Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 422 - 422

Published: Feb. 10, 2025

The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.

Language: Английский

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The gut microbiota in breast cancer development and treatment: The good, the bad, and the useful!

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: June 12, 2023

Regardless of the global progress in early diagnosis and novel therapeutic regimens, breast carcinoma poses a devastating threat, advances are somewhat marred by high mortality rates. Breast cancer risk prediction models based on known factors extremely useful, but large number cancers develop women with no/low risk. The gut microbiome exerts profound impact host health physiology has emerged as pivotal frontier pathogenesis. Progress metagenomic analysis enabled identification specific changes microbial signature. In this review, we discuss metabolomic associated initiation metastatic progression. We summarize bidirectional various cancer-related therapies microbiota vice-versa. Finally, strategies to modulate toward more favorable state that confers anticancer effects.

Language: Английский

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Intestinal Microbiota Influence Doxorubicin Responsiveness in Triple-Negative Breast Cancer

Cancers, Journal Year: 2022, Volume and Issue: 14(19), P. 4849 - 4849

Published: Oct. 4, 2022

Triple-negative breast cancer (TNBC) is highly aggressive with a poor 5-year survival rate. Targeted therapy options are limited and most TNBC patients treated chemotherapy. This study aimed to determine whether doxorubicin (Dox) shifts the gut microbiome populations influence chemotherapeutic responsiveness. Female BALB/c mice (n = 115) were injected 4T1-luciferase cells (a murine syngeneic model) Dox and/or antibiotics, high-fat diet-derived fecal microbiota transplant (HFD-FMT), or exogenous lipopolysaccharide (LPS). Metagenomic sequencing was performed on DNA samples. Mice that received stratified into responders nonresponders. from antibiotics + groups displayed reduced tumor weight metastatic burden. analysis showed associated increased Akkermansia muciniphila proportional abundance. Moreover, an elevated abundance of prior treatment. HFD-FMT potentiated growth decreased Indeed, lipopolysaccharide, structural component Gram-negative bacteria, in plasma nonresponders FMT mice. Treatment LPS increases intestinal inflammation, reduces responsiveness, lung metastasis. Taken together, we show modulating through HFD-FMT, by administering influenced chemotherapy metastasis, inflammation.

Language: Английский

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Examining the Mechanisms behind Exercise’s Multifaceted Impacts on Body Composition, Cognition, and the Gut Microbiome in Cancer Survivors: Exploring the Links to Oxidative Stress and Inflammation

Antioxidants, Journal Year: 2023, Volume and Issue: 12(7), P. 1423 - 1423

Published: July 14, 2023

This review focuses on the effects of exercise various health-related outcomes in cancer survivors, encompassing body composition, cognitive function (including sleep), and gut microbiome health. By analyzing multiple studies, we aimed to summarize existing evidence shed light underlying mechanisms. The findings strongly suggest that serves as a multifaceted non-pharmacological strategy, playing significant role improving overall health survivors by effectively reducing inflammation oxidative stress. Exercise plays crucial preventing muscle wasting, diminishing presence reactive oxygen species pro-inflammatory cytokines, enhancing antioxidant systems. Furthermore, displays notable benefits terms executive functioning fatigue alleviation, largely attributed its anti-inflammatory impact central nervous system ability induce neurogenesis via growth factors. Additionally, positively influences microbial diversity, reduces inflammation, enhances through gut-brain axis. Our key underscore reduction stress primary mechanisms which survivors. delving deeper into these candidate mechanisms, aim provide valuable guidance for future research interventions targeting symptoms experienced

Language: Английский

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Fecal Microbiota Transplantation, a tool to transfer healthy longevity

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 103, P. 102585 - 102585

Published: Nov. 23, 2024

The complex gut microbiome influences host aging and plays an important role in the manifestation of age-related diseases. Restoring a healthy via Fecal Microbiota Transplantation (FMT) is receiving extensive consideration to therapeutically transfer longevity. Herein, we comprehensively review benefits microbial rejuvenation - FMT promote aging, with few studies documenting life length properties. This explores how preconditioning donors standard lifestyle pharmacological antiaging interventions reshape microbiome, resulting being also FMT-transferable. Finally, expose current clinical uses context therapy address challenges regulatory landscape, protocol standardization, health risks that require refinement effectively utilize elderly.

Language: Английский

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A Bibliometric Analysis on the Research Trend of Exercise and the Gut Microbiome

Microorganisms, Journal Year: 2023, Volume and Issue: 11(4), P. 903 - 903

Published: March 30, 2023

This article aims to provide an overview of research hotspots and trends in exercise the gut microbiome, a field which has recently gained increasing attention. The relevant publications on microbiome were identified from Web Science Core Collection database. publication types limited articles reviews. VOSviewer 1.6.18 (Centre for Technology Studies, Leiden University, Leiden, Netherlands) R package “bibliometrix” (R Foundation: Vienna, Austria) used conduct bibliometric analysis. A total 327 eligible eventually identified, including 245 original 82 time trend analysis showed that number rapidly increased after 2014. leading countries/regions this USA, China, Europe. Most active institutions Europe USA. Keyword relationship between disease, occurs throughout development research. interactions microbiota, exercise, status host’s internal environment, probiotics, are important facets as well. topic evolution presents multidisciplinary multi-perspective comprehensive Exercise might become effective intervention disease treatment by regulating microbiome. innovation exercise-centered lifestyle therapy may significant future.

Language: Английский

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Prebiotics: Ignored player in the fight against cancer

Cancer Reports, Journal Year: 2023, Volume and Issue: 6(11)

Published: July 17, 2023

Abstract Background Prebiotics is a relatively neglected area in cancer research, despite evidence suggesting that it plays key role suppressing tumour growth and improving immune function. Recent Findings Including prebiotics the diet has been shown to strengthen system can better slow down or prevent of tumours. It also strongly indicated various scientific studies contribute sustenance healthy microbiome, which turn an important increasing effectiveness reducing side effects treatments. Conclusion In present review article we highlight mechanisms by like inulin, fructooligosaccharide (FOS), β‐glucan, pectin, xylooligosaccharide (XOS) Furthermore, beneficial effect incorporating during therapy improvise gut health prevent/reverse damage caused patients due chemotherapy elaborated.

Language: Английский

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The oncobiome; what, so what, now what?

Microbiome Research Reports, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 27, 2025

Microbial communities inhabiting various body sites play critical roles in the initiation, progression, and treatment of cancer. The gut microbiota, a highly diverse microbial ecosystem, interacts with immune cells to modulate inflammation surveillance, influencing cancer risk therapeutic outcomes. Local tissue microbiota may impact transition from premalignant states malignancy. Characterization intratumoral increasingly reveals distinct microbiomes that influence tumor growth, responses, efficacy. Various bacteria species have been reported therapies through mechanisms such as altering drug metabolism shaping microenvironment (TME). For instance, or bacterial enzymatic activity can convert prodrugs into active forms, enhancing effects or, conversely, inactivating small-molecule chemotherapeutics. Specific also linked improved responses immunotherapy, underscoring microbiome’s role Furthermore, unique signatures patients, compared healthy individuals, demonstrate diagnostic potential microbiota. Beyond gut, tumor-associated local affect therapy by inflammation, resistance. This review explores multifaceted relationships between cancer, focusing on their modulating TME, activation, members represents promising avenue for advancing precision oncology improving patient By leveraging biomarkers interventions, new strategies be developed optimize diagnosis treatment.

Language: Английский

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Anticancer Potential of Prebiotics: Targeting Estrogen Receptors and PI3K/AKT/mTOR in Breast Cancer

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 990 - 990

Published: April 18, 2025

Estrogen receptors (ERs) play a critical role in breast cancer (BC) development and progression, with ERα being oncogenic ERβ exhibiting tumor-suppressive properties. The interaction between ER signaling other molecular pathways, such as PI3K/AKT/mTOR, influences tumor growth endocrine resistance. Emerging research highlights the of prebiotics modulating gut microbiota, which may influence estrogen metabolism, immune function, therapeutic responses BC. This review explores impact on receptor modulation, microbiota composition, regulation, metabolic pathways cancer. potential adjunctive therapies to enhance treatment efficacy mitigate chemotherapy-related side effects is discussed. A comprehensive analysis recent preclinical clinical studies was conducted, examining reprogramming short-chain fatty acids (SCFAs) derived from prebiotic fermentation epigenetic regulation resistance also evaluated. Prebiotics were found modulate microbiota-estrogen axis, reduce inflammation, responses. SCFAs demonstrated selective downregulation reprogramming, suppressing growth. Synbiotic interventions effects, improving quality life patients. offer promising avenue for prevention therapy by pathways. Future trials are needed validate their treatments management.

Language: Английский

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Fecal microbiome transfer an investigative tool and treatment strategy in cancer

AJP Gastrointestinal and Liver Physiology, Journal Year: 2024, Volume and Issue: 327(5), P. G711 - G726

Published: Oct. 8, 2024

The microbiome impacts the onset, progression, and therapy response of certain types cancer. Fecal microbial transplants (FMTs) are an increasingly prevalent tool to test these mechanisms that require standardization by field.

Language: Английский

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