Advanced Amperometric Microsensors for the Electrochemical Quantification of Quercetin in Ginkgo biloba Essential Oil from Regenerative Farming Practices DOI Creative Commons

Elena Oancea,

Ioana Adina Tula,

Gabriela Stanciu

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 15(1), P. 6 - 6

Published: Dec. 31, 2024

In this study, we present a novel approach using amperometric microsensors to detect quercetin in cosmetic formulations and track its metabolic behavior after topical application. This method offers sensitive, real-time alternative conventional techniques, enabling the detection of quercetin’s bioavailability, transformation into active metabolites, potential therapeutic effects when applied skin. Quercetin (Q) is bioactive flavonoid known for potent antioxidant properties, naturally numerous plants, particularly those with applications formulations. response growing interest developing plant-based dermo-cosmetic solutions, study investigates electrochemical quercetin, ketone-type flavonoid, extracted from Gingko biloba essential oil. Three newly designed were developed assess their efficacy detecting botanical samples. The sensor configurations utilized two forms carbon material as foundation: graphite (G) nanoparticles (CNs). These base materials modified paraffin oil, chitosan (CHIT), cobalt(II) tetraphenylporphyrin (Co(II)TPP) enhance sensitivity. Differential pulse voltammetry (DPV) served analytical investigation. Among sensors, CHIT/G–CN microsensor exhibited highest sensitivity, limit 1.22 × 10−7 mol L−1, followed by G–CN (5.64 10−8 L−1) Co(II)TPP/G–CN (9.80 microsensors. minimum detectable concentration was observed CoP/G–CN microsensors, achieving threshold low 0.0001 μmol L−1. Recovery rates relative standard deviation (RSD) values averaged 97.4% ± 0.43, underscoring sensors’ reliability matrices.

Language: Английский

Natural acetylcholinesterase inhibitors: A multi-targeted therapeutic potential in Alzheimer's disease DOI Creative Commons
Gajendra Kumar,

G. Pratap,

D Poornima

et al.

European Journal of Medicinal Chemistry Reports, Journal Year: 2024, Volume and Issue: 11, P. 100154 - 100154

Published: April 7, 2024

Alzheimer's disease (AD), the main dementia type accounting for over 70 % of entire population, progressive decline in memory and executive function. AD pathology is characterized by amyloid fibrils neurofibrillary tangles. Acetylcholinesterase (AChE), an enzyme involved hydrolysis neurotransmitter acetylcholine, consistently colocalizes with deposits characteristic may contribute to generation proteins. AChE a potent amyloid-promoting factor when compared other c-associated inhibitors play vital role prevent formation toxic oligomeric form peptide. Recent studies have reported that acetylcholinesterase (ChE-Is) are present plants, fungi, marine products. Some cholinesterase inhibitors, obtained from plant source such as rivastigmine, donepezil, galantamine, used treatment AD, offer alternative approach alleviate its symptoms reducing Aβ. Due limited efficacy current drugs there huge potential phytomedicines AD. Medicinal herbs herbal drug preparations traditionally been treat neurological disorders exhibiting anti-inflammatory neuroprotective properties. Phytomedicines containing flavonoids, polyphenols, naturally occurring antioxidants crosses blood-brain barrier protect neurons oxidative stress. As synthetic drugs, fewer side effects. Therefore, recent research focused explore develop it effective In our review, we summarized amyloid-deposition, Acetylcholinesterase, phytoconstituents inhibitory activity treatment.

Language: Английский

Citations

22
Recent Developments in Nanoparticle Formulations for Resveratrol Encapsulation as an Anticancer Agent DOI Creative Commons
Muhammad Ali, Viviana Benfante, Domenico Di Raimondo

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(1), P. 126 - 126

Published: Jan. 18, 2024

Resveratrol is a polyphenolic compound that has gained considerable attention in the past decade due to its multifaceted therapeutic potential, including anti-inflammatory and anticancer properties. However, efficacy impeded by low water solubility, dose-limiting toxicity, bioavailability, rapid hepatic metabolism. To overcome these hurdles, various nanoparticles such as organic inorganic nanoparticles, liposomes, polymeric dendrimers, solid lipid gold zinc oxide zeolitic imidazolate frameworks, carbon nanotubes, bioactive glass mesoporous were employed deliver resveratrol, enhancing against types of cancer. Resveratrol-loaded nanoparticle or resveratrol-conjugated administration exhibits excellent potency compared free resveratrol. This review highlights latest developments nanoparticle-based delivery systems for focusing on potential limitations associated with compound’s bioavailability effectiveness.

Language: Английский

Citations

21
Exosome-Based Macromolecular neurotherapeutic drug delivery approaches in overcoming the Blood-Brain barrier for treating brain disorders DOI
Krishna Yadav,

R. Vijayalakshmi,

Kantrol Kumar Sahu

et al.

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 199, P. 114298 - 114298

Published: April 18, 2024

Language: Английский

Citations

12
Vitamin C and/or garlic can antagonize the toxic effects of cadmium on growth performance, hematological, and immunological parameters of growing Japanese quail DOI Creative Commons

Waleed M. Dosoky,

Soha A. Farag,

Areej A. Almuraee

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(3), P. 103457 - 103457

Published: Jan. 11, 2024

This study used 300 one-day-old, sexless, developing chicks of Japanese quail to estimate the ability vitamin C and/or garlic antagonize venomous influence cadmium (Cd) on hematological, immunological, and performance characteristics quail. The was separated into five similar groups 60 apiece, six duplicates (10 each) were given each sub-group. control group received a basal diet without any supplements. Cd nourished with + 80 mg chloride (CdCl2)/kg diet. 3rd fed CdCl2 /kg complemented 200 Vitamin (Cd+ C)/kg 4th by 500 dried powder G)/kg 5th diet, CG)/kg Results showed that in which added together Vit garlic, there an improvement both live weight gain (1-42 days) feed consumption (1-21 & 1-42 compared alone. addition alone seems completely improve cadmium-related increase alkaline phosphatase (ALP), Aspartate aminotransferase (AST) Malondialdehyde (MDA) levels when control. Compared cadmium-polluted diets, got additives significantly reduced residue. In addition, group's serum immunoglobulin M (IgM) level decreased significantly. These data imply dietary supplementation (C) or (G) may be beneficial retrogressing drop G (IgG) IgM caused minimizing Cd's deleterious immunity.

Language: Английский

Citations

11
Current Progress on Central Cholinergic Receptors as Therapeutic Targets for Alzheimer's Disease DOI

Kushagra Nagori,

Madhulika Pradhan, Mukesh Kumar Sharma

et al.

Current Alzheimer Research, Journal Year: 2024, Volume and Issue: 21(1), P. 50 - 68

Published: Jan. 1, 2024

Acetylcholine (ACh) is ubiquitously present in the nervous system and has been involved regulation of various brain functions. By modulating synaptic transmission promoting plasticity, particularly hippocampus cortex, ACh plays a pivotal role learning memory. These procognitive actions are mediated by neuronal muscarinic nicotinic cholinergic receptors. The impairment leads to cognitive decline associated with aging dementia. Therefore, prime focus when concerned Alzheimer's disease (AD), most common cause In AD, extensive destruction neurons occurs amyloid-β plaques tau protein-rich neurofibrillary tangles. Amyloid-β also blocks receptors obstructs signaling. This makes central an important target for development drugs AD. fact, centrally acting cholinesterase inhibitors like donepezil rivastigmine approved treatment although outcome not satisfactory. identification specific subtypes pathogenesis AD essential develop future drugs. Also, endogenous rescue mechanisms can pave way new drug development. this article, we discussed neuroanatomy system. Further, cognition pathophysiology described detail. article reviewed primary neurotransmitters that regulate processes basal forebrain projection neurons.

Language: Английский

Citations

9
Nano revolution of DNA nanostructures redefining cancer therapeutics—A comprehensive review DOI
Krishna Yadav, S. Princely, Kantrol Kumar Sahu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 274, P. 133244 - 133244

Published: June 18, 2024

Language: Английский

Citations

5
Integration of Phytochemical Profiling and Computational Approaches to Evaluate the Neuroprotective Potential of Nardostachys jatamansi in Alzheimer's Disease DOI Creative Commons

Abdul Jalil Shah,

Mohammad Younis Dar,

Mohd Adnan

et al.

Biotechnology Reports, Journal Year: 2025, Volume and Issue: 45, P. e00881 - e00881

Published: Feb. 8, 2025

Despite broad spectrum utility of Nardostachys jatamansi (D. Don) DC, little is known about the molecular processes that underlie its anti-Alzheimer action. To investigate targets and therapeutic potential N. for Alzheimer's disease (AD), we used Gas Chromatography-Mass Spectrometry (GC-MS), ADMET analysis, network pharmacology, differential gene expression docking, dynamics (MD) simulations. The STITCH database was creation protein-protein interaction while Cytoscape visualization Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment Gene Ontology (GO) term enrichment. Additionally, to intermolecular interactions between active chemicals target proteins, docking experiments were conducted using Blind on Achilles server. stability PS1 complex with Spirojatamol, further evaluated MD With Spirojatamol showing highest binding energy scores against (-6.9 kcal/mol), confirmed activity this metabolite AD formed a stable at 100 nanoseconds, according additional investigation Significant ligand-protein verified by free calculations MM/GBSA technique. PS1-Spirojatamol had ΔG: -36.95 ± 5.00 kcal/mol. By focusing several genes pathways, involved in AD, work reveals underpinnings behind possible use treatment AD.

Language: Английский

Citations

0
Alzheimer’s Disease: A Study on Natural and Herbal Treatment DOI
Pramod S. Salve,

Aditya Ashok Pohankar,

S. George

et al.

Research Journal of Pharmacy and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 898 - 906

Published: Feb. 27, 2025

Alzheimer’s disease (AD) is an illness that give rise to the degeneration of neurons. It termed after Dr. Alois Alzheimer and expressed by memory impairment cognitive dysfunction. Major challenges conventional therapies were barriers like blood-brain barrier (BBB) blood-cerebrospinal fluid (BCSFB). Cerebrospinal (CSF) generated specialised ependymal cells in choroid plexus (CP) create blood-CSF There are tight junctions BBB limits paracellular diffusion solutes. Moreover, drugs Acetylcholine (AChE) inhibitors Tacrine, Donepezil, Galantine, Rivastigmine N-Methyl-D-Aspartate (NMDA) antagonist Memantine have gastrointestinal effects such as nausea, vomiting, diarrhoea other common adverse effects. NMDA receptor-mediated excitatory glutamatergic neurotransmission essential for neuronal survival synaptic development. On hand, increased NMDAR activity increases cell death excitotoxicity, which may be a contributing factor neurodegeneration associated with Alzheimer's (AD). The ever-increasing statistics AD stating up 1 crore cases annually all over world its risk factors caused need preventive measures safe methods treat disease. involvement free radicals inflammation aetiology suggests antioxidant anti-inflammatory medicines might therapeutic role. Herbal medications, based on richness traditional knowledge, useful because they can address pathogenesis at numerous places, including cellular molecular levels. has been postulated exert their protective benefits against through generic activities, well particular actions AChE, β-amyloid fibril production tau aggregation. This review discusses various natural herbal alternatives Melissa officinalis, Evolvus alsinoides, Bacopa monnieri, Celastrus paniculatus, Centella asiatica, etc. prepared using nanotechnologies (liposomes, niosome, phytosomes, solid lipid nanoparticle) found show rapid efficient absorption. makes it promising plan future aspects upcoming improvements posing least toxicity harm human health.

Language: Английский

Citations

0
The pathophysiological signaling and efficacy of medicinal herbal compounds in Alzheimer’s disease DOI Creative Commons
Shahram Darabi, Armin Ariaei, Enam Alhagh Charkhat Gorgich

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 29(1), P. 3 - 24

Published: March 1, 2025

Language: Английский

Citations

0
Promising Strategies to Reduce the SARS-CoV-2 Amyloid Deposition in the Brain and Prevent COVID-19-Exacerbated Dementia and Alzheimer’s Disease DOI Creative Commons
Nikita Navolokin,

Viktoria Adushkina,

Daria Zlatogorskaya

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 788 - 788

Published: June 16, 2024

The COVID-19 pandemic, caused by infection with the SARS-CoV-2 virus, is associated cognitive impairment and Alzheimer’s disease (AD) progression. Once it enters brain, virus stimulates accumulation of amyloids in brain that are highly toxic to neural cells. These may trigger neurological symptoms COVID-19. meningeal lymphatic vessels (MLVs) play an important role removal toxins mediate viral drainage from brain. MLVs considered a promising target prevent COVID-19-exacerbated dementia. However, there limited methods for augmentation MLV function. This review highlights new discoveries field COVID-19-mediated amyloid development strategies stimulate clearance through other pathways. based on innovative treating dysfunction induced infection, including use photobiomodulation, plasmalogens, medicinal herbs, which offer hope addressing challenges posed virus.

Language: Английский

Citations

3