Periodontal tissue susceptibility to glycaemic control in type 2 diabetes

Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: 26(10), P. 4684 - 4693

Published: Aug. 14, 2024

Abstract Aim To assess the direct effect of intensive glycaemic control on periodontal tissues in patients with diabetes mellitus. Materials and Methods Twenty‐nine type 2 were enrolled hospitalized to receive a 2‐week regimen. We observed analysed systemic oral disease indicators before after treatment clarified related inflammation. Results A significant reduction parameters, including glycated albumin levels inflamed surface area (PISA), was treatment. The changes PISA per tooth, indicative healing, exhibited bimodal distribution; divided into two groups this basis. Correlations between tooth fasting plasma glucose, acetoacetic acid, beta‐hydroxybutyrate PISA‐improved group. Significantly lower C‐peptide, coefficient variation R‐R interval, ankle‐brachial pressure index non‐improved Conclusions Glycaemic can effectively improve periodontitis diabetes, even absence specific treatments. However, responsiveness depends condition patient.

Language: Английский

---

The Relationship Between Vitamin D, Cardiovascular Health, and Periodontitis in US Adults

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Background Vitamin D deficiency is a prevalent public health issue, and serum vitamin concentrations are linked to the risk of periodontitis. This study aims investigate relationship between these two variables determine whether this association influenced by various factors, particularly focusing on mediating effect cardiovascular (CVH). Methods Data was extracted from National Health Nutrition Examination Survey (NHANES) database for years 2009–2014 in cross-sectional study. The periodontitis examined using univariate multivariate logistic regression analyses, as well restricted cubic spline models. Additionally, subgroup analyses splines were employed assess effects glucose tolerance status, age, gender, smoking alcohol consumption association. Mediation analysis conducted explore LE8 scores serve mediator Results Among 12,714 adults, 4,522 (35.5%) diagnosed with periodontitis, proportions Mild, Moderate, Severe Chronic Periodontitis being 279 (2.2%), 3,438 (27.0%), 805 (6.3%), respectively. After fully adjusting confounding negative associations observed levels Quartile comparisons indicated Q2: 0.91 (0.82 ~ 1.00), Q3: 0.88 (0.79 0.99), Q4: 0.89 (0.78 1.01). In significantly associated across strata, including sex, status. Interaction revealed that age utilizing Life's Essential 8 (LE8) assessed (CVH), demonstrating score factor mediated mediation 8.71% 7.11%, Conclusion We concluded increased decreased demonstrated critical highlighted intricate interplay among D, providing insights into potential avenues intervention management.

Language: Английский

---

Associations Between Lifestyle Factors, Oral Health Behaviors, and Glycemic Control in Type 2 Diabetic Patients

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 450 - 450

Published: Jan. 12, 2025

Introduction: T2DM mellitus (T2DM) is a major global health issue associated with significant morbidity, mortality, and economic burden. While the role of lifestyle factors in glycemic control well-established, influence oral behaviors remains underexplored. Objective: This study aimed to investigate interplay between habits, behaviors, patients T2DM. Methodology: A cross-sectional was conducted on 132 (66 men 66 women) at Pius Brînzeu Emergency Hospital Timișoara, Romania. Data smoking, physical activity, alcohol consumption, tooth brushing frequency, dental visits were collected using structured questionnaires, assessed through HbA1c measurements. Statistical analyses, including Pearson correlations linear regression, performed. Results: Among men, levels negatively exercise frequency (ß = −0.26, p < 0.05) education level (correlation coefficient −0.27, 0.05), positively 0.26, 0.05). In combined analysis, correlated both 0.24, 0.01) consumption 0.22, Conclusions: These findings underscore importance integrating interventions into diabetes management optimize patient outcomes.

Language: Английский

---

Comparative Assessment of Antibiotics and Probiotics: Adjuvants in Nonsurgical Periodontal Treatment for Smokers With Generalized Periodontitis

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Introduction Humankind is suffering from the misuse and overuse of antibiotics, leading to antibiotic resistance. At this point, probiotics, if found effective, can lead a better future. Probiotics are nothing but colony living-friendly bacteria. Lactobacillus reuteri essential for use as probiotic among many healthy This study aims compare effectiveness probiotics in periodontal treatment. Methods One hundred smokers diagnosed with chronic generalized periodontitis were randomly assigned into two groups. Group A received seven-day course amoxicillin 500 mg three day metronidazole twice daily, followed by 30 days while B placebo seven L. (2×10⁸ CFU daily). Periodontal parameters, including plaque index (PI), gingival (GI), probing depth (PD), attachment loss (AL), bleeding on (BOP), utilized asses at baseline, month one, one. Baseline differences adjusted using estimating equation (GEE) model. Results three, (probiotics) showed significantly lower PI (0.52±0.49 vs. 0.88±0.52, p<0.001) 23% greater reduction PD (p=0.004) compared (antibiotics + probiotics). These findings highlight alone improving health smokers. Conclusions Both groups equal health. Hence, should be preferred over antibiotics.

Language: Английский

---

New Insights in Natural Bioactive Compounds for Periodontal Disease: Advanced Molecular Mechanisms and Therapeutic Potential

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 807 - 807

Published: Feb. 10, 2025

Periodontal disease is a chronic inflammatory condition that destroys the tooth-supporting structures due to host's immune response microbial biofilms. Traditional periodontal treatments, such as scaling and root planing, pharmacological interventions, surgical procedures, have significant limitations, including difficulty accessing deep pockets, biofilm recolonization, development of antibiotic resistance. In light these challenges, natural bioactive compounds derived from plants, herbs, other sources offer promising alternative their anti-inflammatory, antioxidant, antimicrobial, tissue-regenerative properties. This review focuses on molecular mechanisms through which compounds, curcumin, resveratrol, epigallocatechin gallate (EGCG), baicalin, carvacrol, berberine, essential oils, Gum Arabic, exert therapeutic effects in disease. Bioactive inhibit critical pathways like NF-κB, JAK/STAT, MAPK while activating protective Nrf2/ARE, reducing cytokine production oxidative stress. They also activity matrix metalloproteinases (MMPs), preventing tissue degradation promoting healing. addition, demonstrated potential disrupt bacterial biofilms by interfering with quorum sensing, targeting cell membranes, enhancing efficacy.Bioactive modulate system shifting balance pro-inflammatory anti-inflammatory responses efferocytosis, helps resolve inflammation supports regeneration. However, despite challenges related poor bioavailability, stability oral cavity, absence large-scale clinical trials need be addressed. Future strategies should prioritize advanced delivery systems nanoparticles hydrogels enhance bioavailability sustain release, alongside long-term studies assess human populations. Furthermore, combining traditional treatments could provide synergistic benefits managing aims explore disease, emphasizing action offering insights into integration conventional therapies for more comprehensive approach health.

Language: Английский

---

An Artificial Intelligence-Based Fuzzy Logic System for Periodontitis Risk Assessment in Patients with Type 2 Diabetes Mellitus

Bioengineering, Journal Year: 2025, Volume and Issue: 12(3), P. 211 - 211

Published: Feb. 20, 2025

Background: Since periodontitis prevalence has increased globally and there is a bidirectional relationship between diabetes mellitus (DM), new methods of preventing screening involving DM biomarkers could impact management. We aimed to develop fuzzy system estimate the risk in patients with DM. Methods: Body mass index (BMI), glycemia (G), total cholesterol (C), triglyceride (T) measurements were collected from 87 diagnosed Oral examinations performed, number periodontal pockets (nrPPs) was determined. A developed: BMI G as inputs resulted Periodontitis Risk 1 (PRisk1) output; C T 2 (PRisk2) output. From PRisk1 PRisk2, cumulative (PCRisk) assessed. Linguistic terms linguistic grades (very small, medium, big, very big) assigned numerical variables by using 25 different membership functions. PCRisk nrPP values statistically processed. Results: In our developed system, BMI, G, C, input data estimation. correlated nrPP: when 1.881 units, unit. The logic-based effectively estimated type patients, showing significant correlation pockets. These findings highlight its potential for early diagnosis improved interdisciplinary care.

Language: Английский

---

Expression of MMP-14 and CD147 in Gingival Tissue of Patients With and Without Diabetes Mellitus Type II

Diagnostics, Journal Year: 2025, Volume and Issue: 15(5), P. 609 - 609

Published: March 3, 2025

Background: Diabetes mellitus (DM) is a major risk factor for the development of periodontal disease and aggravates severity conditions. Matrix metalloproteinases (MMPs) are known to degrade ligament attachment bone matrix proteins. Increased expression CD147 associated with increased synthesis several MMPs, being modulator MMP expression, including that MMP-14. The purpose this study was quantify compare expressions MMP-14 in gingival tissues patients without type 2 diabetes mellitus. Material Methods: In histological study, we included 33 subjects disease: 16 DM (test group) 17 systemically healthy (control group). Tissue fragments were processed using an immunohistochemistry technique determine immunoreactivity (IR) intensity CD147. Results: group periodontitis, 56.2% showed weak positive (+), while 43.8% had intensely (+++) Statistically significant differences between test control groups (p = 0.004, p 0.883, 0.002) found membranous IR moderate (++) CD 147, (+++). 0.001, 0.002, 0.003) Conclusions: significantly higher 147 demonstrates role these biomarkers pathology patients. It can be assumed could further investigated as potential predictive biomarkers.

Language: Английский

---

Development of a Machine Learning Tool for Home-Based Assessment of Periodontitis

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Abstract According to an ADA report, approximately 15% of the US population requires dental care annually but does not receive it. Access care, particularly for periodontal examinations, is challenging many individuals, leading uncontrolled periodontitis progression and systemic health complications. Periodontitis, inflammatory gum disease, affects nearly half American adults over 30. Current diagnostic approaches rely on exams radiographs, requiring clinical settings experienced providers. However, individuals lack access making it difficult obtain up-to-date probing depth, X-rays or CT scans. To address this gap, we developed a machine learning (ML) tool at-home preliminary assessments. This would benefit unaware their undiagnosed conditions those with limited empowering them prioritize seek timely treatment within constraints. Our leverages NHANES database train ML model multimodal features relevant that are radiographic-independent. We labeled different severity based charting records performed feature engineering dataset. first baseline subsequently trained additional classifiers, conducting comprehensive hyperparameter search resulted in consistent performance. The best-performing was evaluated test set, achieving overall precision 0.80 AUC 0.81, demonstrating robust classification performance without overfitting. Feature importance analysis provided guidance questionnaire design real-world application tool. Additionally, our novel approach analyzing misclassified populations offered insights data interpretation, supported improvement, revealed deeper correlations between its risk factors. exemplifies capacity leverage extensive public databases evaluations. Ultimately, ML-driven aims overcome existing barriers by providing users predictions personalized suggestions, all easily accessible from smartphones laptops at home. One sentence summary In study, machine-learning home-based screening demonstrated non-radiographic data—encompassing demographic nutrition information, as well medical oral conditions—possesses strong predictive power periodontitis, properly identify status promote intervention.

Language: Английский

---

Smile-Powered Fitness: Integrating innovative dental care and prosthetics into sports and physical health education programs

Salud Ciencia y Tecnología, Journal Year: 2025, Volume and Issue: 5, P. 1501 - 1501

Published: March 5, 2025

Introduction: The role of dental health in enhancing athletic performance and overall well-being remains underexplored, despite its significant impact on systemic health.This study aims to examine how innovative care prosthetics can be integrated into sports physical education programs optimize promote lifelong wellness.Methods: We conducted a systematic review using PRISMA methodology 58 articles; 20 peer-reviewed articles published between 2014 2024 were utilized. selected literature explored interdisciplinary approaches oral sports, emphasizing preventive care, injury management, interprofessional collaboration.Results: Findings highlight growing recognition the correlation outcomes. Poor conditions, such as caries periodontal disease, linked reduced stamina, slower recovery, heightened risks. Innovative incorporating regular check-ups, customized mouthguards, showed measurable benefits, including 65% improvement 30% reduction sports-related injuries. Educational initiatives enhanced participants’ knowledge retention by 85% improved hygiene practices 70%. also looked at different ways integrate like mobile clinics partnerships dentists coaches.Conclusions: This research underscores need for collaboration strategies embed curricula. By fostering culture proactive institutions enhance contribute public advancements. Future should address gaps empirical evidence provide solutions diverse populations.

Language: Английский

---

Shedding Light on the Therapeutic Efficiency of Oxygen-Releasing Gel and Photodynamic Therapy as Adjuvants in the Treatment of Experimental Periodontitis

Photobiomodulation Photomedicine and Laser Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Objectives: We aimed to compare the effectiveness of oxygen-releasing gel (Blue®M [BM]) alone or associated with photodynamic therapy (PDT), after scaling and root planing (SRP), as adjuvants during treatment ligature-induced experimental periodontitis (EP).

Language: Английский

---