Life Sciences, Journal Year: 2024, Volume and Issue: 351, P. 122804 - 122804
Published: June 7, 2024
Language: Английский
Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)
Published: Jan. 1, 2025
Language: Английский
Citations
4
Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2259 - 2259
Published: July 13, 2024
Dietary components, including dietary fiber, unsaturated fatty acids, and polyphenols, along with meal timing spacing, significantly affect the microbiota’s capacity to produce various metabolites essential for quality sleep overall health. This review explores role of gut microbiota in regulating through such as short-chain tryptophan, serotonin, melatonin, gamma-aminobutyric acid. A balanced diet rich plant-based foods enhances production these sleep-regulating metabolites, potentially benefiting aims investigate how habits composition, it produces, subsequent impact on related health conditions.
Language: Английский
Citations
9
American Journal of Medical Genetics Part B Neuropsychiatric Genetics, Journal Year: 2025, Volume and Issue: 198(4)
Published: Jan. 3, 2025
BackgroundInsomnia is a common neurological disorder that exhibits connections with the gut microbiota; however, exact causal relationship remains unclear. MethodsWe conducted Mendelian randomization (MR) study to systematically evaluate effects of genus-level microbiota on insomnia risk in individuals European ancestry. Summary-level datasets were sourced from genome-wide association (GWAS) MiBioGen, while obtained GWAS Neale Lab and FinnGen. The primary analytical approach used was inverse-variance weighted (IVW) method, supplemented by MR-Egger, maximum likelihood, MR-robust adjusted profile score, median. Sensitivity analyses ensure robustness. ResultsThe microbial taxa Enterorhabdus, Family XIII AD3011 group, Paraprevotella, Lachnospiraceae UCG004 associated an increased insomnia, whereas Coprococcus1, Coprobacter, Desulfovibrio, Flavonifractor, Olsenella, Odoribacter, Oscillibacter linked decreased risk. Regarding phenotype characterized trouble falling asleep, taxon Eisenbergiella correlated risk, Haemophilus Eubacterium brachy group reduced Furthermore, for waking too early, UCG001, FCS020 Olsenella Victivallis lower results remained robust across all sensitivity analyses. ConclusionOur MR identified multiple may exhibit potential genetic perspective. These findings provide evidence supporting theory microbiota-gut-brain axis offer new insights into prevention therapeutic targets insomnia.
Language: Английский
Citations
1
Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14
Published: Nov. 22, 2023
Background The association between gut microbiota and leukemia has been established, but the causal relationship two remains unclear. Methods A bidirectional two-sample Mendelian randomization (MR) was used to analyze leukemia. Microbiome data ( n = 14,306) 1,145) were both sourced from European populations. Single nucleotide polymorphisms (SNPs) selected as instrumental variables based on several criteria. We employed various MR methods, such inverse variance weighted (IVW) method, evaluate effect exposure outcomes conducted sensitivity analyses validate heterogeneity pleiotropy of variables. Results 5,742 qualified included. In primary results, a total 10 microbial taxa associated with risk. Genus Blautia genus Lactococcus are risk factors for acute lymphoblastic [genus odds ratio (OR): 1.643, 95% confidence interval (CI): 1.592 ~ 1.695, Adjusted p < 0.001; OR: 2.152, CI: 1.447 3.199, 0.011]. Rikenellaceae RC9 group, Anaerostipes, Slackia, Lachnospiraceae ND3007 group myeloid 1.964, 1.573 2.453, Anaerostipes 2.515, 1.503 4.209, 0.017; Slackia 2.553, 1.481 4.401, 0.022; 3.417, 1.960 5.959, 0.001]. Ruminococcaceae UCG011 UCG014 chronic (genus 2.010, 1.363 2.963, 0.044; 3.101, 1.626 5.915, 0.044). protective factor 0.166, 0.062 0.443, 0.017). Family Acidaminococcaceae (family 0.208, 0.120 0.361, 0.001). Desulfovibrio 0.581, 0.440 0.768, 0.020). Sensitivity analysis revealed no or SNPs. Conclusion This study leukemia, identified potential pathogenic bacteria probiotic onset research may aid in early detection types offer new direction prevention treatment
Language: Английский
Citations
12
Neuroglia, Journal Year: 2024, Volume and Issue: 5(3), P. 254 - 273
Published: Aug. 1, 2024
The human central nervous system is convolutedly connected to the gut microbiome, a diverse community of microorganisms residing in gastrointestinal tract. Recent research has highlighted bidirectional communication between microbiome and neuroglial cells, which include astrocytes, microglia, oligodendrocytes, ependymal cells. These cells are essential for maintaining CNS homeostasis, supporting neuronal function, responding pathological conditions. This review examines interactions neuroglia, emphasizing their critical roles brain health development neurological disorders. Dysbiosis, or imbalance been associated with various psychiatric conditions, such as autism spectrum disorder, anxiety, depression, neurodegenerative diseases like Alzheimer’s Parkinson’s. influences function through microbial metabolites, immune modulation, neuroinflammatory responses. Understanding these paves way new therapeutic targets strategies preventing treating scoping aims highlight mechanisms microbiome-neuroglia axis its potential target.
Language: Английский
Citations
4
Immunology Letters, Journal Year: 2024, Volume and Issue: 268, P. 106883 - 106883
Published: June 12, 2024
Language: Английский
Citations
3
Genes, Journal Year: 2024, Volume and Issue: 15(6), P. 769 - 769
Published: June 12, 2024
Recent research has highlighted associations between sleep and microbial taxa pathways. However, the causal effect of these remains unknown. To investigate this, we performed a bidirectional two-sample Mendelian randomization (MR) analysis using summary statistics genome-wide association studies (GWAS) from 412 gut microbiome traits (N = 7738) GWAS seven sleep-associated 345,552 to 386,577). We employed multiple MR methods assess causality, with Inverse Variance Weighted (IVW) as primary method, alongside Bonferroni correction ((
Language: Английский
Citations
2
Neuroscience, Journal Year: 2024, Volume and Issue: 565, P. 99 - 116
Published: Nov. 30, 2024
Language: Английский
Citations
2
Published: Feb. 28, 2024
Recent research has highlighted associations between sleep and microbial taxa pathways. However, the causal effect of these remains unknown. To investigate this, we performed a two-sample bidirectional Mendelian randomization (MR) analysis using summary statistics genome-wide association studies (GWAS) from 412 gut microbiome traits (N = 7,738) GWAS seven sleep-associated 345,552 to 386577). We employed multiple MR methods assess causality, with Inverse Variance Weighted (IVW) as primary method. further applied Cochran’s Q statistical analysis, MR-Egger intercept, MR-PRESSO for heterogeneity pleiotropy assessment, alongside Bonferroni correction ((P
Language: Английский
Citations
1
International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(10), P. 1945 - 1963
Published: Jan. 1, 2024
Both observational studies and clinical trials have demonstrated a link between the gut microbiota geriatric syndrome. Nevertheless, exact nature of this relationship, particularly concerning causality, remains elusive. Mendelian randomization (MR) is method inference based on genetic variation to assess causal relationship an exposure outcome. In study, we conducted two-sample (TSMR) study fully reveal potential effects syndromes.
Language: Английский
Citations
1