Journal of the Korean Physical Society, Journal Year: 2024, Volume and Issue: 84(5), P. 394 - 401
Published: Jan. 26, 2024
Language: Английский
Current Obesity Reports, Journal Year: 2024, Volume and Issue: 13(3), P. 510 - 531
Published: May 29, 2024
The prevalence of non-alcoholic fatty liver disease (NAFLD) is rapidly increasing worldwide, making it the leading cause related morbidity and mortality. Currently, biopsy gold standard for assessing individuals with steatohepatitis fibrosis. However, its invasiveness, sampling variability, impracticality large-scale screening has driven search non-invasive methods early diagnosis staging. In this review, we comprehensively summarise evidence on diagnostic performance limitations existing serum biomarkers scores in evaluation steatosis, steatohepatitis,
Language: Английский
Citations
37
Engineering Science & Technology Journal, Journal Year: 2023, Volume and Issue: 4(6), P. 381 - 400
Published: Dec. 7, 2023
The healthcare landscape in the United States is undergoing a transformative evolution fueled by rapid engineering innovations. This study synthesizes and examines key developments at intersection of healthcare, emphasizing advancements that have significantly impacted medical practices, patient outcomes, overall ecosystem. outlines notable applications, including imaging technologies, biomedical devices, telehealth solutions, health information systems. It explores integration artificial intelligence machine learning engineering, their role diagnostics, personalized medicine, treatment optimization. Additionally, abstract discusses implications innovations on accessibility, cost-effectiveness, potential to address emerging challenges. Through comprehensive examination USA, this provides insights into multifaceted shaping present future delivery. Keywords: Engineering Innovations, Healthcare, Review, Public Health, Development
Language: Английский
Citations
30
Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3061 - 3061
Published: Sept. 11, 2024
Metabolic dysfunction-associated steatotic liver disorder (MASLD) is increasingly prevalent globally, highlighting the need for preventive strategies and early interventions. This comprehensive review explores potential of health functional foods (HFFs) to maintain healthy function prevent MASLD through an integrative analysis network pharmacology, gut microbiota, multi-omics approaches. We first examined biomarkers associated with MASLD, emphasizing complex interplay genetic, environmental, lifestyle factors. then applied pharmacology identify food components beneficial effects on metabolic function, elucidating their action mechanisms. identifies evaluates halting or reversing development disease in stages, as well that can evaluate success failure such strategies. The crucial role microbiota its metabolites prevention homeostasis discussed. also cover state-of-the-art omics approaches, including transcriptomics, metabolomics, integrated analyses, research preventing MASLD. These advanced technologies provide deeper insights into physiological mechanisms HFF development. concludes by proposing approach developing HFFs targeting prevention, considering Korean regulatory framework. outline future directions bridge gap between basic science practical applications narrative provides a foundation researchers industry professionals interested support health. Emphasis placed maintaining balance focusing early-stage intervention
Language: Английский
Citations
11
European Journal of Internal Medicine, Journal Year: 2024, Volume and Issue: 125, P. 57 - 66
Published: March 14, 2024
Language: Английский
Citations
10
BMC Medical Imaging, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 20, 2025
The purpose of our study was to investigate the association between non-alcoholic fatty liver disease (NAFLD) and abdominal aortic aneurysms (AAA) progression using non-enhanced computed tomography (CT) CT angiography (CTA). Patients with AAA age- sex-matched healthy subjects who underwent CTA examination January 2015 2023 from four hospitals were retrospectively analyzed. divided into (growth rate > 10 mL/year) non-progression groups, as well those NAFLD without NAFLD, based on results. Kaplan-Meier Cox regression used progression. A total 151 patients (mean age: 69.1 ± 10.5 years old, 133 men) included, among which 66 (43.7%) had NAFLD. During a median 10.7 months (6.0–76.0 months), 57 (37.7%) prevalence significantly higher in group compared control (43.7% vs. 31.1%, p = 0.024). Multivariable analysis revealed that independently associated (HR, 4.28; 95% CI, 2.20–8.31; < 0.001). area under curve combined maximal diameter 0.857 for predicting is an independent predictor It can improve diagnostic efficacy aneurysms. Not applicable. This research retrospective analysis.
Language: Английский
Citations
1
Expert Opinion on Pharmacotherapy, Journal Year: 2024, Volume and Issue: 25(3), P. 223 - 232
Published: Feb. 11, 2024
Introduction Nonalcoholic fatty liver disease (NAFLD) is the most common hepatic affecting almost 30% of world population. Approximately 25% people with NAFLD develop nonalcoholic steatohepatitis (NASH), fulminant version disease. Diabetes mellitus present in 22.5% and 44.60% individuals NASH. This review was undertaken to examine current contribution glucagon-like peptide 1 (GLP-1) receptor agonists pharmacotherapy diabetic steatohepatitis.
Language: Английский
Citations
5
Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11
Published: Jan. 7, 2025
To explore the connection between metabolic parameters and severity of hepatic steatosis determined through ultrasound in elderly individuals with dysfunction-associated fatty liver disease (MAFLD). 4,663 senior who were 65 years age or older included this research. They examined physically at Ninghai Street Community Health Service Center Yantai City June 7, 2021, October 15, 2021. There two categories identified: MAFLD group (n = 2,985) non-MAFLD 1,678). Based on ultrasonography results, further separated into three groups: mild 2,104), moderate 766), severe 115). identify indicators risk for steatosis, data was contrasted groups employing logistic regression. In comparison to group, showed significantly elevated levels body mass index (BMI), blood pressure, gender, age, lipid profile, alanine transaminase (ALT), fasting glucose (FBG; p < 0.05). Among MAFLD, there a positive correlation BMI, FBG, ALT, aspartate (AST) (p Logistic regression analysis indicated that female triglycerides (TG), serum uric acid (SUA) constituted factors increased MAFLD. The patients is correlated TG, SUA.
Language: Английский
Citations
0
Diagnostics, Journal Year: 2023, Volume and Issue: 13(16), P. 2631 - 2631
Published: Aug. 9, 2023
For many years, we have faced the complications of viral hepatitis and alcohol-related liver diseases such as cirrhosis, decompensation, portal hypertension, hepatocellular carcinoma (HCC). Recently, seen a dynamic change in field hepatology. With significant achievements eradicating C virus by direct-acting antiviral agents rising epidemic obesity, diabetes mellitus, metabolic syndrome, there is paradigm shift leading cause cirrhosis cancer to nonalcoholic fatty disease (NAFLD). Current data highlight rapidly incidence NAFLD-related HCC worldwide expose unseen part iceberg. In this review, aim update knowledge about pathogenesis NAFLD-induced HCC, surveillance difficulties, promising markers. Molecular biomarkers, for example, may become cornerstone risk-stratified surveillance, early detection, treatment selection HCC. Physicians can offer personalized tailor-made clinical decisions unique patient subgroup.
Language: Английский
Citations
10
Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)
Published: March 27, 2025
Several anthropometric indices, such as body mass index and waist circumference, have been used clinical screening tools for the prediction of nonalcoholic fatty liver disease (NAFLD). To further refine these NAFLD, roundness (BRI) has recently evaluated. In this systematic review meta-analysis, objective was to evaluate relationship predictive capability BRI in identifying NAFLD. A comprehensive search conducted PubMed, Embase, Web Science, Scopus up December 31, 2024. Eligibility criteria included observational studies on adults (≥ 18 years old) with measured its association The Joanna Briggs Institute tool risk bias assessment. Meta-analyses random-effects models pool data mean difference, odds ratio, sensitivity, specificity, area under curve (AUC), heterogeneity publication assessed. Ten involving 59,466 participants were included. pooled difference between NAFLD non-NAFLD groups 1.73 (95% confidence interval [CI]: 1.31–2.15). sensitivity specificity diagnosing 0.806 0.692, respectively. AUC 0.803 CI: 0.775–0.830), indicating good diagnostic accuracy. Unlike subgroup analysis by country, sex showed no significant differences. Higher values associated increased (pooled OR = 2.87, 95% 1.39; 5.96). Studies provided mixed results ability compared other indices like index, mostly favoring over conventional indices. demonstrates a performance suggesting it may be valuable Further research is necessary validate findings strengthen evidence base.
Language: Английский
Citations
0
Clinical Gastroenterology and Hepatology, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Citations
0