Winemaking: “With One Stone, Two Birds”? A Holistic Review of the Bio-Functional Compounds, Applications and Health Benefits of Wine and Wineries’ By-Products DOI Creative Commons
Αλέξανδρος Τσούπρας,

Victoria Ling Jun Ni,

E. O’Mahony

et al.

Fermentation, Journal Year: 2023, Volume and Issue: 9(9), P. 838 - 838

Published: Sept. 13, 2023

The plethora of bio-functional compounds present in fermented alcoholic beverages like wine, as well the valorisation bioactives from wineries’/breweries’ by-products grape pomace and seed, has gained significant interest functional foods sector. This beverage, always accompanied humanity, for religion or health, especially Mediterranean, while benefits its moderate consumption were documented even by Greek physician Hippocrates Kos (460–370 BC). After a big gap, an outbreak research on wine surfaced only since 1990s, when term “French paradox” was introduced to US public during CBS show, recent evidence outlined that beneficial effects are derived synergisms their digestion-derived metabolites. Within this article, proposed health consumption, component balanced diet (i.e., Mediterranean diet) against inflammation-related chronic disorders, is thoroughly reviewed. various both wineries’ by-products, such bioactive phenolics, unsaturated fatty acids, polar lipids dietary fibres, antioxidant, anti-inflammatory antithrombotic health-promoting properties, also evaluated. mechanisms action synergism, which elicited, explored. Functional properties non-alcoholic products introduced. Emphasis given applications bioactives, ingredients foods, supplements nutraceuticals. Limitations future perspectives popular beverage (wine) rich addressed.

Language: Английский

Unraveling the therapeutic efficacy of resveratrol in Alzheimer’s disease: an umbrella review of systematic evidence DOI Creative Commons
Ali Azargoonjahromi, Fatemeh Abutalebian

Nutrition & Metabolism, Journal Year: 2024, Volume and Issue: 21(1)

Published: March 19, 2024

Abstract Context Resveratrol (RV), a natural compound found in grapes, berries, and peanuts, has been extensively studied for its potential treating Alzheimer’s disease (AD). RV shown promise inhibiting the formation of beta-amyloid plaques (Aβ) neurofibrillary tangles (NFTs), protecting against neuronal damage oxidative stress, reducing inflammation, promoting neuroprotection, improving function blood–brain barrier (BBB). However, conflicting results have reported, necessitating comprehensive umbrella review systematic reviews to provide an unbiased conclusion on therapeutic effectiveness AD. Objective The objective this study was systematically synthesize evaluate meta-analysis investigating role AD using data from both human animal studies. Data sources extraction Of 34 examining association between that were collected, six included based specific selection criteria. To identify pertinent studies, search conducted English-language peer-reviewed journals without any restrictions publication date until October 15, 2023. carried out across multiple databases, including Embase, MEDLINE (PubMed), Cochrane Library, Web Science, Google Scholar, utilizing appropriate terms relevant research field. AMSTAR-2 ROBIS tools also used quality risk bias reviews, respectively. Two researchers independently extracted analyzed data, resolving discrepancies through consensus. note, adhered PRIOR checklist. analysis This presented robust evidence supporting positive impacts AD, irrespective mechanisms involved. It indeed indicated all unanimously concluded consumption can be effective treatment Conclusion exhibits promising benefiting individuals with various mechanisms. observed enhance cognitive function, reduce Aβ accumulation, protect BBB, support mitochondrial facilitate synaptic plasticity, stabilize tau proteins, mitigate neuroinflammation commonly associated Graphical abstract

Language: Английский

Citations

18
Dealcoholized Wine: A Scoping Review of Volatile and Non-Volatile Profiles, Consumer Perception, and Health Benefits DOI Creative Commons
Yogesh Kumar, Arianna Ricci, Giuseppina Paola Parpinello

et al.

Food and Bioprocess Technology, Journal Year: 2024, Volume and Issue: 17(11), P. 3525 - 3545

Published: March 11, 2024

Abstract The dealcoholization technique has gained more attention in the wine industry as it can significantly influence compositions and quality beyond alcohol level reduction. However, changes occurring various processes of are not fully understood yet. This work summarizes literature published last 10 years (2013–2023) about color, sulfur dioxide (SO 2 ), phenolic composition, losses desirable volatile aroma compounds, sensory characteristics after removal ethanol by different processes/techniques. Several factors final during process, including physico-chemical parameters such initial level, retention properties non-volatile matrix, components. Additionally, dealcoholized be affected choice techniques, distillation temperature, operating pressure, membrane properties, filtration pore size. Low- zero-alcohol products have potential to expand market cater diverse consumer segments. comprehensive review would help winemakers choosing best techniques produce wine, limiting adverse effects, meeting needs consumers.

Language: Английский

Citations

17
The Pharmacological Properties of Red Grape Polyphenol Resveratrol: Clinical Trials and Obstacles in Drug Development DOI Open Access
Mohd Farhan, Asim Rizvi

Nutrients, Journal Year: 2023, Volume and Issue: 15(20), P. 4486 - 4486

Published: Oct. 23, 2023

Resveratrol is a stilbenoid from red grapes that possesses strong antioxidant activity. has been shown to have anticancer activity, making it promising drug for the treatment and prevention of numerous cancers. Several in vitro vivo investigations validated resveratrol’s capabilities, demonstrating its ability block all steps carcinogenesis (such as initiation, promotion, progression). Additionally, resveratrol found auxiliary pharmacological effects such anti-inflammatory, cardioprotective, neuroprotective Despite properties, several obstacles, poor solubility bioavailability, well adverse effects, continue be key obstacles development. This review critically evaluates clinical trials date aims develop framework into clinically viable drug.

Language: Английский

Citations

35
Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases DOI Creative Commons
Sehwan Kim, Un Ju Jung, Sang Ryong Kim

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1462 - 1462

Published: Nov. 28, 2024

Upregulation of reactive oxygen species (ROS) levels is a principal feature observed in the brains neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s (AD). In these diseases, oxidative stress can disrupt blood–brain barrier (BBB). This disruption allows neurotoxic plasma components, blood cells, pathogens to enter brain, leading increased ROS production, mitochondrial dysfunction, inflammation. Collectively, factors result protein modification, lipid peroxidation, DNA damage, and, ultimately, neural cell damage. this review article, we present mechanisms by which damage leads BBB breakdown brain diseases. Additionally, summarize potential therapeutic approaches aimed at reducing that contributes

Language: Английский

Citations

10
Food wastes phenolic compounds (PCs): overview of contemporary greener extraction technologies, industrial potential, and its integration into circular bioeconomy DOI
Latika Bhatia,

Dowluru S. V. G. K. Kaladhar,

Tanushree Sarkar

et al.

Energy Ecology and Environment, Journal Year: 2024, Volume and Issue: 9(5), P. 455 - 485

Published: April 6, 2024

Language: Английский

Citations

8
Moderate red wine intake and cardiovascular health protection: a literature review DOI
Francesca Serio, Giovanni Imbriani, Mattia Acito

et al.

Food & Function, Journal Year: 2023, Volume and Issue: 14(14), P. 6346 - 6362

Published: Jan. 1, 2023

Moderate red wine intake improves cardiovascular health by reducing oxidative stress, and playing an important role on lipid glucose metabolism.

Language: Английский

Citations

21
Comprehensive and critical view on the anti-inflammatory and immunomodulatory role of natural phenolic antioxidants DOI
Aurelia Magdalena Pisoschi, Florin Iordache, Loredana Stanca

et al.

European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 265, P. 116075 - 116075

Published: Dec. 21, 2023

Language: Английский

Citations

17
Wine Phenolic Compounds: Chemistry, Functionality and Health Benefits DOI Creative Commons
Youssef El Rayess, Nancy Nehme,

Samar Azzi-Achkouty

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1312 - 1312

Published: Oct. 28, 2024

Wine phenolic compounds, often known as polyphenols, are a diverse group of secondary bioactive compounds derived from grapes. They play crucial role in defining the sensory characteristics, functionality, and health benefits wine. This review explores complex chemistry these focusing on key classes such flavonoids, which include flavanones, flavonols, anthocyanins, flavan-3-ols, non-flavonoids, hydroxycinnamic acids, hydroxybenzoic stilbenes. The wine phenolics, particularly their antioxidant anti-inflammatory properties, also discussed relation to preventing reducing risk non-communicable diseases (NCDs) cardiovascular diseases, cancers, neurodegenerative conditions. Furthermore, this summarized most current data human population-based research that investigated bioactivity red phytochemicals with relevant for NCDs. Finally, proposes some perspectives future better understand bioavailability, metabolism, long-term effects compounds.

Language: Английский

Citations

7
Autophagy and Female Fertility: Mechanisms, Clinical Implications, and Emerging Therapies DOI Creative Commons
Abdel Halim Harrath, Md. Ataur Rahman,

Sujay Kumar Bhajan

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(16), P. 1354 - 1354

Published: Aug. 14, 2024

Autophagy, an evolutionarily conserved cellular mechanism essential for maintaining internal stability, plays a crucial function in female reproductive ability. In this review, we discuss the complex interplay between autophagy and several facets of health, encompassing pregnancy, ovarian functions, gynecologic malignancies, endometriosis, infertility. Existing research emphasizes significance embryo implantation, specifically endometrium, highlighting its necessity ensuring proper fetal development. Although some knowledge has been gained, there is still lack on specific molecular impacts quality oocytes, growth follicles, general health. Autophagy role maturation, quality, development oocytes. It also involved aging, contributing to reductions that occur with age. This review explores physiological functions system, participation toxicity, important connections endometrium embryo. addition, study investigates possibility emerging treatment approaches aim modify autophagy, using both natural substances synthetic molecules, improve fertility outcomes. Additionally, intends inspire future exploration into intricate health by reviewing recent studies pinpointing areas where current lacking. Subsequent investigations should prioritize conversion these discoveries practical uses medical field, which could potentially result groundbreaking therapies infertility other difficulties related reproduction. Therefore, gaining comprehensive understanding many effects would not only further field biology but open new possibilities diagnostic methods.

Language: Английский

Citations

5
Wine-Making; “with one Stone Two Birds”? A Holistic Review of the Bio-Functional Compounds, Applications and Health Benefits of Wine and Wineries’ By-Products DOI Open Access
Αλέξανδρος Τσούπρας,

Victoria Ling Jun Ni,

E. O’Mahony

et al.

Published: June 14, 2023

The plethora of bio-functional compounds present in fermented alcoholic beverages like wine, as well the valorization bioactives from their wineries/breweries by-products grape pomace and seed, has gained significant interest functional foods sector. Wine always accompanied humanity, for religion or health. For example, Christians are using wine “Holy Communion”, following what Jesus Christ himself did said during Last Supper, while benefits consumption moderation was embedded all Mediterranean civilizations, it is mentioned by wise King-Prophet David his psalms, but also Hip-pocrates other men, a Greek-based philosophy “All things Moderation” (Cleobulus Lindos; 6th century BC). In modern times, after outbreak research on since 90’s, when term “French Paradox” introduced US public CBS show, recent evidence outlined that these derived synergisms its digestion-derived metabolites. Within this article, proposed health moderate consumption, component balanced diet (i.e. Mediterra-nean Diet), against inflammation-related chronic disorders, thoroughly reviewed. various both wineries’ by-products, such bioactive phe-nolics, unsaturated fatty acids, polar lipids, dietary fibers, antioxidant, anti-inflammatory antithrombotic promoting properties evaluated. mechanisms actions synergism, which elicited, ex-plored. Functional non-alcoholic products introduced. Emphasis given to applications bioactives, ingredients foods, supplements nutraceuticals. Limitations future perspectives popular beverage (wine) ant rich addressed. .

Language: Английский

Citations

12