Clinical and Immunological Features in Limpet (Patella sp.) Allergy in Subtropical Areas: A New Trigger for Food Anaphylaxis

Allergies, Journal Year: 2025, Volume and Issue: 5(1), P. 2 - 2

Published: Jan. 10, 2025

Seafood is a crucial source of nutrients, with global consumption steadily increasing. Among seafood-related allergies, shellfish are significant cause food allergy and anaphylaxis worldwide, affecting approximately 0.5–2.5% the general population. While majority existing research has focused on crustaceans, allergic reactions to mollusks, including their clinical characteristics, remain poorly understood. In Canary Islands, limpets (a type marine gastropod) widely consumed as part traditional cuisine. Despite isolated reports limpet allergy, no large-scale studies or comprehensive analyses have been published this topic. A cohort patients sensitized was analyzed: 66 were monosensitized (Group A), while 64 demonstrated additional sensitization other B). Limpet ingestion associated delayed severe symptoms, asthma. Notably, only 11.5% in Group tested positive for allergens using ALEX testing compared 67.9% B. The identification protein bands 25–40 50–200 kDa molecular weight ranges provides novel finding that differentiates study from prior research. Our represents largest reported series documented date.

Language: Английский

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A Comparison of asIgE Levels Measured with ALEX and ImmunoCAP ISAC in Polish Children with Food Allergies

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1810 - 1810

Published: Feb. 20, 2025

In order to establish the reliability of new multiplex tests for determining allergen-specific immunoglobulin E (asIgE) levels in serum, results asIgE determinations obtained via ALEX were compared those ImmunoCAP ISAC a group 40 Polish children hospitalized due food allergy and/or anaphylaxis. The analysis was based on 6320 asIgEs relative 79 common allergen molecules included both (80 conducted-40 and ISAC). study showed high correlation between diagnostic tests, with concordance at level 92.5% (n = 2922). this sensitivity test be comparable that test. One indisputable advantage is its number per procedure, which provides more information about patient's molecular profile; moreover, use an inhibitor bind cross-reactive carbohydrate determinants (CCDs) reduces their impact allergens naturally containing determinants. Comparative analyses demonstrate reliable tool assessments. However, significant differences absolute values individual suggest need caution when directly comparing from tests.

Language: Английский

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Desensitization for Vitamin B12 Hypersensitivity and How to Do It

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 801 - 801

Published: March 26, 2025

Vitamin B12 is the common name for a group of cobalamins, which are cobalt corrines. Cobalamins water-soluble B vitamins. B12, as coenzyme various enzymes, an essential component many key metabolic processes in body. deficiency causes dysfunction organs and systems body, including central nervous system. Humans, like other animals, unable to synthesize cobalamin. This vitamin must be supplied with balanced diet. The only valuable dietary sources cobalamin foods animal origin, especially offal (e.g., liver). Vegan vegetarian diets deficient B12. People who follow this nutritional model require systematic supplementation, usually oral form. Other pathogenetic processes, course any stages complicated process absorption from gastrointestinal tract impaired. Disorders intestinal supplementation parenterally (usually by intramuscular or subcutaneous injections) rest life. Supplementary therapy may cause adverse reactions, among hypersensitivity reactions spectrums intensity symptoms possible. According available data, more likely after administration than It also seems that long-term predisposes allergy regardless its chemical Although rather rare, it can great clinical importance. due fact affects significant part population, elderly those chronic diseases impair absorption. In addition, supplementary lifelong) there no alternative form treatment. For these reasons, solutions sought will allow safe continuation treatment supplementing deficiency. Various cyanocobalamin desensitization protocols proposed, differing duration, dynamics gradual dose increase, method injection (intramuscular subcutaneous). An analysis data field suggests effective way obtain tolerance allowing form, size, frequency, route administration.

Language: Английский

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Allergen chip in molecular diagnostic: from cohort analysis to personalized patient care

Russian Journal of Biotherapy, Journal Year: 2025, Volume and Issue: 24(1), P. 10 - 26

Published: April 15, 2025

Background . The allergic diseases are growing everywhere. exact diagnosis of allergens becomes more and critical because it significantly affects the further treatment patient, including question about using allergen-specific immunotherapy. There several laboratory instrumental tests among which skin most available. Despite its low cost, this method is characterized by a large percentage false-positive and, importantly, false-negative results. In addition, that can be detected limited. Aim. To conduct comparative analysis effectiveness diagnostic accuracy allergen chips from different manufacturers to evaluate their applicability in molecular diseases. Results ImmunoCAP ISAC Allergy Explorer (ALEX) gradually occupying niche Both methods have benefits disadvantages. high cost difficulties supplying foreign materials sharply limit widespread use allergy profiles Russia. On other hand, personalized medicine requires doctors patient-centered care, completed existing tools. panels for various regions Russia solve problem. Identifying common clinically significant molecules each region will enable accurate allergies patient treatment. This improve medical care quality increase therapy effectiveness. Conclusion. Developing implementing new creating optimal important steps towards improving These measures help clinicians accurately identify relevant develop individual plans ultimately leading better public health lower economic costs treating allergies.

Language: Английский

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Impact of climate change on aerobiology, rhinitis, and allergen immunotherapy: Work Group Report from the Aerobiology, Rhinitis, Rhinosinusitis & Ocular Allergy, and Immunotherapy, Allergen Standardization & Allergy Diagnostics Committees of the American Academy of Allergy, Asthma & Immunology

Journal of Allergy and Clinical Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Gastropod Allergy: A Comprehensive Narrative Review

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(6), P. 5950 - 5964

Published: June 13, 2024

Food allergies have increased significantly in recent decades, with shellfish being a leading cause of food allergy and anaphylaxis worldwide, affecting both children adults. The prevalence is estimated to be approximately 0.5–2.5% the general population, varying by geographical location, age, consumption habits. Although mollusk has risen, remains unknown. While extensive research focused on crustacean allergies, particularly those related gastropods, received comparatively less attention. Clinical manifestations range from localized symptoms life-threatening systemic reactions, such as anaphylaxis. Notably, severe bronchospasm predominant clinical feature cases involving gastropods. Several allergens been identified mollusks, including paramyosin, tropomyosin, sarcoplasmic calcium-binding protein. In documented include heavy chain myosin, Der p 4 amylase. Diagnosis typically involves thorough history, skin testing, vitro quantification immunoglobulin (Ig) E, confirmation through an oral challenge, although latter reserved for selected cases. This narrative review highlights limited gastropod allergy. It provides comprehensive list purified recombinant discusses applications component-resolved diagnosis well current therapeutic developments.

Language: Английский

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Regulatory framework for development and marketing authorization of allergen products for diagnosis of rare type I and type IV allergies: The current status

Allergologie select, Journal Year: 2024, Volume and Issue: 8(01), P. 212 - 219

Published: Jan. 1, 2024

Development, production, and marketing authorization of allergen products is generally challenging due to several specific characteristics, including the natural source as well multitude allergenic materials. Also, depending on frequency sensitization in population, number patients available for inclusion clinical trials can be a limiting factor product development. In development diagnosis type I IV allergies these challenges are particularly demanding because, contrast certain allergen-specific immunotherapy, no exemptions from foreseen this group Directive 2001/83/EC. Thus, regulatory framework constantly adapted within legal scope order balance necessary requirements ensuring quality, safety, efficacy with need comprehensive range diagnostic products. article, we give an overview current rare allergies.

Language: Английский

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Modern possibilities of allergy diagnostics in real clinical practice

Russian Journal of Allergy, Journal Year: 2024, Volume and Issue: 21(2), P. 321 - 332

Published: June 3, 2024

More than 20% of people worldwide suffer from allergic diseases. The high prevalence and wide range provocative factors, which are increasing daily, complicate the diagnostic search. On one hand, this leads to inadequately extensive dietary lifestyle restrictions that reduce quality life for patients; on other it results in failure identify life-threatening allergens. discovery immunoglobulin E over 60 years ago initiated search specific biomarkers etermine causes Traditional methods allergen diagnostics have several limitations hinder potential disease triggers. article discusses modern laboratory approaches multicomponent molecular diagnostics, describes its differences traditional methods, analyzes advantages, prospects, limitations, shortcomings method. It also presents a comparative characterization test systems available today. four clinical cases demonstrate capabilities ALEX 2 system choice therapy tactics, forming further personalized recommendations patients suffering various

Language: Английский

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Advocacy of Precision Allergy Molecular Diagnosis in Decision Making for the Eligibility of Customized Allergen Immunotherapy

Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(12), P. 9976 - 9984

Published: Dec. 12, 2023

Allergen immunotherapy (AIT) with aeroallergens is the only disease-modifying treatment for patients different allergic conditions. Despite effectiveness of AIT having been proven in both randomized controlled trials and real-world studies, it remains underused less than 10% subjects rhinitis (AR) and/or asthma (A). We aimed to determine current eligibility house dust mite (HDM) by means a precision allergy molecular diagnosis (PAMD@) model selected cohort youngsters phenotypes according available evidence. A complex response HDM storage allergens was depicted regardless subjects' basal atopic condition. No solely specific IgE-binding responses Der p 1, 2, 23 were found studied cohort. dermatitis showing significantly higher serum titers six AR, no profile regarded as disease specific. Given increasing complexity IgE local prevailing aeroallergens, identification presence such molecules are needed commercially era medicine.

Language: Английский

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Sensitization profiles to house dust mite Dermatophagoides pteronyssinus molecular allergens in the Lithuanian population: Understanding allergic sensitization patterns

Clinical and Translational Allergy, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 1, 2024

Abstract Background House dust mite (HDM) allergy is a prevalent global health concern, with varying sensitization profiles observed across populations. We aimed to provide comprehensive assessment of molecular allergen patterns in the Lithuanian population, focus on Dermatophagoides pteronyssinus (Der p), and investigate concomitant reactivity among different allergens enhance accuracy HDM diagnostics. Methods A analysis 1520 patient test results Lithuania from 2020 2022 was performed. Sensitization major p 1, Der 2, 23) minor 5, 7, 21) components were described using molecular‐based Additionally, we investigated other sources, including tropomyosins 10, Per Pen m Ani s 3, Blo t 10) arginine kinases (Pen Bla g 9, 20). Results This study reveals high prevalence ‐ 481 individuals (45.38% sensitized group) exhibited at least one component. Importantly, within group, 37.21% patients or 21 addition allergenic components. Distinct age groups, indicating influence age‐related factors. Furthermore, confirmed cross‐reactivity between 5 as well 21, emphasizing clinical relevance these associations. also highlighted complexity kinases. Conclusion provides valuable insights into Lithuania, importance considering for accurate diagnosis management HDM‐related allergic diseases. Differences populations factors impact patterns. Understanding allergens, such tropomyosins, kinases, crucial improving diagnostic strategies developing targeted interventions individuals.

Language: Английский

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