The Effect of Virgin Coconut and Black Cumin Oils on TNF-alpha Expression and Histopathological in Diabetic Rat Wound Healing DOI

Eliza Arman,

A Almahdy,

Putri Dafriani

et al.

Research Journal of Pharmacy and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 6076 - 6083

Published: Dec. 27, 2024

Background: Wound healing is a multifaceted process requiring the collaboration of various elements to facilitate repair damaged tissue. To accelerate process, Virgin Coconut Oil (VCO) and black cumin oil are plant oils that have been proven offer several beneficial pharmacological effects. Therefore, this study aimed determine effect VCO oil, as well their combination, on expression TNF-α histopathological features during wound in diabetic rat. Methods: Rat were injected with streptozotocin (55 mg/kg BW) 10 mm was created (n=30). Subsequently, rat randomly divided into six groups (n=5), consisting control (Untreated), VCO, C1, C2, C3 groups. Topical application performed once daily for 14 days. between evaluated using visual observation, hematoxylin eosin staining. Meanwhile, gene analyzed RT-PCR days 7 14, followed by data analysis one-way ANOVA. Results: The C1 group receiving topical combination showed moderate closure pattern characterized good shape, thickest epidermis, higher granulation, greater collagen density, fibroblast, lower inflammatory cell infiltration compared others. C2 significantly decreased day 7. In contrast, reduced group. Regarding features, provided optimal others.Conclusion: accelerated inducing decrease providing an intermediate pattern.

Language: Английский

Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases DOI Creative Commons

Kamil Sghier,

Maja Mur,

Francisco Veiga

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(1), P. 45 - 45

Published: Jan. 6, 2024

Topical and transdermal drug delivery are advantageous administration routes, especially when treating diseases conditions with a skin etiology. Nevertheless, conventional dosage forms often lead to low therapeutic efficacy, safety issues, patient noncompliance. To tackle these novel topical platforms involving nanotechnology have been developed. This review focuses on the latest advances regarding development of nanoemulgels for application, encapsulating wide variety molecules, including already marketed drugs (miconazole, ketoconazole, fusidic acid, imiquimod, meloxicam), repurposed (atorvastatin, omeprazole, leflunomide), natural-derived compounds (eucalyptol, naringenin, thymoquinone, curcumin, chrysin, brucine, capsaicin), other synthetic molecules (ebselen, tocotrienols, retinyl palmitate), wound healing, appendage infections, inflammatory diseases, cancer, neuropathy, or anti-aging purposes. Developed formulations revealed adequate droplet size, PDI, viscosity, spreadability, pH, stability, release, permeation and/or retention capacity, having more characteristics than current formulations. In vitro in vivo studies established efficacy developed formulations, confirming their potential, making them promising replacement therapies, as possible adjuvant treatments, which might someday effectively reach market help fight highly incident systemic conditions.

Language: Английский

Citations

17
Ethnobotanical Insights Into the Bioactive Properties of Commercially Important Spice Seeds DOI
Bancha Yingngam

Advances in bioinformatics and biomedical engineering book series, Journal Year: 2024, Volume and Issue: unknown, P. 123 - 190

Published: May 7, 2024

Ethnobotany provides key insights from ancient traditions, particularly focusing on spice seeds. Despite their growing commercial value in food and pharmaceuticals, there is still a need for thorough research into traditional uses scientifically validated properties. The objective of this chapter to compile integrate current ethnobotanical knowledge with recent scientific findings highlight the inherent medicinal pharmacological properties these plants. A comprehensive examination was conducted range applications, methods preparation, cultural significance plants have been described, latest confirmed therapeutic potential. In summary, numerous seeds are traditionally considered healing agents, modern has benefits. convergence advancements established foundation integration practices.

Language: Английский

Citations

12
Nanoparticles of Natural Product-derived Medicines: Beyond the Pandemic DOI Creative Commons
Yedi Herdiana

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42739 - e42739

Published: Feb. 1, 2025

This review explores the synergistic potential of natural products and nanotechnology for viral infections, highlighting key antiviral, immunomodulatory, antioxidant properties to combat pandemics caused by highly infectious viruses. These often result in severe public health crises, particularly affecting vulnerable populations due respiratory complications increased mortality rates. A cytokine storm is initiated when an overload pro-inflammatory cytokines chemokines released, leading a systemic inflammatory response. Viral mutations limited availability effective drugs, vaccines, therapies contribute continuous transmission virus. The coronavirus disease-19 (COVID-19) pandemic has sparked renewed interest product-derived antivirals. efficacy traditional medicines against infections examined. Their anti-inflammatory, are highlighted. discusses how enhances herbal combating infections.

Language: Английский

Citations

1
Antimicrobial Properties and Therapeutic Potential of Bioactive Compounds in Nigella sativa: A Review DOI Creative Commons
Munawar Abbas, Mayank Anand Gururani, Amjad Ali

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(20), P. 4914 - 4914

Published: Oct. 17, 2024

(

Citations

7
Plant-Based Nanotherapeutics: A New Frontier in Disease Management and Prevention DOI Creative Commons
Sumitha Elayaperumal, Yuvaraj Sivamani,

P. N. Agarwal

et al.

Nano TransMed, Journal Year: 2025, Volume and Issue: unknown, P. 100086 - 100086

Published: May 1, 2025

Language: Английский

Citations

0
Nano-based formulations of thymoquinone are new approaches for psoriasis treatment: a literature review DOI Creative Commons
Amir Modarresi Chahardehi,

Hamid Reza Ojaghi,

Hossein Motedayyen

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 12, 2024

Psoriasis, a persistent immune-mediated inflammatory skin condition, affects approximately 2-3% of the global population. Current treatments for psoriasis are fraught with limitations, including adverse effects, high costs, and diminishing efficacy over time. Thymoquinone (TQ), derived from Nigella sativa seeds, exhibits promising anti-inflammatory, antioxidant, immunomodulatory properties that could prove beneficial in managing psoriasis. However, TQ’s hydrophobic nature poor bioavailability have hindered its usefulness as therapeutic agent. Recent research has strategically addressed these challenges by developing nano-thymoquinone (nano-TQ) formulations to enhance delivery treating Preclinical studies employing mouse models demonstrated nano-TQ effectively mitigates inflammation, erythema, scaling, epidermal thickness, cytokine levels psoriatic lesions. Various formulations, nanoemulsions, lipid vesicles, nanostructured carriers, ethosomes, been explored improve solubility, facilitate penetration, ensure sustained release, achieve site-specific targeting. Although clinical trials currently scarce, outcomes vitro animal promising. The potential co-delivery other anti-psoriatic agents also presents avenues further investigation.

Language: Английский

Citations

1
"The Benefits of Nigella sativa for Skin Diseases and Heal Skin Injuries: An Overview of Phytochemicals and Pharmacological Properties" DOI Open Access
Abdalsalam Kmail

Biomedical Journal of Scientific & Technical Research, Journal Year: 2023, Volume and Issue: 54(1)

Published: Dec. 13, 2023

Nigella sativa (N. sativa) is a medicinal plant with long history of use in various traditional systems medicine, such as Arab and Islamic Unani, Ayurveda, Chinese medicine. N. has many active compounds, alkaloids, saponins, thymoquinone, that give it wide range health benefits. It can act diuretic, bronchodilator, antihypertensive, antidiabetic, analgesic. Moreover, antimicrobial, anti-inflammatory, antineoplastic properties, which make promising natural treatment for skin conditions.

Language: Английский

Citations

2
Nigella sativa, active principle thymoquinone, alleviates palmitate-induced cytotoxicity, inflammation and bioenergetic disruptions in macrophages: An invitro study model DOI
Rashad Qasem Ali Othman,

Amal Misbah Aggour,

Ekramy Elmorsy

et al.

Toxicon, Journal Year: 2024, Volume and Issue: 244, P. 107754 - 107754

Published: May 16, 2024

Language: Английский

Citations

0
Nigella Sativa L. (Black Seed) DOI
Pervin Rayaman

Published: June 10, 2024

Nigella sativa, known also as black seed or cumin is found in Middle Europe, North America, East, and East Africa, South Southwest Asia Black grows a terrestrial environment plant which annual flowering used broadly for medical purposes.N. sativa has been comprehensively researched its biological activities therapeutic value. It to have wide range of effects, most important are their anticancer, antihypertensive, antiasthmatic, antidiabetic, immunomodulatory ones. Additionally, it that analgesic, antibacterial, antifungal, anthelmintic, spasmolytic, bronchodilator, gastroprotective, hepatoprotective, nephroprotective antioxidant activities.

Language: Английский

Citations

0
SYNERGISTIC POTENTIAL OF NIGELLA SATIVA L. AND TRIGONELLA FOENUM-GRAECUM: INTEGRATED NETWORK PHARMACOLOGY FOR DIABETIC WOUND HEALING DOI Open Access
Maharani Retna Duhita, Retno Susilowati, Siti Qurrotul Aini

et al.

International Journal of Applied Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 345 - 351

Published: Nov. 7, 2024

Objective: Diabetes Mellitus (DM) is a metabolic disorder marked by elevated blood glucose levels, and one of the issues linked to DM involves development Diabetic Wounds (DW). DW susceptible infection develops into chronic wounds if not treated properly. This study aimed investigate network pharmacology N. sativa L. T. foenum-graecum, emphasizing on their potential as treatment candidates. Methods: Various databases were used in this study, including PubChem, Dr. Duke's phytochemistry Ethnobotany, KNApSAcK Family. Swiss Target Prediction Way2Drug PASS Online utilized for biological activity protein target prediction. The pathway's protein-protein interactions examined with Kyoto Encyclopedia Genes Genomes (KEGG) pathway, Gene Cards, STRING databases. was predict metabolite's action. relationship between metabolites proteins predicted using STITCH, Cytoscape visualize network. Result: results showed that ten active ingredients (five five foenoem-graecum) contributed healing affecting Tumor Necrosis Factor (TNF), Interleukin-1beta (IL1B), JUN, Caspase 3 (CASP3), Interleukin-6 (IL-6), Alpha Kinase Threonine-1 (AKT1), Vascular Endothelial Growth Factor-A (VEGFA), Mitogen-Activated Protein (MAPK3) genes. Furthermore, correlated twenty-eight intracellular proteins, resulting mechanism involving eight signalling pathways. Conclusion: Based analysis, we determine foenoem-graecum combination can potentially treat DW.

Language: Английский

Citations

0