with the host, particularly central nervous system (CNS), creating so-called “gut–brain axis”. Communication between gut, intestinal microbiota, brain involves secretion of various metabolites such as short-chain fatty acids (SCFAs), structural components bacteria, signaling molecules. Moreover, an imbalance composition modulates immune function tissue barriers blood–brain barrier (BBB). Therefore, aim this literature review is to describe how gut–brain interplay may contribute development neurological disorders, combining fields gastroenterology neuroscience. We present findings concerning effect altered on neurodegeneration neuroinflammation, including Alzheimer’s Parkinson’s diseases, well multiple sclerosis. impact pathological shift selected neuropsychological i.e., major depressive disorders (MDD) autism spectrum disorder (ASD), also discussed. Future research balanced axis would help identify new potential opportunities for therapeutic interventions presented diseases.

Language: Английский

The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets DOI Creative Commons

Alhamdu Adamu,

Shuo Li,

Fankai Gao

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: April 12, 2024

Neuroinflammation refers to a highly complicated reaction of the central nervous system (CNS) certain stimuli such as trauma, infection, and neurodegenerative diseases. This is cellular immune response whereby glial cells are activated, inflammatory mediators liberated reactive oxygen nitrogen species synthesized. key process that helps protect brain from pathogens, but inappropriate, or protracted inflammation yields pathological states Parkinson’s disease, Alzheimer’s, Multiple Sclerosis, other disorders showcase various pathways neurodegeneration distributed in parts CNS. review reveals major neuroinflammatory signaling associated with neurodegeneration. Additionally, it explores promising therapeutic avenues, stem cell therapy, genetic intervention, nanoparticles, aiming regulate neuroinflammation potentially impede decelerate advancement these conditions. A comprehensive understanding intricate connection between diseases pivotal for development future treatment strategies can alleviate burden imposed by devastating disorders.

Language: Английский

Citations

95
Neuroinflammation and Parkinson’s Disease—From Neurodegeneration to Therapeutic Opportunities DOI Creative Commons
Bruna Araújo, Rita Caridade-Silva, Carla Guedes

et al.

Cells, Journal Year: 2022, Volume and Issue: 11(18), P. 2908 - 2908

Published: Sept. 17, 2022

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide. Clinically, it characterized by a progressive degeneration of dopaminergic neurons (DAn), resulting in severe motor complications. Preclinical and clinical studies have indicated that neuroinflammation can play role PD pathophysiology, being associated with its onset progression. Nevertheless, several key points concerning neuroinflammatory process remain to be answered. Bearing this mind, present review, we cover impact on exploring inflammatory cells (i.e., microglia astrocytes) interconnections between brain peripheral system. Furthermore, discuss both innate adaptive immune responses regarding pathology explore gut-brain axis communication influence progression disease.

Language: Английский

Citations

87
Curcumin-Based Nanomedicines in the Treatment of Inflammatory and Immunomodulated Diseases: An Evidence-Based Comprehensive Review DOI Creative Commons
Lucas Fornari Laurindo,

Gabriel Magno de Carvalho,

Bárbara de Oliveira Zanuso

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 229 - 229

Published: Jan. 10, 2023

Curcumin (CUR) is a polyphenol extracted from the rhizome of Curcuma longa that possesses potent anti-inflammatory and antioxidant potential. Despite CUR’s numerous beneficial effects on human health, it has limitations, such as poor absorption. Nano-based drug delivery systems have recently been applied to improve solubility bioavailability potentialize its health effects. This review investigated different CUR-based nanomedicines inflammatory immunomodulated diseases. PUBMED, EMBASE, COCHRANE, GOOGLE SCHOLAR databases were searched, Scale for Assessment Narrative Review Articles (SANRA) was used quality assessment PRISMA guidelines. Overall, 66 studies included comprising atherosclerosis, rheumatoid arthritis (RA), Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), Huntington’s (HD), bowel diseases (IBD), psoriasis, liver fibrosis, epilepsy, COVID-19. The available scientific show there are many known nanoformulations with curcumin. They can be found in nanosuspensions, nanoparticles, nanoemulsions, solid lipid particles, nanocapsules, nanospheres, liposomes. These formulations CUR effectively adjuvants several immune-mediated atheroma plaque formation, RA, dementia, AD, PD, MS, IBD, COVID-19, anti-fibrotic fibrotic disease.

Language: Английский

Citations

53
The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword DOI Creative Commons

Yuxiang Xu,

Yongjie Li, Changqing Wang

et al.

Journal of Neuroinflammation, Journal Year: 2023, Volume and Issue: 20(1)

Published: Feb. 12, 2023

In Parkinson's disease (PD), neurotoxic microglia, Th1 cells, and Th17 cells are overactivated. Overactivation of these immune exacerbates the process leads to pathological development pro-inflammatory cytokines, chemokines, contact-killing compounds, causing loss dopaminergic neurons. So far, we have mainly focused on role specific class in PD while neglecting impact interactions among disease. Therefore, this review demonstrates reciprocal interplays between microglia T associated subpopulations through cytokine chemokine production that impair and/or protect PD. Furthermore, potential targets models neuroinflammation highlighted provide new ideas/directions for future research.

Language: Английский

Citations

47
Polyamines in Parkinson's Disease: Balancing Between Neurotoxicity and Neuroprotection DOI Creative Commons
Stephanie Vrijsen, Marine Houdou, Ana Cascalho

et al.

Annual Review of Biochemistry, Journal Year: 2023, Volume and Issue: 92(1), P. 435 - 464

Published: April 5, 2023

The polyamines putrescine, spermidine, and spermine are abundant polycations of vital importance in mammalian cells. Their cellular levels tightly regulated by degradation synthesis, as well uptake export. Here, we discuss the delicate balance between neuroprotective neurotoxic effects context Parkinson's disease (PD). Polyamine decline with aging altered patients PD, whereas recent mechanistic studies on ATP13A2 (PARK9) demonstrated a driving role disturbed polyamine homeostasis PD. Polyamines affect pathways PD pathogenesis, such α-synuclein aggregation, influence PD-related processes like autophagy, heavy metal toxicity, oxidative stress, neuroinflammation, lysosomal/mitochondrial dysfunction. We formulate outstanding research questions regarding their potential biomarkers, possible therapeutic strategies for targeting homeostasis.

Language: Английский

Citations

43
Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis DOI Creative Commons

Luiz José Valotto Neto,

Matheus Reverete de Araujo,

Renato Cesar Moretti

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 393 - 393

Published: March 25, 2024

The aging of the global population has increased prevalence neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic quercetin, demonstrates potential for brain health. Limited research been conducted on therapeutic applications BM in This systematic review aims to project BM’s beneficial role disorders. anti-apoptotic antioxidant actions can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, increase neuroprotection. included twenty-two clinical trials demonstrated that reduce Nuclear Factor-κB phosphorylation, emotional cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, psychiatric problems. Moreover, levels pro-inflammatory biomarkers oxidative stress. Here, we highlight provides notable benefits serve a complementary approach care patients conditions associated adds growing interest natural products their by improving our understanding mechanisms underlying function neurodegeneration informing development new strategies diseases.

Language: Английский

Citations

39
Recent Research Trends in Neuroinflammatory and Neurodegenerative Disorders DOI Creative Commons
Jessica R. Cohen,

Annette Mathew,

Kirk D. Dourvetakis

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 511 - 511

Published: March 14, 2024

Neuroinflammatory and neurodegenerative disorders including Alzheimer’s disease (AD), Parkinson’s (PD), traumatic brain injury (TBI) Amyotrophic lateral sclerosis (ALS) are chronic major health disorders. The exact mechanism of the neuroimmune dysfunctions these pathogeneses is currently not clearly understood. These show dysregulated inflammatory responses, activation neurons, glial cells, neurovascular unit damage associated with excessive release proinflammatory cytokines, chemokines, neurotoxic mediators, infiltration peripheral immune cells into brain, as well entry mediators through damaged endothelial blood–brain barrier tight junction proteins. Activation leads to many molecules that cause neuroinflammation neurodegeneration. Gulf War Illness (GWI) myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) also dysfunctions. Currently, there no effective disease-modifying therapeutic options available for diseases. Human induced pluripotent stem cell (iPSC)-derived astrocytes, microglia, pericytes used models drug discovery. This review highlights certain recent trends in neuroinflammatory responses iPSC-derived applications

Language: Английский

Citations

30
Cellular and molecular mechanisms of the blood–brain barrier dysfunction in neurodegenerative diseases DOI Creative Commons

Tongli Chen,

Yan Dai,

Chenghao Hu

et al.

Fluids and Barriers of the CNS, Journal Year: 2024, Volume and Issue: 21(1)

Published: July 19, 2024

Abstract Background Maintaining the structural and functional integrity of blood–brain barrier (BBB) is vital for neuronal equilibrium optimal brain function. Disruptions to BBB performance are implicated in pathology neurodegenerative diseases. Main body Early indicators multiple disorders humans animal models include impaired stability, regional cerebral blood flow shortfalls, vascular inflammation associated with dysfunction. Understanding cellular molecular mechanisms dysfunction crucial elucidating sustenance neural computations under pathological conditions developing treatments these This paper initially explores definition BBB, along signaling pathways regulating flow, inflammation. Subsequently, we review current insights into dynamics Alzheimer’s disease, Parkinson's amyotrophic lateral sclerosis, sclerosis. The concludes by proposing a unified mechanism whereby contributes disorders, highlights potential BBB-focused therapeutic strategies targets, outlines lessons learned future research directions. Conclusions breakdown significantly impacts development progression diseases, unraveling underlying elucidate how sustained devise approaches.

Language: Английский

Citations

28
Focus on senescence: Clinical significance and practical applications DOI Creative Commons
Virginia Boccardi, Miranda E. Orr, Maria Cristina Polidori

et al.

Journal of Internal Medicine, Journal Year: 2024, Volume and Issue: 295(5), P. 599 - 619

Published: March 6, 2024

Abstract The older population is increasing worldwide, and life expectancy continuously rising, predominantly thanks to medical technological progress. Healthspan refers the number of years an individual can live in good health. From a gerontological viewpoint, mission extend spent health, promoting well‐being minimizing impact aging‐related diseases slow aging process. Biologically, malleable process characterized by intra‐ inter‐individual heterogeneous dynamic balance between accumulating damage repair mechanisms. Cellular senescence key component this process, with senescent cells different tissues organs, leading age‐related disease susceptibility over time. Removing from body or slowing down burden rate has been proposed as efficient way reduce age‐dependent deterioration. In animal models, senotherapeutic molecules lifespan either senolytic senomorphic activity. Much research shows that dietary physical activity‐driven lifestyle interventions protect against senescence. This narrative review aims summarize current knowledge on targeting risk models their translational potential for humans. We focused studies have examined role senotherapeutics modifying burdens. concludes general discussion mechanisms underlying unique trajectory its implications future research.

Language: Английский

Citations

18
Exploration beyond osteoarthritis: the association and mechanism of its related comorbidities DOI Creative Commons
Bo Li,

Zhenguo Yang,

Yang Li

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: April 19, 2024

Osteoarthritis is the most prevalent age-related degenerative joint disease and a leading cause of pain disability in aged people. Its etiology multifaceted, involving factors such as biomechanics, pro-inflammatory mediators, genetics, metabolism. Beyond its evident impact on functionality erosion patients' quality life, OA exhibits symbiotic relationships with various systemic diseases, giving rise to complications. This review reveals OA's extensive impact, encompassing osteoporosis, sarcopenia, cardiovascular diabetes mellitus, neurological disorders, mental health, even cancer. Shared inflammatory processes, genetic factors, lifestyle elements link these conditions. Consequently, recognizing connections addressing them offers opportunities enhance patient care reduce burden associated emphasizing need for holistic approach managing

Language: Английский

Citations

18