Dietary Polyphenols, Food Processing and Gut Microbiome: Recent Findings on Bioavailability, Bioactivity, and Gut Microbiome Interplay

Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1220 - 1220

Published: Oct. 10, 2024

Polyphenols are organic chemical compounds naturally present in plants, renowned for their anti-inflammatory, antioxidant, immunomodulatory, anticancer, and cardiovascular protective properties. Their bioactivity bioavailability can vary widely depending on the methods of food processing interactions with gut microbiome. These factors induce changes polyphenols, affecting ability to achieve intended health benefits. Thus, it is essential develop apply that optimize polyphenol content while maintaining bioavailability. This review aims explore how various techniques affect quantity, bioactivity, as well microbiome, which may ultimately determine effects.

Language: Английский

---

The Effect of Sleep Disruption on Cardiometabolic Health

Life, Journal Year: 2025, Volume and Issue: 15(1), P. 60 - 60

Published: Jan. 7, 2025

Sleep disruption has emerged as a significant public health concern with profound implications for metabolic health. This review synthesizes current evidence demonstrating the intricate relationships between sleep disturbances and cardiometabolic dysfunction. Epidemiological studies have consistently demonstrated that insufficient duration (<7 h) poor quality are associated increased risks of obesity, type 2 diabetes, cardiovascular disease. The underlying mechanisms multifaceted, involving circadian clock genes, alterations in glucose lipid metabolism, activation inflammatory pathways, modulation gut microbiome. loss affects key regulators, including AMPK signaling disrupts secretion hormones such leptin ghrelin. latest points to role sleep-induced changes composition function microbiota, which may contribute dysfunction through modifications intestinal barrier responses. NLRP3 inflammasome NF-κB pathways been identified crucial mediators linking inflammation. An understanding these clinical practice, suggesting improving could be an effective strategy preventing treating disorders modern society.

Language: Английский

---

The Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10757 - 10757

Published: Oct. 6, 2024

With the aging of global population, neurodegenerative diseases are emerging as a major public health issue. The adoption less sedentary lifestyle has been shown to have beneficial effect on cognitive decline, but molecular mechanisms responsible clear. Here we provide detailed analysis complex molecular, cellular, and systemic underlying age-related decline how choices influence these processes. A review evidence from animal models, human studies, postmortem analyses emphasizes importance integrating physical exercise with cognitive, multisensory, motor stimulation part multifaceted approach mitigating decline. We highlight potential non-pharmacological interventions address key hallmarks, such genomic instability, telomere attrition, neuroinflammation, underscore need for comprehensive personalized strategies promote resilience healthy aging.

Language: Английский

---

Relationship Among Macronutrients, Dietary Components, and Objective Sleep Variables Measured by Smartphone Apps: Real-World Cross-Sectional Study

Journal of Medical Internet Research, Journal Year: 2025, Volume and Issue: 27, P. e64749 - e64749

Published: Jan. 30, 2025

Background Few studies have explored the relationship between macronutrient intake and sleep outcomes using daily data from mobile apps. Objective This cross-sectional study aimed to examine associations macronutrients, dietary components, parameters, considering their interdependencies. Methods We analyzed 4825 users of Pokémon Sleep Asken smartphone apps, each used for at least 7 days record objective parameters respectively. Multivariable regression quartiles macronutrients (protein; carbohydrate; total fat, including saturated, monounsaturated, polyunsaturated fats), components (sodium, potassium, fiber, sodium-to-potassium ratio), variables (total time [TST], latency [SL], percentage wakefulness after onset [%WASO]). The lowest group was reference. Compositional analysis accounted Models were adjusted age, sex, BMI. Results Greater protein associated with longer TST in third (+0.17, 95% CI 0.09-0.26 h) fourth (+0.18, 0.09-0.27 quartiles. In contrast, greater fat linked shorter (–0.11, –0.20 –0.27 (–0.16, –0.25 –0.07 carbohydrate %WASO (–0.82%, –1.37% –0.26%) (–0.57%, –1.13% –0.01%) quartiles, while quartile (+0.62%, 0.06%-1.18%). Dietary fiber correlated SL. A ratio –0.02 (–0.19, –0.28 –0.10 quartiles; SL second (+1.03, 0.08-1.98 min) (+1.50, 0.53-2.47 (0.71%, 0.15%-1.28%). analysis, involving 6% changes proportions, showed that an elevated (+0.27, 0.18-0.35 h), monounsaturated a (+4.6, 1.93-7.34 larger (+2.2%, 0.63%-3.78%). reduced (–0.22, –0.39 –0.05 (–4.7, 6.58 –2.86 min), (+2.0%, –3.08% –0.92%). Conclusions TST, ratios WASO. Increasing place other nutrients higher improved

Language: Английский

---

The effects of waxy barley on defecation, sleep, mental health, and quality of life: A randomized double-blind parallel-group comparison study

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Background Dietary fiber (DF) is beneficial for preventing constipation, and the metabolites produced by gut microbiota fermentation are suggested to positively influence on depression sleep. Additionally, constipation has been reported affect mental health health-related quality of life (HRQoL). This study aimed increase DF intake examined its effects daily β-G consumption using two types waxy barley (WB), rich in with varying β-glucan (β-G) content. this WB defecation, sleep, health, HRQoL. Methods A randomized double-blind parallel-group comparison was conducted 68 young Japanese women, Kirarimochi (Group K) as common cultivar Fukumi Fiber F) high-β-G cultivar. Participants consumed rice four weeks, targeting 3 g/day (48 WB). We estimated including from records. Defecation evaluated through records Rome IV criteria-based surveys. Sleep, HRQoL were PSQI-J, J-PHQ-9, SF-36, respectively. Results Both groups about 40 WB. intakes 6.3 g/2.5 g Group K 10.7 g/4.3 F. Regarding both showed increases defecation days, frequency stool amount, no differences between groups. F a decrease (improvement) PSQI global score, improvements noted decreases (improvements) PHQ-9 showing improvement HRQoL, summary scores improvements: physical Conclusion To intake, cultivars effective; however, overall can potentially serve excellent sources DF. Effects may be expected not only but also below target g/day. Although high have more sleep additional studies required.

Language: Английский

---

Role of Fiber in Sports

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 91 - 146

Published: Feb. 28, 2025

This chapter examines dietary fiber's evolving role in sports nutrition, extending beyond digestive health to impact athletic performance, recovery, and overall wellness. Fiber enhances gut by fostering beneficial microbiota, improving nutrient absorption, reducing GI issues—vital for endurance strength athletes alike. It aids metabolic regulation stabilizing blood glucose insulin sensitivity, promoting sustained energy efficient recovery. also supports immunity, lowers inflammation, reduces exercise-induced oxidative stress, helping accelerate recovery ease muscle soreness. However, excessive fiber intake can cause discomfort, so tailored guidelines are provided optimizing across training phases. Specific fibers, including prebiotics, beta-glucans, resistant starches, discussed with strategies integrating fiber-rich foods supplements based on activity type, diet preferences, athlete needs.

Language: Английский

---

The effects of waxy barley on defecation, sleep, mental health, and quality of life: a randomized double-blind parallel-group comparison study

Journal of PHYSIOLOGICAL ANTHROPOLOGY, Journal Year: 2025, Volume and Issue: 44(1)

Published: May 7, 2025

Language: Английский

---

Gut Microbiota: Association with Fiber Intake, Ultra-Processed Food Consumption, Sex, Body Mass Index, and Socioeconomic Status in Medical Students

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4241 - 4241

Published: Dec. 9, 2024

The gut microbiota plays a vital role in various physical and physiological processes, including immune system regulation, neurotransmitter production, inflammatory response modulation, the inhibition of pathogenic organisms. An imbalance microbial community, known as dysbiosis, has been associated with numerous health issues. Biological influences, behaviors, socioeconomic determinants, nutritional status can disrupt this balance.

Language: Английский

---

Relationship between macronutrients, dietary components, and objective sleep variables measured by smartphone applications

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 26, 2024

Abstract Background Few studies have used daily data from objective applications to explore macronutrient interactions in sleep and nutrition research. Objective This cross-sectional study examined the relationships between macronutrients, dietary components, parameters, considering their interdependencies. Methods Data 4,825 users of apps for at least 7 days were analyzed. Multivariable regression analysis investigated associations quartiles macronutrients (protein, carbohydrate, total fat, including saturated, monounsaturated, polyunsaturated fats), components (sodium, potassium, fiber, sodium-to-potassium ratio), variables (total time [TST], latency [SL], % wakefulness after onset [%WASO]). Nutrients divided into quartiles, with lowest intake group as reference. Compositional accounted interdependencies among macronutrients. Analyses adjusted age, sex, body mass index (BMI). Results Higher protein was associated longer TST 3rd (B = 0.17, 95% CI 0.09, 0.26) 4th 0.18, 0.27). fat linked shorter -0.11, -0.20, -0.27) -0.16, -0.25, -0.07). carbohydrate %WASO -0.82, -1.37, -0.26) -0.57, -1.13, -0.01), while higher quartile 0.62, 0.06, 1.18). fiber consistently 0.11, 0.02, 0.19) 0.26), SL 2nd -1.71, -2.66, -0.76), -2.23, -3.19, -1.27), -2.30, -3.27, -1.33), -1.06, -1.61, -0.51), -1.04, -1.59, -0.48), -1.05, -0.48). A ratio -0.02) -0.19, -0.28, -0.10), 1.03, 0.08, 1.98) 1.50, 0.53, 2.47), 0.71, 0.15, 1.28). analysis, involving 6% changes proportions, showed correlated 0.27, 0.35), more monounsaturated fats 4.64, 1.93, 7.34) 2.21, 0.63, 3.78). -0.22, -0.39, -0.05), -4.72, -6.58, -2.86), -2.00, -3.08, -0.92). Conclusions These findings highlight intricate factors outcomes. Prospective are warranted determine whether interventions result positive

Language: Английский

---

Relationship Among Macronutrients, Dietary Components, and Objective Sleep Variables Measured by Smartphone Apps: Real-World Cross-Sectional Study (Preprint)

Published: July 25, 2024

Few studies have explored the relationship between macronutrient intake and sleep outcomes using daily data from mobile apps. This cross-sectional study aimed to examine associations macronutrients, dietary components, parameters, considering their interdependencies. We analyzed 4825 users of Pokémon Sleep Asken smartphone apps, each used for at least 7 days record objective parameters respectively. Multivariable regression quartiles macronutrients (protein; carbohydrate; total fat, including saturated, monounsaturated, polyunsaturated fats), components (sodium, potassium, fiber, sodium-to-potassium ratio), variables (total time [TST], latency [SL], percentage wakefulness after onset [%WASO]). The lowest group was reference. Compositional analysis accounted Models were adjusted age, sex, BMI. Greater protein associated with longer TST in third (+0.17, 95% CI 0.09-0.26 h) fourth (+0.18, 0.09-0.27 quartiles. In contrast, greater fat linked shorter (–0.11, –0.20 –0.27 (–0.16, –0.25 –0.07 carbohydrate %WASO (–0.82%, –1.37% –0.26%) (–0.57%, –1.13% –0.01%) quartiles, while quartile (+0.62%, 0.06%-1.18%). Dietary fiber correlated SL. A ratio –0.02 (–0.19, –0.28 –0.10 quartiles; SL second (+1.03, 0.08-1.98 min) (+1.50, 0.53-2.47 (0.71%, 0.15%-1.28%). analysis, involving 6% changes proportions, showed that an elevated (+0.27, 0.18-0.35 h), monounsaturated a (+4.6, 1.93-7.34 larger (+2.2%, 0.63%-3.78%). reduced (–0.22, –0.39 –0.05 (–4.7, 6.58 –2.86 min), (+2.0%, –3.08% –0.92%). TST, ratios WASO. Increasing place other nutrients higher improved

Language: Английский

---